Buch(mittelhochdeutsch=Buoch,angelschsich=boc)im allgemeinen sind das mehrere zu einem ganzen verbundene Bltter oder Bogen Papier,Pergament.Unabhngig davon ob beschrieben oder nicht.Der Name'Buch'hngt ...Buch(mittelhochdeutsch=Buoch,angelschsich=boc)im allgemeinen sind das mehrere zu einem ganzen verbundene Bltter oder Bogen Papier,Pergament.Unabhngig davon ob beschrieben oder nicht.Der Name'Buch'hngt jedenfalls mit der Buche zusammen(angelschsisch ein identischer Begriff)und展开更多
通过单因素试验和正交试验对金雀花(Parochetus communis Buch.)异黄酮提取工艺中提取溶剂类型、提取剂体积分数、提取时间、提取温度、料液比等影响异黄酮提取率的因素进行了探讨,应用紫外分光光度法测定不同提取条件下金雀花异黄酮的...通过单因素试验和正交试验对金雀花(Parochetus communis Buch.)异黄酮提取工艺中提取溶剂类型、提取剂体积分数、提取时间、提取温度、料液比等影响异黄酮提取率的因素进行了探讨,应用紫外分光光度法测定不同提取条件下金雀花异黄酮的含量。确定金雀花异黄酮最佳提取工艺参数为甲醇体积分数65%,提取温度90℃,料液比为1∶40(m/V,g∶m L),提取2次,每次2.0 h,在此提取工艺条件下,金雀花总异黄酮得率为2.38%。展开更多
There is no effective treatment to face Alzheimer’s disease complexity.Multitarget molecules are a good approach against the multiple physiopathological events associated with its development and progression.In this ...There is no effective treatment to face Alzheimer’s disease complexity.Multitarget molecules are a good approach against the multiple physiopathological events associated with its development and progression.In this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising results.ASS234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than donepezil.Besides,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and B.Moreover,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 self-aggregation.Inquiring about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant genes.Finally,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning deficits.Here we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.展开更多
This project is to study chemical constituents of Rubus biflorus Buch(Chinese name“Fenzhimei”),isolated by silica gel chromatography and structure determined by spectroscopic.techniques.Two flavones were isolated fr...This project is to study chemical constituents of Rubus biflorus Buch(Chinese name“Fenzhimei”),isolated by silica gel chromatography and structure determined by spectroscopic.techniques.Two flavones were isolated from Rubus bflorus Buch and identified as 8-methyl6-(3"-methylbut-2"-enyl)-5,7-dihydroxy-5'-methoxy-3',4'-methylenedioxy flavone(A)and 8-methyl-5-methoxy 6,7-(2",2"-dimethylpyran)-3',4'-methylenedioxy-5'-(3"-methylbut-2"-enyl)flavone(B),named as fenzhimines A and B,respectively.Compounds A and B are two new flavonoids.展开更多
Die Thebais des Statius ist ein umfangreiches lateinisches Epos aus dem1.Jahrhundert v.Chr.mit rund zehntausend Hexametem in zwolfBüchem über den Kampf um Theben.Bei diesem Umfang nimmt es nichtwunder,wenn i...Die Thebais des Statius ist ein umfangreiches lateinisches Epos aus dem1.Jahrhundert v.Chr.mit rund zehntausend Hexametem in zwolfBüchem über den Kampf um Theben.Bei diesem Umfang nimmt es nichtwunder,wenn in die fortlaufende Erzahlung auch Einlagen eingefügt sind,die anderes mythisches Gut zum Inhalt haben.Die Frage stellt sich leicht,ob diese Digressionen das Werk im ganzen bereichern oder es belasten.展开更多
Alzheimer’s disease(AD)is a common neurodegenerative disorder among the elderly,and BuChE has emerged as a potential therapeutic target.In this study,we reported the development of compound 8e,a selective reversible ...Alzheimer’s disease(AD)is a common neurodegenerative disorder among the elderly,and BuChE has emerged as a potential therapeutic target.In this study,we reported the development of compound 8e,a selective reversible BuChE inhibitor(eqBuChE IC_(50)=0.049 mmol/L,huBuChE IC_(50)=0.066 mmol/L),identified through extensive virtual screening and lead optimization.Compound 8e demonstrated favorable bloodebrain barrier permeability,good drug-likeness property and pronounced neuroprotective efficacy.Additionally,8e exhibited significant therapeutic effects in zebrafish AD models and scopolamine-induced cognitive impairments in mice.Further,8e significantly improved cognitive function in APP/PS1 transgenic mice.Proteomics analysis demonstrated that 8e markedly elevated the expression levels of very low-density lipoprotein receptor(VLDLR),offering valuable insights into its potential modulation of the Reelin-mediated signaling pathway.Thus,compound 8e emerges as a novel and potent BuChE inhibitor for the treatment of AD,with significant implications for further exploration into its mechanisms of action and therapeutic applications.展开更多
: The floral morphogenesis and androecium developmental sequence of Anemone rivularis Buch.-Ham. ex DC. var. flore-minore Maxim. were observed under a scanning electron microscope (SEM) and by means of histological me...: The floral morphogenesis and androecium developmental sequence of Anemone rivularis Buch.-Ham. ex DC. var. flore-minore Maxim. were observed under a scanning electron microscope (SEM) and by means of histological methods in order to expand our knowledge of the morphogenesis and development of the floral organs of the Ranunculaceae. The initiation of the floral elements is a centripetal spiral and the direction of the spiral is clockwise or anti-clockwise. However, the development of the androecium is highly unusual: in a longitudinal series of four stamens, the second stamen develops first from the inner to outer, then the third one, the fourth one and the first one in turn. The microsporogenesis and anther maturation follows the same developmental sequence. The tepals are different from the bracts and the stamens in both shape and size in the early developmental stage, but there is no difference between the stamens and carpels in the early developmental stage. Therefore, we established a spatio-temporal process of the floral morphogenesis of A. rivularis var. flore-minore and offer another meaning of the floral diversity patterns attributed to the level of the genus.展开更多
