BACKGROUND Acute liver failure(ALF)is a life-threatening multisystemic condition with high short-term mortality.With the growing prevalence of obesity and metabolic syndrome,it is important to investigate the clinical...BACKGROUND Acute liver failure(ALF)is a life-threatening multisystemic condition with high short-term mortality.With the growing prevalence of obesity and metabolic syndrome,it is important to investigate the clinical implications of high body mass index(BMI)on survival outcomes in ALF.AIM To explore the impact of overweight and obesity on the clinical outcomes of patients with ALF.METHODS A retrospective observational cohort study was conducted involving patients with ALF admitted to the Johns Hopkins Health System between January 1,2000 and May 1,2020.We performed Cox proportional hazards regression to identify outcomes,including the need for liver transplantation(LT)or all-cause mortality.RESULTS A total of 196 patients were included,the median age was 43.5 years,63.3%were female,and 59.7%were of Caucasian ethnicity.Acetaminophen-induced ALF was the most common etiology(45%).The mean BMI was significantly greater among patients who underwent LT or died(29.64 kg/m^(2)vs 26.59 kg/m^(2),P=0.008)than among survivors.Patients with overweight and obesity had a higher risk of all-cause mortality or need for LT by 2.22-fold(95%CI:1.30-3.78)and 2.04-fold(95%CI:1.29-3.39),respectively.Elevated BMI was associated with renal failure and higher grades of hepatic encephalopathy.Derangements in serologic markers,including alanine transaminase,lactate,and ammonia,were associated with a mortality risk or need for LT.CONCLUSION In this large,retrospective study,with a diverse cohort of United States patients,Overweight and obese were independently associated with an increased risk of all-cause mortality or need for LT.This work highlights the importance of closely monitoring ALF patients who are overweight or obese for adverse complications and measures to improve outcomes in this vulnerable patient population.展开更多
BACKGROUND Overweight children exhibit a higher prevalence of functional gastrointestinal disorders compared with their normal-weight peers,yet the underlying reasons remain unclear.Gastrointestinal motility,a key pat...BACKGROUND Overweight children exhibit a higher prevalence of functional gastrointestinal disorders compared with their normal-weight peers,yet the underlying reasons remain unclear.Gastrointestinal motility,a key pathophysiological factor in functional gastrointestinal disorders,may be influenced by body mass index(BMI).AIM To evaluate the impact of BMI on gastric motility parameters in children with functional abdominal pain disorders(FAPDs).METHODS We assessed gastric motility in 176 children with FAPDs(61.4%females,mean age 7.94 years,SD 1.96 years)and 63 healthy controls(57.1%females,mean age 9.17 years,SD 1.90 years)at the Gastroenterology Research Laboratory,University of Kelaniya,Sri Lanka.FAPDs were diagnosed and subtyped using the Rome IV criteria:Functional abdominal pain 97 patients;irritable bowel syndrome 39 patients,functional dyspepsia(FD)25 patients;and abdominal migraine 15 patients.Gastric motility was measured using a validated ultrasound method.Weight and height were measured using sensitive standard scales.RESULTS The BMIs of children with FAPDs and controls were 15.04 and 15.46 kg/m^(2),respectively(P=0.33).Fasting antral area(FAA)and antral area at 1 min(AA1)and 15 min(AA15)were significantly greater in patients with FAPD with a higher BMI(2.71 cm^(2),12.57 cm^(2),and 7.19 cm^(2),respectively)compared with those with a lower BMI(2.12 cm^(2),10.68 cm^(2),and 6.13 cm^(2),respectively)(P<0.01).BMI positively correlated with FAA and AA15(r=0.18 and r=0.19,respectively)(P<0.01)in those with FAPDs.In controls,only AA1 was greater in the higher BMI group(12.51 cm^(2)vs 9.93 cm^(2))and had a positive correlation(r=0.33)(P≤0.01).Subgroup analysis revealed that in patients with FD,BMI negatively correlated with gastric emptying rate(GER)(r=-0.59)and antral motility index(MI)(r=-0.49),while in functional abdominal pain,MI positively correlated(r=0.25)with BMI(P≤0.01).CONCLUSION In children with FAPDs,higher BMI was associated with increased gastric antral distention during fasting and postprandial periods(as indicated by FAA,AA1,and AA15)but not with contractility and transit(MI,GER).However,in the FD subgroup,high BMI correlated with reduced GER and MI.This indicates the possible role of BMI in gastric hypomotility and the pathophysiology of FD.These findings underscore the importance of lifestyle and dietary interventions aimed at optimizing BMI in the management of FAPDs,particularly FD.展开更多
Body mass index(BMI),with its simple formula of weight divided by height squared,has become a cornerstone tool in global public health for assessing obesity and health risks.However,as populations aging and the demand...Body mass index(BMI),with its simple formula of weight divided by height squared,has become a cornerstone tool in global public health for assessing obesity and health risks.However,as populations aging and the demand for precise health evaluation grows,the limitations of this single metric have become increasingly apparent—it fails to distinguish between muscle and adipose tissue and cannot capture the complex relationship between inflammatory status and body composition.A recent study published in Biomedical and Environmental Sciences(BES)by Zhang et al.[1],which explores the association of white blood cell(WBC)count,platelet(PLT)count,and platelet-to-white blood cell ratio(PWR)with muscle mass among Chinese communitydwelling older adults,provides critical evidence for rethinking the role of BMI.Additionally,several studies published in BES,spanning from childhood nutrition to adult metabolism,further illuminate the complexity of health assessment[2−5].Building on these findings and integrating evidence from multiple Chinese population studies,this commentary revisits the historical context,utility,inherent limitations,and future directions of this classic indicator.展开更多
BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS...BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS:Data were summarized using genome-wide association studies (GWAS).Twosample MR analyses were performed using the inverse variance weighting (IVW) method,the weighted median method,and the MR-Egger analysis.Heterogeneity test and sensitivity analysis were performed using Cochran’s Q test and the leave-one-out method,respectively.The Steiger test was used to detect reverse causality.Bayesian model-averaged MR was used to identify the most influential risk factors.RESULTS:A total of 13 GWAS data were collected for BMI,body weight and WC.IVW analyses showed a positive correlation of body weight,BMI,and WC with CA (all OR>1 and P<0.05),with MR-Egger and weighted median methods confirming the IVW findings.No horizontal pleiotropy or heterogeneity was observed.Sensitivity analysis indicated that no single nucleotide polymorphism(SNP) caused significant changes in overall causality.Bayesian model-averaged MR was also used to rank causality based on marginal inclusion probability (MIP),and the corresponding modelaveraged causal estimate (MACE) were confirmed,which indicated that WC (GWAS ID:ukb-b-9405)was the highest-ranked risk factor (MIP=0.119,MACE=0.011);its posterior probability was 0.057.A total of 14 sex-specific GWAS data on weight,BMI,and WC were analyzed in relationship with CA,and the MR results showed no significant effects of sex-specific factors.CONCLUSION:Body weight,BMI,and WC are causally associated with an increased risk of CA,with WC identified as the most important risk factor.展开更多
Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospe...Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospective study was conducted at four sites in rural China between 2013 and 2023.Multivariate Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between BMI and mortality.Stratified analyses were performed based on the individual characteristics of the participants.Results Overall,19,107 participants with a sum of 163,095 person-years were included and 1,910 participants died.The underweight(<18.5 kg/m^(2))presented an increase in all-cause mortality(adjusted hazards ratio[aHR]=2.00,95%confidence interval[CI]:1.66–2.41),while overweight(≥24.0 to<28.0 kg/m^(2))and obesity(≥28.0 kg/m^(2))presented a decrease with an aHR of 0.61(95%CI:0.52–0.73)and 0.51(95%CI:0.37–0.70),respectively.Overweight(aHR=0.76,95%CI:0.67–0.86)and mild obesity(aHR=0.72,95%CI:0.59–0.87)had a positive impact on mortality in people older than 60 years.All-2 cause mortality decreased rapidly until reaching a BMI of 25.7 kg/m(aHR=0.95,95%CI:0.92–0.98)and increased slightly above that value,indicating a U-shaped association.The beneficial impact of being overweight on mortality was robust in most subgroups and sensitivity analyses.Conclusion This study provides additional evidence that overweight and mild obesity may be inversely related to the risk of death in individuals older than 60 years.Therefore,it is essential to consider age differences when formulating health and weight management strategies.展开更多
Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the a...Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the alterations related to reproductive hormones,semen parameters and their association with body mass index(BMI).Methods:Participants in this observational study were divided into three groups based on their BMI:proven fertile,normal weight men(n=200);overweight men(n=200);and obese men(n=200).After 3 days of abstinence,seminal fluid was collected from all participants and analyzed.Blood samples were also collected on the same day for hormonal analysis.Sperm DNA fragmentation and protamine deficiency were also assessed.Results:A total of 600 men with a mean age of(34.3±7.9)2 years were included in the study.Obese males(BMI 30 kg/m or higher)exhibited significant reductions in semen volume,sperm concentration,total sperm motility percentage,progressive motility,non-progressive motility,and levels of total testosterone,follicle-stimulating hormone(FSH)and luteinizing hormone(LH)compared to overweight(BMI 25 to 29.9 kg/m2)and normal weight males(BMI 18.5 to 24.9 kg/m2)(P<0.001).Conversely,obese males showed a significant increase in prolactin level,sperm DNA fragmentation,and protamine deficiency compared to overweight and normal weight males(P<0.001).Significant negative correlations were demonstrated between BMI and sperm concentration,motility,total testosterone,FSH and LH(P<0.001),whereas prolactin,sperm DNA fragmentation and protamine deficiency were positively correlated with BMI(P<0.001).Conclusions:This study provides clear evidence that obesity contributes potentially to male infertility by inducing sperm DNA fragmentation and protamine deficiency,as well as negatively impacting reproductive hormones and semen quality.展开更多
Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several ha...Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several harmful outcomes,such as diabetes mellitus and cardiovascular diseases[1].展开更多
The prognostic impact of obesity in acute liver failure(ALF)remains underexplored in recent United States cohorts despite the global rise in obesity prevalence.The aim of this letter is to appraise and contextualize t...The prognostic impact of obesity in acute liver failure(ALF)remains underexplored in recent United States cohorts despite the global rise in obesity prevalence.The aim of this letter is to appraise and contextualize the findings of Krishnan et al,who examined the association between body mass index(BMI)and ALF outcomes in a large,retrospective United States cohort.Krishnan et al analyzed 196 ALF patients over two decades,demonstrating that both overweight and obesity independently doubled the risk of death or need for liver transplantation after adjustment for confounders.Elevated BMI was also associated with higher grades of hepatic encephalopathy and renal dysfunction;two major contributors to ALF mortality.Future research should consider additional markers of metabolic health beyond BMI to refine prognostication.This study provides timely,robust evidence linking elevated BMI to adverse ALF outcomes and highlights the need for targeted clinical strategies in this vulnerable subgroup.展开更多
Krishnan et al’s article is a comprehensive and vigorous retrospective cohort study regarding the association between obesity and clinical outcomes in acute liver failure(ALF).Among patients with ALF in the United St...Krishnan et al’s article is a comprehensive and vigorous retrospective cohort study regarding the association between obesity and clinical outcomes in acute liver failure(ALF).Among patients with ALF in the United States,mean body mass index(BMI)was significantly greater in those who underwent liver transplantation or who died than among survivors,although acetaminophen induced ALF was the most common etiology.A high BMI was associated with renal failure and high grades of hepatic encephalopathy.The prevalence of obesity and its related fatty liver diseases,such as metabolic dysfunction-associated fatty liver disease/metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis,has increased worldwide.Obesity is related to increased serum cytokines and immune abnormalities.These findings may explain why ALF in patients with high BMI is associated with worse clinical outcomes.Further studies are needed to determine the associations among BMI,ALF and acute-on-chronic liver failure.展开更多
BACKGROUND The association between adiposity parameters and incident hepatocellular carcinoma(HCC)in individuals with nonalcoholic fatty liver disease(NAFLD)is yet to be evaluated.AIM To investigate the risk of HCC ac...BACKGROUND The association between adiposity parameters and incident hepatocellular carcinoma(HCC)in individuals with nonalcoholic fatty liver disease(NAFLD)is yet to be evaluated.AIM To investigate the risk of HCC according to body mass index(BMI)and waist circumference(WC)in people with NAFLD.METHODS This population-based cohort study included Korean National Health Insurance Service examination participants with NAFLD(n=1110773).NAFLD was defined as a fatty liver index of≥30.The risk of HCC was determined by Cox propor-tional hazards regression according to BMI and WC after adjusting for age,sex,health behaviors,income,comorbidities,and WC or BMI.RESULTS HCC was diagnosed in 4773(0.43%)participants during a median follow-up of 10.3 years.A U-shaped association between BMI or WC and HCC was observed,with the highest risk observed in the lowest BMI and WC groups.Compared to normal BMI,the adjusted hazard ratio(aHR)of the underweight BMI group was 2.02[95%confidence interval(CI):1.25-3.28].The lowest risk was found in groups with overweight BMI(aHR=0.67,95%CI:0.60-0.73;reference:normal BMI)and WC:85-89.9/80-84.9 cm for men/women(aHR=0.55,95%CI:0.49-0.63;reference:<80/<75 cm).Subgroup analyses of age,sex,health behaviors,and fatty liver index showed consistent results.CONCLUSION The development of HCC shows a U-shaped relationship with BMI and WC in people with NAFLD,with the highest risk in underweight individuals.展开更多
