“Journal of Jilin University(Science Edition)” is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People's Republic o...“Journal of Jilin University(Science Edition)” is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People's Republic of China.The journal started publication in 1955.The original name at starting publication was “Journal of Natural Science of Northeast People University”,which was changed into “Acta Scientiarum Naturalium Universitatis Jilinensis” in 1958owing to the name change of the university.展开更多
On the morning of January 15,the China-Laos Cultural Road Dialogue took place in Vientiane,Laos.A ceremony was held during the event to release the January 2025 special editions of China Report ASEAN(an English journa...On the morning of January 15,the China-Laos Cultural Road Dialogue took place in Vientiane,Laos.A ceremony was held during the event to release the January 2025 special editions of China Report ASEAN(an English journal)and Champa(a Chinese-Lao bilingual journal named after the national flower of Laos which is considered a symbol of sincerity and joy).Part of the 2025“One River,One Family”Spring Festival cultural series in Laos,the event was supervised by China International Communications Group(CICG),the Chinese Embassy in Laos,and China State Railway Group Company,hosted by the Publicity Department of the CPC Yunnan Provincial Committee and the Publicity Department of the Central Committee of the Lao People’s Revolutionary Party(LPRP),and organized by CICG Asia-Pacific,Yunnan Daily,Yunnan International Communication Center for South and Southeast Asia,Pasaxon(“The People”newspaper in Laos),and China Railway Kunming Group.展开更多
纯粹驾驶乐趣始终深植于宝马品牌的基因血脉之中。宝马Z4正是这一理念的完美化身——以敞篷跑车的极致魅力诠释无与伦比的驾驭激情。自2002年初代车型问世以来,这款双座敞篷跑车便凭借独树一帜的设计美学、纯粹至臻的驾驶体验和运动性...纯粹驾驶乐趣始终深植于宝马品牌的基因血脉之中。宝马Z4正是这一理念的完美化身——以敞篷跑车的极致魅力诠释无与伦比的驾驭激情。自2002年初代车型问世以来,这款双座敞篷跑车便凭借独树一帜的设计美学、纯粹至臻的驾驶体验和运动性能的完美平衡,持续征服全球车迷。即将推出的宝马Z4 Final Edition将为爱好者开启限时珍藏通道,提供订购这款特别版车型的专属机遇——它的限量身份和专属或将使它成为车坛的不朽经典。该版本配备了独特的配置元素,在外观和内饰方面均营造出个性化的亮点。同时,Final Edition也象征着这款标志性双座跑车迎来了其巅峰荣耀。宝马Z4的生产将于2026年3月正式结束。展开更多
The monumental second edition Petroleum Geology of China has been published by the Petroleum Industry Press.This definitive work was compiled under the leadership of Academician Zhai Guangming,a preeminent authority i...The monumental second edition Petroleum Geology of China has been published by the Petroleum Industry Press.This definitive work was compiled under the leadership of Academician Zhai Guangming,a preeminent authority in petroleum exploration.As the culmination of eight years of dedicated effort by over a thousand experts and scholars,this monumental publication comprises 25 volumes(bound in 32 books).展开更多
On March l3th,the three-day Intertextile Shanghai Apparel Fabrics-Spring Edition 2025 concluded successfully at the National Exhibition andConvention Center(Shanghai).This bustling event,carrying the expectationsof th...On March l3th,the three-day Intertextile Shanghai Apparel Fabrics-Spring Edition 2025 concluded successfully at the National Exhibition andConvention Center(Shanghai).This bustling event,carrying the expectationsof the industry,conveyed the enthusiasm for business cooperation in China'stextile industry at the beginning of 2025 through its exhibition data.展开更多
Acta Geologica Sinica (English Edition) is a bimonthly,SCI-indexed academic journal produced by the Geological Society of China.With the latest 2023 Impact Factor of 2.1,it has long been indexed by many international ...Acta Geologica Sinica (English Edition) is a bimonthly,SCI-indexed academic journal produced by the Geological Society of China.With the latest 2023 Impact Factor of 2.1,it has long been indexed by many international databases and websites,such as SCI,CA,BIG,etc.Internationally,the journal cooperates with John Wiley&Sons,Inc.to publish the electronic version;all papers can be downloaded online.Contributors wishing to submit,read,enquire and download can log in via http://mc.manuscriptcentral.com/ags.展开更多
Acta Geologica Sinica(English Edition)is a bimonthly,SCI-indexed academic journal produced by the Geological Society of China.With the latest 2023 Impact Factor of 2.1,it has long been indexed by many international da...Acta Geologica Sinica(English Edition)is a bimonthly,SCI-indexed academic journal produced by the Geological Society of China.With the latest 2023 Impact Factor of 2.1,it has long been indexed by many international databases and websites,such as SCI,CA,BIG,etc.Internationally,the journal cooperates with John Wiley&Sons,Inc.to publish the electronic version;all papers can be downloaded online.Contributors wishing to submit,read,enquire and download can log in via http://mc.manuscriptcentral.com/ags.展开更多
