Image processing plays a vital role in various fields such as autonomous systems,healthcare,and cataloging,especially when integrated with deep learning(DL).It is crucial in medical diagnostics,including the early det...Image processing plays a vital role in various fields such as autonomous systems,healthcare,and cataloging,especially when integrated with deep learning(DL).It is crucial in medical diagnostics,including the early detection of diseases like chronic obstructive pulmonary disease(COPD),which claimed 3.2 million lives in 2015.COPD,a life-threatening condition often caused by prolonged exposure to lung irritants and smoking,progresses through stages.Early diagnosis through image processing can significantly improve survival rates.COPD encompasses chronic bronchitis(CB)and emphysema;CB particularly increases in smokers and generally affects individuals between 50 and 70 years old.It damages the lungs’air sacs,reducing oxygen transport and causing symptoms like coughing and shortness of breath.Treatments such as beta-agonists and inhaled steroids are used to manage symptoms and prolong lung function.Moreover,COVID-19 poses an additional risk to individuals with CB due to its impact on the respiratory system.The proposed system utilizes convolutional neural networks(CNN)to diagnose CB.In this system,CNN extracts essential and significant features from X-ray modalities,which are then fed into the neural network.The network undergoes training to recognize patterns and make accurate predictions based on the learned features.By leveraging DL techniques,the system aims to enhance the precision and reliability of CB detection.Our research specifically focuses on a subset of 189 lung disease images,carefully selected for model evaluation.To further refine the training process,various data augmentation and noise removal techniques are implemented.These techniques significantly enhance the quality of the training data,improving the model’s robustness and generalizability.As a result,the diagnostic accuracy has improved from 98.6%to 99.2%.This advancement not only validates the efficacy of our proposed model but also represents a significant improvement over existing literature.It highlights the potential of CNN-based approaches in transforming medical diagnostics through refined image analysis,learning capabilities,and automated feature extraction.展开更多
Chronic bronchitis(CB),characterized by persistent coughing with mucus production for at least three consecutive months in two successive years and caused by multiple factors[1],is a progressive condition.Acute exacer...Chronic bronchitis(CB),characterized by persistent coughing with mucus production for at least three consecutive months in two successive years and caused by multiple factors[1],is a progressive condition.Acute exacerbation of chronic bronchitis(AECB),marked by recurrent episodes of bronchial inflammation,have been linked to various adverse health outcomes[2].展开更多
Mutations in the cystic fibrosis transmembrane conductance regulator （CFTR） gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated t...Mutations in the cystic fibrosis transmembrane conductance regulator （CFTR） gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated the role of CFTR variations, poly-T, TG-repeats, and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province, China. A total of 72 bronchial asthma patients, 68 chronic bronchitis pa- tients, and 117 healthy subjects were included in this study. The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism （RFLP）. We found that the fre- quency of TS-TG12-V470 in chronic bronchitis patients was 0.07%, which was notably higher than that in healthy subjects （0.01%） and bronchial asthma patients （0.04%）. Thus, the presence of the TS-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions, such as chronic bronchitis.展开更多
The association between ambient temperature and acute exacerbation of chronic bronchitis （AECB） was still unknown. Therefore, we performed an epidemiological study in a large hospital of Shanghai to explore the rela...The association between ambient temperature and acute exacerbation of chronic bronchitis （AECB） was still unknown. Therefore, we performed an epidemiological study in a large hospital of Shanghai to explore the relationship about temperature and outpatient visit for AECB. We adopted a quasi-Poisson generalized additive models and distributed lag nonlinear models to estimate the accumulative effects of temperature on AECB across multiple days. We found significant non-linear effects of cold temperature on hospital visits for AECB, and the potential effect of cold temperature might last more than 2 weeks. The relative risks of extreme cold （first percentiles of temperature throughout the study period） and cold （10th percentile of temperature） temperature over lags 0-14 d were 2.98 [95% confidence intervals （CI）： 1.77, 5.04] and 1.63 （95% Ch 1.21, 2.19）, compared with the 25th percentile of temperature. However, we found no positive association between hospital visits and hot weather. This study showed that exposure to both extreme cold and cold temperatures were associated with increased outpatient visits for AECB in a large hospital of Shanghai.展开更多
To observe the therapeutic effects of a Chinese drug Bufei Keli (补肺颗粒 granules for invigorating the lung) in the treatment of chronic bronchitis at remission stage, 62 cases were randomly divided into a treatment ...To observe the therapeutic effects of a Chinese drug Bufei Keli (补肺颗粒 granules for invigorating the lung) in the treatment of chronic bronchitis at remission stage, 62 cases were randomly divided into a treatment group (treated with Bufei Keli) and a control group (treated with Yupingfeng Keli 玉屏风颗粒). The results turned out to be that the short-term clinically controlled and markedly effective rate was 77.42% and the long-term relapse-resisting markedly effective rate was 74.2% in the treatment group, which were obviously higher than 45.16% and 38.71% respectively in the control group (P<0.05). And the increase in contents of SOD and CD_3 and the decrease in LPO content in the treatment group were also bigger than that in the control group (P<0.01). It is therefore concluded that Bufei Keli can improve qi deficiency syndrome and raise the immunity of patients with chronic bronchitis, hence its effect of resisting relapse of chronic bronchitis.展开更多