文摘Buch(mittelhochdeutsch=Buoch,angelschsich=boc)im allgemeinen sind das mehrere zu einem ganzen verbundene Bltter oder Bogen Papier,Pergament.Unabhngig davon ob beschrieben oder nicht.Der Name'Buch'hngt jedenfalls mit der Buche zusammen(angelschsisch ein identischer Begriff)und
文摘通过单因素试验和正交试验对金雀花(Parochetus communis Buch.)异黄酮提取工艺中提取溶剂类型、提取剂体积分数、提取时间、提取温度、料液比等影响异黄酮提取率的因素进行了探讨,应用紫外分光光度法测定不同提取条件下金雀花异黄酮的含量。确定金雀花异黄酮最佳提取工艺参数为甲醇体积分数65%,提取温度90℃,料液比为1∶40(m/V,g∶m L),提取2次,每次2.0 h,在此提取工艺条件下,金雀花总异黄酮得率为2.38%。
文摘There is no effective treatment to face Alzheimer’s disease complexity.Multitarget molecules are a good approach against the multiple physiopathological events associated with its development and progression.In this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising results.ASS234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than donepezil.Besides,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and B.Moreover,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 self-aggregation.Inquiring about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant genes.Finally,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning deficits.Here we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.
文摘This project is to study chemical constituents of Rubus biflorus Buch(Chinese name“Fenzhimei”),isolated by silica gel chromatography and structure determined by spectroscopic.techniques.Two flavones were isolated from Rubus bflorus Buch and identified as 8-methyl6-(3"-methylbut-2"-enyl)-5,7-dihydroxy-5'-methoxy-3',4'-methylenedioxy flavone(A)and 8-methyl-5-methoxy 6,7-(2",2"-dimethylpyran)-3',4'-methylenedioxy-5'-(3"-methylbut-2"-enyl)flavone(B),named as fenzhimines A and B,respectively.Compounds A and B are two new flavonoids.
文摘Die Thebais des Statius ist ein umfangreiches lateinisches Epos aus dem1.Jahrhundert v.Chr.mit rund zehntausend Hexametem in zwolfBüchem über den Kampf um Theben.Bei diesem Umfang nimmt es nichtwunder,wenn in die fortlaufende Erzahlung auch Einlagen eingefügt sind,die anderes mythisches Gut zum Inhalt haben.Die Frage stellt sich leicht,ob diese Digressionen das Werk im ganzen bereichern oder es belasten.
基金supported by the China Postdoctoral Science Foundation(2022M712153)The National Natural Science Foundation of China(22367007,82304384)+6 种基金The Fundamental Research Funds for Hainan University(KYQD(ZR)23002,China)Hainan Provincial Natural Science Foundation of China(824RC500)National-Local Joint Engineering Research Center for Innovative&Generic Chemical Drug,and Guizhou High-level Innovative Talents Supporting Program(2016-4015,China)The State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Grant number FAMP202107K,China)Guizhou Science and Technology Platform Talents(QKHRCPT[2019]5627,China)Program for Innovative Research Team in Universities of Inner Mongolia Autonomous Region(NMGIRT2216,China)Natural Science Foundation of Inner Mongolia Autonomous Region of China(2020MS08103).
文摘Alzheimer’s disease(AD)is a common neurodegenerative disorder among the elderly,and BuChE has emerged as a potential therapeutic target.In this study,we reported the development of compound 8e,a selective reversible BuChE inhibitor(eqBuChE IC_(50)=0.049 mmol/L,huBuChE IC_(50)=0.066 mmol/L),identified through extensive virtual screening and lead optimization.Compound 8e demonstrated favorable bloodebrain barrier permeability,good drug-likeness property and pronounced neuroprotective efficacy.Additionally,8e exhibited significant therapeutic effects in zebrafish AD models and scopolamine-induced cognitive impairments in mice.Further,8e significantly improved cognitive function in APP/PS1 transgenic mice.Proteomics analysis demonstrated that 8e markedly elevated the expression levels of very low-density lipoprotein receptor(VLDLR),offering valuable insights into its potential modulation of the Reelin-mediated signaling pathway.Thus,compound 8e emerges as a novel and potent BuChE inhibitor for the treatment of AD,with significant implications for further exploration into its mechanisms of action and therapeutic applications.
文摘: The floral morphogenesis and androecium developmental sequence of Anemone rivularis Buch.-Ham. ex DC. var. flore-minore Maxim. were observed under a scanning electron microscope (SEM) and by means of histological methods in order to expand our knowledge of the morphogenesis and development of the floral organs of the Ranunculaceae. The initiation of the floral elements is a centripetal spiral and the direction of the spiral is clockwise or anti-clockwise. However, the development of the androecium is highly unusual: in a longitudinal series of four stamens, the second stamen develops first from the inner to outer, then the third one, the fourth one and the first one in turn. The microsporogenesis and anther maturation follows the same developmental sequence. The tepals are different from the bracts and the stamens in both shape and size in the early developmental stage, but there is no difference between the stamens and carpels in the early developmental stage. Therefore, we established a spatio-temporal process of the floral morphogenesis of A. rivularis var. flore-minore and offer another meaning of the floral diversity patterns attributed to the level of the genus.
