Objective C/eome rutidosperma(Capparidaceae),commonly known as"Fringed Spider Flower",is a medicinal plant found in Southeast Asia.C.rutidosperma is used in folk medicine for diuretic,laxative,analgesic,anti...Objective C/eome rutidosperma(Capparidaceae),commonly known as"Fringed Spider Flower",is a medicinal plant found in Southeast Asia.C.rutidosperma is used in folk medicine for diuretic,laxative,analgesic,anti-inflammatory,antipyretic,antimicrobial,anti-oxidant,hypoglycemic,and anthelmintic activities.We have evaluated the anti-nociceptive properties of methanol extract from C.rutidosperma(MECR)in vivo.Methods Thermal method(hot plate test and tail flick test)was induced to judge the anti-inflammatory effect and couple of chemical method also used(formalin induced licking test;writhing test carried by acetic acid)to evaluate analgesic effect.Both of these tests were made over animal models,like mice and rats.Two different doses(1 O0 and 200 mg/kg)were used for each case of test,while morphine sulphate(5mg/kg,ip)was used as reference drug.Results MECR demonstrated the significantly anti-nociceptive activity in the analgesic and anti-inflammatory tests by reducing nociception in mice models(P〈0.001).in the hot-plate and tail-flick tests,MECR significantly elongated the time to response to the thermal stimuli(100 and 200 mg/kg with P〈0.05,0.001).The remarkable increase in the latency was observed at 90 and 120 min.In acetic acid-induced writhing test and formalin induced licking test for anti-inflammatory activity,MECR at 100 and 200 mg/kg doses exhibited significant(P〈0.001)reduction of writhing and licking response.Conclusion The anti-inflammatory and analgesic effects of C.rutidosperma propose that this effect may be a result of both peripheral and central mechanisms.Further study is required to ensure the proper mechanism of action as well as the active ingredient.展开更多
文摘Objective C/eome rutidosperma(Capparidaceae),commonly known as"Fringed Spider Flower",is a medicinal plant found in Southeast Asia.C.rutidosperma is used in folk medicine for diuretic,laxative,analgesic,anti-inflammatory,antipyretic,antimicrobial,anti-oxidant,hypoglycemic,and anthelmintic activities.We have evaluated the anti-nociceptive properties of methanol extract from C.rutidosperma(MECR)in vivo.Methods Thermal method(hot plate test and tail flick test)was induced to judge the anti-inflammatory effect and couple of chemical method also used(formalin induced licking test;writhing test carried by acetic acid)to evaluate analgesic effect.Both of these tests were made over animal models,like mice and rats.Two different doses(1 O0 and 200 mg/kg)were used for each case of test,while morphine sulphate(5mg/kg,ip)was used as reference drug.Results MECR demonstrated the significantly anti-nociceptive activity in the analgesic and anti-inflammatory tests by reducing nociception in mice models(P〈0.001).in the hot-plate and tail-flick tests,MECR significantly elongated the time to response to the thermal stimuli(100 and 200 mg/kg with P〈0.05,0.001).The remarkable increase in the latency was observed at 90 and 120 min.In acetic acid-induced writhing test and formalin induced licking test for anti-inflammatory activity,MECR at 100 and 200 mg/kg doses exhibited significant(P〈0.001)reduction of writhing and licking response.Conclusion The anti-inflammatory and analgesic effects of C.rutidosperma propose that this effect may be a result of both peripheral and central mechanisms.Further study is required to ensure the proper mechanism of action as well as the active ingredient.
