Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms.However,the neurobiological mechanisms underlying specific impairments are not fully understood.Advances in neuroimagi...Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms.However,the neurobiological mechanisms underlying specific impairments are not fully understood.Advances in neuroimaging techniques（such as diffusion tensor imaging and functional MRI）have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease.The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks.Using these powerful neuroimaging approaches,changes at the microstructural level can be detected through regional and global properties of neuronal networks.Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury,mainly focusing on structural and functional connectivity.Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury.These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae,as well as predicting outcome and prognosis.展开更多
基金supported by a grant from the Medical Scientific Research Programs of Nanjing Military Command,No.14MS122
文摘Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms.However,the neurobiological mechanisms underlying specific impairments are not fully understood.Advances in neuroimaging techniques（such as diffusion tensor imaging and functional MRI）have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease.The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks.Using these powerful neuroimaging approaches,changes at the microstructural level can be detected through regional and global properties of neuronal networks.Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury,mainly focusing on structural and functional connectivity.Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury.These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae,as well as predicting outcome and prognosis.
文摘目的探讨基于静息态功能磁共振成像(Resting-State Functional Magnetic Resonance Imaging,rs-fMRI)的创伤性脑损伤(Traumatic Brain Injury,TBI)患者功能连接。方法以14例TBI患者和12例健康对照(Healthy Controls,HC)为研究对象,对其rs-fMRI图像进行预处理,再通过独立成分分析(Independent Component Analysis,ICA)得到默认模式网络(Default Model Network,DMN)和执行控制网络(Executive Control Network,ECN),从两个脑网络中各选取4个脑区作为种子点进行功能连接分析,最后使用单样本t检验、双样本t检验以及配对t检验探索TBI被试脑损伤后3、6和12个月与HC组的DMN与ECN功能联通性差异及变化情况。结果TBI患者恢复期三个时间点的功能连接均与HC组有显著差异,DMNECN双网络之间的功能联通性与单个网络内部相比变化更为突出。此外,左侧顶叶为一个关键节点,可能为TBI的后续治疗提供新方向。结论TBI后患者大脑静息态脑网络DMN与ECN的功能连接存在显著异常,这种异常可能是导致患者存在长期认知障碍及其他后遗症的原因。
