The developing olfactory system - merging of the periph- eral and central nervous systems： The olfactory system is responsible for the sense of smell and is comprised of a complex topographic map that regenerates thr...The developing olfactory system - merging of the periph- eral and central nervous systems： The olfactory system is responsible for the sense of smell and is comprised of a complex topographic map that regenerates throughout life. In rodents each olfactory sensory neuron expresses one of N 1,300 odorant receptors with the neurons being distributed mosaically within the epithelium. The axons of the sensory neurons do not maintain near-neighbour relationships and instead project to disparate topographic targets in the olfac- tory bulb within the central nervous system. The develop- ment of the targets relies on the intermingling of the sensory axons with the interneurons, glia and second order neurons of the olfactory bulb. Thus the formation of the olfactory system involves the coordinated integration of the axons of the peripheral olfactory sensory neurons with the cells of the olfactory bulb.展开更多
基金supported by an Australian Postgraduate Award to D.A
文摘The developing olfactory system - merging of the periph- eral and central nervous systems： The olfactory system is responsible for the sense of smell and is comprised of a complex topographic map that regenerates throughout life. In rodents each olfactory sensory neuron expresses one of N 1,300 odorant receptors with the neurons being distributed mosaically within the epithelium. The axons of the sensory neurons do not maintain near-neighbour relationships and instead project to disparate topographic targets in the olfac- tory bulb within the central nervous system. The develop- ment of the targets relies on the intermingling of the sensory axons with the interneurons, glia and second order neurons of the olfactory bulb. Thus the formation of the olfactory system involves the coordinated integration of the axons of the peripheral olfactory sensory neurons with the cells of the olfactory bulb.
文摘为了研究慈姑球茎发育过程中转录组功能基因表达情况,本研究对其不同时期进行转录组测序,获得表达基因信息,以探讨球茎发育相关基因的表达特征及淀粉合成代谢相关调控。结果显示,慈姑球茎测序组装后共获得63.53 Gb的Clean Reads,总共获得60884个Unigene,平均长度为897.34 bp,N50为1.368 kb。使用五个公共数据库成功注释了总共36590个Unigene。组装完整性较高,效果好。差异表达基因分析表明,慈姑匍匐茎膨大为球茎初期,差异基因最多,表现最为活跃。GO(Gene ontology)功能富集中,21453个基因获得功能注释,分为分子功能、细胞组分和生物学过程3大类和54个亚类。COG(Clusters of orthologous groups)功能分类中,13653个基因分布于25个功能区域,其中碳水化合物代谢占重要地位。KEGG(Kyoto encyclopedia of genes and genomes)代谢通路注释中,14226个基因获得功能注释,共有118条代谢途径,其中淀粉-蔗糖代谢占主要作用。本研究首次建立了丰富的慈姑球茎的转录组数据库,对进一步深化解析慈姑球茎淀粉生物合成的分子机制提供数据基础。
