The issue of light pollution has garnered increased attention recently,largely due to the widespread use of electronic devices.Blue light(BL)holds the highest energy level among visible light and has been extensively ...The issue of light pollution has garnered increased attention recently,largely due to the widespread use of electronic devices.Blue light(BL)holds the highest energy level among visible light and has been extensively researched for its potential to cause damage to the retina.Ferroptosis,a recently identified form of programmed cell death form,has been linked to retinal diseases.However,the connection between BL-induced retinal damage and ferroptosis remains elusive.This study aims to investigate the involvement of ferroptosis in retinal damage under BL exposure and its underlying mechanism.In this study,a mouse retinal damage model and cultured ARPE-19 cells exposed to BL were employed.Various techniques including Haematoxylin-eosin staining,fundus photography,immunostaining,and transmission electron microscopywere employed to examine retinal structure and morphology changes resulting from BL exposure.To identify ferroptosis levels in vitro,we employed DCFH-DA,C11-BODIPY 581/591,and FeRhoNox^(TM)-1 probes.Additionally,real-time PCR and western blotting techniques were used to uncover potential targets in BL-induced ferroptosis.Our study showed that BL exposure can result in iron overload,oxidative stress,evidenced by increased markers TFR1,ACSL4,HO-1 and decreased expression level of SOD2,CAT and ferroptosis-associated gene of GPX4.Interestingly,we found that Deferoxamine mesylate,a compound capable of chelating excess Fe2+caused by BL,effectively mitigated lipid peroxidation,and alleviated retinal damage both in vivo and in vitro.The discoveries will advance our knowledge of BL-induced retinal damage.展开更多
White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual healt...White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual health.In this study,yellow-emitting carbon dots(CDs)with a quantum yield exceeding 94%were synthesized using citric acid and urea.These CDs effectively absorb blue light.By incorporating them into polystyrene,multiple films termed CDs-based blue light blocking films(CBFs)were developed,each offering different levels of blue light absorption.These CBFs exhibited excellent transparency and efficient blue light filtering capabilities.This study highlights the potential of high quantum yield CDs,which specifically absorb blue light,as foundational materials for developing light-blocking solutions against highenergy short-wavelength light.展开更多
In recent years, the harmful effects of blue light (400 - 500 nm) as a component of visible light (400 - 700 nm) have increasingly gained attention of science, industry, and consumers. To date, only a few in vivo test...In recent years, the harmful effects of blue light (400 - 500 nm) as a component of visible light (400 - 700 nm) have increasingly gained attention of science, industry, and consumers. To date, only a few in vivo test methods for measuring the effects of blue light on the skin have been described. A direct measurement method that can detect the immediate effects of blue light on the epidermal permeability barrier (EPB) is still lacking. In this study, we present a new methodological approach that can be used to investigate both the protective and regenerative effects of cosmetic products on the EPB after blue light irradiation. In a study with 14 female volunteers, it was investigated whether the regular application of an O/W emulsion (day cream) can strengthen and protect the epidermal barrier against damaging blue light radiation of 60 J/cm2 (protective study design) and also whether a disruption of the epidermal barrier caused by blue light radiation is restored faster and better by the regular application of another O/W emulsion (night cream) than in product-untreated skin (regenerative study design). The two O/W emulsions are different in plant oil, active ingredient composition and texture. The seven-day treatment with the day cream initially led to a significant increase in the normalized lipid lamellae length in the intercellular space, whereas the irradiation with blue light after 24 hours led to a significant decrease in the lipid lamellae length in the untreated test area, but not in the area previously treated with the product. Regarding the regenerative study design, a two-day treatment with the night cream was able to restore a blue-light-induced decrease in lipid lamellae length in the intercellular space. In summary, with the study designs presented here, the protective and regenerative effect of two cosmetic products could be demonstrated for the first time on the integrity of the EPB after blue light irradiation and the data showed that the Lipbarvis® method is suitable for investigating the damaging effects of blue light on the EPB in vivo.展开更多
Objective: to investigate the effect difference of intermittent and continuous treatment with Yinzhi Huang oral liquid in the treatment of neonatal jaundice (NNJ). Methods: a total of 200 children with NNJ from Januar...Objective: to investigate the effect difference of intermittent and continuous treatment with Yinzhi Huang oral liquid in the treatment of neonatal jaundice (NNJ). Methods: a total of 200 children with NNJ from January 2019 to December 2019 in our hospital were divided into two groups by odd-even method. The levels of bilirubin (BILirubin) before and after treatment, the outcome, the time of disease improvement and the incidence of phototherapy damage events in the two groups were compared. Results: there were significant differences in BILI level, outcome, improvement time and incidence of phototherapy damage events between the intermittent blue light treatment group and the continuous blue light treatment group (P < 0.05). Conclusion: in the aspect of blue light therapy for CHILDREN with NNJ, intermittent intervention can more significantly promote the decline of BILI level, accelerate the regression of yellow skin stain, accelerate the rehabilitation of children, and improve bilirubin level, which is worth promoting.展开更多
To evaluate the supplementary blue light intensity on growth and health-promoting compounds in pak choi（Brassica campestris ssp.chinensis var.communis）,four blue light intensity treatments（T0,T50,T100 and T150 indi...To evaluate the supplementary blue light intensity on growth and health-promoting compounds in pak choi（Brassica campestris ssp.chinensis var.communis）,four blue light intensity treatments（T0,T50,T100 and T150 indicate 0,50,100,and 150μmol m^（-2） s^（-1）,respectively）were applied 10 days before harvest under greenhouse conditions.Both of cultivars（greenand red-leaf pak choi）under T50 had the highest yield,content of chlorophyll and sugars.With light intensity increasing,antioxidant compounds（vitamin C and carotenoids）significantly increased,while nitrate content showed an opposite trend.The health-promoting compounds（phenolics,flavonoids,anthocyanins,and glucosinolates）were significantly higher under supplementary light treatment than T0,so as the antioxidant capacity（2,2-diphenyl-1-picrylhydrazyl and ferric-reducing antioxidant power）.The species-specific differences in photosynthetic pigment and health-promoting compounds was found in green-and red-leaf pak choi.T50 treatment could be used for yield improvement,whereas T100 treatment could be applied for quality improvement.Results showed that blue light intensity can regulate the accumulation of biomass,morphology and health-promoting compounds in pak choi under greenhouse conditions.展开更多
