Heckman Sampel Selection Model (PSSM) has been adopted widely in the study of labour work. This model contains exogenous, endogenous and standard error variables. However, this model is constantly exposed to high inac...Heckman Sampel Selection Model (PSSM) has been adopted widely in the study of labour work. This model contains exogenous, endogenous and standard error variables. However, this model is constantly exposed to high inaccuracy of estimation result. Therefore, to obtain an accurate and precise estimation, the bootstrap approach is introduced. The bootstrap approach will be hybrid with PSSM model known as BPSSM to achieve estimation result that is more precise. Then, the BPSSM is applied to Malaysian Population and Family Survey 1994 (MPFS-1994) data. The results showed that BPSSM provide a smaller standard error and shorter confidence intervals.展开更多
We propose a new nonparametric method for assessing non-inferiority of an experimental therapy compared to a standard of care. The ratio μE/μR of true median survival times is the parameter of interest. This is of c...We propose a new nonparametric method for assessing non-inferiority of an experimental therapy compared to a standard of care. The ratio μE/μR of true median survival times is the parameter of interest. This is of considerable interest in clinical trials of generic drugs. We think of the ratio mE/mR of the sample medians as a point estimate of the ratioμE/μR. We use the Fieller-Hinkley distribution of the ratio of two normally distributed random variables to derive an unbiased level-α test of inferiority null hypothesis, which is stated in terms of the ratio μE/μR and a pre-specified fixed non-inferiority margin δ. We also explain how to assess equivalence and non-inferiority using bootstrap equivalent confidence intervals on the ratioμE/μR. The proposed new test does not require the censoring distributions for the two arms to be equal and it does not require the hazard rates to be proportional. If the proportional hazards assumption holds good, the proposed new test is more attractive. We also discuss sample size determination. We claim that our test procedure is simple and attains adequate power for moderate sample sizes. We extend the proposed test procedure to stratified analysis. We propose a “two one-sided tests” approach for assessing equivalence.展开更多
文摘Heckman Sampel Selection Model (PSSM) has been adopted widely in the study of labour work. This model contains exogenous, endogenous and standard error variables. However, this model is constantly exposed to high inaccuracy of estimation result. Therefore, to obtain an accurate and precise estimation, the bootstrap approach is introduced. The bootstrap approach will be hybrid with PSSM model known as BPSSM to achieve estimation result that is more precise. Then, the BPSSM is applied to Malaysian Population and Family Survey 1994 (MPFS-1994) data. The results showed that BPSSM provide a smaller standard error and shorter confidence intervals.
文摘We propose a new nonparametric method for assessing non-inferiority of an experimental therapy compared to a standard of care. The ratio μE/μR of true median survival times is the parameter of interest. This is of considerable interest in clinical trials of generic drugs. We think of the ratio mE/mR of the sample medians as a point estimate of the ratioμE/μR. We use the Fieller-Hinkley distribution of the ratio of two normally distributed random variables to derive an unbiased level-α test of inferiority null hypothesis, which is stated in terms of the ratio μE/μR and a pre-specified fixed non-inferiority margin δ. We also explain how to assess equivalence and non-inferiority using bootstrap equivalent confidence intervals on the ratioμE/μR. The proposed new test does not require the censoring distributions for the two arms to be equal and it does not require the hazard rates to be proportional. If the proportional hazards assumption holds good, the proposed new test is more attractive. We also discuss sample size determination. We claim that our test procedure is simple and attains adequate power for moderate sample sizes. We extend the proposed test procedure to stratified analysis. We propose a “two one-sided tests” approach for assessing equivalence.
