目的应用荟萃分析探讨维生素D受体（VDR）的BsmI基因多态性与结核易感性的关系。方法在PubMed、EMBASE和中国期刊全文数据库（CM（I）对1998年1月1日一2013年3月19日数据进行系统的文献检索，对检索得到的15项研究进行全面荟萃分析。评...目的应用荟萃分析探讨维生素D受体（VDR）的BsmI基因多态性与结核易感性的关系。方法在PubMed、EMBASE和中国期刊全文数据库（CM（I）对1998年1月1日一2013年3月19日数据进行系统的文献检索，对检索得到的15项研究进行全面荟萃分析。评估VDR的BsmI基因多态性与结核发病风险之间的关联强度，并进行人群种族亚组分析。结果Meta分析结果发现VDR的BsmI基因多态性合并OR（95%CI）分别为等位基因模型（b vs B：OR=0．78，95％CI=0．67，0．89），纯合子模型（bb vs BB：OR=0．61，95％CI=0．43，0．87），显性遗传模型（bb＋Bb伪BB：OR=0．77，95％CI=0．61，0．97），隐形遗传模型（bb vs Bb＋BB：OR=0．70，95％CI=0．56，0．88）。亚组分析结果显示VDR的BsmI基因多态性与亚洲人群的结核发病风险存在显著关联。结论荟萃分析表明，VDR的BsmI基因多态性为结核发病的危险因素，尤其在亚洲人群中风险更加显著。展开更多
Objective:To investigate the relationship between vitamin D receptor gene polymorphism and prognosis in patients with end stage renal disease(ESRD)undergoing dialysis.Methods:80 patients with ESRD who underwent regula...Objective:To investigate the relationship between vitamin D receptor gene polymorphism and prognosis in patients with end stage renal disease(ESRD)undergoing dialysis.Methods:80 patients with ESRD who underwent regular hemodialysis in our hospital were admitted from January 2016 to June 2016,and 80 healthy volunteers from our hospital were collected as control group during the same period.The polymorphisms of rs1544410(BsmI)of vitamin D receptor gene were identified by peripheral blood DNA amplification and specific enzyme digestion,including wild type GG(bb)and mutant GA(Bb)and AA(BB).Then analyze and compare the distribution of BsmI in patients with ESRD and normal volunteers,further analyze the correlation between BsmI locus and clinical characteristics of patients with ESRD,and analyze the relationship between BsmI locus and prognosis of patients with ESRD according to the follow-up results of patients.Results:The incidence of wild type(bb)of vitamin D receptor BsmI locus in patients with ESRD was significantly lower than that in the control group,while the incidence of mutant type(Bb and BB)was higher than that in the control group,with an advantage ratio of 1.378(P=0.004).The allele frequency of BsmI locus showed that the incidence of A-base in patients with ESRD was higher than that in control group,with an advantage ratio of 1.368(P=0.010).Comparing the genotype and clinical characteristics of BsmI locus in patients with ESRD,it was found that there were no differences in age,sex ratio between men and women,BMI,hypertension,diabetes,LDL,HDL,TG,urea nitrogen,creatinine,calcium,phosphorus,albumin and vitamin D levels among different genotypes.One year after treatment,the survival rate of bb group was significantly higher than that of Bb group and BB group(P=0.006).K-M analysis showed that the median survival time of BB group was 20 months,that of BB group was 8 months,and that of BB group was 4 months(P=0.000).Conclusion:There is a high mutation rate of BsmI locus(GA,AA type)in patients with ESRD,that is,the mutation rate of G-base to A is higher,and the survival time of patients with mutation is significantly shortened.展开更多
文摘目的应用荟萃分析探讨维生素D受体（VDR）的BsmI基因多态性与结核易感性的关系。方法在PubMed、EMBASE和中国期刊全文数据库（CM（I）对1998年1月1日一2013年3月19日数据进行系统的文献检索，对检索得到的15项研究进行全面荟萃分析。评估VDR的BsmI基因多态性与结核发病风险之间的关联强度，并进行人群种族亚组分析。结果Meta分析结果发现VDR的BsmI基因多态性合并OR（95%CI）分别为等位基因模型（b vs B：OR=0．78，95％CI=0．67，0．89），纯合子模型（bb vs BB：OR=0．61，95％CI=0．43，0．87），显性遗传模型（bb＋Bb伪BB：OR=0．77，95％CI=0．61，0．97），隐形遗传模型（bb vs Bb＋BB：OR=0．70，95％CI=0．56，0．88）。亚组分析结果显示VDR的BsmI基因多态性与亚洲人群的结核发病风险存在显著关联。结论荟萃分析表明，VDR的BsmI基因多态性为结核发病的危险因素，尤其在亚洲人群中风险更加显著。
基金Innovation of medical research youth of Sichuan Medical Association Project(No.Q15007).
文摘Objective:To investigate the relationship between vitamin D receptor gene polymorphism and prognosis in patients with end stage renal disease(ESRD)undergoing dialysis.Methods:80 patients with ESRD who underwent regular hemodialysis in our hospital were admitted from January 2016 to June 2016,and 80 healthy volunteers from our hospital were collected as control group during the same period.The polymorphisms of rs1544410(BsmI)of vitamin D receptor gene were identified by peripheral blood DNA amplification and specific enzyme digestion,including wild type GG(bb)and mutant GA(Bb)and AA(BB).Then analyze and compare the distribution of BsmI in patients with ESRD and normal volunteers,further analyze the correlation between BsmI locus and clinical characteristics of patients with ESRD,and analyze the relationship between BsmI locus and prognosis of patients with ESRD according to the follow-up results of patients.Results:The incidence of wild type(bb)of vitamin D receptor BsmI locus in patients with ESRD was significantly lower than that in the control group,while the incidence of mutant type(Bb and BB)was higher than that in the control group,with an advantage ratio of 1.378(P=0.004).The allele frequency of BsmI locus showed that the incidence of A-base in patients with ESRD was higher than that in control group,with an advantage ratio of 1.368(P=0.010).Comparing the genotype and clinical characteristics of BsmI locus in patients with ESRD,it was found that there were no differences in age,sex ratio between men and women,BMI,hypertension,diabetes,LDL,HDL,TG,urea nitrogen,creatinine,calcium,phosphorus,albumin and vitamin D levels among different genotypes.One year after treatment,the survival rate of bb group was significantly higher than that of Bb group and BB group(P=0.006).K-M analysis showed that the median survival time of BB group was 20 months,that of BB group was 8 months,and that of BB group was 4 months(P=0.000).Conclusion:There is a high mutation rate of BsmI locus(GA,AA type)in patients with ESRD,that is,the mutation rate of G-base to A is higher,and the survival time of patients with mutation is significantly shortened.