In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to ey...In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light’s effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment.展开更多
We evaluated the effects of red and blue light on the repair of UV-B radiation-induced damage in tetraspores of Chondrus ocellatus Holm. Tetraspores of C. ocellatus were treated with different UV-B radiation levels(0,...We evaluated the effects of red and blue light on the repair of UV-B radiation-induced damage in tetraspores of Chondrus ocellatus Holm. Tetraspores of C. ocellatus were treated with different UV-B radiation levels(0,36,72,108,144 and 180 J/m2),and thereafter subjected to PAR,darkness,or red or blue light during a 2-h repair stage,each day for 48 days. The diameters and cellular contents of cyclobutane pyrimidine dimmers(CPDs),chlorophyll a(Chl a),phycoerythrin,and UV-B-absorbing mycosporinelike amino acids(MAAs) contents of the tetraspores were determined. Our results show that low doses of UV-B radiation(36 and 72 J/m 2) promoted the growth of C. ocellatus; however,increased UV-B radiation gradually reduced the C. ocellatus growth(greater than 72 J/m2). The MAAs(palythine and asterina-330) in C. ocellatus were detected and analyzed by LC/MS. Our results suggest that moderate red light could induce the growth of this alga in aquaculture. In addition,photorepair was inhibited by red light,so there may be some other DNA repair mechanism activated by red light. Blue light promoted the activity of DNA photolyase,greatly improving remediation efficiency. Red and blue lights were found to reduce the capacity of C. ocellatus to form MAAs. Therefore,PAR,red light,and blue light play different roles during the repair processes for damage induced by UV-B radiation.展开更多
Laminaria gametophyte was greatly influenced by light in its growth and development. Using light-emitting diodes (LED) as blue and red light sources, we analyzed the light effect on gametophytes devel- opment of Lamin...Laminaria gametophyte was greatly influenced by light in its growth and development. Using light-emitting diodes (LED) as blue and red light sources, we analyzed the light effect on gametophytes devel- opment of Laminaria japonica Aresch. The gametophytes were obtained from zoospores collected in April, May, July, 2003 and September, 2004. We found that the growth of gametophytes was stimulated by increasing inten- sity of blue light (BL) and red light (RL) illumination, of which BL was obviously stronger than that of RL. The fertilization of gametophytes depended largely on BL, and only sufficient BL illumination could take the repro- ductive effect. In addition, we noticed that there was a significant difference in light responses for gametophytes developed from zoospore collected in different times. For zoospores released in April, under BL1 (73.90 μmol photons/m·s), the unicellular female gametophytes and multi-cellular male gametophytes produced eggs and sperms respectively, and further developed towards sporophytes. However, for gametophytes developed in May, July or September, they became multi-cellular and never formed oogonia or antheridia. It is believed that the Laminaria sporangium maturation stage could affect the gametophytes reaction to BL under laboratory culture conditions. Therefore, cryptochrome- or phototropin-like BL photoreceptors is probably involved in BL-induced development of Laminaria gametophytes.展开更多
Blue and red light are spectral wavelengths more effective for plants. The effects of different ratios of red and blue light （R/B=2, R/B=4, R/B=8, R/B=12） provided by LEDs on morphology and photosynthetic characteri...Blue and red light are spectral wavelengths more effective for plants. The effects of different ratios of red and blue light （R/B=2, R/B=4, R/B=8, R/B=12） provided by LEDs on morphology and photosynthetic characteristics of tomato seedlings were studied. The results showed that plant height, stem diameter, fresh weight, dry weight, seedling index and G value increased with the increase of R/B ratio until 8. On the contrary, SPDA value decreased with the increase of R/B ratio. Photosynthetic characteristics were measured by CO 2 assimilation （ Pn ）, stomatal conductance （ gs ） and intracellular CO 2 concentration （ Ci） . Pn and gs decreased with the increase of R/B ratio. Furthermore, similar trend was investigated in photochemical quenching （qP） and electron transport rate （ETR）. Results of this study suggest that compared with white LED, appropriate combination of red and blue light can enhance plant growth and photosynthetic characteristics, and the optimal blue/red ratio for tomato growth was R/B=8.展开更多
The InGaN/GaN blue light emitting diode（LED） is numerically investigated using a triangular-shaped quantum well model,which involves analysis on its energy band,carrier concentration,overlap of electron and hole wav...The InGaN/GaN blue light emitting diode（LED） is numerically investigated using a triangular-shaped quantum well model,which involves analysis on its energy band,carrier concentration,overlap of electron and hole wave functions,radiative recombination rate,and internal quantum efficiency.The simulation results reveal that the InGaN/GaN blue light emitting diode with triangular quantum wells exhibits a higher radiative recombination rate than the conventional light emitting diode with rectangular quantum wells due to the enhanced overlap of electron and hole wave functions（above 90%） under the polarization field.Consequently,the efficiency droop is only 18% in the light emitting diode with triangular-shaped quantum wells,which is three times lower than that in a conventional LED.展开更多
AIM:To analyze abnormal gene expressions of mice eyes exposed to blue light using RNA-seq and analyze the related signaling pathways.METHODS:Kunming mice were divided into an experimental group that was exposed to blu...AIM:To analyze abnormal gene expressions of mice eyes exposed to blue light using RNA-seq and analyze the related signaling pathways.METHODS:Kunming mice were divided into an experimental group that was exposed to blue light and a control group that was exposed to natural light.After 14 d,the mice were euthanized and their eyeballs were collected.Whole transcriptome analysis was attempted to analyze the gene expression of the eyeballs using RNA-seq to reconstruct genetic networks.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis were used to reveal the related signaling pathways.RESULTS:The 737 differentially expressed genes were identified,including 430 up and 307 down regulated genes,by calculating the gene FPKM in each sample and conducting differential gene analysis.GO and KEGG pathway enrichment analysis showed that blue light damage may associated with the visual perception,sensory perception of light stimulus,phototransduction,and JAKSTAT signaling pathways.Differential lnc RNA,circ RNA and mi RNA analysis showed that blue light exposure affected pathways for retinal cone cell development and phototransduction,among others.CONCLUSION:Exposure to blue light can cause a certain degree of abnormal gene expression and modulate signaling pathways in the eye.展开更多