BACKGROUND： The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear...BACKGROUND： The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear. OBJECTIVE： To study whether the chronic bronchitis is the risk factor for senile cerebral infarction. DESIGN： 1 ： 1 pair, case contrast, and risk factor study. SETTINGS： Department of Respiratory Medicine, Third Hospital of Tangshan; Department of Neurology, Affiliated Hospital of North China Coal Medical College. PARTICIPANTS： A total of 147 patients with acute cerebral infarction who were regarded as case group were selected from Department of Neurology, the Third Hospital of Tangshan from January 2004 to December 2006. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting. There were 87 males and 60 females, and their ages ranged from 65 to 83 years. Based on 1 ： 1 pair study, another 147 subjects without cerebrovascular disease were regarded as control group. Except the diseases about infection, there were 73 males and 74 females, and their ages ranged from 62 to 81 years. All subjects provided the confirm consent and agreed with the coordinate experiment. METHODS： ①Questionnaire of risk factor of cerebral infarction was designed to measure the following items： chronic bronchitis, hypertension, diabetes mellitus, hyperlipemia, coronary heart disease, primary cerebral infarction/transient ischemic attack and history of smoking. ②Cerebral infarction was regarded as the dependent variance, while chronic bronchitis, hypertension, diabetes mellitus, hypedipemia, primary cerebral infarction/transient ischemic attack, coronary heart disease and smoking were regarded as the independent variance for multiple regression analysis, MAIN OUTCOME MEASURES： Risk factors of senile cerebral infarction. RESULTS： All 147 patients with acute cerebral infarction and 147 subjects without cerebrovascular diseases were involved in the final analysis. ①Risk factor analysis of senile cerebral infarction： There were no significant differences in age, hyperlipemia and history of smoking between the two groups （P 〉 0.05）. But, chronic bronchitis, diabetes mellitus, hypertension, cerebral infarction/transient ischemic attack and history of coronary heart disease were higher in the case group than those in the control group （33.6% vs. 19.0%, 38.8% vs. 23.3%, 54.3% vs. 36.2%, 29.3% vs. 17.2%, 44.0% vs. 29.3%, P 〈 0.05- 0.01）. ②Multiple Logistic regression analysis of risk factor of senile cerebral infarction Hyperlipemia, smoking and coronary heart disease were not correlated with cerebral infarction （P 〉0.05）, but chronic bronchitis, hypertension, diabetes mellitus and cerebral infarction/transient ischemic attack were risk factors for senile cerebral infarction （OR =2.47, 2.28, 2.18, 2.01, P 〈 0.05 - 0.01）. CONCLUSION： The chronic bronchitis mac become an independent risk factor senile cerebral infarction.展开更多
Background: Poverty is an important surrogate marker for obstructive airway diseases (OAD). Slum constitutes a habitat wherein various poverty related parameters are perpetually prevalent in the ambience. 1/6th of wor...Background: Poverty is an important surrogate marker for obstructive airway diseases (OAD). Slum constitutes a habitat wherein various poverty related parameters are perpetually prevalent in the ambience. 1/6th of world population lives in slums yet there is no information regarding their health status in context to asthma and COPD. Aims: We investigated the prevalence of asthma and chronic-bronchitis symptoms and associated risk-factors in slum habitats of Pune city. Methodology: 7062 adult slum-dwellers living in 12 slums of Pune city were cross-sectionally interviewed by local healthcare workers with respiratory health questionnaire which was designed using respiratory symptoms of validated European Community Respiratory Health Survey (ECRHS II) questionnaire and International Union against Tuberculosis and Lung Disease (IUATLD) bronchial symptoms questionnaire. Results: The overall prevalence of selfreported asthma symptoms was 10% (18 - 40 years: 6.5%;>40 years: 13.5%). The overall prevalence of chronic bronchitis was 8.5% [18 - 40 years: 7% (males: 7%, females: 7%);>40 years: 10% (males: 10%, females: 10%)]. Increasing age (p = 0.00), female gender (p = 0.001), unemployment (0.00) current smoking (p = 0.00) and ex-smoking (p = 0.004) emerged as significant risk factor for asthma. While, ex-smoking (p = 0.004) and low-education status (p = 0.00) emerged as significant risk factors for chronic bronchitis. Conclusion: In slums reporting of asthma and chronic-bronchitis symptoms was much higher than what has been reported earlier from India. Asthma was commonly seen in females, old age, unemployed and ever-smokers. While chronic bronchitis was commonly seen in ex-smokers and illiterate subjects. Chronic bronchitis was equally distributed amongst male and females, despite 0% prevalence of smoking in females.展开更多
Moxibustion in dog days" is a unique therapy for chronic bronchitis and bronchial asthma by means of drug-seperated moxibustion. In the present paper, therapeutic methods, and clinical short-and long-term therape...Moxibustion in dog days" is a unique therapy for chronic bronchitis and bronchial asthma by means of drug-seperated moxibustion. In the present paper, therapeutic methods, and clinical short-and long-term therapeutic effects of "moxibustion in dog days" are introduced and it is indicated that "moxibustion in dog days" has very good the short-and long-term therapeutic effects, with the long-term therapeutic effect better than the short-term one, for chronic bronchitis and bronchial asthma. Also, the concrete methods for increase of the short-term therapeutic effect are put forward.展开更多
Background and Objectives: In clinical practice, spirometry plays a key role in the diagnosis of chronic obstructive pulmonary disease (COPD), however, it provides no information about structural pulmonary abnormality...Background and Objectives: In clinical practice, spirometry plays a key role in the diagnosis of chronic obstructive pulmonary disease (COPD), however, it provides no information about structural pulmonary abnormality. The aim of this study was to evaluate whether there is a relation between the clinical criteria and chest radiography or CT studies in differentiating chronic bronchitis from emphysema in COPD. Patients and methods: In a prospective study, data analysis on 165 COPD subjects who were enrolled between September, 2011 and December 2012 was completed. Data were collected including clinical characteristics of stable COPD, pulmonary function tests, chest X-ray and multidetector computerized tomography (MDCT) findings. Results: Emphysema was diagnosed in 90 (55%) of 165 CT scans. The median emphysema score was 58 (range 48 - 72) and significantly correlated with lower FEV1 values (r = 0.542, p = 0.003). In chronic bronchitis, bronchial wall thickening was diagnosed approximately as often in chest radiography (56%) as in CT (64%) as a major finding. Body mass index (BMI), forced expiratory volume in the first second (FEV1), and diffusion capacity of the lung for carbon monoxide (DL,CO) were significantly lower, whereas total lung capacity (TLC) was higher in patients with emphysema. Cardiovascular diseases and obstructive sleep apnea syndrome (OSAS) were more common in chronic bronchitis group. Conclusions: Chest radiography is a valuable, inexpensive means of diagnosing emphysema or bronchial wall thickening in chronic bronchitis. Emphysematous patients show a worse pulmonary function and a greater dyspnea. Greater comorbidity in chronic bronchitis may require specific treatment strategies in this subgroup.展开更多
