Objective:To examine the change in COVID-19 booster vaccine hesitancy according to descriptive characteristics,characteristics related to COVID-19,health literacy(HL)skills related to booster dose.Methods:The inclusio...Objective:To examine the change in COVID-19 booster vaccine hesitancy according to descriptive characteristics,characteristics related to COVID-19,health literacy(HL)skills related to booster dose.Methods:The inclusion criterion was the completion of the primary scheme as two doses of COVID-19 vaccine.The study was conducted in January 2022 by applying face-to-face interview technique.Questions regarding HL were used to question the ability of individuals to access,understand,interpret and use information regarding the COVID-19 booster dose in their decisions.Results:A total of 1210 people were included in this study with an mean age of(41.3±16.6)years,and 51.4%were women.In multivariate analysis,hesitation increased in the"moderately concerned"(aOR 2.65,95%CI 1.09-6.45),"slightly concerned"(aOR 3.01,95%CI 1.26-7.19),"not concerned at all”(aOR 5.69,95%CI 2.27-14.28)groups compared to the group“extremely concerned”about COVID-19 transmission.Those with Sinovac-CoronaVac as their most recent vaccine had increased hesitation compared to those with Pfizer-BioNTech(aOR 3.68,95%CI 2.05-6.61).The effect of HL skills including“accessing”,“understanding”,and“appraising”information on hesitation was not statistically significant(P>0.05).HL skill of“applying”was assessed with ability of information to help decision making.Whether the information is helpful for decision-making,the risk of hesitancy increased for those who stated that it"sometimes helps"(aOR 2.55;95%CI 1.31-4.99)and"never helps"(aOR 11.62;95%CI 3.03-44.58)compared to those who stated that it"always helps".Conclusions:The increased propability of hesitation in those less concerned about COVID-19 transmission shows the importance of appropriately guiding individuals'concern levels with a health communication strategy based on risk communication.The fact that the only HL skill with a significant effect in the multivariate model was“applying”,shows the critical role of this skill in influencing behavioral changes.展开更多
The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the ...The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the electron beam from the Linac and increases its energy to the value required for the storage ring.The full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target values.These milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam commissioning.As measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,respectively.This paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.展开更多
Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based c...Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.展开更多
The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key...The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key technologies for ensuring the success of rocket flights and has been a core topic in carrier rocket technology research. The Gravity-1 solid carrier rocket is the first solid rocket bundled rocket developed by China, adopting a configuration with four boosters and a core stage bundled together. During the actual flight process, the four booster engines are ignited first, and then, in the event of insufficient control force from the boosters, the core stage engine is ignited to participate in control. To address thrust asynchrony during the descent of the four boosters, an Extended State Observer(ESO) is employed in the control scheme for this flight segment. This involves real-time estimation and compensation of attitude parameters during flight, identification of thrust asynchrony among the boosters, and simultaneous determination of whether the core stage engine is ignited to participate in control.Through six degrees of freedom simulation analysis and Y1 flight test validation, this method has been proven to be correct and feasible.展开更多
Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron variants.Questions concerning about memory B cells(MBCs)and T cells immunity a...Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron variants.Questions concerning about memory B cells(MBCs)and T cells immunity against Omicron variants,features of long-term immunity,after booster and OBI,needs to be explored.Here,comparative analysis demonstrate antibody and T cell immunity against ancestral strain,Delta and Omicron variants in Omicron breakthrough infected patients(OBIPs)are comparable to that in Ad5-nCoV boosted healthy volunteers(HVs),higher than that in inactivated vaccine(InV)boosted HVs.However,memory B cells(MBCs)immunity against Omicron variants was highest in OBIPs,followed by Ad5-nCoV boosted and InV boosted HVs.OBIPs and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs,and lower naïve MBCs and atypical MBCs relative to both vaccine boosted HVs.Collectively,these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.展开更多