AIM:To investigate the phototoxic effect of long-term excessive narrow-band blue light in staurosporine-induced differentiated retinal ganglion cells-5(SSRGC-5).METHODS:SSRGC-5 cells were divided into two groups,blue ...AIM:To investigate the phototoxic effect of long-term excessive narrow-band blue light in staurosporine-induced differentiated retinal ganglion cells-5(SSRGC-5).METHODS:SSRGC-5 cells were divided into two groups,blue light group(BL group)and control group.Cell viability was assessed by using CCK-8 assay.Metabolic profile analysis was performed by using Seahorse extracellular flux analyzer.Mitochondria ultrastructure were studied via transmission electron microscope(TEM).Mitochondria contents and oxidative stress was evaluated by flow cytometry.Western blotting was performed to monitor the changes in mitogen-activated protein kinases(MAPK)pathway and PI3 K/AKT pathway.RESULTS:Blue light caused morphological changes of SSRGC-5 cells.The cell viability was significantly decreased from 3 h in BL group.Intercellular ROS and mitochondrial superoxide levels were increased following blue light exposure.Metabolic profiling identified blue light induced SSRGC-5 cells to have severely compromised mitochondrial function.This was accompanied by impaired mitochondrial ultrastructure and remodeling,increased expression of the mitochondrial related proteins,and increased glycolysis as compensation.Moreover,the results showed that blue light induced higher expression of p-p38,p38,p-JNK,p-ERK,p-cJun,c-Jun,and p-AKT.CONCLUSION:These findings indicate that excessive narrow-band blue light induces oxidative stress and mitochondrial metabolic remodeling dysregulate in SSRGC-5 cells.Activated MAPK and AKT signaling pathways are involved in this process.展开更多
Ethylene is the main factor controlling fruit ripening of pear(Pyrus ussuriensis).Ethylene production rate is negatively correlated with fruit shelf life;therefore,it is important to decrease the ethylene levels for o...Ethylene is the main factor controlling fruit ripening of pear(Pyrus ussuriensis).Ethylene production rate is negatively correlated with fruit shelf life;therefore,it is important to decrease the ethylene levels for optimal fruit storage.Here,we observed that blue light treatment could inhibit ethylene production and promote the expression of ELONGATED HYPOCOTYL 5(PuHY5),a basic leucine zipper domain(bZIP)transcription factor.The following studies showed that PuHY5 could bind to the promoter of ACC synthase 1(PuACS1),a rate-limiting enzyme in ethylene biosynthesis,and inhibit its expression.For pears in which Pu HY5 was silenced,the ethylene production and PuACS1 expression were much higher than those in the control fruit.These results demonstrated that blue light inhibited ethylene production through the induction of Pu HY5 in pear.Our finding provides a new method for prolonging fruit shelf life.展开更多
Previous studies demonstrated that cryptochromes are involved in blue light-induced coiling and prehaustoria development in young de-etiolated dodder seedlings. In this study, we suggest that carotenoids and chlorophy...Previous studies demonstrated that cryptochromes are involved in blue light-induced coiling and prehaustoria development in young de-etiolated dodder seedlings. In this study, we suggest that carotenoids and chlorophyll are not the blue light absorbing chromophores involved in the mediation of prehaustoria development to blue light. Norflurazon-bleached dodder segments coiled and formed prehaustoria under blue light. However, norflurazon significantly reduced prehaustoria number （62%） under a mixture of red and far-red light, suggesting that phytochromes could be altered by norflurazon.展开更多
A number of studies have shown that oxidative stress can be harmful for the retina. The real causal circumstances that lead to degenerative diseases like age related macular degeneration remain obscure. Whether light ...A number of studies have shown that oxidative stress can be harmful for the retina. The real causal circumstances that lead to degenerative diseases like age related macular degeneration remain obscure. Whether light induced radical stress is a direct interaction of light with photoreceptors or a secondary mechanism within the pigment epithelium or choroid is in discussion. Among the molecular mechanisms involved are production of reactive oxygen species(ROS), secondary lipid peroxidation, protein oxidation and DNA-damage. The initial trigger to write this review was first a recent finding of our group that the photoreceptor outer segments produce great amounts of ROS and second the detection of ectopic enzymes of the respiratory chainlocalized there- in addition to the hitherto known ROS sources like the visual pigments with their intermediates and the photoreceptor mitochondria harbouring the respiratory chain.展开更多
<strong>Objective: </strong>The objective is to evaluate the visual acuity, high-order aberrations and satisfaction in the cataract patients with the implantation of different types of AcrySof blue light f...<strong>Objective: </strong>The objective is to evaluate the visual acuity, high-order aberrations and satisfaction in the cataract patients with the implantation of different types of AcrySof blue light filtering intraocular lens, which would provide the clinical guidance for the selection of individualized intraocular lens. <strong>Methods:</strong> From January 2019 to December 2020, the patients with age-related cataract in Guangzhou Red Cross Hospital were equally randomized to be divided into four groups. 20 patients (20 eyes) were implanted with AcrySof (SN60WF), which was the blue light filtering single focus group;20 patients (20 eyes) were implanted with blue light filtering aspheric multifocal intraocular lens (AcrySof ReSTOR IOL +3.0D, SN6AD1), which was the multifocal intraocular lens group;20 patients (20 eyes) were implanted with aspheric astigmatism correction intraocular lens (Toric SN6AT), which was the astigmatism group;20 patients (20 eyes) were implanted with blue filtering aspheric multifocal astigmatism correction intraocular lens (AcrySof ReSTOR IOL +2.5D IQ, SV25T0), which was the ART group. Three months after the operation, the patients were followed up with slit lamp to check the visual acuity, including uncorrected distance visual acuity (UCDVA), uncorrected near visual acuity (UCNVA), best corrected distance visual acuity, (BCDVA);the questionnaire surveys on the satisfaction of different intraocular lens implantation (far and near vision, glare, halo and abnormal visual symptoms);the iTrace visual function analyzer was used to check the total high-order aberrations (spherical aberration, wisdom aberration and Clover aberration) in the 3 mm pupil diameter. <strong>Results:</strong> Three months after cataract surgery, American Simplified version of questionnaire survey showed that the scores of near removing glasses in the multifocal group and the ART group were significantly better than those in the single focus group and the astigmatism group (<em>P</em> < 0.05);there was no significant difference in the satisfaction of far removing glasses, glare and halo in each group (<em>P</em> > 0.05). Three months after cataract surgery, there were statistically significant differences about UCDVA, BCDVA and UCNVA among the four groups (<em>F</em> = 18.189, <em>P </em>< 0.001), the UCNVA in the multifocal group and ART group was significantly better than that in the single focus group and the astigmatism group (<em>P</em> < 0.01). The difference of higher-order aberrations (total higher-order aberrations, wisdom aberrations, spherical aberrations, clover aberrations) was no statistically significant among the four groups (<em>P</em> > 0.05). <strong>Conclusion: </strong>Different types of AcrySof blue light filtering intraocular lens implantation could improve the far vision and satisfaction of cataract patients, without different higher-order aberrations. Multifocal intraocular lens and ART intraocular lens could significantly improve the far vision of patients and reduce the dependence on near glasses.展开更多