BACKGROUND Esophageal cancer(EC),primarily esophageal squamous cell carcinoma in China,has a poor prognosis with a 5-year survival rate of approximately 25%after surgery alone.Neoadjuvant chemoradiotherapy combined wi...BACKGROUND Esophageal cancer(EC),primarily esophageal squamous cell carcinoma in China,has a poor prognosis with a 5-year survival rate of approximately 25%after surgery alone.Neoadjuvant chemoradiotherapy combined with surgery is the standard treatment for locally advanced EC,with a 47%5-year survival rate,although adverse events are common.Immunotherapy,particularly PD-1 inhibitors,has shown promise in treating advanced EC,and neoadjuvant chemotherapy with immunotherapy is effective.However,the efficacy of postoperative immunotherapy remains unclear,with studies like Checkmate577 showing promising results but limited applicability to surgery-only patients,highlighting the need for further research.AIM To evaluate the efficacy,prognostic factors,and safety of adjuvant immunotherapy with anti-PD-1 inhibitors following radical surgery for EC.METHODS A retrospective analysis was conducted on EC patients who received adjuvant immunotherapy after radical treatment at the 900th Hospital of the China Joint Logistics Force between January 2018 and October 2024.Demographic,treatment and laboratory data were collected.Progression-free survival(PFS)was assessed using the Kaplan-Meier method,and independent prognostic factors were identified using Cox regression.Optimal cutoff values for continuous variables,including body mass index(BMI)difference and neutrophil-to-lymphocyte ratio(NLR),were determined using the maxstat package in R.RESULTS A total of 44 patients were included,with a 2-year PFS rate of 68.6%[95%confidence interval(CI):53%-88.7%].Univariate analysis identified several factors significantly associated with prognosis,including the interval between surgery and immunotherapy,BMI difference between before surgery and first immunotherapy,presurgical lymphocyte count,and presurgical NLR.Multivariable Cox regression revealed that a BMI difference<3.86 was an independent protective factor for PFS(hazard ratio:0.42,95%CI:0.21-0.85,P<0.05).At the last followup,the median PFS for patients with BMI<3.86 had not been reached,compared to 8.83 months for those with BMI>3.86.The 1-year PFS for patients receiving postoperative chemotherapy combined with immunotherapy was 88.5%,suggesting superior efficacy over chemotherapy alone.CONCLUSION Adjuvant immunotherapy for EC shows good efficacy and safety.A BMI difference<3.86 is a protective factor for PFS,highlighting the importance of monitoring nutrition and inflammation for personalized treatment.展开更多
Objective This study aimed to explore the interplay between the life-course body mass index(BMI)trajectories and insulin resistance(IR)on incident diabetes.Methods This longitudinal cohort included 2,336 participants ...Objective This study aimed to explore the interplay between the life-course body mass index(BMI)trajectories and insulin resistance(IR)on incident diabetes.Methods This longitudinal cohort included 2,336 participants who had BMI repeatedly measured 3–8times between 1989 and 2009,as well as glucose and insulin measured in 2009.BMI trajectories were identified using a latent class growth mixed model.The interplay between BMI trajectories and IR on diabetes was explored using the four-way effect decomposition method.Logistic regression and mediation models were used to estimate the interaction and mediation effects,respectively.Results Three distinct BMI trajectory groups were identified:low-stable(n=1,625),mediumincreasing(n=613),and high-increasing(n=98).Both interaction and mediation effects of BMI trajectories and IR on incident diabetes were significant(P<0.05).The proportion of incident diabetes was higher in the IR-obesity than in the insulin-sensitivity(IS)obesity group(18.9%vs.5.8%,P<0.001).After adjusting for covariates,the odds ratios(95%confidence intervals)of the IR,IS-obesity,and IRobesity groups vs.the normal group were 3.22(2.05,5.16),2.05(1.00,3.97),and 7.98(5.19,12.62),respectively.IR mediated 10.7%of the total effect of BMI trajectories on incident diabetes(P<0.001).Conclusion We found strong interactions and weak mediation effects of IR on the relationship between life-course BMI trajectories and incident diabetes.IS-obesity is associated with a lower risk of incident diabetes than IR-obesity.展开更多
BACKGROUND The association between body mass index(BMI)and bone mineral density(BMD)has shown inconsistent results,varying by sex and skeletal site.Despite normal or elevated bone mass,individuals with type 2 diabetes...BACKGROUND The association between body mass index(BMI)and bone mineral density(BMD)has shown inconsistent results,varying by sex and skeletal site.Despite normal or elevated bone mass,individuals with type 2 diabetes have an increased risk of hip and vertebral fractures.AIM To assess lumbar spine trabecular volumetric BMD(vBMD)across different BMI categories in individuals with and without diabetes.METHODS This cross-sectional study included 966 men over 50 years old and 1001 postmenopausal women from the Pinggu Metabolic Disease Study.The vBMD of lumbar vertebrae 2 through 4 was measured using quantitative computed tomography.Total adipose tissue,subcutaneous adipose tissue(SAT),visceral adipose tissue(VAT),and lumbar skeletal muscle area were also quantified.RESULTS In men with obesity(P=0.038)and overweight(P=0.032),vBMD was significantly higher in the diabetes group compared to non-diabetic men.After adjusting for age and sex,no significant saturation effect between BMI and BMD was found in participants with diabetes or in women without diabetes.However,a BMI threshold of 22.33 kg/m²indicated a saturation point for vBMD in nondiabetic men.Independent predictors of vBMD in men included age(r=-0.387,P<0.001),BMI(r=0.130,P=0.004),and VAT(r=-0.145,P=0.001).For women,significant predictors were age(r=-0.594,P<0.001),BMI(r=0.157,P=0.004),VAT(r=-0.112,P=0.001),and SAT(r=-0.068,P=0.035).CONCLUSION The relationship between BMI and trabecular vBMD differs in individuals with and without diabetes.Overweight and obese men with diabetes exhibit higher vBMD.展开更多