The demand for Erigeron breviscapus,a medicinal Compositae plant with cardiovascular therapeutic properties,has been increasing by 15%annually,exceeding production capacity and necessitating improvements in yield and ...The demand for Erigeron breviscapus,a medicinal Compositae plant with cardiovascular therapeutic properties,has been increasing by 15%annually,exceeding production capacity and necessitating improvements in yield and bioactive compound content.Genetic transformation remains essential for functional genomics,yet current Agrobacterium and biolistic methods are inefficient and expensive.In this study,we cloned the full-length sequences of the BABY BOOM,WUSCHEL and GROWTH-REGULATING FACTOR(GRF)genes of E.breviscapus and then transformed them into E.breviscapus explants.The transformation efficiency for the GRF gene reached 45%,and all the transgenic E.breviscapus plants were fertile without obvious developmental defects.Furthermore,we inserted EbGRF4 and Cas9-EbPDS-sgRNA into the same vector for Agrobacterium-mediated transformation to effectively knock out the PDS gene,resulting in albino seedlings,with a gene editing efficiency of 33.3%.These findings provide a solid foundation for functional genomic research and the genetic improvement of E.breviscapus,as well as an important reference for establishing high-efficiency genetic transformation systems for other medicinal plants.展开更多
As we welcome the spring of 2026,we extend our sincere greetings and best wishes to colleagues worldwide in the field of crop science,our partners,and all those committed to sustainable agricultural development!The Ye...As we welcome the spring of 2026,we extend our sincere greetings and best wishes to colleagues worldwide in the field of crop science,our partners,and all those committed to sustainable agricultural development!The Year of the Horse symbolizes endeavor and far-reaching journeys,reflecting our own spirit of continuous exploration and breakthrough innovation on the path of crop science.Here,I extendmysincere appreciation to all our authors and reviewers for their invaluable time,expertise,and dedication,which are instrumental in the success of The Crop Journal,establishing it as a premier platform for the global crop science research community.The Crop Journal publishes its 2026 first issue as a special issue themed“Synthetic Biology for Crop Improvement”,ably vip-edited by four young scientists.The issue provides a comprehensive overview of major advances in the field.In the past few years,crop science has made long strides in metabolic engineering of important pathways in secondary metabolism.The achievements expedite the emergence of synthetic biology as a potent methodology for crop breeding and represent a fundamental paradigm shift from“deciphering crops”to“designing crops”,which is further empowered by artificial intelligence(AI).At this turning point of the New Year,I would like to take this opportunity to provide a brief retrospective and future perspective.展开更多
Brain organoids are artificial neural tissues derived in vitro,containing a variety of cell types,as well as structural and/or functional brain regions.They can partially mimic brain physiological activities and disea...Brain organoids are artificial neural tissues derived in vitro,containing a variety of cell types,as well as structural and/or functional brain regions.They can partially mimic brain physiological activities and diseased processes.Owing to their operability and sample accessibility,brain organoids serve as a bridge between in vitro monolayer cell culture models and in vivo animal models.An increasing number of induction protocols for brain organoids have been developed over the preceding decade.A key future research direction will focus on ensuring the complexity and quality of brain organoids.The integration of powerful technologies,such as the CRISP R/Cas9 genome editing and lineage tra cing systems,shall precipitate practical and broad applications of brain organoids.In this review,we discuss the generation and application of brain organoids,as well as their integration with genome editing technologies,in the study of neural development,disease modeling,and mechanistic investigations.The innovative combination of these two technologies may offer a fresh perspective for exploring the fundamental aspects of the human nervous system and related diseases.展开更多