Background:Lesion to the retinal pigment epithelium(RPE)is a crucial event in age-related macular degeneration(AMD)development.Although the pathogenesis of this complex disease is poorly understood,sunlight exposure a...Background:Lesion to the retinal pigment epithelium(RPE)is a crucial event in age-related macular degeneration(AMD)development.Although the pathogenesis of this complex disease is poorly understood,sunlight exposure and smoking are major environmental risk factors associated with AMD.High-energy visible blue light(HEV;400-500 nm)is the most energetic and potentially harmful solar wavelengths reaching adults retina.On the other hand,RPE cells can be exposed to a large range of pollutants from cigarette smoke,with polycyclic aromatic hydrocarbons(PAH)being among the most toxic.Some PAH from cigarette smoke can absorb HEV light.This led us hypothesize that in RPE cells,the combination of PAH and HEV could synergize to exacerbate the stress caused by either factor alone.We thus investigate the combined effect of PAH and HEV light in RPE cells.Methods:Confluent RPE immortalized cells(ARPE19)were exposed to nanomolar concentrations of benzo[a]pyrene(BaP)or indeno[1,2,3-cd]pyrene(IcdP).While IcdP efficiently absorbs HEV wavelengths,BaP,the most studied PAH,does not significantly absorb HEV light and was used as a control.BaP or IcdP contaminated ARPE19 were then irradiated with increasing sub-lethal doses of HEV light(150-500 J/cm2)using a setup that mimics the light spectrum normally reaching the retina.Cytotoxicity,apoptosis and reactive oxygen species(ROS)generation were assessed in each condition.Results:In presence of low concentrations of IcdP,sub-lethal amounts of HEV light trigger,in a dose-dependent way,up to 70%of apoptotic cell death.Co-exposure to IcdP and HEV also leads to a synergistic ROS generation in ARPE19 cells,thus inducing oxidative stress.None of these effects were observed with BaP.Efficient inhibition of ROS production by specific antioxidants only decreases death by 20%in cells simultaneously exposed to both IcdP and HEV light.Conclusions:Low concentrations of IcdP synergize with HEV light to induce phototoxicity in ARPE19 cells.An increased oxidative stress results from the interaction between both agents and partially explains the enhanced HEV phototoxicity in IcdP contaminated ARPE19 cells.This suggests that another major mechanism is involved in the synergetic toxicity.For smokers,this synergy between HEV and PAH may accelerate RPE cells loss and contribute to their greater risk of developing AMD.展开更多
Phototherapy with blue light emitting diodes (LEDs) is gaining interest because of the efficient antimicrobial benefits reported in several studies in the last decade. The aim in this study was to investigate if a too...Phototherapy with blue light emitting diodes (LEDs) is gaining interest because of the efficient antimicrobial benefits reported in several studies in the last decade. The aim in this study was to investigate if a toothbrush with incorporated blue light used in daily oral care can reduce dental plaque and gingival inflammation. An 8-week single-blinded randomized controlled clinical study including 48 subjects compared effects of toothbrushes with/without 450 nm blue LED light emission, on clinical parameters (plaque index, gingival index, bleeding on probing), and on inflammatory markers in saliva and gingival crevicular fluid. Significant reductions in dental plaque and gingival inflammation (p < 0.001), and in some inflammatory markers (p ≤ 0.05), matrix metalloproteinase (MMP)-8, tissue inhibitor metalloproteinase inhibitor (TIMP)-1, interleukin (IL)-1β and interleukin (IL)-8, were detected within both groups from baseline to follow-up. For all subjects dental plaque was reduced with 57%, and a reduction in gingival inflammation was demonstrated by a decrease in gingival index (GI) with 46% and in bleeding on probing (BOP) with a decrease of 15%. No significant differences were found between the groups at a level of p = 0.05. However, the amount of plaque was reduced by 62% in the blue light group and 51% in the control group, a difference established at a level of p = 0.058. A toothbrush with a 450 nm LED did not show any statistical significant adjunctive effect of toothbrushing regarding reduction in measurements of dental plaque and gingival inflammation.展开更多
Objective: to analyze the nursing experience of probiotic-assisted blue light therapy in neonates with hyperbilirubinemia. Methods: in our college in July 2020 to October 2021 newborns treated 40 cases of children wit...Objective: to analyze the nursing experience of probiotic-assisted blue light therapy in neonates with hyperbilirubinemia. Methods: in our college in July 2020 to October 2021 newborns treated 40 cases of children with high blood bilirubin, random number table method is divided into research group and control group, 20 cases, and blue light therapy and routine nursing care, the team with auxiliary intervention at the same time to carry out the probiotics, the treatment effect in two groups of children with treatment basic statistical comparison. Results: after treatment, the therapeutic effect of the study group was higher than the control group, daily defecation times were more than the control group, jaundice duration and neonatal treatment time were shorter than the control group, the differences were statistically significant (P < 0.05). Conclusion: probiotic-assisted blue light therapy combined with neonatal nursing can improve the curative effect and promote rehabilitation in neonates with hyperbilirubinemia.展开更多
Objective: to explore the clinical value of phenobarbital, Yinzhihuang Granule, Bifidobacterium quadruple live bacteria combined with blue light irradiation in the treatment of early neonatal jaundice. Methods: 120 ca...Objective: to explore the clinical value of phenobarbital, Yinzhihuang Granule, Bifidobacterium quadruple live bacteria combined with blue light irradiation in the treatment of early neonatal jaundice. Methods: 120 cases of early neonatal jaundice in our hospital from January 2020 to January 2022 were randomly divided into control group (60 cases were treated with triple therapy of phenobarbital, Yinzhihuang granules and Bifidobacterium) and research group (60 cases were treated with triple therapy of drugs combined with blue light irradiation). The bilirubin level, clinical indicators, curative effect and adverse reactions were compared between the two groups on the 1st to 5th day of treatment (Day 1 to Day 5). Results: the transcutaneous bilirubin of the study group (drug triple therapy combined with blue light irradiation) was lower than that of the control group (drug triple therapy) from day 1 to day 5 (t=3.800, 6.637, 8.649, 9.292, 4.548) (P < 0.05). The duration of jaundice (t=16.932), defecation emptying time (t=12.153) and hospitalization time (t=14.225) in the study group (drug triple therapy combined with blue light irradiation) were shorter than those in the control group (P < 0.05). The total effective rate (81.67% Vs 95.00%) of the study group (drug triple therapy combined with blue light irradiation) was higher than that of the control group (drug triple therapy) (P < 0.05). There was no significant difference in the adverse reaction rate between the study group (drug triple therapy combined with blue light irradiation) and the control group (drug triple therapy) (P > 0.05). Conclusion: the triple therapy of phenobarbital and other drugs combined with blue light irradiation can promote the clearance of bilirubin in early neonatal jaundice, improve the symptoms of jaundice, with high safety and simple operation.展开更多
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDA16040200)the National Nature Science Foundation of China(Nos.82201194 and 82371084).