Body Mass Index (BMI), defined as the ratio of individual mass (in kilograms) to the square of the associated height (in meters), is one of the most widely discussed and utilized risk factors in medicine and public he...Body Mass Index (BMI), defined as the ratio of individual mass (in kilograms) to the square of the associated height (in meters), is one of the most widely discussed and utilized risk factors in medicine and public health, given the increasing obesity worldwide and its relation to metabolic disease. Statistically, BMI is a composite random variable, since human weight (converted to mass) and height are themselves random variables. Much effort over the years has gone into attempts to model or approximate the BMI distribution function. This paper derives the mathematically exact BMI probability density function (PDF), as well as the exact bivariate PDF for human weight and height. Taken together, weight and height are shown to be correlated bivariate lognormal variables whose marginal distributions are each lognormal in form. The mean and variance of each marginal distribution, together with the linear correlation coefficient of the two distributions, provide 5 nonadjustable parameters for a given population that uniquely determine the corresponding BMI distribution, which is also shown to be lognormal in form. The theoretical analysis is tested experimentally by gender against a large anthropometric data base, and found to predict with near perfection the profile of the empirical BMI distribution and, to great accuracy, individual statistics including mean, variance, skewness, kurtosis, and correlation. Beyond solving a longstanding statistical problem, the significance of these findings is that, with knowledge of the exact BMI distribution functions for diverse populations, medical and public health professionals can then make better informed statistical inferences regarding BMI and public health policies to reduce obesity.展开更多
The aim of the study was to determine the rela-tionship between Body Mass Index (BMI) and accelerated dental development. The dental developmental ages of 100 children aged between 8 and 12 years were determined using...The aim of the study was to determine the rela-tionship between Body Mass Index (BMI) and accelerated dental development. The dental developmental ages of 100 children aged between 8 and 12 years were determined using the Demirjian method and panoramic radiographs. BMI status was determined for each subject on the basis of the system developed by the International Obesity Task Force. There was a significant direct relationship between dental development and BMI (P < 0.01). Obese children have a higher rate of dental development compared to normal children. CLINICAL RELEVANCE: This is an important variable to be considered when planning for dental and orthodontic treatments in obese children. Brief objectives statement: Overweight or obesity can accelerate dental development. Accelerated dental development in overweight children is important to be considered in pediatric dentistry and orthodontics.展开更多
Body mass index(BMI)has been increasing globally in recent decades.Previous studies reported that BMI was associated with sex hormone levels,but the results were generated via linear regression or logistic regression,...Body mass index(BMI)has been increasing globally in recent decades.Previous studies reported that BMI was associated with sex hormone levels,but the results were generated via linear regression or logistic regression,which would lose part of information.Quantile regression analysis can maximize the use of variable information.Our study compared the associations among different regression models.The participants were recruited from the Center of Reproductive Medicine,The First Hospital of Jilin University(Changchun,China)between June 2018 and June 2019.We used linear,logistic,and quantile regression models to calculate the associations between sex hormone levels and BMI.In total,448 men were included in this study.The average BMI was 25.7(standard deviation[s.d.]:3.7)kg m^(-2);29.7%(n=133)of the participants were normal weight,45.3%(n=203)of the participants were overweight,and 23.4%(n=105)of the participants were obese.The levels of testosterone and estradiol significantly differed among BMI groups(all P<0.05).In linear regression and logistic regression,BMI was associated with testosterone and estradiol levels(both P<0.05).In quantile regression,BMI was negatively associated with testosterone levels in all quantiles after adjustment for age(all P<0.05).BMI was positively associated with estradiol levels in most quantiles(≤80^(th))after adjustment for age(all P<0.05).Our study suggested that BMI was one of the influencing factors of testosterone and estradiol.Of note,the quantile regression showed that BMI was associated with estradiol only up to the 80^(th) percentile of estradiol.展开更多
The aim of this research was to examine the effect of eating habits and family flexibility on the body mass index in gifted students of the eighth and ninth grade of high school. The research design of this study was ...The aim of this research was to examine the effect of eating habits and family flexibility on the body mass index in gifted students of the eighth and ninth grade of high school. The research design of this study was descriptive-correlation. The statistical population of this research included all high school gifted students of the eighth and ninth grade. The sample consisted of 220 gifted students who were selected by random sampling method. The average age of these participants was 14.56 years old, SD 10.41. Average participants BMI was 31.25, SD 3.12. One hundred and fifteen (52.28%) of these students were females and one hundred and five (47.72%) were males. Family flexibility was measured by Shakeri flexibility scale, eating habits were measured through Coker and Roger Eating Habits Questionnaire and body mass index was tested by Omron digital device. Using SPSS software, the data were analyzed to calculate correlation and simultaneous regression. The results of correlation showed that in these students, concern with weight and dieting and total eating habits have significant relationship with BMI (P < 0.001). The result of simultaneous regression also showed that concern with weight and dieting and total eating habits could explain BMI in these students (P < 0.001) and family flexibility could not explain BMI in these students (P < 0.005). The results emphasize the more important role of eating habits than family flexibility on BMI in gifted students because of sensitive and higher level of intelligence and high peer competitions.展开更多
Background: Japanese women’s body mass index (BMI) was known to be the lowest among people in OECD countries. We wanted to compare foods intakes and relationships between intakes of particular food species and BMI. M...Background: Japanese women’s body mass index (BMI) was known to be the lowest among people in OECD countries. We wanted to compare foods intakes and relationships between intakes of particular food species and BMI. Methods: We asked young and middle-aged women to participate and used a brief-type self-administered diet history questionnaire (BDHQ) to know the amounts of various food species they took. Results: Weights and BMI of young and middle-aged women were not different. Middle-aged women took almost all species of foods and energy more than young women. Except for cholesterol of soluble dietary fibers, there was no correlation between foods intakes and BMI. Conclusion: Both young and middle-aged Japanese women are lean (BMI;around 22). Middle-aged women took more energy, and proteins, carbohydrates, and lipids compared with young women. Middle-aged women spend more energy on house workings than young women in Japan.展开更多