Superconducting diodes,which enable dissipationless supercurrent flow in one direction while blocking it in the reverse direction,are emerging as pivotal components for superconducting electronics.The development of e...Superconducting diodes,which enable dissipationless supercurrent flow in one direction while blocking it in the reverse direction,are emerging as pivotal components for superconducting electronics.The development of editable superconducting diodes could unlock transformative applications,including dynamically reconfigurable quantum circuits that adapt to operational requirements.Here,we report the first observation of the superconducting diode effect(SDE)in LaAlO_(3)/KTaO_(3) heterostructures—a two-dimensional oxide interface superconductor with exceptional tunability.We observe a strong SDE in Hall-bar(or strip-shaped)devices under perpendicular magnetic fields(<15 Oe),with efficiencies above 40%and rectification signals exceeding 10 mV.Through conductive atomic force microscope lithography,we demonstrate reversible nanoscale editing of the SDE’s polarity and efficiency by locally modifying the superconducting channel edges.This approach enables multiple nonvolatile configurations within a single device,realizing an editable superconducting diode.Our work establishes LaAlO_(3)/KTaO_(3) as a platform for vortex-based nonreciprocal transport and provides a pathway toward designer quantum circuits with on-demand functionalities.展开更多
Emerging and powerful genome editing tools,particularly CRISPR/Cas9,are facilitating functional genomics research and accelerating crop improvement(Jiang et al.2021;Cao et al.2023;Chen C et al.2023;Liu et al.2023a).Ho...Emerging and powerful genome editing tools,particularly CRISPR/Cas9,are facilitating functional genomics research and accelerating crop improvement(Jiang et al.2021;Cao et al.2023;Chen C et al.2023;Liu et al.2023a).However,the detection and screening of transgenic lines remain major bottlenecks,being time-consuming,labor-intensive,and inefficient during transformation and subsequent mutation identification.A simple and efficient visual marker system plays a critical role in addressing these challenges.Recent studies demonstrated that the GmW1 and RUBY reporter systems were used to obtain visual transgenic soybean(Glycine max) plants(Chen L et al.2023;Chen et al.2024).展开更多
Genomic disorders affecting the central nervous system(CNS)are among the most complex and devastating conditions in human health.Moreover,these disorders,such as Rett syndrome,spinal muscular atrophy,and Fragile X syn...Genomic disorders affecting the central nervous system(CNS)are among the most complex and devastating conditions in human health.Moreover,these disorders,such as Rett syndrome,spinal muscular atrophy,and Fragile X syndrome,are typically caused by mutations in genes essential for neural development,synaptic function,or cellular homeostasis.Despite the genetic diversity involved,these diseases share key pathological features,including progressive neurodegeneration,disruption of neural circuits,and loss of cognitive or motor function.Meanwhile,one of the significant clinical challenges in treating CNS disorders is the limited regenerative capacity of the adult nervous system,which makes reversing disease progression extremely difficult once symptoms appear.In addition,the blood-brain barrier(BBB)restricts the passage of most systemically administered therapeutics,further complicating effective intervention.Consequently,current treatment options remain largely palliative,and effective cures remain elusive.展开更多
Wolfram syndrome(WS)is a rare autosomal rece s s i ve disease characte r i zed by the development of diabetes insipidus,diabetes mellitus,optic atrophy,and deafness(often referred to as DIDMOAD),and overall severe neu...Wolfram syndrome(WS)is a rare autosomal rece s s i ve disease characte r i zed by the development of diabetes insipidus,diabetes mellitus,optic atrophy,and deafness(often referred to as DIDMOAD),and overall severe neurodegenerative fallback.The global prevalence of this disease is estimated at 1 in 770,000(Lee et al.,2023).It is most commonly caused by biallelic(point)mutations in the Wolframin endoplasmic reticulum(ER)transmembrane glycoprotein(WFS1)gene(in case of WS type 1),but mutations in the CDGSH Iron Sulfur Domain 2(CISD2)are also linked to WS(type 2).The latter,however,often present with less severe pathological manifestations(Lee et al.,2023).WFS1 is located on chromosome 4p16.1 and spans over 33 kilobases.Many mutation variants have been identified in WFS1,encompassing missense,nonsense,and frameshift mutations.These mutations are spread across the coding region of WFS1,but certain regions,such as exon 8,the largest exon,appear particularly mutation-prone and associated with the classical WS type 1 phenotype(Lee et al.,2023).展开更多
