Layered double hydroxides(LDHs)hold great promise as cathode materials for aqueous zinc-ion batteries(AZIBs).Nevertheless,they also face challenges of sluggish kinetics and rapid capacity loss.Herein,a conformational ...Layered double hydroxides(LDHs)hold great promise as cathode materials for aqueous zinc-ion batteries(AZIBs).Nevertheless,they also face challenges of sluggish kinetics and rapid capacity loss.Herein,a conformational entropy regulation strategy has been applied to surmount the shortcomings.A medium-entropy iron-based metal organic framework(MIL-88)derived NiCoFeInZnV-based layered double hydroxide with carbon loaded(ME-NiCoFeInZnV-LDH/C)has been first proposed and prepared with a designed method.The increased entropy optimizes electron conductivity and alleviates structure alteration and diffusion barrier during interactions with charge carriers,due to electron-induced effect and“cocktail”effect.Moreover,the nanosheet assembled hollow prismatic structures could homogenize flux distribution and electric field distribution.Therefore,the electrochemical kinetics,crystal structure stability,and activity could be dramatically improved.Leveraging the advantages of structure and composition regulation,Zn||ME-NiCoFeInZnV-LDH/C zinc battery delivers high specific capacities,rate performance,and cycling stability.This work proposes a novel and feasible medium-entropy strategy to prepare a high-performance cathode for advanced AZIBs,which is of prominent significance for the development of charge storage devices.展开更多
等离子体处理作为一种高效的表面改性技术,在二维纳米材料/碳基复合结构的形貌调控中具有独特优势。本文通过调控等离子体处理参数(例如气体氛围),研究其对二硫化钨/碳(WS2/C)复合结构表面形貌和缺陷分布的影响。结合扫描电子显微镜(Sca...等离子体处理作为一种高效的表面改性技术,在二维纳米材料/碳基复合结构的形貌调控中具有独特优势。本文通过调控等离子体处理参数(例如气体氛围),研究其对二硫化钨/碳(WS2/C)复合结构表面形貌和缺陷分布的影响。结合扫描电子显微镜(Scanning Electron Microscope,SEM)和基于拉曼光谱的表征,揭示了等离子体处理诱导的WS2边缘选择性和碳纳米纤维骨架的协同效应,提高了复合材料的比表面积和边缘活性位点暴露程度。试验结果表明,参数优化后,等离子体处理可以有效调控WS2纳米晶片在碳纤维骨架中的分散性,并抑制晶片层间堆叠和层片团聚,从而增加边缘位置的暴露程度。该研究为高性能WS2/C复合材料的可控制备提供了新思路,推动其在能源存储与转换领域的实际应用。展开更多
目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)...目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)通路的影响。方法把MCF-7人乳腺癌细胞中NC组和AKR1C3组分别转染空质粒和AKR1C3质粒,采用MTT法检测转染后24 h、48 h、72 h细胞活力;采用流式细胞技术测定各组细胞的存活率以及早期、晚期凋亡比例;通过Transwell实验对各组细胞的迁移和侵袭能力进行检测;通过Western blot检测各组细胞PD-1、PD-L1、蛋白激酶B(protein kinase b,AKT)蛋白表达水平。使用C57BL/6小鼠构建荷瘤模型,将采用人乳腺癌MCF-7细胞转染NC质粒和AKR1C3质粒进行细胞荷瘤,每3 d测量瘤体积,持续21 d,绘制两组小鼠肿瘤生长曲线,并于实验终点测量肿瘤质量。结果相较于NC组,AKR1C3组细胞活力降低(P<0.05),并且具有时间依赖效应(P<0.05),迁移和侵袭能力降低(P<0.05),早期凋亡和晚期凋亡比例升高(P<0.05),PD-1、PD-L1、AKT蛋白表达水平降低(P<0.05)。动物实验表明,AKR1C3组小鼠肿瘤体积降低,肿瘤质量下降(P<0.05)。结论AKR1C3可以抑制人乳腺癌细胞恶性生物学行为,抑制PD-1/PDL1信号通路蛋白表达。展开更多
基金the funding support from the National Natural Science Foundation of China(Grant No.52202217,52471222)the Natural Science Foundation of Jilin Province(Grant No.YDZJ202201ZYTS375).
文摘Layered double hydroxides(LDHs)hold great promise as cathode materials for aqueous zinc-ion batteries(AZIBs).Nevertheless,they also face challenges of sluggish kinetics and rapid capacity loss.Herein,a conformational entropy regulation strategy has been applied to surmount the shortcomings.A medium-entropy iron-based metal organic framework(MIL-88)derived NiCoFeInZnV-based layered double hydroxide with carbon loaded(ME-NiCoFeInZnV-LDH/C)has been first proposed and prepared with a designed method.The increased entropy optimizes electron conductivity and alleviates structure alteration and diffusion barrier during interactions with charge carriers,due to electron-induced effect and“cocktail”effect.Moreover,the nanosheet assembled hollow prismatic structures could homogenize flux distribution and electric field distribution.Therefore,the electrochemical kinetics,crystal structure stability,and activity could be dramatically improved.Leveraging the advantages of structure and composition regulation,Zn||ME-NiCoFeInZnV-LDH/C zinc battery delivers high specific capacities,rate performance,and cycling stability.This work proposes a novel and feasible medium-entropy strategy to prepare a high-performance cathode for advanced AZIBs,which is of prominent significance for the development of charge storage devices.
文摘等离子体处理作为一种高效的表面改性技术,在二维纳米材料/碳基复合结构的形貌调控中具有独特优势。本文通过调控等离子体处理参数(例如气体氛围),研究其对二硫化钨/碳(WS2/C)复合结构表面形貌和缺陷分布的影响。结合扫描电子显微镜(Scanning Electron Microscope,SEM)和基于拉曼光谱的表征,揭示了等离子体处理诱导的WS2边缘选择性和碳纳米纤维骨架的协同效应,提高了复合材料的比表面积和边缘活性位点暴露程度。试验结果表明,参数优化后,等离子体处理可以有效调控WS2纳米晶片在碳纤维骨架中的分散性,并抑制晶片层间堆叠和层片团聚,从而增加边缘位置的暴露程度。该研究为高性能WS2/C复合材料的可控制备提供了新思路,推动其在能源存储与转换领域的实际应用。
