Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these b...Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clin- ical rating scales of the Fugl-Meyer Motor Assessment （r = -0.609, P = 0.047） and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale （r = -0.737, P = 0.010）. Our findings call objectively identify the functional abnormality in some brain regions of ischemic stroke patients.展开更多
Objective: to analyze the abnormal CT findings in schizophrenia. Methods: the selected study subjects were 60 schizophrenia patients treated in our hospital from May to December 2021. All the selected subjects were co...Objective: to analyze the abnormal CT findings in schizophrenia. Methods: the selected study subjects were 60 schizophrenia patients treated in our hospital from May to December 2021. All the selected subjects were confirmed according to the relevant diagnostic criteria of schizophrenia and underwent CT examination including the CT detection rate, CT typing, age distribution and disease course distribution of the patients. Results: after the 60 schizophrenia patients were selected for a CT scan, forty-one patients were found to have structural brain abnormalities. The CT classification was: 5 cases of diffuse cerebral atrophy, 12.19%), 25 (60.97%) and 11 (26.83%) respectively;at the same time, Schizophrenic patients with structural brain abnormalities are mainly 21-55 years old;for 85.36% (35 / 41), the disease duration is mainly 10 years, accounting for 53.66% (22 / 41);the CT value of the left frontal CT was lower than that of the healthy group. Statistical significance was observed (P 0.05). Conclusion: using CT examination can evaluate the brain structure of schizophrenia patients. This study found that the most common clinical symptoms of schizophrenia is brain atrophy in the elderly compared with age. CT can provide more reliable information for clinical diagnosis and treatment of schizophrenia. But because of abnormal brain structure, there is no high specificity, so patients with schizophrenia will not have significant performance, clinical to do further research in this aspect.展开更多
基金financially supported by the National Program on Key Basic Research Project of China(973 Program)No.2012CB518501the National Natural Science Foundation of China,No.81072864
文摘Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clin- ical rating scales of the Fugl-Meyer Motor Assessment （r = -0.609, P = 0.047） and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale （r = -0.737, P = 0.010）. Our findings call objectively identify the functional abnormality in some brain regions of ischemic stroke patients.
文摘Objective: to analyze the abnormal CT findings in schizophrenia. Methods: the selected study subjects were 60 schizophrenia patients treated in our hospital from May to December 2021. All the selected subjects were confirmed according to the relevant diagnostic criteria of schizophrenia and underwent CT examination including the CT detection rate, CT typing, age distribution and disease course distribution of the patients. Results: after the 60 schizophrenia patients were selected for a CT scan, forty-one patients were found to have structural brain abnormalities. The CT classification was: 5 cases of diffuse cerebral atrophy, 12.19%), 25 (60.97%) and 11 (26.83%) respectively;at the same time, Schizophrenic patients with structural brain abnormalities are mainly 21-55 years old;for 85.36% (35 / 41), the disease duration is mainly 10 years, accounting for 53.66% (22 / 41);the CT value of the left frontal CT was lower than that of the healthy group. Statistical significance was observed (P 0.05). Conclusion: using CT examination can evaluate the brain structure of schizophrenia patients. This study found that the most common clinical symptoms of schizophrenia is brain atrophy in the elderly compared with age. CT can provide more reliable information for clinical diagnosis and treatment of schizophrenia. But because of abnormal brain structure, there is no high specificity, so patients with schizophrenia will not have significant performance, clinical to do further research in this aspect.