The analysis of natural vibration characteristics has become one of important steps of the manufacture and dynamic design in the aerospace industry. This paper presents a new scenario called virtual cutting in the con...The analysis of natural vibration characteristics has become one of important steps of the manufacture and dynamic design in the aerospace industry. This paper presents a new scenario called virtual cutting in the context of the transfer matrix method of linear multibody systems closed- loop topology for computing the free vibration characteristics of elastically coupled flexible launch vehicle boosters. In this approach, the coupled system is idealized as a triple-beam system-like structure coupled by linear translational springs, where a non-uniform free-free Euler-Bemoulli beam is used. A large thrust-to-weight ratio leads to large axial accelera- tions that result in an axial inertia load distribution from nose to tail. Consequently, it causes the development of significant compressive forces along the length of the launch vehicle. Therefore, it is important to take into account this effect in the transverse vibration model. This scenario does not need the global dynamics equations of a system, and it has high computational efficiency and low memory requirements. The validity of the presented scenario is achieved through com- parison to other approaches published in the literature.展开更多
Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-b...Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.展开更多
Recirculation is prohibited in many coal mining countries because of the fear that the re-use of return air would allow the build-up of air contaminants at the workings. The incorrect design and location of a booster ...Recirculation is prohibited in many coal mining countries because of the fear that the re-use of return air would allow the build-up of air contaminants at the workings. The incorrect design and location of a booster fan in any ventilation network can create unsafe condition due to recirculation. The current approach to investigating recirculation using simulation software requires manual effort which becomes tedious in a complex and a large network. An algorithm-based C++ program was designed to detect the recirculation in a booster fan ventilation networks. This program needed an input file prepared from output file generated by any ventilation simulator. This program created an output file for recirculation. This program demonstrated the strong capability to detect the recirculation in a sample network and a coal mine ventilation network. The outcomes of this program were documented in this paper.展开更多
The most common booster is called input pressure reduced （IPR） booster. However, this type of booster has its own shortages, such as its small output flow, when the boosting ratio is higher, the shortage becomes mor...The most common booster is called input pressure reduced （IPR） booster. However, this type of booster has its own shortages, such as its small output flow, when the boosting ratio is higher, the shortage becomes more distinct. Recent research on pneumatic boosters mainly focused on the factors that influence the characteristics of the boosters, some new kinds of pneumatic booster structures were designed, but the efficiency and output flow of these boosters are still not improved sufficiently. In order to improve the output flow of the pneumatic booster, a new kind of booster, expansion energy used （EEU） booster, is proposed. Non-linear differential equations of the pneumatic booster are set up. By using the software MATLAB/Simulink for simulation, the motion characteristics of the pistons, the characteristics of the output flow of the boosters are obtained for analysis of a principle. The principle, which is used to elevate the output flow of the two kinds of boosters, is that the average pressure of the air in the driving chambers of the EEU booster is higher than that of the IPR booster. The simulation and experimental research of the output flow characteristics are done. The simulation and experimental results are in a good accordance. And the simulation and experimental results show that when the air source pressure and the output pressure are set at 0.6 MPa and 0.8 MPa, respectively, with the increase of the terminal pressure of the air in the driving chamber, the output flow of the IPR booster ascends stably. As the terminal pressure of the air in the driving chamber goes up, the output flow of the EEU booster rises, and later it almost remains constant. In addition, with the same terminal pressure, the output flow of the EEU booster is greater than that of the IPR booster, and the difference decreases when the terminal pressure grows. At last, the output pressure is set at 0.8 MPa, under the optimum work state of the EEU booster, the output flow of the two kinds of boosters all declines with the rise of the boosting ratio. Furthermore, the output flow of the EEU booster is higher than that of IPR booster by 95 L/min approximately. The proposed research lays the foundation for optimistic of the EEU booster.展开更多
