The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord,but also to a novel type of communication ...The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord,but also to a novel type of communication called volume transmission.It is a major mode of communication in the central nervous system that takes places in the extracellular fluid and the cerebral spinal fluid through diffusion and flow of molecules,like neurotransmitters and extracellular vesicles.The integration of synaptic and volume transmission takes place through allosteric receptor-receptor interactions in heteroreceptor complexes.These heterocomplexes represent major integrator centres in the plasma membrane and their protomers act as moonlighting proteins undergoing dynamic changes and their structure and function.In fact,we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses.展开更多
Professor Duzheng YE＇s name has been familiar to me ever since my postdoctoral years at MIT with Professors Jule CHARNEY and Norman PHILLIPS, back in the late 1960 s. I had the enormous pleasure of meeting Professor ...Professor Duzheng YE＇s name has been familiar to me ever since my postdoctoral years at MIT with Professors Jule CHARNEY and Norman PHILLIPS, back in the late 1960 s. I had the enormous pleasure of meeting Professor YE personally in 1992 in Beijing. His concern to promote the very best science and to use it well, and his thinking on multi-level orderly human activities, reminds me not only of the communication skills we need as scientists but also of the multi-level nature of science itself. Here I want to say something（a） about what science is;（b） about why multi-level thinking—and taking more than one viewpoint—is so important for scientific as well as for other forms of understanding; and（c） about what is meant, at a deep level, by ＂scientific understanding＂ and trying to communicate it, not only with lay persons but also across professional disciplines. I hope that Professor YE would approve.展开更多
基金supported by grants from the Swedish Medical Research Council(04X-715)to KFby AFA Försakring(130328)to KF and DOBEby Hjarnfonden to DOBE.DOBE belong to Academia de Biólogos Cubanos
文摘The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord,but also to a novel type of communication called volume transmission.It is a major mode of communication in the central nervous system that takes places in the extracellular fluid and the cerebral spinal fluid through diffusion and flow of molecules,like neurotransmitters and extracellular vesicles.The integration of synaptic and volume transmission takes place through allosteric receptor-receptor interactions in heteroreceptor complexes.These heterocomplexes represent major integrator centres in the plasma membrane and their protomers act as moonlighting proteins undergoing dynamic changes and their structure and function.In fact,we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses.
文摘Professor Duzheng YE＇s name has been familiar to me ever since my postdoctoral years at MIT with Professors Jule CHARNEY and Norman PHILLIPS, back in the late 1960 s. I had the enormous pleasure of meeting Professor YE personally in 1992 in Beijing. His concern to promote the very best science and to use it well, and his thinking on multi-level orderly human activities, reminds me not only of the communication skills we need as scientists but also of the multi-level nature of science itself. Here I want to say something（a） about what science is;（b） about why multi-level thinking—and taking more than one viewpoint—is so important for scientific as well as for other forms of understanding; and（c） about what is meant, at a deep level, by ＂scientific understanding＂ and trying to communicate it, not only with lay persons but also across professional disciplines. I hope that Professor YE would approve.