Objective:To systematically evaluate the efficacy and safety of Shufeng Jiedu Capsules in the treatment of acute attacks of chronic bronchitis.Methods:CNKI,VIP,CBM,WanFang,PubMed,EMbase,Cochrane Library and ChiCTR wer...Objective:To systematically evaluate the efficacy and safety of Shufeng Jiedu Capsules in the treatment of acute attacks of chronic bronchitis.Methods:CNKI,VIP,CBM,WanFang,PubMed,EMbase,Cochrane Library and ChiCTR were searched by computer,and randomized controlled trials of Shufeng Jiedu capsules in the treatment of AECB were integrated.The retrieval time was from the date of establishing the database to December 31,2020.Meta-analysis of outcome indicators[including effective rate,C-reactive protein(CRP),lung function[FEV1%and/or FEV1/FVC],interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]were carried out by RevMan 5.3 software,and the effective rate was tested by sequential analysis(TSA),and the quality of evidence was evaluated according to GRADE standards.Results:A total of 680 cases in 8 articles were included.Shufeng Jiedu Capsules improved the effective rate of clinicaltreatment[RR=1.20,95%CI(1.13,1.28)],improved lung function[FEV1:MD=0.33,95%CI(0.22,0.45),FEV1/FVC:MD=10.17,95%CI(8.15,12.19)],reduced CRP[MD=-7.32,95%CI(-8.42,-6.22)],IL-8[MD=-63.39,95%CI(-73.49,-53.29)],TNF-α[MD=-7.44,95%CI(-8.35,-6.53)]levels.The above differences were statistically significant(P<0.05),and no serious adverse reactions were reported in all studies.The results of TSA analysis showed that the experimental group had definite evidence for improving the efficiency.According to the GRADE evaluation system,the efficiency,TNF-αwere medium-quality evidences,FEV1 was low-quality evidence,and FEV1/FVC,CRP,and IL-8 were extremely low-quality evidence.Conclusions:The curative effect of Shufeng Jiedu capsule combined with western medicine in the treatment of AECB was better than that of single western medicine.Nevertheless,considering the limited sample size and the quality of included articles,higher quality RCTs are still needed to further confirm its effectiveness and safety.展开更多
Objectives： To determine whether traditional Chinese medicine （TCM） aerosol inhalation treatment is effective inthe treatment of acute exacerbation of chronic bronchitis. Methods： Search double-blind randomised cl...Objectives： To determine whether traditional Chinese medicine （TCM） aerosol inhalation treatment is effective inthe treatment of acute exacerbation of chronic bronchitis. Methods： Search double-blind randomised clinical trials（RCT） about the use of TCM aerosol inhalation in patient with acute exacerbation of chronic bronchitis via database including Chinese biomedicine literature database, Wanfang Data, CNKI, Pubmed, EMBASE and CochraneLibrary from the beginning to October 2016. Quality evaluation, data extraction and data analysis of these RCT wascarried out with reference to the Cochrane systematic review. Results： 16 studies with 738 patients in TCM aerosolinhalation group and 675 in control group were included. The results of meta-analysis showed, （1） TCM aerosolinhalation group could improve the total cure rate. （2） TCM aerosol inhalation could increase the expression of IL-2while decrease the expression of IL-8 and MDA in sputum and blood. （3） TCM aerosol inhalation could improvethe symptoms of cough, cough with sputum, cough with dyspnea and lung wet rales. It also improve the symptomsof cough, expectorate and lung wet rales. （4） Shorten the time of cough and lung rale. （5） The adverse reactionswere light only with 1 occurrence of nausea and vomiting. Conclusions： The use of TCM aerosol inhalation in thetreatment of acute exacerbation of chronic bronchitis was effective. However, the inclusion researches quality werenot very high, which only provided limited evidence for clinical application. Higher-quality randomized controlledtrials were needed for further study.展开更多
Chronic bronchitis is a clinical common disease,which is a chronic nonspecific inflammation of the tracheal and bronchial mucosa and its surrounding tissues caused by a variety of factors.It is clinically characterize...Chronic bronchitis is a clinical common disease,which is a chronic nonspecific inflammation of the tracheal and bronchial mucosa and its surrounding tissues caused by a variety of factors.It is clinically characterized by symptoms such as cough,excessive phlegm,shortness of breath,and a recurrent chronic process.Chronic bronchitis has a high incidence and severe symptoms in winter.In severe cases,there are long-term clinical symptoms that impact the patient’s spirit and life.At the same time,the disease causes numerous diseases such as emphysema and pulmonary heart disease.Therefore,patients have an essential need for the treatment of chronic bronchitis.This article tells the etiology,treatment methods,process,prevention,and nursing of the disease from the perspective of western medicine and traditional Chinese medicine,respectively.展开更多
Objective: To observe the clinical effect of Fifty ying acupuncture therapy for treatment of chronic bronchitis, and to explore its underlying mechanisms. Methods: A total of 36 out and in patients with chronic bronch...Objective: To observe the clinical effect of Fifty ying acupuncture therapy for treatment of chronic bronchitis, and to explore its underlying mechanisms. Methods: A total of 36 out and in patients with chronic bronchitis including 10 cases of asthma were subjected into this study. Among them, 20 cases were qi deficiency type and 16 qi yin deficiency with phlegm damp type. The changes of symptoms, T lymphocyte subgroups of CD 3 +, CD 4 +, CD 8 +, CD 4 +/CD 8 +, soluble interleuki 2 receptor (SIL 2 R), interleukin 6(IL 6), IgG, IgA and IgM before and after treatment were observed and detected using monoclonal indirect fluorescence method, enzyme linked immunosorbent assay (ELISA) and nephelometry respectively. Results: (1)The effective rate of qi dificiency type was 100% and that of qi yin deficiency with phlegm damp type 87.5%. (2) After acupuncture treatment, in qi deficiency type patients, serum IgG, IgA and IgM contents increased significantly (P<0.001) in comparison with pre treatment and in qi yin deficiency with phlegm damp type patients, IgG level lowered obviously. Serum SIL 2R and CD 4 +/CD 8 + decreased obviously (P<0.01, 0.001), CD 3 +, CD 4 + and CD 8 + increased evidently (P<0.01). Conclusion: The Fifty ying acupuncture therapy can better clinical symptoms of chronic bronchitis patients through its resultant up regulation of the immune system function.展开更多
Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy on hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis, ...Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy on hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis, thus to offer relevant help for clinical therapies on patients with chronic bronchitis. Methods:120 cases of patients with chronic bronchitis treated in our hospital were selected and randomly divided to be the therapeutic group and the control group, 60 cases each. Patients in control group were provided some basic treatments, such as spasmolysis, anti-inflammation, asthma relieving, oxygen inhalation and dissolve phlegm. For therapeutic group on this basis, Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy was provided. Hemorheology, inflammatory factors and pulmonary functions in the two groups of patients were detected before and after treatment. Results:Differences of hemorheology indexes, inflammatory factors and pulmonary function relevant indexes between the two groups of patients with chronic bronchitis before treatment showed no statistical significance (P>0.05). Compared with prior treatment, hemorheology relevant indexes [whole blood high shear viscosity (WHV), whole blood low shear viscosity (WLV), packed cell volume (PCV), plasma viscosity (PV) and red cell assembling index (RCAI)], inflammatory factors [IL-8 (interleukin-8) and TNF-α(tumor necrosis factor-α)] were significantly decreased and pulmonary function relevant indexes [forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0), peak expiratory flow (PEF), maximal voluntary ventilation (MVV) and expiratory flow rate when exhale vital capacity was 0.50], inflammatory factors (IL-4, IL-2) were significantly increased in the two groups of patients with chronic bronchitis after relevant treatments;The differences between the groups showed statistical significance (P<0.05). After combined therapy provided, pulmonary function relevant indexes (FVC, FEV1.0, PEF, MVV and V0.50) and inflammatory factors (IL-4, IL-2) in therapeutic group were significantly higher than control group after basic therapy. Hemorheology relevant indexes (WHV, WLV, PV, PCV and RCAI) and inflammatory factors (IL-8 and TNF-α) in therapeutic group were significantly lower than control group;Differences between the two groups showed statistical significance (P<0.05). Conclusions: Combination of Jin-Shui-Liu-Jun-Jian and Acupoint Application significantly improved the levels of hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis. It has a great important clinical significance on therapies for patients with chronic bronchitis.展开更多