文摘The issue of light pollution has garnered increased attention recently,largely due to the widespread use of electronic devices.Blue light(BL)holds the highest energy level among visible light and has been extensively researched for its potential to cause damage to the retina.Ferroptosis,a recently identified form of programmed cell death form,has been linked to retinal diseases.However,the connection between BL-induced retinal damage and ferroptosis remains elusive.This study aims to investigate the involvement of ferroptosis in retinal damage under BL exposure and its underlying mechanism.In this study,a mouse retinal damage model and cultured ARPE-19 cells exposed to BL were employed.Various techniques including Haematoxylin-eosin staining,fundus photography,immunostaining,and transmission electron microscopywere employed to examine retinal structure and morphology changes resulting from BL exposure.To identify ferroptosis levels in vitro,we employed DCFH-DA,C11-BODIPY 581/591,and FeRhoNox^(TM)-1 probes.Additionally,real-time PCR and western blotting techniques were used to uncover potential targets in BL-induced ferroptosis.Our study showed that BL exposure can result in iron overload,oxidative stress,evidenced by increased markers TFR1,ACSL4,HO-1 and decreased expression level of SOD2,CAT and ferroptosis-associated gene of GPX4.Interestingly,we found that Deferoxamine mesylate,a compound capable of chelating excess Fe2+caused by BL,effectively mitigated lipid peroxidation,and alleviated retinal damage both in vivo and in vitro.The discoveries will advance our knowledge of BL-induced retinal damage.
基金supported by Medical Science and Technology Research Project of Henan Province(Joint Construction Project)(No.LHGJ20200433)National Natural Science Foundation of China(No.52122308)。
文摘White light illumination is essential in daily life,however,the substantial amount of blue light it contains can damage human eyes.Therefore,it is important to block this high-energy blue light to protect visual health.In this study,yellow-emitting carbon dots(CDs)with a quantum yield exceeding 94%were synthesized using citric acid and urea.These CDs effectively absorb blue light.By incorporating them into polystyrene,multiple films termed CDs-based blue light blocking films(CBFs)were developed,each offering different levels of blue light absorption.These CBFs exhibited excellent transparency and efficient blue light filtering capabilities.This study highlights the potential of high quantum yield CDs,which specifically absorb blue light,as foundational materials for developing light-blocking solutions against highenergy short-wavelength light.
文摘In recent years, the harmful effects of blue light (400 - 500 nm) as a component of visible light (400 - 700 nm) have increasingly gained attention of science, industry, and consumers. To date, only a few in vivo test methods for measuring the effects of blue light on the skin have been described. A direct measurement method that can detect the immediate effects of blue light on the epidermal permeability barrier (EPB) is still lacking. In this study, we present a new methodological approach that can be used to investigate both the protective and regenerative effects of cosmetic products on the EPB after blue light irradiation. In a study with 14 female volunteers, it was investigated whether the regular application of an O/W emulsion (day cream) can strengthen and protect the epidermal barrier against damaging blue light radiation of 60 J/cm2 (protective study design) and also whether a disruption of the epidermal barrier caused by blue light radiation is restored faster and better by the regular application of another O/W emulsion (night cream) than in product-untreated skin (regenerative study design). The two O/W emulsions are different in plant oil, active ingredient composition and texture. The seven-day treatment with the day cream initially led to a significant increase in the normalized lipid lamellae length in the intercellular space, whereas the irradiation with blue light after 24 hours led to a significant decrease in the lipid lamellae length in the untreated test area, but not in the area previously treated with the product. Regarding the regenerative study design, a two-day treatment with the night cream was able to restore a blue-light-induced decrease in lipid lamellae length in the intercellular space. In summary, with the study designs presented here, the protective and regenerative effect of two cosmetic products could be demonstrated for the first time on the integrity of the EPB after blue light irradiation and the data showed that the Lipbarvis® method is suitable for investigating the damaging effects of blue light on the EPB in vivo.
文摘Objective: to investigate the effect difference of intermittent and continuous treatment with Yinzhi Huang oral liquid in the treatment of neonatal jaundice (NNJ). Methods: a total of 200 children with NNJ from January 2019 to December 2019 in our hospital were divided into two groups by odd-even method. The levels of bilirubin (BILirubin) before and after treatment, the outcome, the time of disease improvement and the incidence of phototherapy damage events in the two groups were compared. Results: there were significant differences in BILI level, outcome, improvement time and incidence of phototherapy damage events between the intermittent blue light treatment group and the continuous blue light treatment group (P < 0.05). Conclusion: in the aspect of blue light therapy for CHILDREN with NNJ, intermittent intervention can more significantly promote the decline of BILI level, accelerate the regression of yellow skin stain, accelerate the rehabilitation of children, and improve bilirubin level, which is worth promoting.
基金supported by the National Key Research and Development Program of China (2017YFD0701500)the Teamwork Projects Funded by Guangdong Natural Science Foundation, China (S2013030012842)+1 种基金the Guangdong Provincial Science & Technology Project, China (2015A020209146, 2015B090903074)the Guangzhou Science & Technology Project, China (201605030005, 201704020058)
文摘To evaluate the supplementary blue light intensity on growth and health-promoting compounds in pak choi（Brassica campestris ssp.chinensis var.communis）,four blue light intensity treatments（T0,T50,T100 and T150 indicate 0,50,100,and 150μmol m^（-2） s^（-1）,respectively）were applied 10 days before harvest under greenhouse conditions.Both of cultivars（greenand red-leaf pak choi）under T50 had the highest yield,content of chlorophyll and sugars.With light intensity increasing,antioxidant compounds（vitamin C and carotenoids）significantly increased,while nitrate content showed an opposite trend.The health-promoting compounds（phenolics,flavonoids,anthocyanins,and glucosinolates）were significantly higher under supplementary light treatment than T0,so as the antioxidant capacity（2,2-diphenyl-1-picrylhydrazyl and ferric-reducing antioxidant power）.The species-specific differences in photosynthetic pigment and health-promoting compounds was found in green-and red-leaf pak choi.T50 treatment could be used for yield improvement,whereas T100 treatment could be applied for quality improvement.Results showed that blue light intensity can regulate the accumulation of biomass,morphology and health-promoting compounds in pak choi under greenhouse conditions.