A booster fan is an underground main fan which is installed in series with a main surface fan and used to boost the air pressure of the ventilation to overcome mine resistance.Currently booster fans are used in severa...A booster fan is an underground main fan which is installed in series with a main surface fan and used to boost the air pressure of the ventilation to overcome mine resistance.Currently booster fans are used in several major coal mining countries including the United Kingdom,Australia,Poland and China.In the United States booster fans are prohibited in coal mines although they are used in several metal and non-metal mines.A study has been undertaken to examine alternatives for ventilating an underground room and pillar coal mine system.A feasibility study of a hypothetical situation has shown that current ventilation facilities are incapable of fulfilling mine air requirements in the future due to increased seam methane levels.A current ventilation network model has been prepared and projected to a mine five years plan."Ventsim visual" software simulations of different possible ventilation options have been conducted in which varying methane levels are found at working faces.The software can also undertake financial simulations and project present value total costs for the options under study.Several scenarios for improving the ventilation situation such as improving main surface fans,adding intake shafts,adding exhaust shafts and utilizing booster fans have been examined.After taking into account the total capital and operating costs for the five years mine plan the booster fan scenarios are recommended as being the best alternatives for further serious consideration by the mine.The optimum option is a properly sized and installed booster fan system that can be used to create safe work conditions,maintain adequate air quantity with lowest cost,generate a reduction in energy consumption and decrease mine system air leakage.展开更多
Air-driven boosters are widely used to obtain high-pressure gas. Through analysis of the boosting process of an air-driven booster, the basic mathematical model of working processes can be set up. By selecting the app...Air-driven boosters are widely used to obtain high-pressure gas. Through analysis of the boosting process of an air-driven booster, the basic mathematical model of working processes can be set up. By selecting the appropriate reference values, the basic mathematical model is transformed to a dimensionless expression. Using MATLAB/Simulink for simulation and studying the booster experimentally, the dimensionless outlet flow characteristics of the booster were obtained and the simulation results agree well with the experimental results. Through analysis, it can be seen that the dimensionless outlet flow of the booster is mainly determined by the dimensionless input pressure of the driving chamber, the dimensionless outlet condition pressure of the booster and the dimensionless area of the piston in the driving chamber. The dimensionless average outlet flow becomes larger with an increasing dimensionless input pressure of the driving chamber, but it becomes smaller with an increase in the dimen- sionless outlet condition pressure of the booster. Especially when the dimensionless outlet condition pressure is approximately 1.4, the dimensionless average outlet flow reaches zero. With an increase in the dimensionless area of the piston in the driving chamber, the dimensionless average outlet flow increases and peaks at approximately 1.89, and after this peak, it starts to decrease. This research can be referred to in the design of air-driven boosters.展开更多
Chronic liver disease(CLD)entails elevated risk of COVID-19 severity and mortality.The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear.Th...Chronic liver disease(CLD)entails elevated risk of COVID-19 severity and mortality.The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear.Therefore,we conducted a cross-sectional study involving 237 adult CLD patients and 170 healthy controls(HC)to analyze neutralizing antibodies(NAbs)against SARS-CoV-2 prototype and BA.4/5 variant,anti-receptor binding domain(RBD)IgG,and total anti-SARS-CoV-2 antibodies.Serum levels of the total anti-SARS-CoV-2 antibodies,anti-RBD IgG and inhibition efficacy of NAbs were significantly elevated in CLD patients after the booster dose compared with the pre-booster dose,but were relatively lower than those of HCs.Induced humoral responses decreased over time after booster vaccination.The neutralization efficiency of the serum against BA.4/5 increased but remained below the inhibition threshold.All four SARS-CoV-2 antibodies,including total anti-SARS-CoV-2 antibodies,anti-RBD IgG and NAbs against prototype and BA.4/5,were lower in patients with severe CLD than those with non-severe CLD.After booster shot,age and time after the last vaccine were the risk factors for seropositivity of NAb against BA.4/5 in CLD patients.Additionally,white blood cell counts and hepatitis B core antibodies were the protective factors,and severe liver disease was the risk factor associated with seropositivity of total anti-SARS-CoV-2 antibodies.Overall,our data uncovered that antibody responses were improved in CLD patients and peaked at 120 days after the booster vaccines.All antibodies excepting total anti-SARS-CoV-2 antibodies declined after peak.CLD patients exhibited impaired immunologic responses to vaccination and weakened NAbs against BA.4/5,which hindered the protective effect of the booster shot against Omicron prevalence.Cellular immune responses should be further evaluated to determine the optimal vaccine regimen for CLD patients.展开更多