Objective: to explore the effect of valsartan in the treatment of chronic bronchitis complicated with hypertension. Methods: 200 patients with chronic bronchitis and hypertension were randomly selected from July 2019 ...Objective: to explore the effect of valsartan in the treatment of chronic bronchitis complicated with hypertension. Methods: 200 patients with chronic bronchitis and hypertension were randomly selected from July 2019 to July 2020. Then, according to the principles of randomness and average, they are explored in groups. One group of patients was treated with nifedipine, which was called the control group, and the other group was treated with valsartan, which was called the experimental group. After a period of treatment, all aspects of the performance of the two groups of patients were compared. Results: before treatment, the blood pressure levels of the two groups of patients were measured. The data showed that there was no significant difference between the two groups. After different treatments, the blood pressure of the two groups of patients was measured and compared again. At this time, the average blood pressure level of the experimental group was better than that of the control group. In addition, the levels of serum inflammatory factors such as CRP and IL-6 in the experimental group were significantly lower than those in the control group. The two groups of patients were evaluated from the adverse reactions. The probability of occurrence in the experimental group was less than that in the control group. The results of comparison between the two groups were significantly different and had a higher reference value. Conclusion: valsartan can be used in the treatment of patients with chronic bronchitis and hypertension, which can not only effectively improve the blood pressure level and inflammatory reaction degree of patients, but also has higher safety guarantee and higher clinical value.展开更多
Objective: to analyze the specific efficacy of moxifloxacin in the treatment of acute attack of chronic bronchitis. Methods: the sample selection work began in February 2020. Patients with acute attack of chronic bron...Objective: to analyze the specific efficacy of moxifloxacin in the treatment of acute attack of chronic bronchitis. Methods: the sample selection work began in February 2020. Patients with acute attack of chronic bronchitis previously treated were taken as samples. By March 2021, 48 patients were randomly selected and divided into groups. Among them, 24 patients treated with roxithromycin were the control group, and the other 24 patients treated with moxifloxacin were the observation group. The time of symptom regression was observed, the curative effect was reflected by the improvement of cough and other symptoms and the total effective rate of treatment, and the total proportion of adverse reactions and the difference between groups were calculated. Results: compared with the control group, the expectoration (2.24±1.22), wheezing (2.35±1.13) and cough stopping time (1.42±0.33) in the observation group were significantly shorter (P < 0.05);Compared with 79.17% (19 cases) in the control group, the total effective rate in the observation group was 95.83% (23 cases), which was more advantageous (P < 0.05);The incidence of adverse reactions was 20.83% (5 cases) in the control group and 8.33% (2 cases) in the observation group, which was significantly lower than that in the control group (P < 0.05). Conclusion: moxifloxacin can further improve the condition of patients with acute attack of chronic bronchitis, and the drug safety of patients is also higher.展开更多
Objective: to explore the value of disease education in the care of chronic bronchitis. Methods: a total of 100 patients with chronic bronchitis in our hospital from August 2019 to August 2020 were randomly divided in...Objective: to explore the value of disease education in the care of chronic bronchitis. Methods: a total of 100 patients with chronic bronchitis in our hospital from August 2019 to August 2020 were randomly divided into two groups by number table method. The general care group provided general care, and the disease mission group carried out general care combined with disease mission. The degree of knowledge and recognition of disease were compared between the two groups before and after care. Results: the degree of disease knowledge mastery of the two groups before care was significantly higher than that of the two groups after care (P > 0.05), but the disease education group was higher than that of the two groups after care (P < 0.05). The recognition of disease education group was higher than that of general care group, P < 0.05. Conclusion: general care combined with disease education is effective for chronic bronchitis patients, which is beneficial to improve the degree of disease knowledge and recognition.展开更多
To explore the clinical efficacy of TCM syndrome differentiation in the treatment of senile chronic bronchitis complicated with emphysema.Methods: from January 2019 to June 2021, 96 elderly patients with chronic bronc...To explore the clinical efficacy of TCM syndrome differentiation in the treatment of senile chronic bronchitis complicated with emphysema.Methods: from January 2019 to June 2021, 96 elderly patients with chronic bronchitis complicated with emphysema who went to our hospital for treatment were randomly divided into two groups: Western medicine treatment control group and TCM dialectical treatment observation group.Results: the symptom relief time, pulmonary function index and curative effect evaluation in the observation group were better than those in the control group (P < 0.05);There was no difference in adverse reaction rate (P > 0.05).Conclusion: the dialectical method of traditional Chinese medicine is used to treat senile chronic bronchitis complicated with emphysema.展开更多
Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the patho-logical change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lav-age flu...Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the patho-logical change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lav-age fluid (BALF) in various stages. Methods Chronic bronchitis sequential rat model was established by passively inhaling smoke mixture. Experiments were performed in 30 young male Sprague-Dawley rats, which comprised 5 groups in random, i.e.,4 chronic bronchitis model groups and 1 control group. After stained with hematoxylin and eosin, the specimens were studied by semi-quantitative method to evaluate the morphologic changes in various stages. Meanwhile, the inflammatory cells of the BALF and the activity of myeloperoxidase (MPO) of lung tissue were analysed. Results During the process of the chronic bronchitis, the pathologic score was increasing as time went on, and the typical morphologic changes of chronic bronchitis emerged in the group 7 weeks. The total number of inflammatory cells in BALF was increasing as time went on, correlated with the pathologic scores (P <0.01). And the percentage of lymphocyte increased as well as positively correlated with pathologic scores (P < 0. 05) , whereas that of macrophage decreased and negatively correlated with pathologic scores (P <0. 05). The MPO lever of lung tissue was correlated with the pathologic scores (P < 0. 01). But the percentage of the neutrophil in the BALF was just in a high level during the first week, then it maintained relatively lower. Conclusion Smoke-induced chronic bronchitis is a slowly progressive inflammation process. The model we established is convenient and simple for the longitudinal study on the inflammatory process of chronic bronchitis and the therapy in the early stage. The semi-quantitative evaluation for the pathological change is with much more value. During the inflammatory sequential process of early stage of chronic bronchitis, the cellular characteristics are similar to that of the common chronic inflammation.展开更多
文摘Image processing plays a vital role in various fields such as autonomous systems,healthcare,and cataloging,especially when integrated with deep learning(DL).It is crucial in medical diagnostics,including the early detection of diseases like chronic obstructive pulmonary disease(COPD),which claimed 3.2 million lives in 2015.COPD,a life-threatening condition often caused by prolonged exposure to lung irritants and smoking,progresses through stages.Early diagnosis through image processing can significantly improve survival rates.COPD encompasses chronic bronchitis(CB)and emphysema;CB particularly increases in smokers and generally affects individuals between 50 and 70 years old.It damages the lungs’air sacs,reducing oxygen transport and causing symptoms like coughing and shortness of breath.Treatments such as beta-agonists and inhaled steroids are used to manage symptoms and prolong lung function.Moreover,COVID-19 poses an additional risk to individuals with CB due to its impact on the respiratory system.The proposed system utilizes convolutional neural networks(CNN)to diagnose CB.In this system,CNN extracts essential and significant features from X-ray modalities,which are then fed into the neural network.The network undergoes training to recognize patterns and make accurate predictions based on the learned features.By leveraging DL techniques,the system aims to enhance the precision and reliability of CB detection.Our research specifically focuses on a subset of 189 lung disease images,carefully selected for model evaluation.To further refine the training process,various data augmentation and noise removal techniques are implemented.These techniques significantly enhance the quality of the training data,improving the model’s robustness and generalizability.As a result,the diagnostic accuracy has improved from 98.6%to 99.2%.This advancement not only validates the efficacy of our proposed model but also represents a significant improvement over existing literature.It highlights the potential of CNN-based approaches in transforming medical diagnostics through refined image analysis,learning capabilities,and automated feature extraction.
基金supported by the Natural Science Foundation of Henan Province(Grant No:23230042151)the Support Plan of the Health Commission in the Jinshan District of Shanghai(Grant No.JSFCZK202103)Foundation of National Key Program of Research and Development of China(Grant NO:2016YFC0900803).
文摘Chronic bronchitis(CB),characterized by persistent coughing with mucus production for at least three consecutive months in two successive years and caused by multiple factors[1],is a progressive condition.Acute exacerbation of chronic bronchitis(AECB),marked by recurrent episodes of bronchial inflammation,have been linked to various adverse health outcomes[2].
基金supported by the Key Talent's Subsidy Project in Science and Education of the Jiangsu Province (No. 2007158)
文摘Mutations in the cystic fibrosis transmembrane conductance regulator （CFTR） gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated the role of CFTR variations, poly-T, TG-repeats, and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province, China. A total of 72 bronchial asthma patients, 68 chronic bronchitis pa- tients, and 117 healthy subjects were included in this study. The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism （RFLP）. We found that the fre- quency of TS-TG12-V470 in chronic bronchitis patients was 0.07%, which was notably higher than that in healthy subjects （0.01%） and bronchial asthma patients （0.04%）. Thus, the presence of the TS-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions, such as chronic bronchitis.
基金supported by the National Clinical key subject construction funds(occupational disease program)the National Basic Research Program(973 program)of China(2011CB503802)+3 种基金Gong-Yi Program of China Ministry of Environmental Protection(201209008)China Medical Board Collaborating Program(13-152)Public Welfare Research Program of National HealthFamily Planning Commission of China(201402022)
文摘The association between ambient temperature and acute exacerbation of chronic bronchitis （AECB） was still unknown. Therefore, we performed an epidemiological study in a large hospital of Shanghai to explore the relationship about temperature and outpatient visit for AECB. We adopted a quasi-Poisson generalized additive models and distributed lag nonlinear models to estimate the accumulative effects of temperature on AECB across multiple days. We found significant non-linear effects of cold temperature on hospital visits for AECB, and the potential effect of cold temperature might last more than 2 weeks. The relative risks of extreme cold （first percentiles of temperature throughout the study period） and cold （10th percentile of temperature） temperature over lags 0-14 d were 2.98 [95% confidence intervals （CI）： 1.77, 5.04] and 1.63 （95% Ch 1.21, 2.19）, compared with the 25th percentile of temperature. However, we found no positive association between hospital visits and hot weather. This study showed that exposure to both extreme cold and cold temperatures were associated with increased outpatient visits for AECB in a large hospital of Shanghai.
文摘To observe the therapeutic effects of a Chinese drug Bufei Keli (补肺颗粒 granules for invigorating the lung) in the treatment of chronic bronchitis at remission stage, 62 cases were randomly divided into a treatment group (treated with Bufei Keli) and a control group (treated with Yupingfeng Keli 玉屏风颗粒). The results turned out to be that the short-term clinically controlled and markedly effective rate was 77.42% and the long-term relapse-resisting markedly effective rate was 74.2% in the treatment group, which were obviously higher than 45.16% and 38.71% respectively in the control group (P<0.05). And the increase in contents of SOD and CD_3 and the decrease in LPO content in the treatment group were also bigger than that in the control group (P<0.01). It is therefore concluded that Bufei Keli can improve qi deficiency syndrome and raise the immunity of patients with chronic bronchitis, hence its effect of resisting relapse of chronic bronchitis.