Objective:compare the habits and features of obese (BMI>25) and normal (BMI<25) individuals and express a method to ameliorate the life styles using a cross-sectional experiment.Methods:A total of 220 randomly s...Objective:compare the habits and features of obese (BMI>25) and normal (BMI<25) individuals and express a method to ameliorate the life styles using a cross-sectional experiment.Methods:A total of 220 randomly selected cases were divided into case group (n=110) and control group (n=100) according to the calculated BMI level.Samples with BMI>25 kg/m2 were assigned to the case (obsess) group and those with BMI ranging from 20 to 25 were assigned to control (normal) group.The Miller-Smith life style questionnaires consisting 20 questions each with 5 different answers were given to both groups.Data of the questionnaires were collected and analyzed using t-test and Chi-square with SPSS.Results:No significant differences were found among the two groups in terms of the mean age,gender,level of education,marital status,insurance,breakfast,lunch or dinner,fried meat,legumes,caffeinated beverages,the length of sleep during 24 h,cigarette smoking and losing job or spouse.However,in regards to use of vegetables,sausage,fried potatoes,enriched breads,low fat milk,low salt,candies and chocolates significant relations were found (P<0.05).Conclusion:The present study suggests one way to control obesity and prevent diseases is to ameliorate the life styles.There is a relation between health and stress and irregularity of meals,such as breakfast skipping,is associated with overweight and obesity in adolescence.展开更多
文摘BACKGROUND Acute liver failure(ALF)is a life-threatening multisystemic condition with high short-term mortality.With the growing prevalence of obesity and metabolic syndrome,it is important to investigate the clinical implications of high body mass index(BMI)on survival outcomes in ALF.AIM To explore the impact of overweight and obesity on the clinical outcomes of patients with ALF.METHODS A retrospective observational cohort study was conducted involving patients with ALF admitted to the Johns Hopkins Health System between January 1,2000 and May 1,2020.We performed Cox proportional hazards regression to identify outcomes,including the need for liver transplantation(LT)or all-cause mortality.RESULTS A total of 196 patients were included,the median age was 43.5 years,63.3%were female,and 59.7%were of Caucasian ethnicity.Acetaminophen-induced ALF was the most common etiology(45%).The mean BMI was significantly greater among patients who underwent LT or died(29.64 kg/m^(2)vs 26.59 kg/m^(2),P=0.008)than among survivors.Patients with overweight and obesity had a higher risk of all-cause mortality or need for LT by 2.22-fold(95%CI:1.30-3.78)and 2.04-fold(95%CI:1.29-3.39),respectively.Elevated BMI was associated with renal failure and higher grades of hepatic encephalopathy.Derangements in serologic markers,including alanine transaminase,lactate,and ammonia,were associated with a mortality risk or need for LT.CONCLUSION In this large,retrospective study,with a diverse cohort of United States patients,Overweight and obese were independently associated with an increased risk of all-cause mortality or need for LT.This work highlights the importance of closely monitoring ALF patients who are overweight or obese for adverse complications and measures to improve outcomes in this vulnerable patient population.
基金Supported by The University of Kelaniya,Sri Lanka,Research Council Grant No.G23.
文摘BACKGROUND Overweight children exhibit a higher prevalence of functional gastrointestinal disorders compared with their normal-weight peers,yet the underlying reasons remain unclear.Gastrointestinal motility,a key pathophysiological factor in functional gastrointestinal disorders,may be influenced by body mass index(BMI).AIM To evaluate the impact of BMI on gastric motility parameters in children with functional abdominal pain disorders(FAPDs).METHODS We assessed gastric motility in 176 children with FAPDs(61.4%females,mean age 7.94 years,SD 1.96 years)and 63 healthy controls(57.1%females,mean age 9.17 years,SD 1.90 years)at the Gastroenterology Research Laboratory,University of Kelaniya,Sri Lanka.FAPDs were diagnosed and subtyped using the Rome IV criteria:Functional abdominal pain 97 patients;irritable bowel syndrome 39 patients,functional dyspepsia(FD)25 patients;and abdominal migraine 15 patients.Gastric motility was measured using a validated ultrasound method.Weight and height were measured using sensitive standard scales.RESULTS The BMIs of children with FAPDs and controls were 15.04 and 15.46 kg/m^(2),respectively(P=0.33).Fasting antral area(FAA)and antral area at 1 min(AA1)and 15 min(AA15)were significantly greater in patients with FAPD with a higher BMI(2.71 cm^(2),12.57 cm^(2),and 7.19 cm^(2),respectively)compared with those with a lower BMI(2.12 cm^(2),10.68 cm^(2),and 6.13 cm^(2),respectively)(P<0.01).BMI positively correlated with FAA and AA15(r=0.18 and r=0.19,respectively)(P<0.01)in those with FAPDs.In controls,only AA1 was greater in the higher BMI group(12.51 cm^(2)vs 9.93 cm^(2))and had a positive correlation(r=0.33)(P≤0.01).Subgroup analysis revealed that in patients with FD,BMI negatively correlated with gastric emptying rate(GER)(r=-0.59)and antral motility index(MI)(r=-0.49),while in functional abdominal pain,MI positively correlated(r=0.25)with BMI(P≤0.01).CONCLUSION In children with FAPDs,higher BMI was associated with increased gastric antral distention during fasting and postprandial periods(as indicated by FAA,AA1,and AA15)but not with contractility and transit(MI,GER).However,in the FD subgroup,high BMI correlated with reduced GER and MI.This indicates the possible role of BMI in gastric hypomotility and the pathophysiology of FD.These findings underscore the importance of lifestyle and dietary interventions aimed at optimizing BMI in the management of FAPDs,particularly FD.
文摘Body mass index(BMI),with its simple formula of weight divided by height squared,has become a cornerstone tool in global public health for assessing obesity and health risks.However,as populations aging and the demand for precise health evaluation grows,the limitations of this single metric have become increasingly apparent—it fails to distinguish between muscle and adipose tissue and cannot capture the complex relationship between inflammatory status and body composition.A recent study published in Biomedical and Environmental Sciences(BES)by Zhang et al.[1],which explores the association of white blood cell(WBC)count,platelet(PLT)count,and platelet-to-white blood cell ratio(PWR)with muscle mass among Chinese communitydwelling older adults,provides critical evidence for rethinking the role of BMI.Additionally,several studies published in BES,spanning from childhood nutrition to adult metabolism,further illuminate the complexity of health assessment[2−5].Building on these findings and integrating evidence from multiple Chinese population studies,this commentary revisits the historical context,utility,inherent limitations,and future directions of this classic indicator.