移动设备从服务器下载数据,在本地进行数据查询、更改、插入等操作,再与服务器进行数据同步,这是企业应用当中的一种模式。在基于SQL Server 2005 Compact Edition的环境下,可以通过数据库复制及远程数据存取实现。通过对移动设备与数...移动设备从服务器下载数据,在本地进行数据查询、更改、插入等操作,再与服务器进行数据同步,这是企业应用当中的一种模式。在基于SQL Server 2005 Compact Edition的环境下,可以通过数据库复制及远程数据存取实现。通过对移动设备与数据库服务器同步机制的研究,论述了复制及远程数据存取的编程思想,并通过示例给出程序实现方法。展开更多
The Wild Flowers of Japan,Revised Edition.Field Version.Ohashi H,Kadota Y,Murata J,Yonekura K and Kihara H(eds),Vols.1‒2,25 June 2021.Heibonsha Ltd.,Publisher,Tokyo.第一卷:苏铁科-叶下珠科.共717页+图版668幅;第二卷:沟...The Wild Flowers of Japan,Revised Edition.Field Version.Ohashi H,Kadota Y,Murata J,Yonekura K and Kihara H(eds),Vols.1‒2,25 June 2021.Heibonsha Ltd.,Publisher,Tokyo.第一卷:苏铁科-叶下珠科.共717页+图版668幅;第二卷:沟繁缕科-忍冬科.共741页+图版664幅。1982年日本首发3卷版《日本野生植物·草本》,深受读者欢迎,考虑到野外携带的方便性,1985年出版了简易版本。展开更多
The twenty years history of Journal of Southeast University (English Edition) and its significant achievements are briefly reviewed. Based on the experiences accumulated over its twenty years, some suggestions for imp...The twenty years history of Journal of Southeast University (English Edition) and its significant achievements are briefly reviewed. Based on the experiences accumulated over its twenty years, some suggestions for improving the quality of this English-language academic journal are proposed, including focusing on the report of the excellent disciplines of its sponsoring university, attracting high-level papers by giving the priority of publication, publishing special issues for experts and scholars at home and abroad, shortening publication period, and realizing the internationalization of the members of the editorial committee, etc.展开更多
Richard T.Le Gates,Frederic Stout编著自1996年第一次印刷以来,《The City Reader》英文版已经在2000、2003、2007、2011和2015年经过了6次修订和重印。作为一本城市研究、城市规划、城市地理学和城市社会学经典文献的集锦,《The City...Richard T.Le Gates,Frederic Stout编著自1996年第一次印刷以来,《The City Reader》英文版已经在2000、2003、2007、2011和2015年经过了6次修订和重印。作为一本城市研究、城市规划、城市地理学和城市社会学经典文献的集锦,《The City Reader》已经在北美、欧洲以及其他英语国家畅销了近20年;而如今,我们相关领域学者也都熟悉此书,在城市规划或城市研究类的推荐文献中都会将其列入。然而,展开更多
文摘“Journal of Jilin University(Science Edition)” is a comprehensive academic journal in the fields of science sponsored by Jilin University and administrated by the Ministry of Education of the People's Republic of China.The journal started publication in 1955.The original name at starting publication was “Journal of Natural Science of Northeast People University”,which was changed into “Acta Scientiarum Naturalium Universitatis Jilinensis” in 1958owing to the name change of the university.
文摘On the morning of January 15,the China-Laos Cultural Road Dialogue took place in Vientiane,Laos.A ceremony was held during the event to release the January 2025 special editions of China Report ASEAN(an English journal)and Champa(a Chinese-Lao bilingual journal named after the national flower of Laos which is considered a symbol of sincerity and joy).Part of the 2025“One River,One Family”Spring Festival cultural series in Laos,the event was supervised by China International Communications Group(CICG),the Chinese Embassy in Laos,and China State Railway Group Company,hosted by the Publicity Department of the CPC Yunnan Provincial Committee and the Publicity Department of the Central Committee of the Lao People’s Revolutionary Party(LPRP),and organized by CICG Asia-Pacific,Yunnan Daily,Yunnan International Communication Center for South and Southeast Asia,Pasaxon(“The People”newspaper in Laos),and China Railway Kunming Group.
文摘纯粹驾驶乐趣始终深植于宝马品牌的基因血脉之中。宝马Z4正是这一理念的完美化身——以敞篷跑车的极致魅力诠释无与伦比的驾驭激情。自2002年初代车型问世以来,这款双座敞篷跑车便凭借独树一帜的设计美学、纯粹至臻的驾驶体验和运动性能的完美平衡,持续征服全球车迷。即将推出的宝马Z4 Final Edition将为爱好者开启限时珍藏通道,提供订购这款特别版车型的专属机遇——它的限量身份和专属或将使它成为车坛的不朽经典。该版本配备了独特的配置元素,在外观和内饰方面均营造出个性化的亮点。同时,Final Edition也象征着这款标志性双座跑车迎来了其巅峰荣耀。宝马Z4的生产将于2026年3月正式结束。
文摘The monumental second edition Petroleum Geology of China has been published by the Petroleum Industry Press.This definitive work was compiled under the leadership of Academician Zhai Guangming,a preeminent authority in petroleum exploration.As the culmination of eight years of dedicated effort by over a thousand experts and scholars,this monumental publication comprises 25 volumes(bound in 32 books).