基金Supported by National Natural Science Foundation of China(No.81400424)Science and Technology Research and Development Project of Shaanxi Province(No.2014K11-03-07-04)+1 种基金Innovative Talents Promotion Project of Shaanxi Province(No.2017KJXX-87)Hunan Province Education Department Outstanding Youth Science Foundation(No.15B210)
文摘In recent years, people have become increasingly attentive to light pollution influences on their eyes. In the visible spectrum, short-wave blue light with wavelength between 415 nm and 455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration, even stimulating the brain, inhibiting melatonin secretion, and enhancing adrenocortical hormone production, which will destroy the hormonal balance and directly affect sleep quality. Therefore, the effect of Blu-rays on ocular is becoming an important concern for the future. We describe blue light’s effects on eye tissues, summarize the research on eye injury and its physical prevention and medical treatment.
基金Supported by the Program for New Century Excellent Talents in University(No.NCET-05-0597)the National Natural Science Foundation of China(No.30270258)
文摘We evaluated the effects of red and blue light on the repair of UV-B radiation-induced damage in tetraspores of Chondrus ocellatus Holm. Tetraspores of C. ocellatus were treated with different UV-B radiation levels(0,36,72,108,144 and 180 J/m2),and thereafter subjected to PAR,darkness,or red or blue light during a 2-h repair stage,each day for 48 days. The diameters and cellular contents of cyclobutane pyrimidine dimmers(CPDs),chlorophyll a(Chl a),phycoerythrin,and UV-B-absorbing mycosporinelike amino acids(MAAs) contents of the tetraspores were determined. Our results show that low doses of UV-B radiation(36 and 72 J/m 2) promoted the growth of C. ocellatus; however,increased UV-B radiation gradually reduced the C. ocellatus growth(greater than 72 J/m2). The MAAs(palythine and asterina-330) in C. ocellatus were detected and analyzed by LC/MS. Our results suggest that moderate red light could induce the growth of this alga in aquaculture. In addition,photorepair was inhibited by red light,so there may be some other DNA repair mechanism activated by red light. Blue light promoted the activity of DNA photolyase,greatly improving remediation efficiency. Red and blue lights were found to reduce the capacity of C. ocellatus to form MAAs. Therefore,PAR,red light,and blue light play different roles during the repair processes for damage induced by UV-B radiation.
基金This research was supported by the NSFC (No.40376049) and Japan Society for the Promotion of Science (The Invitation Fellowship for Research in Japan 2002)
文摘Laminaria gametophyte was greatly influenced by light in its growth and development. Using light-emitting diodes (LED) as blue and red light sources, we analyzed the light effect on gametophytes devel- opment of Laminaria japonica Aresch. The gametophytes were obtained from zoospores collected in April, May, July, 2003 and September, 2004. We found that the growth of gametophytes was stimulated by increasing inten- sity of blue light (BL) and red light (RL) illumination, of which BL was obviously stronger than that of RL. The fertilization of gametophytes depended largely on BL, and only sufficient BL illumination could take the repro- ductive effect. In addition, we noticed that there was a significant difference in light responses for gametophytes developed from zoospore collected in different times. For zoospores released in April, under BL1 (73.90 μmol photons/m·s), the unicellular female gametophytes and multi-cellular male gametophytes produced eggs and sperms respectively, and further developed towards sporophytes. However, for gametophytes developed in May, July or September, they became multi-cellular and never formed oogonia or antheridia. It is believed that the Laminaria sporangium maturation stage could affect the gametophytes reaction to BL under laboratory culture conditions. Therefore, cryptochrome- or phototropin-like BL photoreceptors is probably involved in BL-induced development of Laminaria gametophytes.
基金Supported by Shanghai Science and Technology Commission Project,China(14DZ1206303)National Key Technology R&D Program(2014BAD05B05-05)Shanghai Agriculture Applied Technology Development Program,China(Grant No.20170201)
文摘Blue and red light are spectral wavelengths more effective for plants. The effects of different ratios of red and blue light （R/B=2, R/B=4, R/B=8, R/B=12） provided by LEDs on morphology and photosynthetic characteristics of tomato seedlings were studied. The results showed that plant height, stem diameter, fresh weight, dry weight, seedling index and G value increased with the increase of R/B ratio until 8. On the contrary, SPDA value decreased with the increase of R/B ratio. Photosynthetic characteristics were measured by CO 2 assimilation （ Pn ）, stomatal conductance （ gs ） and intracellular CO 2 concentration （ Ci） . Pn and gs decreased with the increase of R/B ratio. Furthermore, similar trend was investigated in photochemical quenching （qP） and electron transport rate （ETR）. Results of this study suggest that compared with white LED, appropriate combination of red and blue light can enhance plant growth and photosynthetic characteristics, and the optimal blue/red ratio for tomato growth was R/B=8.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 61076013,51102003,and 60990313)the National Basic Research Program of China (Grant No. 2012CB619304)the Specialized Research Fund for the Doctoral Program of Higher Education,China (Grant No. 20100001120014)
文摘The InGaN/GaN blue light emitting diode（LED） is numerically investigated using a triangular-shaped quantum well model,which involves analysis on its energy band,carrier concentration,overlap of electron and hole wave functions,radiative recombination rate,and internal quantum efficiency.The simulation results reveal that the InGaN/GaN blue light emitting diode with triangular quantum wells exhibits a higher radiative recombination rate than the conventional light emitting diode with rectangular quantum wells due to the enhanced overlap of electron and hole wave functions（above 90%） under the polarization field.Consequently,the efficiency droop is only 18% in the light emitting diode with triangular-shaped quantum wells,which is three times lower than that in a conventional LED.
基金Supported by the National Natural Science Foundation of China(No.11802209)the Natural Science Foundation of Shandong Province China(No.ZR2019MA018,No.ZR2019BC095)Shandong Project for Talents Introduction and Development on Youth Innovation Team of Higher Education。
文摘AIM:To analyze abnormal gene expressions of mice eyes exposed to blue light using RNA-seq and analyze the related signaling pathways.METHODS:Kunming mice were divided into an experimental group that was exposed to blue light and a control group that was exposed to natural light.After 14 d,the mice were euthanized and their eyeballs were collected.Whole transcriptome analysis was attempted to analyze the gene expression of the eyeballs using RNA-seq to reconstruct genetic networks.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis were used to reveal the related signaling pathways.RESULTS:The 737 differentially expressed genes were identified,including 430 up and 307 down regulated genes,by calculating the gene FPKM in each sample and conducting differential gene analysis.GO and KEGG pathway enrichment analysis showed that blue light damage may associated with the visual perception,sensory perception of light stimulus,phototransduction,and JAKSTAT signaling pathways.Differential lnc RNA,circ RNA and mi RNA analysis showed that blue light exposure affected pathways for retinal cone cell development and phototransduction,among others.CONCLUSION:Exposure to blue light can cause a certain degree of abnormal gene expression and modulate signaling pathways in the eye.
