THE chemistry of nitronic esters remains relatively unknown due to their conspicuous feature ofinstability. In the preceding papers, we described the late progress in the researchof nitronic esters: (i) nitronic ester...THE chemistry of nitronic esters remains relatively unknown due to their conspicuous feature ofinstability. In the preceding papers, we described the late progress in the researchof nitronic esters: (i) nitronic esters were first synthesized via O-alkylation of the alkali met-展开更多
A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp*Ir complex[Cp*Ir(2,20-bpyO)(OH)]Na with a bipyridine-based functional ligand.In particular,H_(2)O was selected as...A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp*Ir complex[Cp*Ir(2,20-bpyO)(OH)]Na with a bipyridine-based functional ligand.In particular,H_(2)O was selected as the solvent instead of the organic solvent in this catalytic system.Through mild reaction conditions gave a variety of corresponding alkylated heterocyclic compounds with good to excellent yields.More importantly,the gramscale C-alkylation reaction was successfully carried out with good yield using a common route with only a single purification by column chromatography.展开更多
C-Alkyl glycosides are found in natural products and are indispensable in drug development programs;owing to their diverse range of medicinal properties. Two-component reactions involving glycosyl radical addition are...C-Alkyl glycosides are found in natural products and are indispensable in drug development programs;owing to their diverse range of medicinal properties. Two-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides synthesis. However;multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity;compatibility;and selectivity. Herein;we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl glycosides. This protocol exhibits broad substrate scope and excellent chemoand regioselectivity. Furthermore;nine types of sugars are compatible with this reaction. In addition;the generality of this catalytic strategy was further highlighted by the potential for scalable production;the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.展开更多
文摘THE chemistry of nitronic esters remains relatively unknown due to their conspicuous feature ofinstability. In the preceding papers, we described the late progress in the researchof nitronic esters: (i) nitronic esters were first synthesized via O-alkylation of the alkali met-
基金support from the National Natural Science Foundation of China(No.22005179)the Natural Science Foundation of Shandong Province(Nos.ZR2020QB113,ZR2020MB018 and ZR2021QB049).
文摘A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp*Ir complex[Cp*Ir(2,20-bpyO)(OH)]Na with a bipyridine-based functional ligand.In particular,H_(2)O was selected as the solvent instead of the organic solvent in this catalytic system.Through mild reaction conditions gave a variety of corresponding alkylated heterocyclic compounds with good to excellent yields.More importantly,the gramscale C-alkylation reaction was successfully carried out with good yield using a common route with only a single purification by column chromatography.
基金supported by the National Natural Science Foundation of China(22171114 and 22371097).
文摘C-Alkyl glycosides are found in natural products and are indispensable in drug development programs;owing to their diverse range of medicinal properties. Two-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides synthesis. However;multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity;compatibility;and selectivity. Herein;we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl glycosides. This protocol exhibits broad substrate scope and excellent chemoand regioselectivity. Furthermore;nine types of sugars are compatible with this reaction. In addition;the generality of this catalytic strategy was further highlighted by the potential for scalable production;the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.