Objective:To determine the proportion of HBV surface antigen(anti-HBs)antibody positive children under five years of age born to HBs Ag-negative mothers and to analyze the possible related factors following implementa...Objective:To determine the proportion of HBV surface antigen(anti-HBs)antibody positive children under five years of age born to HBs Ag-negative mothers and to analyze the possible related factors following implementation of a hepatitis B vaccination program for infants in Indonesia 22 years ago.Methods:Blood samples were taken from children under five years of age born to HBsAg-negative mothers who have completed primary vaccination series.Anti-HBs antibodies were determined by using rapid test.Data of age,gender,nutritional status,vaccination timing or vaccination compliance,and booster vaccination were collected from vaccination card.Results:Ninety children were enrolled,consisting of 47 females and 43 males with a mean age of 2.3 years.Twenty two(24.4%)children received booster vaccine between 18 and 24 months and 55(61.1%)were anti-HBs positive.Among factors of age,gender,nutritional status,compliance to vaccination and booster vaccine,only administration of booster vaccine was significantly associated with anti-HBs status(OR 5.45,95%CI 1.45,20.52).Children who received booster vaccine at age of 18-24 months were 5.45 times more likely to be anti-HBs positive than that of children who did not receive booster vaccine.Conclusions:Booster vaccine rate is low among children under 5 years of age but is associated with anti-HBs positivity.Booster vaccination may be required to improve anti-HBs seropositivity.展开更多
Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of...Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of the medical preparations development, for changing chemicals to naturally produced ones based on herbal natural remedies. Since homeopathy is a branch of medicine that includes not only herbal preparations, but also chemical ingredients, our newly developed patent—although it belongs to the field of homeopathy—is its offshoot aimed solely at maintaining the body’s strength without harming it, increasing the survival of the body in a polluted environment removing toxins from the body by strengthening adaptive immune mechanisms. Thus, thyme, cumin, oregano, licorice, and other natural resources of the earth, which are the basis of our patent, successfully fight cold and diseases of the upper respiratory tract. The article presents a methodology for the development of a new herbal preparation, its dosage, and use as the main ingredient in a treatment course in infectious diseases.展开更多
文摘Objective:To examine the change in COVID-19 booster vaccine hesitancy according to descriptive characteristics,characteristics related to COVID-19,health literacy(HL)skills related to booster dose.Methods:The inclusion criterion was the completion of the primary scheme as two doses of COVID-19 vaccine.The study was conducted in January 2022 by applying face-to-face interview technique.Questions regarding HL were used to question the ability of individuals to access,understand,interpret and use information regarding the COVID-19 booster dose in their decisions.Results:A total of 1210 people were included in this study with an mean age of(41.3±16.6)years,and 51.4%were women.In multivariate analysis,hesitation increased in the"moderately concerned"(aOR 2.65,95%CI 1.09-6.45),"slightly concerned"(aOR 3.01,95%CI 1.26-7.19),"not concerned at all”(aOR 5.69,95%CI 2.27-14.28)groups compared to the group“extremely concerned”about COVID-19 transmission.Those with Sinovac-CoronaVac as their most recent vaccine had increased hesitation compared to those with Pfizer-BioNTech(aOR 3.68,95%CI 2.05-6.61).The effect of HL skills including“accessing”,“understanding”,and“appraising”information on hesitation was not statistically significant(P>0.05).HL skill of“applying”was assessed with ability of information to help decision making.Whether the information is helpful for decision-making,the risk of hesitancy increased for those who stated that it"sometimes helps"(aOR 2.55;95%CI 1.31-4.99)and"never helps"(aOR 11.62;95%CI 3.03-44.58)compared to those who stated that it"always helps".Conclusions:The increased propability of hesitation in those less concerned about COVID-19 transmission shows the importance of appropriately guiding individuals'concern levels with a health communication strategy based on risk communication.The fact that the only HL skill with a significant effect in the multivariate model was“applying”,shows the critical role of this skill in influencing behavioral changes.
基金This work was supported by the National Natural Science Foundation of China(No.12005239).
文摘The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the electron beam from the Linac and increases its energy to the value required for the storage ring.The full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target values.These milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam commissioning.As measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,respectively.This paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.
文摘Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.