基金Supported by the National Natural Science Foundation of China(No.81670821,No.81400440)。
文摘AIM:To investigate the phototoxic effect of long-term excessive narrow-band blue light in staurosporine-induced differentiated retinal ganglion cells-5(SSRGC-5).METHODS:SSRGC-5 cells were divided into two groups,blue light group(BL group)and control group.Cell viability was assessed by using CCK-8 assay.Metabolic profile analysis was performed by using Seahorse extracellular flux analyzer.Mitochondria ultrastructure were studied via transmission electron microscope(TEM).Mitochondria contents and oxidative stress was evaluated by flow cytometry.Western blotting was performed to monitor the changes in mitogen-activated protein kinases(MAPK)pathway and PI3 K/AKT pathway.RESULTS:Blue light caused morphological changes of SSRGC-5 cells.The cell viability was significantly decreased from 3 h in BL group.Intercellular ROS and mitochondrial superoxide levels were increased following blue light exposure.Metabolic profiling identified blue light induced SSRGC-5 cells to have severely compromised mitochondrial function.This was accompanied by impaired mitochondrial ultrastructure and remodeling,increased expression of the mitochondrial related proteins,and increased glycolysis as compensation.Moreover,the results showed that blue light induced higher expression of p-p38,p38,p-JNK,p-ERK,p-cJun,c-Jun,and p-AKT.CONCLUSION:These findings indicate that excessive narrow-band blue light induces oxidative stress and mitochondrial metabolic remodeling dysregulate in SSRGC-5 cells.Activated MAPK and AKT signaling pathways are involved in this process.
基金supported by the National Natural Science Foundation of China(Grant Nos.32125034 and 31801834)。
文摘Ethylene is the main factor controlling fruit ripening of pear(Pyrus ussuriensis).Ethylene production rate is negatively correlated with fruit shelf life;therefore,it is important to decrease the ethylene levels for optimal fruit storage.Here,we observed that blue light treatment could inhibit ethylene production and promote the expression of ELONGATED HYPOCOTYL 5(PuHY5),a basic leucine zipper domain(bZIP)transcription factor.The following studies showed that PuHY5 could bind to the promoter of ACC synthase 1(PuACS1),a rate-limiting enzyme in ethylene biosynthesis,and inhibit its expression.For pears in which Pu HY5 was silenced,the ethylene production and PuACS1 expression were much higher than those in the control fruit.These results demonstrated that blue light inhibited ethylene production through the induction of Pu HY5 in pear.Our finding provides a new method for prolonging fruit shelf life.
文摘Previous studies demonstrated that cryptochromes are involved in blue light-induced coiling and prehaustoria development in young de-etiolated dodder seedlings. In this study, we suggest that carotenoids and chlorophyll are not the blue light absorbing chromophores involved in the mediation of prehaustoria development to blue light. Norflurazon-bleached dodder segments coiled and formed prehaustoria under blue light. However, norflurazon significantly reduced prehaustoria number （62%） under a mixture of red and far-red light, suggesting that phytochromes could be altered by norflurazon.
文摘A number of studies have shown that oxidative stress can be harmful for the retina. The real causal circumstances that lead to degenerative diseases like age related macular degeneration remain obscure. Whether light induced radical stress is a direct interaction of light with photoreceptors or a secondary mechanism within the pigment epithelium or choroid is in discussion. Among the molecular mechanisms involved are production of reactive oxygen species(ROS), secondary lipid peroxidation, protein oxidation and DNA-damage. The initial trigger to write this review was first a recent finding of our group that the photoreceptor outer segments produce great amounts of ROS and second the detection of ectopic enzymes of the respiratory chainlocalized there- in addition to the hitherto known ROS sources like the visual pigments with their intermediates and the photoreceptor mitochondria harbouring the respiratory chain.
文摘<strong>Objective: </strong>The objective is to evaluate the visual acuity, high-order aberrations and satisfaction in the cataract patients with the implantation of different types of AcrySof blue light filtering intraocular lens, which would provide the clinical guidance for the selection of individualized intraocular lens. <strong>Methods:</strong> From January 2019 to December 2020, the patients with age-related cataract in Guangzhou Red Cross Hospital were equally randomized to be divided into four groups. 20 patients (20 eyes) were implanted with AcrySof (SN60WF), which was the blue light filtering single focus group;20 patients (20 eyes) were implanted with blue light filtering aspheric multifocal intraocular lens (AcrySof ReSTOR IOL +3.0D, SN6AD1), which was the multifocal intraocular lens group;20 patients (20 eyes) were implanted with aspheric astigmatism correction intraocular lens (Toric SN6AT), which was the astigmatism group;20 patients (20 eyes) were implanted with blue filtering aspheric multifocal astigmatism correction intraocular lens (AcrySof ReSTOR IOL +2.5D IQ, SV25T0), which was the ART group. Three months after the operation, the patients were followed up with slit lamp to check the visual acuity, including uncorrected distance visual acuity (UCDVA), uncorrected near visual acuity (UCNVA), best corrected distance visual acuity, (BCDVA);the questionnaire surveys on the satisfaction of different intraocular lens implantation (far and near vision, glare, halo and abnormal visual symptoms);the iTrace visual function analyzer was used to check the total high-order aberrations (spherical aberration, wisdom aberration and Clover aberration) in the 3 mm pupil diameter. <strong>Results:</strong> Three months after cataract surgery, American Simplified version of questionnaire survey showed that the scores of near removing glasses in the multifocal group and the ART group were significantly better than those in the single focus group and the astigmatism group (<em>P</em> < 0.05);there was no significant difference in the satisfaction of far removing glasses, glare and halo in each group (<em>P</em> > 0.05). Three months after cataract surgery, there were statistically significant differences about UCDVA, BCDVA and UCNVA among the four groups (<em>F</em> = 18.189, <em>P </em>< 0.001), the UCNVA in the multifocal group and ART group was significantly better than that in the single focus group and the astigmatism group (<em>P</em> < 0.01). The difference of higher-order aberrations (total higher-order aberrations, wisdom aberrations, spherical aberrations, clover aberrations) was no statistically significant among the four groups (<em>P</em> > 0.05). <strong>Conclusion: </strong>Different types of AcrySof blue light filtering intraocular lens implantation could improve the far vision and satisfaction of cataract patients, without different higher-order aberrations. Multifocal intraocular lens and ART intraocular lens could significantly improve the far vision of patients and reduce the dependence on near glasses.