基金This study is supported by the National Natural Science Foundation of China (No. 82072127)。
文摘BACKGROUND:This study aims to explore the causal relationship of body weight,body mass index(BMI),and waist circumference (WC) with the risk of cardiac arrest (CA) using two-sample Mendelian randomization (MR).METHODS:Data were summarized using genome-wide association studies (GWAS).Twosample MR analyses were performed using the inverse variance weighting (IVW) method,the weighted median method,and the MR-Egger analysis.Heterogeneity test and sensitivity analysis were performed using Cochran’s Q test and the leave-one-out method,respectively.The Steiger test was used to detect reverse causality.Bayesian model-averaged MR was used to identify the most influential risk factors.RESULTS:A total of 13 GWAS data were collected for BMI,body weight and WC.IVW analyses showed a positive correlation of body weight,BMI,and WC with CA (all OR>1 and P<0.05),with MR-Egger and weighted median methods confirming the IVW findings.No horizontal pleiotropy or heterogeneity was observed.Sensitivity analysis indicated that no single nucleotide polymorphism(SNP) caused significant changes in overall causality.Bayesian model-averaged MR was also used to rank causality based on marginal inclusion probability (MIP),and the corresponding modelaveraged causal estimate (MACE) were confirmed,which indicated that WC (GWAS ID:ukb-b-9405)was the highest-ranked risk factor (MIP=0.119,MACE=0.011);its posterior probability was 0.057.A total of 14 sex-specific GWAS data on weight,BMI,and WC were analyzed in relationship with CA,and the MR results showed no significant effects of sex-specific factors.CONCLUSION:Body weight,BMI,and WC are causally associated with an increased risk of CA,with WC identified as the most important risk factor.
基金supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)[grant number 2021-I2M-1-037]the National Natural Science Foundation of China[grant numbers 82373647,and 82473697].
文摘Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospective study was conducted at four sites in rural China between 2013 and 2023.Multivariate Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between BMI and mortality.Stratified analyses were performed based on the individual characteristics of the participants.Results Overall,19,107 participants with a sum of 163,095 person-years were included and 1,910 participants died.The underweight(<18.5 kg/m^(2))presented an increase in all-cause mortality(adjusted hazards ratio[aHR]=2.00,95%confidence interval[CI]:1.66–2.41),while overweight(≥24.0 to<28.0 kg/m^(2))and obesity(≥28.0 kg/m^(2))presented a decrease with an aHR of 0.61(95%CI:0.52–0.73)and 0.51(95%CI:0.37–0.70),respectively.Overweight(aHR=0.76,95%CI:0.67–0.86)and mild obesity(aHR=0.72,95%CI:0.59–0.87)had a positive impact on mortality in people older than 60 years.All-2 cause mortality decreased rapidly until reaching a BMI of 25.7 kg/m(aHR=0.95,95%CI:0.92–0.98)and increased slightly above that value,indicating a U-shaped association.The beneficial impact of being overweight on mortality was robust in most subgroups and sensitivity analyses.Conclusion This study provides additional evidence that overweight and mild obesity may be inversely related to the risk of death in individuals older than 60 years.Therefore,it is essential to consider age differences when formulating health and weight management strategies.
文摘Objective:To investigate whether differences exist in DNA fragmentation levels and protamine deficiency in the sperm of obese men compared to those of overweight and proven fertile,normal weight men and evaluate the alterations related to reproductive hormones,semen parameters and their association with body mass index(BMI).Methods:Participants in this observational study were divided into three groups based on their BMI:proven fertile,normal weight men(n=200);overweight men(n=200);and obese men(n=200).After 3 days of abstinence,seminal fluid was collected from all participants and analyzed.Blood samples were also collected on the same day for hormonal analysis.Sperm DNA fragmentation and protamine deficiency were also assessed.Results:A total of 600 men with a mean age of(34.3±7.9)2 years were included in the study.Obese males(BMI 30 kg/m or higher)exhibited significant reductions in semen volume,sperm concentration,total sperm motility percentage,progressive motility,non-progressive motility,and levels of total testosterone,follicle-stimulating hormone(FSH)and luteinizing hormone(LH)compared to overweight(BMI 25 to 29.9 kg/m2)and normal weight males(BMI 18.5 to 24.9 kg/m2)(P<0.001).Conversely,obese males showed a significant increase in prolactin level,sperm DNA fragmentation,and protamine deficiency compared to overweight and normal weight males(P<0.001).Significant negative correlations were demonstrated between BMI and sperm concentration,motility,total testosterone,FSH and LH(P<0.001),whereas prolactin,sperm DNA fragmentation and protamine deficiency were positively correlated with BMI(P<0.001).Conclusions:This study provides clear evidence that obesity contributes potentially to male infertility by inducing sperm DNA fragmentation and protamine deficiency,as well as negatively impacting reproductive hormones and semen quality.
基金supported in part by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.82304253).
文摘Obesity,a chronic,complex disease characterized by excess fat deposits,has become a major public health issue worldwide.Epidemiological studies have demonstrated that obesity can result in a greater risk of several harmful outcomes,such as diabetes mellitus and cardiovascular diseases[1].
文摘The prognostic impact of obesity in acute liver failure(ALF)remains underexplored in recent United States cohorts despite the global rise in obesity prevalence.The aim of this letter is to appraise and contextualize the findings of Krishnan et al,who examined the association between body mass index(BMI)and ALF outcomes in a large,retrospective United States cohort.Krishnan et al analyzed 196 ALF patients over two decades,demonstrating that both overweight and obesity independently doubled the risk of death or need for liver transplantation after adjustment for confounders.Elevated BMI was also associated with higher grades of hepatic encephalopathy and renal dysfunction;two major contributors to ALF mortality.Future research should consider additional markers of metabolic health beyond BMI to refine prognostication.This study provides timely,robust evidence linking elevated BMI to adverse ALF outcomes and highlights the need for targeted clinical strategies in this vulnerable subgroup.
基金Supported by the Japan Agency for Medical Research and Development,No.JP24fk0210132 and No.JP25fk0210132JSPS KAKENHI,No.JP23K15055.
文摘Krishnan et al’s article is a comprehensive and vigorous retrospective cohort study regarding the association between obesity and clinical outcomes in acute liver failure(ALF).Among patients with ALF in the United States,mean body mass index(BMI)was significantly greater in those who underwent liver transplantation or who died than among survivors,although acetaminophen induced ALF was the most common etiology.A high BMI was associated with renal failure and high grades of hepatic encephalopathy.The prevalence of obesity and its related fatty liver diseases,such as metabolic dysfunction-associated fatty liver disease/metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis,has increased worldwide.Obesity is related to increased serum cytokines and immune abnormalities.These findings may explain why ALF in patients with high BMI is associated with worse clinical outcomes.Further studies are needed to determine the associations among BMI,ALF and acute-on-chronic liver failure.