文摘BACKGROUND： The inflammatory reaction already becomes an important risk factor of causing acute cerebral infarction; however, the correlation between chronic bronchitis and senile cerebral infarction is still unclear. OBJECTIVE： To study whether the chronic bronchitis is the risk factor for senile cerebral infarction. DESIGN： 1 ： 1 pair, case contrast, and risk factor study. SETTINGS： Department of Respiratory Medicine, Third Hospital of Tangshan; Department of Neurology, Affiliated Hospital of North China Coal Medical College. PARTICIPANTS： A total of 147 patients with acute cerebral infarction who were regarded as case group were selected from Department of Neurology, the Third Hospital of Tangshan from January 2004 to December 2006. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Diseases Meeting. There were 87 males and 60 females, and their ages ranged from 65 to 83 years. Based on 1 ： 1 pair study, another 147 subjects without cerebrovascular disease were regarded as control group. Except the diseases about infection, there were 73 males and 74 females, and their ages ranged from 62 to 81 years. All subjects provided the confirm consent and agreed with the coordinate experiment. METHODS： ①Questionnaire of risk factor of cerebral infarction was designed to measure the following items： chronic bronchitis, hypertension, diabetes mellitus, hyperlipemia, coronary heart disease, primary cerebral infarction/transient ischemic attack and history of smoking. ②Cerebral infarction was regarded as the dependent variance, while chronic bronchitis, hypertension, diabetes mellitus, hypedipemia, primary cerebral infarction/transient ischemic attack, coronary heart disease and smoking were regarded as the independent variance for multiple regression analysis, MAIN OUTCOME MEASURES： Risk factors of senile cerebral infarction. RESULTS： All 147 patients with acute cerebral infarction and 147 subjects without cerebrovascular diseases were involved in the final analysis. ①Risk factor analysis of senile cerebral infarction： There were no significant differences in age, hyperlipemia and history of smoking between the two groups （P 〉 0.05）. But, chronic bronchitis, diabetes mellitus, hypertension, cerebral infarction/transient ischemic attack and history of coronary heart disease were higher in the case group than those in the control group （33.6% vs. 19.0%, 38.8% vs. 23.3%, 54.3% vs. 36.2%, 29.3% vs. 17.2%, 44.0% vs. 29.3%, P 〈 0.05- 0.01）. ②Multiple Logistic regression analysis of risk factor of senile cerebral infarction Hyperlipemia, smoking and coronary heart disease were not correlated with cerebral infarction （P 〉0.05）, but chronic bronchitis, hypertension, diabetes mellitus and cerebral infarction/transient ischemic attack were risk factors for senile cerebral infarction （OR =2.47, 2.28, 2.18, 2.01, P 〈 0.05 - 0.01）. CONCLUSION： The chronic bronchitis mac become an independent risk factor senile cerebral infarction.
文摘Background: Poverty is an important surrogate marker for obstructive airway diseases (OAD). Slum constitutes a habitat wherein various poverty related parameters are perpetually prevalent in the ambience. 1/6th of world population lives in slums yet there is no information regarding their health status in context to asthma and COPD. Aims: We investigated the prevalence of asthma and chronic-bronchitis symptoms and associated risk-factors in slum habitats of Pune city. Methodology: 7062 adult slum-dwellers living in 12 slums of Pune city were cross-sectionally interviewed by local healthcare workers with respiratory health questionnaire which was designed using respiratory symptoms of validated European Community Respiratory Health Survey (ECRHS II) questionnaire and International Union against Tuberculosis and Lung Disease (IUATLD) bronchial symptoms questionnaire. Results: The overall prevalence of selfreported asthma symptoms was 10% (18 - 40 years: 6.5%;>40 years: 13.5%). The overall prevalence of chronic bronchitis was 8.5% [18 - 40 years: 7% (males: 7%, females: 7%);>40 years: 10% (males: 10%, females: 10%)]. Increasing age (p = 0.00), female gender (p = 0.001), unemployment (0.00) current smoking (p = 0.00) and ex-smoking (p = 0.004) emerged as significant risk factor for asthma. While, ex-smoking (p = 0.004) and low-education status (p = 0.00) emerged as significant risk factors for chronic bronchitis. Conclusion: In slums reporting of asthma and chronic-bronchitis symptoms was much higher than what has been reported earlier from India. Asthma was commonly seen in females, old age, unemployed and ever-smokers. While chronic bronchitis was commonly seen in ex-smokers and illiterate subjects. Chronic bronchitis was equally distributed amongst male and females, despite 0% prevalence of smoking in females.
文摘Moxibustion in dog days" is a unique therapy for chronic bronchitis and bronchial asthma by means of drug-seperated moxibustion. In the present paper, therapeutic methods, and clinical short-and long-term therapeutic effects of "moxibustion in dog days" are introduced and it is indicated that "moxibustion in dog days" has very good the short-and long-term therapeutic effects, with the long-term therapeutic effect better than the short-term one, for chronic bronchitis and bronchial asthma. Also, the concrete methods for increase of the short-term therapeutic effect are put forward.
文摘Background and Objectives: In clinical practice, spirometry plays a key role in the diagnosis of chronic obstructive pulmonary disease (COPD), however, it provides no information about structural pulmonary abnormality. The aim of this study was to evaluate whether there is a relation between the clinical criteria and chest radiography or CT studies in differentiating chronic bronchitis from emphysema in COPD. Patients and methods: In a prospective study, data analysis on 165 COPD subjects who were enrolled between September, 2011 and December 2012 was completed. Data were collected including clinical characteristics of stable COPD, pulmonary function tests, chest X-ray and multidetector computerized tomography (MDCT) findings. Results: Emphysema was diagnosed in 90 (55%) of 165 CT scans. The median emphysema score was 58 (range 48 - 72) and significantly correlated with lower FEV1 values (r = 0.542, p = 0.003). In chronic bronchitis, bronchial wall thickening was diagnosed approximately as often in chest radiography (56%) as in CT (64%) as a major finding. Body mass index (BMI), forced expiratory volume in the first second (FEV1), and diffusion capacity of the lung for carbon monoxide (DL,CO) were significantly lower, whereas total lung capacity (TLC) was higher in patients with emphysema. Cardiovascular diseases and obstructive sleep apnea syndrome (OSAS) were more common in chronic bronchitis group. Conclusions: Chest radiography is a valuable, inexpensive means of diagnosing emphysema or bronchial wall thickening in chronic bronchitis. Emphysematous patients show a worse pulmonary function and a greater dyspnea. Greater comorbidity in chronic bronchitis may require specific treatment strategies in this subgroup.
