Background: The forehead is particularly prone to repetitive facial expressions and hyperdynamic activity, resulting in deep wrinkles and a loss of elasticity and hydration. Although botulinum toxin type A (BoNTA) has...Background: The forehead is particularly prone to repetitive facial expressions and hyperdynamic activity, resulting in deep wrinkles and a loss of elasticity and hydration. Although botulinum toxin type A (BoNTA) has been shown to reduce the appearance of wrinkles and allow patients to have a smoother and hence younger upper face, it cannot help to improve the other aspects that determine overall skin quality. Objective: This case series aims to evaluate the clinical efficacy of combining BoNTA injections with a biorevitalizing treatment (NCTF®135HA) on skin aging signs and quality using a split face approach. Patients and Methods: A total of eight patients from 30 to 55 years old were treated with botulinum toxin type A combined with NCTF®-135HA or alone. Results: At D60, clinical skin quality scoring showed that NCTF®135HA injection significantly reduced wrinkles and enhanced skin homogeneity, hydration, firmness, and radiance. The Global Aesthetic Improvement Scale (GAIS) by the evaluator at D60 reported mean scores of 2375 (much improved) on the side of the face treated with BoNTA + NCTF®-135HA compared to the side of the face without NCTF®135HA. According to patients, the NCTF®135HA injections resulted in a significantly better aesthetic improvement score on D60 (mean score of 2.5 compared to 0.125 without NCTF®135HA, p 0.001). Conclusions: Our findings show that combining a biorevitalizing treatment with a BoNTA injection can significantly improve the skin’s overall appearance and decrease the wrinkle score when compared to the BoNTA injections alone. The results suggest that the combinatory strategy is effective, safe, and associated with a high level of patient satisfaction.展开更多
The study evaluated new watermelon varieties grown in Guyana (Bonta, Sugar Doll, Santa Matilde, Delta and Sentinel) for sustainability under local conditions. The trial was conducted at Mahaica using a randomized comp...The study evaluated new watermelon varieties grown in Guyana (Bonta, Sugar Doll, Santa Matilde, Delta and Sentinel) for sustainability under local conditions. The trial was conducted at Mahaica using a randomized complete block design (RCBD) with six treatments and three replicates. Data was collected on seedling emergence, flowering, fruiting and harvesting time. Data was also collected to create plant descriptors, according to the International Union for the Protection of New Varieties of Plants, for the new varieties. Average production was recorded at 54,857.6 Kg/ha, 76,387 Kg /ha, 56,940.8 Kg/ha, 65,968 Kg/ha and 22,915.2 Kg/ha for Santa Matilde, Delta, Bonta, Sentinel and Mickylee, respectively. All varieties began flowering at the same time, however, Bonta and Mickylee were the first to produce fruits. Bonta and Mickylee were also harvested at the same time (73 days after germination). Delta had the seeds with more width (6.3 mm) while Santa Matilde had the longest seeds (9.4 mm). Average brix for Santa Matilde, Delta, Bonta, Sentinel and Mickylee were 10.8, 7.9, 8.2, 6.9 and 10.4 respectively. Mickylee and Bonta had ovaries with the same average circumference of 4.5 cm while Delta had the average longest ovary with 2.5 cm. Sentinel had the average thickest stem (9.8 mm), broadest (19.1 cm) and longest (22.1 cm) leaf. Bonta had the average longest petiole (11.4 cm) and Delta had the longest fruits (51.6 cm). Bonta could be a suitable replacement for Mickylee since there is no significant difference between the time of harvest.展开更多
文摘Background: The forehead is particularly prone to repetitive facial expressions and hyperdynamic activity, resulting in deep wrinkles and a loss of elasticity and hydration. Although botulinum toxin type A (BoNTA) has been shown to reduce the appearance of wrinkles and allow patients to have a smoother and hence younger upper face, it cannot help to improve the other aspects that determine overall skin quality. Objective: This case series aims to evaluate the clinical efficacy of combining BoNTA injections with a biorevitalizing treatment (NCTF®135HA) on skin aging signs and quality using a split face approach. Patients and Methods: A total of eight patients from 30 to 55 years old were treated with botulinum toxin type A combined with NCTF®-135HA or alone. Results: At D60, clinical skin quality scoring showed that NCTF®135HA injection significantly reduced wrinkles and enhanced skin homogeneity, hydration, firmness, and radiance. The Global Aesthetic Improvement Scale (GAIS) by the evaluator at D60 reported mean scores of 2375 (much improved) on the side of the face treated with BoNTA + NCTF®-135HA compared to the side of the face without NCTF®135HA. According to patients, the NCTF®135HA injections resulted in a significantly better aesthetic improvement score on D60 (mean score of 2.5 compared to 0.125 without NCTF®135HA, p 0.001). Conclusions: Our findings show that combining a biorevitalizing treatment with a BoNTA injection can significantly improve the skin’s overall appearance and decrease the wrinkle score when compared to the BoNTA injections alone. The results suggest that the combinatory strategy is effective, safe, and associated with a high level of patient satisfaction.
文摘The study evaluated new watermelon varieties grown in Guyana (Bonta, Sugar Doll, Santa Matilde, Delta and Sentinel) for sustainability under local conditions. The trial was conducted at Mahaica using a randomized complete block design (RCBD) with six treatments and three replicates. Data was collected on seedling emergence, flowering, fruiting and harvesting time. Data was also collected to create plant descriptors, according to the International Union for the Protection of New Varieties of Plants, for the new varieties. Average production was recorded at 54,857.6 Kg/ha, 76,387 Kg /ha, 56,940.8 Kg/ha, 65,968 Kg/ha and 22,915.2 Kg/ha for Santa Matilde, Delta, Bonta, Sentinel and Mickylee, respectively. All varieties began flowering at the same time, however, Bonta and Mickylee were the first to produce fruits. Bonta and Mickylee were also harvested at the same time (73 days after germination). Delta had the seeds with more width (6.3 mm) while Santa Matilde had the longest seeds (9.4 mm). Average brix for Santa Matilde, Delta, Bonta, Sentinel and Mickylee were 10.8, 7.9, 8.2, 6.9 and 10.4 respectively. Mickylee and Bonta had ovaries with the same average circumference of 4.5 cm while Delta had the average longest ovary with 2.5 cm. Sentinel had the average thickest stem (9.8 mm), broadest (19.1 cm) and longest (22.1 cm) leaf. Bonta had the average longest petiole (11.4 cm) and Delta had the longest fruits (51.6 cm). Bonta could be a suitable replacement for Mickylee since there is no significant difference between the time of harvest.