文摘The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key technologies for ensuring the success of rocket flights and has been a core topic in carrier rocket technology research. The Gravity-1 solid carrier rocket is the first solid rocket bundled rocket developed by China, adopting a configuration with four boosters and a core stage bundled together. During the actual flight process, the four booster engines are ignited first, and then, in the event of insufficient control force from the boosters, the core stage engine is ignited to participate in control. To address thrust asynchrony during the descent of the four boosters, an Extended State Observer(ESO) is employed in the control scheme for this flight segment. This involves real-time estimation and compensation of attitude parameters during flight, identification of thrust asynchrony among the boosters, and simultaneous determination of whether the core stage engine is ignited to participate in control.Through six degrees of freedom simulation analysis and Y1 flight test validation, this method has been proven to be correct and feasible.
基金Guangzhou Health Science and Technology Project(20201A011078)Guangzhou Science and Technology Project(202102010094)+5 种基金Guangdong Basic and Applied Basic Research Foundation(2021A1515012550)Clinical research project of Guangzhou Medical University Second Affiliated Hospital(2021-LCYJ-05)Guangdong Medical Research Fund(A2022255)Key Clinical Specialty of Guangzhou Medical University(0F03031)Guangzhou Laboratory(EKPG21-30-3)Guangzhou key discipline of urology.The funding sources had no role in the study design,data collection,analysis,interpretation,or writing of the report.
文摘Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron variants.Questions concerning about memory B cells(MBCs)and T cells immunity against Omicron variants,features of long-term immunity,after booster and OBI,needs to be explored.Here,comparative analysis demonstrate antibody and T cell immunity against ancestral strain,Delta and Omicron variants in Omicron breakthrough infected patients(OBIPs)are comparable to that in Ad5-nCoV boosted healthy volunteers(HVs),higher than that in inactivated vaccine(InV)boosted HVs.However,memory B cells(MBCs)immunity against Omicron variants was highest in OBIPs,followed by Ad5-nCoV boosted and InV boosted HVs.OBIPs and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs,and lower naïve MBCs and atypical MBCs relative to both vaccine boosted HVs.Collectively,these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.
基金supported by the Research Fund for the Doctoral Program of Higher Education of China(Grants 20113219110025,20133219110037)the National Natural Science Foundation of China(Grants 11102089,61304137)the Program for New Century Excellent Talents in University(NCET-10-0075)
文摘The analysis of natural vibration characteristics has become one of important steps of the manufacture and dynamic design in the aerospace industry. This paper presents a new scenario called virtual cutting in the context of the transfer matrix method of linear multibody systems closed- loop topology for computing the free vibration characteristics of elastically coupled flexible launch vehicle boosters. In this approach, the coupled system is idealized as a triple-beam system-like structure coupled by linear translational springs, where a non-uniform free-free Euler-Bemoulli beam is used. A large thrust-to-weight ratio leads to large axial accelera- tions that result in an axial inertia load distribution from nose to tail. Consequently, it causes the development of significant compressive forces along the length of the launch vehicle. Therefore, it is important to take into account this effect in the transverse vibration model. This scenario does not need the global dynamics equations of a system, and it has high computational efficiency and low memory requirements. The validity of the presented scenario is achieved through com- parison to other approaches published in the literature.
基金supported by the Science Fund of the Republic of Serbia,#Grant No:7748088。
文摘Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.
基金the National Institute for Occupational Safety and Health of USA for providing financial support for this project
文摘Recirculation is prohibited in many coal mining countries because of the fear that the re-use of return air would allow the build-up of air contaminants at the workings. The incorrect design and location of a booster fan in any ventilation network can create unsafe condition due to recirculation. The current approach to investigating recirculation using simulation software requires manual effort which becomes tedious in a complex and a large network. An algorithm-based C++ program was designed to detect the recirculation in a booster fan ventilation networks. This program needed an input file prepared from output file generated by any ventilation simulator. This program created an output file for recirculation. This program demonstrated the strong capability to detect the recirculation in a sample network and a coal mine ventilation network. The outcomes of this program were documented in this paper.