基金Inheritance and Innovation of TCM“Ten Million”Talent Project(Qihuang Project)(No.2019-QTL-003)。
文摘Objective:To systematically evaluate the efficacy and safety of Shufeng Jiedu Capsules in the treatment of acute attacks of chronic bronchitis.Methods:CNKI,VIP,CBM,WanFang,PubMed,EMbase,Cochrane Library and ChiCTR were searched by computer,and randomized controlled trials of Shufeng Jiedu capsules in the treatment of AECB were integrated.The retrieval time was from the date of establishing the database to December 31,2020.Meta-analysis of outcome indicators[including effective rate,C-reactive protein(CRP),lung function[FEV1%and/or FEV1/FVC],interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]were carried out by RevMan 5.3 software,and the effective rate was tested by sequential analysis(TSA),and the quality of evidence was evaluated according to GRADE standards.Results:A total of 680 cases in 8 articles were included.Shufeng Jiedu Capsules improved the effective rate of clinicaltreatment[RR=1.20,95%CI(1.13,1.28)],improved lung function[FEV1:MD=0.33,95%CI(0.22,0.45),FEV1/FVC:MD=10.17,95%CI(8.15,12.19)],reduced CRP[MD=-7.32,95%CI(-8.42,-6.22)],IL-8[MD=-63.39,95%CI(-73.49,-53.29)],TNF-α[MD=-7.44,95%CI(-8.35,-6.53)]levels.The above differences were statistically significant(P<0.05),and no serious adverse reactions were reported in all studies.The results of TSA analysis showed that the experimental group had definite evidence for improving the efficiency.According to the GRADE evaluation system,the efficiency,TNF-αwere medium-quality evidences,FEV1 was low-quality evidence,and FEV1/FVC,CRP,and IL-8 were extremely low-quality evidence.Conclusions:The curative effect of Shufeng Jiedu capsule combined with western medicine in the treatment of AECB was better than that of single western medicine.Nevertheless,considering the limited sample size and the quality of included articles,higher quality RCTs are still needed to further confirm its effectiveness and safety.
文摘Objectives： To determine whether traditional Chinese medicine （TCM） aerosol inhalation treatment is effective inthe treatment of acute exacerbation of chronic bronchitis. Methods： Search double-blind randomised clinical trials（RCT） about the use of TCM aerosol inhalation in patient with acute exacerbation of chronic bronchitis via database including Chinese biomedicine literature database, Wanfang Data, CNKI, Pubmed, EMBASE and CochraneLibrary from the beginning to October 2016. Quality evaluation, data extraction and data analysis of these RCT wascarried out with reference to the Cochrane systematic review. Results： 16 studies with 738 patients in TCM aerosolinhalation group and 675 in control group were included. The results of meta-analysis showed, （1） TCM aerosolinhalation group could improve the total cure rate. （2） TCM aerosol inhalation could increase the expression of IL-2while decrease the expression of IL-8 and MDA in sputum and blood. （3） TCM aerosol inhalation could improvethe symptoms of cough, cough with sputum, cough with dyspnea and lung wet rales. It also improve the symptomsof cough, expectorate and lung wet rales. （4） Shorten the time of cough and lung rale. （5） The adverse reactionswere light only with 1 occurrence of nausea and vomiting. Conclusions： The use of TCM aerosol inhalation in thetreatment of acute exacerbation of chronic bronchitis was effective. However, the inclusion researches quality werenot very high, which only provided limited evidence for clinical application. Higher-quality randomized controlledtrials were needed for further study.
文摘Chronic bronchitis is a clinical common disease,which is a chronic nonspecific inflammation of the tracheal and bronchial mucosa and its surrounding tissues caused by a variety of factors.It is clinically characterized by symptoms such as cough,excessive phlegm,shortness of breath,and a recurrent chronic process.Chronic bronchitis has a high incidence and severe symptoms in winter.In severe cases,there are long-term clinical symptoms that impact the patient’s spirit and life.At the same time,the disease causes numerous diseases such as emphysema and pulmonary heart disease.Therefore,patients have an essential need for the treatment of chronic bronchitis.This article tells the etiology,treatment methods,process,prevention,and nursing of the disease from the perspective of western medicine and traditional Chinese medicine,respectively.
文摘Objective: To observe the clinical effect of Fifty ying acupuncture therapy for treatment of chronic bronchitis, and to explore its underlying mechanisms. Methods: A total of 36 out and in patients with chronic bronchitis including 10 cases of asthma were subjected into this study. Among them, 20 cases were qi deficiency type and 16 qi yin deficiency with phlegm damp type. The changes of symptoms, T lymphocyte subgroups of CD 3 +, CD 4 +, CD 8 +, CD 4 +/CD 8 +, soluble interleuki 2 receptor (SIL 2 R), interleukin 6(IL 6), IgG, IgA and IgM before and after treatment were observed and detected using monoclonal indirect fluorescence method, enzyme linked immunosorbent assay (ELISA) and nephelometry respectively. Results: (1)The effective rate of qi dificiency type was 100% and that of qi yin deficiency with phlegm damp type 87.5%. (2) After acupuncture treatment, in qi deficiency type patients, serum IgG, IgA and IgM contents increased significantly (P<0.001) in comparison with pre treatment and in qi yin deficiency with phlegm damp type patients, IgG level lowered obviously. Serum SIL 2R and CD 4 +/CD 8 + decreased obviously (P<0.01, 0.001), CD 3 +, CD 4 + and CD 8 + increased evidently (P<0.01). Conclusion: The Fifty ying acupuncture therapy can better clinical symptoms of chronic bronchitis patients through its resultant up regulation of the immune system function.
文摘Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy on hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis, thus to offer relevant help for clinical therapies on patients with chronic bronchitis. Methods:120 cases of patients with chronic bronchitis treated in our hospital were selected and randomly divided to be the therapeutic group and the control group, 60 cases each. Patients in control group were provided some basic treatments, such as spasmolysis, anti-inflammation, asthma relieving, oxygen inhalation and dissolve phlegm. For therapeutic group on this basis, Jin-Shui-Liu-Jun-Jian and Acupoint Application combined therapy was provided. Hemorheology, inflammatory factors and pulmonary functions in the two groups of patients were detected before and after treatment. Results:Differences of hemorheology indexes, inflammatory factors and pulmonary function relevant indexes between the two groups of patients with chronic bronchitis before treatment showed no statistical significance (P>0.05). Compared with prior treatment, hemorheology relevant indexes [whole blood high shear viscosity (WHV), whole blood low shear viscosity (WLV), packed cell volume (PCV), plasma viscosity (PV) and red cell assembling index (RCAI)], inflammatory factors [IL-8 (interleukin-8) and TNF-α(tumor necrosis factor-α)] were significantly decreased and pulmonary function relevant indexes [forced vital capacity (FVC), forced expiratory volume in one second (FEV1.0), peak expiratory flow (PEF), maximal voluntary ventilation (MVV) and expiratory flow rate when exhale vital capacity was 0.50], inflammatory factors (IL-4, IL-2) were significantly increased in the two groups of patients with chronic bronchitis after relevant treatments;The differences between the groups showed statistical significance (P<0.05). After combined therapy provided, pulmonary function relevant indexes (FVC, FEV1.0, PEF, MVV and V0.50) and inflammatory factors (IL-4, IL-2) in therapeutic group were significantly higher than control group after basic therapy. Hemorheology relevant indexes (WHV, WLV, PV, PCV and RCAI) and inflammatory factors (IL-8 and TNF-α) in therapeutic group were significantly lower than control group;Differences between the two groups showed statistical significance (P<0.05). Conclusions: Combination of Jin-Shui-Liu-Jun-Jian and Acupoint Application significantly improved the levels of hemorheology, inflammatory factors and pulmonary functions in patients with chronic bronchitis. It has a great important clinical significance on therapies for patients with chronic bronchitis.