文摘BACKGROUND The association between adiposity parameters and incident hepatocellular carcinoma(HCC)in individuals with nonalcoholic fatty liver disease(NAFLD)is yet to be evaluated.AIM To investigate the risk of HCC according to body mass index(BMI)and waist circumference(WC)in people with NAFLD.METHODS This population-based cohort study included Korean National Health Insurance Service examination participants with NAFLD(n=1110773).NAFLD was defined as a fatty liver index of≥30.The risk of HCC was determined by Cox propor-tional hazards regression according to BMI and WC after adjusting for age,sex,health behaviors,income,comorbidities,and WC or BMI.RESULTS HCC was diagnosed in 4773(0.43%)participants during a median follow-up of 10.3 years.A U-shaped association between BMI or WC and HCC was observed,with the highest risk observed in the lowest BMI and WC groups.Compared to normal BMI,the adjusted hazard ratio(aHR)of the underweight BMI group was 2.02[95%confidence interval(CI):1.25-3.28].The lowest risk was found in groups with overweight BMI(aHR=0.67,95%CI:0.60-0.73;reference:normal BMI)and WC:85-89.9/80-84.9 cm for men/women(aHR=0.55,95%CI:0.49-0.63;reference:<80/<75 cm).Subgroup analyses of age,sex,health behaviors,and fatty liver index showed consistent results.CONCLUSION The development of HCC shows a U-shaped relationship with BMI and WC in people with NAFLD,with the highest risk in underweight individuals.
基金Supported by Wu Jieping Medical Foundation,No.320.6750.2024-16-28.
文摘BACKGROUND Esophageal cancer(EC),primarily esophageal squamous cell carcinoma in China,has a poor prognosis with a 5-year survival rate of approximately 25%after surgery alone.Neoadjuvant chemoradiotherapy combined with surgery is the standard treatment for locally advanced EC,with a 47%5-year survival rate,although adverse events are common.Immunotherapy,particularly PD-1 inhibitors,has shown promise in treating advanced EC,and neoadjuvant chemotherapy with immunotherapy is effective.However,the efficacy of postoperative immunotherapy remains unclear,with studies like Checkmate577 showing promising results but limited applicability to surgery-only patients,highlighting the need for further research.AIM To evaluate the efficacy,prognostic factors,and safety of adjuvant immunotherapy with anti-PD-1 inhibitors following radical surgery for EC.METHODS A retrospective analysis was conducted on EC patients who received adjuvant immunotherapy after radical treatment at the 900th Hospital of the China Joint Logistics Force between January 2018 and October 2024.Demographic,treatment and laboratory data were collected.Progression-free survival(PFS)was assessed using the Kaplan-Meier method,and independent prognostic factors were identified using Cox regression.Optimal cutoff values for continuous variables,including body mass index(BMI)difference and neutrophil-to-lymphocyte ratio(NLR),were determined using the maxstat package in R.RESULTS A total of 44 patients were included,with a 2-year PFS rate of 68.6%[95%confidence interval(CI):53%-88.7%].Univariate analysis identified several factors significantly associated with prognosis,including the interval between surgery and immunotherapy,BMI difference between before surgery and first immunotherapy,presurgical lymphocyte count,and presurgical NLR.Multivariable Cox regression revealed that a BMI difference<3.86 was an independent protective factor for PFS(hazard ratio:0.42,95%CI:0.21-0.85,P<0.05).At the last followup,the median PFS for patients with BMI<3.86 had not been reached,compared to 8.83 months for those with BMI>3.86.The 1-year PFS for patients receiving postoperative chemotherapy combined with immunotherapy was 88.5%,suggesting superior efficacy over chemotherapy alone.CONCLUSION Adjuvant immunotherapy for EC shows good efficacy and safety.A BMI difference<3.86 is a protective factor for PFS,highlighting the importance of monitoring nutrition and inflammation for personalized treatment.
基金supported by Grant 82222064 from the National Natural Science Foundation of Chinathe Shandong University Distinguished Young Scholars。
文摘Objective This study aimed to explore the interplay between the life-course body mass index(BMI)trajectories and insulin resistance(IR)on incident diabetes.Methods This longitudinal cohort included 2,336 participants who had BMI repeatedly measured 3–8times between 1989 and 2009,as well as glucose and insulin measured in 2009.BMI trajectories were identified using a latent class growth mixed model.The interplay between BMI trajectories and IR on diabetes was explored using the four-way effect decomposition method.Logistic regression and mediation models were used to estimate the interaction and mediation effects,respectively.Results Three distinct BMI trajectory groups were identified:low-stable(n=1,625),mediumincreasing(n=613),and high-increasing(n=98).Both interaction and mediation effects of BMI trajectories and IR on incident diabetes were significant(P<0.05).The proportion of incident diabetes was higher in the IR-obesity than in the insulin-sensitivity(IS)obesity group(18.9%vs.5.8%,P<0.001).After adjusting for covariates,the odds ratios(95%confidence intervals)of the IR,IS-obesity,and IRobesity groups vs.the normal group were 3.22(2.05,5.16),2.05(1.00,3.97),and 7.98(5.19,12.62),respectively.IR mediated 10.7%of the total effect of BMI trajectories on incident diabetes(P<0.001).Conclusion We found strong interactions and weak mediation effects of IR on the relationship between life-course BMI trajectories and incident diabetes.IS-obesity is associated with a lower risk of incident diabetes than IR-obesity.
基金National Natural Science Foundation of China,No.81970698 and No.81900805Peking University People's Hospital Research and Development Funds,No.Project RS2022-03。
文摘BACKGROUND The association between body mass index(BMI)and bone mineral density(BMD)has shown inconsistent results,varying by sex and skeletal site.Despite normal or elevated bone mass,individuals with type 2 diabetes have an increased risk of hip and vertebral fractures.AIM To assess lumbar spine trabecular volumetric BMD(vBMD)across different BMI categories in individuals with and without diabetes.METHODS This cross-sectional study included 966 men over 50 years old and 1001 postmenopausal women from the Pinggu Metabolic Disease Study.The vBMD of lumbar vertebrae 2 through 4 was measured using quantitative computed tomography.Total adipose tissue,subcutaneous adipose tissue(SAT),visceral adipose tissue(VAT),and lumbar skeletal muscle area were also quantified.RESULTS In men with obesity(P=0.038)and overweight(P=0.032),vBMD was significantly higher in the diabetes group compared to non-diabetic men.After adjusting for age and sex,no significant saturation effect between BMI and BMD was found in participants with diabetes or in women without diabetes.However,a BMI threshold of 22.33 kg/m²indicated a saturation point for vBMD in nondiabetic men.Independent predictors of vBMD in men included age(r=-0.387,P<0.001),BMI(r=0.130,P=0.004),and VAT(r=-0.145,P=0.001).For women,significant predictors were age(r=-0.594,P<0.001),BMI(r=0.157,P=0.004),VAT(r=-0.112,P=0.001),and SAT(r=-0.068,P=0.035).CONCLUSION The relationship between BMI and trabecular vBMD differs in individuals with and without diabetes.Overweight and obese men with diabetes exhibit higher vBMD.
