Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to Augus...Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to August 2024 were selected as samples and randomly divided into two groups.Group A received conventional medication plus TMS treatment,while Group B received medication only.The efficacy of motor function improvement,neurological symptoms,mental state,sleep quality,quality of life,and adverse reactions was compared between the two groups.Results:The efficacy of Group A was higher than that of Group B(P<0.05).The scores of the Scales for Outcomes in Parkinson’s Disease-Autonomic(SCOPA-AUT),Mini-Mental State Examination(MMSE),and Pittsburgh Sleep Quality Index(PSQI)in Group A were lower than those in Group B(P<0.05).The quality of life scale(SF-36)score in Group A was higher than that in Group B(P<0.05).The adverse reaction rate in Group A was lower than that in Group B(P<0.05).Conclusion:TMS used in the treatment of PD patients can improve patients’mental state and motor function,optimize sleep quality and quality of life,and is safe and efficient.展开更多
Production of this crop is experiencing significant challenges, resulting in a decline in seed and fiber quality. To address this challenge, generations of high-performance cotton plants of the Gossypium hirsutum L. s...Production of this crop is experiencing significant challenges, resulting in a decline in seed and fiber quality. To address this challenge, generations of high-performance cotton plants of the Gossypium hirsutum L. species have been developed and are currently being commercialized. This study evaluated the impact of gin types on the agro-industrial quality of cotton in Côte d’Ivoire. To this end, cotton from the G3, R1, and R2 generations was harvested, sampled, and ginned on machines with 10 and 170 saws in the localities of Ouangolodougou, Ferkessédougou, Korhogo, M’Bengué, Boundiali, Séguéla, and Mankono, as well as at the Centre National de Recherche Agronomique CNRA) in Bouaké. The results demonstrated that cotton fibers obtained from ginning on 10-saw machines exhibited superior quality compared to those from 170-saw machines. Fiber length, fiber length uniformity, and short fiber rate exhibited the highest deviations according to gin type. The use of 170-saw gins resulted in a notable decline in quality. Conversely, micronaire index, fiber tenacity and elongation, and reflectance remained consistent across machine types. These results will enable us to more effectively regulate and advise cotton-processing factories, which primarily utilize 170-saw gins to enhance agro-industrial quality in Côte d’Ivoire. Furthermore, these results will assist breeders in incorporating them into their processes to enhance the quality of the varieties they offer to farmers.展开更多
Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal sur...Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.展开更多
文摘Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to August 2024 were selected as samples and randomly divided into two groups.Group A received conventional medication plus TMS treatment,while Group B received medication only.The efficacy of motor function improvement,neurological symptoms,mental state,sleep quality,quality of life,and adverse reactions was compared between the two groups.Results:The efficacy of Group A was higher than that of Group B(P<0.05).The scores of the Scales for Outcomes in Parkinson’s Disease-Autonomic(SCOPA-AUT),Mini-Mental State Examination(MMSE),and Pittsburgh Sleep Quality Index(PSQI)in Group A were lower than those in Group B(P<0.05).The quality of life scale(SF-36)score in Group A was higher than that in Group B(P<0.05).The adverse reaction rate in Group A was lower than that in Group B(P<0.05).Conclusion:TMS used in the treatment of PD patients can improve patients’mental state and motor function,optimize sleep quality and quality of life,and is safe and efficient.
文摘Production of this crop is experiencing significant challenges, resulting in a decline in seed and fiber quality. To address this challenge, generations of high-performance cotton plants of the Gossypium hirsutum L. species have been developed and are currently being commercialized. This study evaluated the impact of gin types on the agro-industrial quality of cotton in Côte d’Ivoire. To this end, cotton from the G3, R1, and R2 generations was harvested, sampled, and ginned on machines with 10 and 170 saws in the localities of Ouangolodougou, Ferkessédougou, Korhogo, M’Bengué, Boundiali, Séguéla, and Mankono, as well as at the Centre National de Recherche Agronomique CNRA) in Bouaké. The results demonstrated that cotton fibers obtained from ginning on 10-saw machines exhibited superior quality compared to those from 170-saw machines. Fiber length, fiber length uniformity, and short fiber rate exhibited the highest deviations according to gin type. The use of 170-saw gins resulted in a notable decline in quality. Conversely, micronaire index, fiber tenacity and elongation, and reflectance remained consistent across machine types. These results will enable us to more effectively regulate and advise cotton-processing factories, which primarily utilize 170-saw gins to enhance agro-industrial quality in Côte d’Ivoire. Furthermore, these results will assist breeders in incorporating them into their processes to enhance the quality of the varieties they offer to farmers.
基金supported by the National Natural Science Foundation of China(Youth Science Fund Project),No.81901292(to GC)the National Key Research and Development Program of China,No.2021YFC2502100(to GC)the National Natural Science Foundation of China,No.82071183(to ZZ).
文摘Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.