文摘The most common booster is called input pressure reduced （IPR） booster. However, this type of booster has its own shortages, such as its small output flow, when the boosting ratio is higher, the shortage becomes more distinct. Recent research on pneumatic boosters mainly focused on the factors that influence the characteristics of the boosters, some new kinds of pneumatic booster structures were designed, but the efficiency and output flow of these boosters are still not improved sufficiently. In order to improve the output flow of the pneumatic booster, a new kind of booster, expansion energy used （EEU） booster, is proposed. Non-linear differential equations of the pneumatic booster are set up. By using the software MATLAB/Simulink for simulation, the motion characteristics of the pistons, the characteristics of the output flow of the boosters are obtained for analysis of a principle. The principle, which is used to elevate the output flow of the two kinds of boosters, is that the average pressure of the air in the driving chambers of the EEU booster is higher than that of the IPR booster. The simulation and experimental research of the output flow characteristics are done. The simulation and experimental results are in a good accordance. And the simulation and experimental results show that when the air source pressure and the output pressure are set at 0.6 MPa and 0.8 MPa, respectively, with the increase of the terminal pressure of the air in the driving chamber, the output flow of the IPR booster ascends stably. As the terminal pressure of the air in the driving chamber goes up, the output flow of the EEU booster rises, and later it almost remains constant. In addition, with the same terminal pressure, the output flow of the EEU booster is greater than that of the IPR booster, and the difference decreases when the terminal pressure grows. At last, the output pressure is set at 0.8 MPa, under the optimum work state of the EEU booster, the output flow of the two kinds of boosters all declines with the rise of the boosting ratio. Furthermore, the output flow of the EEU booster is higher than that of IPR booster by 95 L/min approximately. The proposed research lays the foundation for optimistic of the EEU booster.
基金Supported by National Institute for Occupational Safety and Health (NIOSH) of USA(200-2009-30328)
文摘A booster fan is an underground main fan which is installed in series with a main surface fan and used to boost the air pressure of the ventilation to overcome mine resistance.Currently booster fans are used in several major coal mining countries including the United Kingdom,Australia,Poland and China.In the United States booster fans are prohibited in coal mines although they are used in several metal and non-metal mines.A study has been undertaken to examine alternatives for ventilating an underground room and pillar coal mine system.A feasibility study of a hypothetical situation has shown that current ventilation facilities are incapable of fulfilling mine air requirements in the future due to increased seam methane levels.A current ventilation network model has been prepared and projected to a mine five years plan."Ventsim visual" software simulations of different possible ventilation options have been conducted in which varying methane levels are found at working faces.The software can also undertake financial simulations and project present value total costs for the options under study.Several scenarios for improving the ventilation situation such as improving main surface fans,adding intake shafts,adding exhaust shafts and utilizing booster fans have been examined.After taking into account the total capital and operating costs for the five years mine plan the booster fan scenarios are recommended as being the best alternatives for further serious consideration by the mine.The optimum option is a properly sized and installed booster fan system that can be used to create safe work conditions,maintain adequate air quantity with lowest cost,generate a reduction in energy consumption and decrease mine system air leakage.
文摘Air-driven boosters are widely used to obtain high-pressure gas. Through analysis of the boosting process of an air-driven booster, the basic mathematical model of working processes can be set up. By selecting the appropriate reference values, the basic mathematical model is transformed to a dimensionless expression. Using MATLAB/Simulink for simulation and studying the booster experimentally, the dimensionless outlet flow characteristics of the booster were obtained and the simulation results agree well with the experimental results. Through analysis, it can be seen that the dimensionless outlet flow of the booster is mainly determined by the dimensionless input pressure of the driving chamber, the dimensionless outlet condition pressure of the booster and the dimensionless area of the piston in the driving chamber. The dimensionless average outlet flow becomes larger with an increasing dimensionless input pressure of the driving chamber, but it becomes smaller with an increase in the dimen- sionless outlet condition pressure of the booster. Especially when the dimensionless outlet condition pressure is approximately 1.4, the dimensionless average outlet flow reaches zero. With an increase in the dimensionless area of the piston in the driving chamber, the dimensionless average outlet flow increases and peaks at approximately 1.89, and after this peak, it starts to decrease. This research can be referred to in the design of air-driven boosters.