文摘Background:Lesion to the retinal pigment epithelium(RPE)is a crucial event in age-related macular degeneration(AMD)development.Although the pathogenesis of this complex disease is poorly understood,sunlight exposure and smoking are major environmental risk factors associated with AMD.High-energy visible blue light(HEV;400-500 nm)is the most energetic and potentially harmful solar wavelengths reaching adults retina.On the other hand,RPE cells can be exposed to a large range of pollutants from cigarette smoke,with polycyclic aromatic hydrocarbons(PAH)being among the most toxic.Some PAH from cigarette smoke can absorb HEV light.This led us hypothesize that in RPE cells,the combination of PAH and HEV could synergize to exacerbate the stress caused by either factor alone.We thus investigate the combined effect of PAH and HEV light in RPE cells.Methods:Confluent RPE immortalized cells(ARPE19)were exposed to nanomolar concentrations of benzo[a]pyrene(BaP)or indeno[1,2,3-cd]pyrene(IcdP).While IcdP efficiently absorbs HEV wavelengths,BaP,the most studied PAH,does not significantly absorb HEV light and was used as a control.BaP or IcdP contaminated ARPE19 were then irradiated with increasing sub-lethal doses of HEV light(150-500 J/cm2)using a setup that mimics the light spectrum normally reaching the retina.Cytotoxicity,apoptosis and reactive oxygen species(ROS)generation were assessed in each condition.Results:In presence of low concentrations of IcdP,sub-lethal amounts of HEV light trigger,in a dose-dependent way,up to 70%of apoptotic cell death.Co-exposure to IcdP and HEV also leads to a synergistic ROS generation in ARPE19 cells,thus inducing oxidative stress.None of these effects were observed with BaP.Efficient inhibition of ROS production by specific antioxidants only decreases death by 20%in cells simultaneously exposed to both IcdP and HEV light.Conclusions:Low concentrations of IcdP synergize with HEV light to induce phototoxicity in ARPE19 cells.An increased oxidative stress results from the interaction between both agents and partially explains the enhanced HEV phototoxicity in IcdP contaminated ARPE19 cells.This suggests that another major mechanism is involved in the synergetic toxicity.For smokers,this synergy between HEV and PAH may accelerate RPE cells loss and contribute to their greater risk of developing AMD.
基金The Swedish Research Council,Contract No K2014-70X-22533-01-3,Praktikertjanst AB,Karolinska Institutet,Huddinge,Sweden and Stockholm University,Stockholm,Sweden supported the study
文摘Phototherapy with blue light emitting diodes (LEDs) is gaining interest because of the efficient antimicrobial benefits reported in several studies in the last decade. The aim in this study was to investigate if a toothbrush with incorporated blue light used in daily oral care can reduce dental plaque and gingival inflammation. An 8-week single-blinded randomized controlled clinical study including 48 subjects compared effects of toothbrushes with/without 450 nm blue LED light emission, on clinical parameters (plaque index, gingival index, bleeding on probing), and on inflammatory markers in saliva and gingival crevicular fluid. Significant reductions in dental plaque and gingival inflammation (p < 0.001), and in some inflammatory markers (p ≤ 0.05), matrix metalloproteinase (MMP)-8, tissue inhibitor metalloproteinase inhibitor (TIMP)-1, interleukin (IL)-1β and interleukin (IL)-8, were detected within both groups from baseline to follow-up. For all subjects dental plaque was reduced with 57%, and a reduction in gingival inflammation was demonstrated by a decrease in gingival index (GI) with 46% and in bleeding on probing (BOP) with a decrease of 15%. No significant differences were found between the groups at a level of p = 0.05. However, the amount of plaque was reduced by 62% in the blue light group and 51% in the control group, a difference established at a level of p = 0.058. A toothbrush with a 450 nm LED did not show any statistical significant adjunctive effect of toothbrushing regarding reduction in measurements of dental plaque and gingival inflammation.
文摘Objective: to analyze the nursing experience of probiotic-assisted blue light therapy in neonates with hyperbilirubinemia. Methods: in our college in July 2020 to October 2021 newborns treated 40 cases of children with high blood bilirubin, random number table method is divided into research group and control group, 20 cases, and blue light therapy and routine nursing care, the team with auxiliary intervention at the same time to carry out the probiotics, the treatment effect in two groups of children with treatment basic statistical comparison. Results: after treatment, the therapeutic effect of the study group was higher than the control group, daily defecation times were more than the control group, jaundice duration and neonatal treatment time were shorter than the control group, the differences were statistically significant (P < 0.05). Conclusion: probiotic-assisted blue light therapy combined with neonatal nursing can improve the curative effect and promote rehabilitation in neonates with hyperbilirubinemia.
文摘Objective: to explore the clinical value of phenobarbital, Yinzhihuang Granule, Bifidobacterium quadruple live bacteria combined with blue light irradiation in the treatment of early neonatal jaundice. Methods: 120 cases of early neonatal jaundice in our hospital from January 2020 to January 2022 were randomly divided into control group (60 cases were treated with triple therapy of phenobarbital, Yinzhihuang granules and Bifidobacterium) and research group (60 cases were treated with triple therapy of drugs combined with blue light irradiation). The bilirubin level, clinical indicators, curative effect and adverse reactions were compared between the two groups on the 1st to 5th day of treatment (Day 1 to Day 5). Results: the transcutaneous bilirubin of the study group (drug triple therapy combined with blue light irradiation) was lower than that of the control group (drug triple therapy) from day 1 to day 5 (t=3.800, 6.637, 8.649, 9.292, 4.548) (P < 0.05). The duration of jaundice (t=16.932), defecation emptying time (t=12.153) and hospitalization time (t=14.225) in the study group (drug triple therapy combined with blue light irradiation) were shorter than those in the control group (P < 0.05). The total effective rate (81.67% Vs 95.00%) of the study group (drug triple therapy combined with blue light irradiation) was higher than that of the control group (drug triple therapy) (P < 0.05). There was no significant difference in the adverse reaction rate between the study group (drug triple therapy combined with blue light irradiation) and the control group (drug triple therapy) (P > 0.05). Conclusion: the triple therapy of phenobarbital and other drugs combined with blue light irradiation can promote the clearance of bilirubin in early neonatal jaundice, improve the symptoms of jaundice, with high safety and simple operation.
