A ligand-accelerated, branch-selective oxidative cyanation of alkenes has been developed in the presence of catalytic Cu_2O.Both styrenes and aliphatic alkenes with directing groups are well tolerated in this inexpens...A ligand-accelerated, branch-selective oxidative cyanation of alkenes has been developed in the presence of catalytic Cu_2O.Both styrenes and aliphatic alkenes with directing groups are well tolerated in this inexpensive protocol.The mild condition allows for a good tolerance of functional groups, enabling facile access to a diverse array of simple and complex branched vinyl nitriles.The wide synthetic utility of this methodology has been further demonstrated via the efficient scaleup in both batch and continuous flow processes.展开更多
基金supported by the National Natural Science Foundation of China (21702029)the ‘‘Thousand Plan" Youth programthe Shanghai Sailing Program (17YF1400100)
文摘A ligand-accelerated, branch-selective oxidative cyanation of alkenes has been developed in the presence of catalytic Cu_2O.Both styrenes and aliphatic alkenes with directing groups are well tolerated in this inexpensive protocol.The mild condition allows for a good tolerance of functional groups, enabling facile access to a diverse array of simple and complex branched vinyl nitriles.The wide synthetic utility of this methodology has been further demonstrated via the efficient scaleup in both batch and continuous flow processes.