文摘Body Mass Index (BMI), defined as the ratio of individual mass (in kilograms) to the square of the associated height (in meters), is one of the most widely discussed and utilized risk factors in medicine and public health, given the increasing obesity worldwide and its relation to metabolic disease. Statistically, BMI is a composite random variable, since human weight (converted to mass) and height are themselves random variables. Much effort over the years has gone into attempts to model or approximate the BMI distribution function. This paper derives the mathematically exact BMI probability density function (PDF), as well as the exact bivariate PDF for human weight and height. Taken together, weight and height are shown to be correlated bivariate lognormal variables whose marginal distributions are each lognormal in form. The mean and variance of each marginal distribution, together with the linear correlation coefficient of the two distributions, provide 5 nonadjustable parameters for a given population that uniquely determine the corresponding BMI distribution, which is also shown to be lognormal in form. The theoretical analysis is tested experimentally by gender against a large anthropometric data base, and found to predict with near perfection the profile of the empirical BMI distribution and, to great accuracy, individual statistics including mean, variance, skewness, kurtosis, and correlation. Beyond solving a longstanding statistical problem, the significance of these findings is that, with knowledge of the exact BMI distribution functions for diverse populations, medical and public health professionals can then make better informed statistical inferences regarding BMI and public health policies to reduce obesity.
文摘The aim of the study was to determine the rela-tionship between Body Mass Index (BMI) and accelerated dental development. The dental developmental ages of 100 children aged between 8 and 12 years were determined using the Demirjian method and panoramic radiographs. BMI status was determined for each subject on the basis of the system developed by the International Obesity Task Force. There was a significant direct relationship between dental development and BMI (P < 0.01). Obese children have a higher rate of dental development compared to normal children. CLINICAL RELEVANCE: This is an important variable to be considered when planning for dental and orthodontic treatments in obese children. Brief objectives statement: Overweight or obesity can accelerate dental development. Accelerated dental development in overweight children is important to be considered in pediatric dentistry and orthodontics.
基金funded by Science and Technology Department of jilin Province (Changchun,China,No.20200404186YY).
文摘Body mass index(BMI)has been increasing globally in recent decades.Previous studies reported that BMI was associated with sex hormone levels,but the results were generated via linear regression or logistic regression,which would lose part of information.Quantile regression analysis can maximize the use of variable information.Our study compared the associations among different regression models.The participants were recruited from the Center of Reproductive Medicine,The First Hospital of Jilin University(Changchun,China)between June 2018 and June 2019.We used linear,logistic,and quantile regression models to calculate the associations between sex hormone levels and BMI.In total,448 men were included in this study.The average BMI was 25.7(standard deviation[s.d.]:3.7)kg m^(-2);29.7%(n=133)of the participants were normal weight,45.3%(n=203)of the participants were overweight,and 23.4%(n=105)of the participants were obese.The levels of testosterone and estradiol significantly differed among BMI groups(all P<0.05).In linear regression and logistic regression,BMI was associated with testosterone and estradiol levels(both P<0.05).In quantile regression,BMI was negatively associated with testosterone levels in all quantiles after adjustment for age(all P<0.05).BMI was positively associated with estradiol levels in most quantiles(≤80^(th))after adjustment for age(all P<0.05).Our study suggested that BMI was one of the influencing factors of testosterone and estradiol.Of note,the quantile regression showed that BMI was associated with estradiol only up to the 80^(th) percentile of estradiol.
文摘The aim of this research was to examine the effect of eating habits and family flexibility on the body mass index in gifted students of the eighth and ninth grade of high school. The research design of this study was descriptive-correlation. The statistical population of this research included all high school gifted students of the eighth and ninth grade. The sample consisted of 220 gifted students who were selected by random sampling method. The average age of these participants was 14.56 years old, SD 10.41. Average participants BMI was 31.25, SD 3.12. One hundred and fifteen (52.28%) of these students were females and one hundred and five (47.72%) were males. Family flexibility was measured by Shakeri flexibility scale, eating habits were measured through Coker and Roger Eating Habits Questionnaire and body mass index was tested by Omron digital device. Using SPSS software, the data were analyzed to calculate correlation and simultaneous regression. The results of correlation showed that in these students, concern with weight and dieting and total eating habits have significant relationship with BMI (P < 0.001). The result of simultaneous regression also showed that concern with weight and dieting and total eating habits could explain BMI in these students (P < 0.001) and family flexibility could not explain BMI in these students (P < 0.005). The results emphasize the more important role of eating habits than family flexibility on BMI in gifted students because of sensitive and higher level of intelligence and high peer competitions.
文摘Background: Japanese women’s body mass index (BMI) was known to be the lowest among people in OECD countries. We wanted to compare foods intakes and relationships between intakes of particular food species and BMI. Methods: We asked young and middle-aged women to participate and used a brief-type self-administered diet history questionnaire (BDHQ) to know the amounts of various food species they took. Results: Weights and BMI of young and middle-aged women were not different. Middle-aged women took almost all species of foods and energy more than young women. Except for cholesterol of soluble dietary fibers, there was no correlation between foods intakes and BMI. Conclusion: Both young and middle-aged Japanese women are lean (BMI;around 22). Middle-aged women took more energy, and proteins, carbohydrates, and lipids compared with young women. Middle-aged women spend more energy on house workings than young women in Japan.
文摘Objective:compare the habits and features of obese (BMI>25) and normal (BMI<25) individuals and express a method to ameliorate the life styles using a cross-sectional experiment.Methods:A total of 220 randomly selected cases were divided into case group (n=110) and control group (n=100) according to the calculated BMI level.Samples with BMI>25 kg/m2 were assigned to the case (obsess) group and those with BMI ranging from 20 to 25 were assigned to control (normal) group.The Miller-Smith life style questionnaires consisting 20 questions each with 5 different answers were given to both groups.Data of the questionnaires were collected and analyzed using t-test and Chi-square with SPSS.Results:No significant differences were found among the two groups in terms of the mean age,gender,level of education,marital status,insurance,breakfast,lunch or dinner,fried meat,legumes,caffeinated beverages,the length of sleep during 24 h,cigarette smoking and losing job or spouse.However,in regards to use of vegetables,sausage,fried potatoes,enriched breads,low fat milk,low salt,candies and chocolates significant relations were found (P<0.05).Conclusion:The present study suggests one way to control obesity and prevent diseases is to ameliorate the life styles.There is a relation between health and stress and irregularity of meals,such as breakfast skipping,is associated with overweight and obesity in adolescence.