基金This work was supported by the Beijing Natural Science Foundation(M23008)the National Key Research and Development Program of China(2018YFE0207300)+2 种基金Beijing Municipal Science&Technology Commission(Z211100002521021)the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-124)Key Research and Development Plan of Hebei Province,Special Health Innovation Project(22377744D).
文摘Chronic liver disease(CLD)entails elevated risk of COVID-19 severity and mortality.The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear.Therefore,we conducted a cross-sectional study involving 237 adult CLD patients and 170 healthy controls(HC)to analyze neutralizing antibodies(NAbs)against SARS-CoV-2 prototype and BA.4/5 variant,anti-receptor binding domain(RBD)IgG,and total anti-SARS-CoV-2 antibodies.Serum levels of the total anti-SARS-CoV-2 antibodies,anti-RBD IgG and inhibition efficacy of NAbs were significantly elevated in CLD patients after the booster dose compared with the pre-booster dose,but were relatively lower than those of HCs.Induced humoral responses decreased over time after booster vaccination.The neutralization efficiency of the serum against BA.4/5 increased but remained below the inhibition threshold.All four SARS-CoV-2 antibodies,including total anti-SARS-CoV-2 antibodies,anti-RBD IgG and NAbs against prototype and BA.4/5,were lower in patients with severe CLD than those with non-severe CLD.After booster shot,age and time after the last vaccine were the risk factors for seropositivity of NAb against BA.4/5 in CLD patients.Additionally,white blood cell counts and hepatitis B core antibodies were the protective factors,and severe liver disease was the risk factor associated with seropositivity of total anti-SARS-CoV-2 antibodies.Overall,our data uncovered that antibody responses were improved in CLD patients and peaked at 120 days after the booster vaccines.All antibodies excepting total anti-SARS-CoV-2 antibodies declined after peak.CLD patients exhibited impaired immunologic responses to vaccination and weakened NAbs against BA.4/5,which hindered the protective effect of the booster shot against Omicron prevalence.Cellular immune responses should be further evaluated to determine the optimal vaccine regimen for CLD patients.
文摘Objective:To determine the proportion of HBV surface antigen(anti-HBs)antibody positive children under five years of age born to HBs Ag-negative mothers and to analyze the possible related factors following implementation of a hepatitis B vaccination program for infants in Indonesia 22 years ago.Methods:Blood samples were taken from children under five years of age born to HBsAg-negative mothers who have completed primary vaccination series.Anti-HBs antibodies were determined by using rapid test.Data of age,gender,nutritional status,vaccination timing or vaccination compliance,and booster vaccination were collected from vaccination card.Results:Ninety children were enrolled,consisting of 47 females and 43 males with a mean age of 2.3 years.Twenty two(24.4%)children received booster vaccine between 18 and 24 months and 55(61.1%)were anti-HBs positive.Among factors of age,gender,nutritional status,compliance to vaccination and booster vaccine,only administration of booster vaccine was significantly associated with anti-HBs status(OR 5.45,95%CI 1.45,20.52).Children who received booster vaccine at age of 18-24 months were 5.45 times more likely to be anti-HBs positive than that of children who did not receive booster vaccine.Conclusions:Booster vaccine rate is low among children under 5 years of age but is associated with anti-HBs positivity.Booster vaccination may be required to improve anti-HBs seropositivity.
文摘Recently, due to the growth of environmental pollution and the increase in the resistance of microorganisms to artificially create chemical drugs, there has been an urgent need for a radical change in the direction of the medical preparations development, for changing chemicals to naturally produced ones based on herbal natural remedies. Since homeopathy is a branch of medicine that includes not only herbal preparations, but also chemical ingredients, our newly developed patent—although it belongs to the field of homeopathy—is its offshoot aimed solely at maintaining the body’s strength without harming it, increasing the survival of the body in a polluted environment removing toxins from the body by strengthening adaptive immune mechanisms. Thus, thyme, cumin, oregano, licorice, and other natural resources of the earth, which are the basis of our patent, successfully fight cold and diseases of the upper respiratory tract. The article presents a methodology for the development of a new herbal preparation, its dosage, and use as the main ingredient in a treatment course in infectious diseases.