文摘Objective: to explore the effect of valsartan in the treatment of chronic bronchitis complicated with hypertension. Methods: 200 patients with chronic bronchitis and hypertension were randomly selected from July 2019 to July 2020. Then, according to the principles of randomness and average, they are explored in groups. One group of patients was treated with nifedipine, which was called the control group, and the other group was treated with valsartan, which was called the experimental group. After a period of treatment, all aspects of the performance of the two groups of patients were compared. Results: before treatment, the blood pressure levels of the two groups of patients were measured. The data showed that there was no significant difference between the two groups. After different treatments, the blood pressure of the two groups of patients was measured and compared again. At this time, the average blood pressure level of the experimental group was better than that of the control group. In addition, the levels of serum inflammatory factors such as CRP and IL-6 in the experimental group were significantly lower than those in the control group. The two groups of patients were evaluated from the adverse reactions. The probability of occurrence in the experimental group was less than that in the control group. The results of comparison between the two groups were significantly different and had a higher reference value. Conclusion: valsartan can be used in the treatment of patients with chronic bronchitis and hypertension, which can not only effectively improve the blood pressure level and inflammatory reaction degree of patients, but also has higher safety guarantee and higher clinical value.
文摘Objective: to analyze the specific efficacy of moxifloxacin in the treatment of acute attack of chronic bronchitis. Methods: the sample selection work began in February 2020. Patients with acute attack of chronic bronchitis previously treated were taken as samples. By March 2021, 48 patients were randomly selected and divided into groups. Among them, 24 patients treated with roxithromycin were the control group, and the other 24 patients treated with moxifloxacin were the observation group. The time of symptom regression was observed, the curative effect was reflected by the improvement of cough and other symptoms and the total effective rate of treatment, and the total proportion of adverse reactions and the difference between groups were calculated. Results: compared with the control group, the expectoration (2.24±1.22), wheezing (2.35±1.13) and cough stopping time (1.42±0.33) in the observation group were significantly shorter (P < 0.05);Compared with 79.17% (19 cases) in the control group, the total effective rate in the observation group was 95.83% (23 cases), which was more advantageous (P < 0.05);The incidence of adverse reactions was 20.83% (5 cases) in the control group and 8.33% (2 cases) in the observation group, which was significantly lower than that in the control group (P < 0.05). Conclusion: moxifloxacin can further improve the condition of patients with acute attack of chronic bronchitis, and the drug safety of patients is also higher.
文摘Objective: to explore the value of disease education in the care of chronic bronchitis. Methods: a total of 100 patients with chronic bronchitis in our hospital from August 2019 to August 2020 were randomly divided into two groups by number table method. The general care group provided general care, and the disease mission group carried out general care combined with disease mission. The degree of knowledge and recognition of disease were compared between the two groups before and after care. Results: the degree of disease knowledge mastery of the two groups before care was significantly higher than that of the two groups after care (P > 0.05), but the disease education group was higher than that of the two groups after care (P < 0.05). The recognition of disease education group was higher than that of general care group, P < 0.05. Conclusion: general care combined with disease education is effective for chronic bronchitis patients, which is beneficial to improve the degree of disease knowledge and recognition.
文摘To explore the clinical efficacy of TCM syndrome differentiation in the treatment of senile chronic bronchitis complicated with emphysema.Methods: from January 2019 to June 2021, 96 elderly patients with chronic bronchitis complicated with emphysema who went to our hospital for treatment were randomly divided into two groups: Western medicine treatment control group and TCM dialectical treatment observation group.Results: the symptom relief time, pulmonary function index and curative effect evaluation in the observation group were better than those in the control group (P < 0.05);There was no difference in adverse reaction rate (P > 0.05).Conclusion: the dialectical method of traditional Chinese medicine is used to treat senile chronic bronchitis complicated with emphysema.
基金Supported by the fund from Shanghai Science and Technology Committee (004119060)
文摘Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the patho-logical change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lav-age fluid (BALF) in various stages. Methods Chronic bronchitis sequential rat model was established by passively inhaling smoke mixture. Experiments were performed in 30 young male Sprague-Dawley rats, which comprised 5 groups in random, i.e.,4 chronic bronchitis model groups and 1 control group. After stained with hematoxylin and eosin, the specimens were studied by semi-quantitative method to evaluate the morphologic changes in various stages. Meanwhile, the inflammatory cells of the BALF and the activity of myeloperoxidase (MPO) of lung tissue were analysed. Results During the process of the chronic bronchitis, the pathologic score was increasing as time went on, and the typical morphologic changes of chronic bronchitis emerged in the group 7 weeks. The total number of inflammatory cells in BALF was increasing as time went on, correlated with the pathologic scores (P <0.01). And the percentage of lymphocyte increased as well as positively correlated with pathologic scores (P < 0. 05) , whereas that of macrophage decreased and negatively correlated with pathologic scores (P <0. 05). The MPO lever of lung tissue was correlated with the pathologic scores (P < 0. 01). But the percentage of the neutrophil in the BALF was just in a high level during the first week, then it maintained relatively lower. Conclusion Smoke-induced chronic bronchitis is a slowly progressive inflammation process. The model we established is convenient and simple for the longitudinal study on the inflammatory process of chronic bronchitis and the therapy in the early stage. The semi-quantitative evaluation for the pathological change is with much more value. During the inflammatory sequential process of early stage of chronic bronchitis, the cellular characteristics are similar to that of the common chronic inflammation.