文摘On March l3th,the three-day Intertextile Shanghai Apparel Fabrics-Spring Edition 2025 concluded successfully at the National Exhibition andConvention Center(Shanghai).This bustling event,carrying the expectationsof the industry,conveyed the enthusiasm for business cooperation in China'stextile industry at the beginning of 2025 through its exhibition data.
文摘Acta Geologica Sinica (English Edition) is a bimonthly,SCI-indexed academic journal produced by the Geological Society of China.With the latest 2023 Impact Factor of 2.1,it has long been indexed by many international databases and websites,such as SCI,CA,BIG,etc.Internationally,the journal cooperates with John Wiley&Sons,Inc.to publish the electronic version;all papers can be downloaded online.Contributors wishing to submit,read,enquire and download can log in via http://mc.manuscriptcentral.com/ags.
文摘Acta Geologica Sinica(English Edition)is a bimonthly,SCI-indexed academic journal produced by the Geological Society of China.With the latest 2023 Impact Factor of 2.1,it has long been indexed by many international databases and websites,such as SCI,CA,BIG,etc.Internationally,the journal cooperates with John Wiley&Sons,Inc.to publish the electronic version;all papers can be downloaded online.Contributors wishing to submit,read,enquire and download can log in via http://mc.manuscriptcentral.com/ags.
基金supported by the National Natural Science Foundation of China(82160727)the Major Science and Technique Programs in Yunnan Province(202304BT090021-ML05)Yunnan Agricultural University research start-up Fund(KY2022-02).
文摘The demand for Erigeron breviscapus,a medicinal Compositae plant with cardiovascular therapeutic properties,has been increasing by 15%annually,exceeding production capacity and necessitating improvements in yield and bioactive compound content.Genetic transformation remains essential for functional genomics,yet current Agrobacterium and biolistic methods are inefficient and expensive.In this study,we cloned the full-length sequences of the BABY BOOM,WUSCHEL and GROWTH-REGULATING FACTOR(GRF)genes of E.breviscapus and then transformed them into E.breviscapus explants.The transformation efficiency for the GRF gene reached 45%,and all the transgenic E.breviscapus plants were fertile without obvious developmental defects.Furthermore,we inserted EbGRF4 and Cas9-EbPDS-sgRNA into the same vector for Agrobacterium-mediated transformation to effectively knock out the PDS gene,resulting in albino seedlings,with a gene editing efficiency of 33.3%.These findings provide a solid foundation for functional genomic research and the genetic improvement of E.breviscapus,as well as an important reference for establishing high-efficiency genetic transformation systems for other medicinal plants.
文摘As we welcome the spring of 2026,we extend our sincere greetings and best wishes to colleagues worldwide in the field of crop science,our partners,and all those committed to sustainable agricultural development!The Year of the Horse symbolizes endeavor and far-reaching journeys,reflecting our own spirit of continuous exploration and breakthrough innovation on the path of crop science.Here,I extendmysincere appreciation to all our authors and reviewers for their invaluable time,expertise,and dedication,which are instrumental in the success of The Crop Journal,establishing it as a premier platform for the global crop science research community.The Crop Journal publishes its 2026 first issue as a special issue themed“Synthetic Biology for Crop Improvement”,ably vip-edited by four young scientists.The issue provides a comprehensive overview of major advances in the field.In the past few years,crop science has made long strides in metabolic engineering of important pathways in secondary metabolism.The achievements expedite the emergence of synthetic biology as a potent methodology for crop breeding and represent a fundamental paradigm shift from“deciphering crops”to“designing crops”,which is further empowered by artificial intelligence(AI).At this turning point of the New Year,I would like to take this opportunity to provide a brief retrospective and future perspective.
基金Special Projectfor Clinical Research of Shanghai Municipal Health Commission,No.202140403Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai,No.PWZxq2022-05+2 种基金Natural Science Foundation of Ningxia Hui Autonomous Region,No.2024AAC05084Ningxia Hui Autonomous Region Key Research and Development Program,No.2021BEG03084National Natural Science Foundation of China,Nos.32370895,32070862。
文摘Brain organoids are artificial neural tissues derived in vitro,containing a variety of cell types,as well as structural and/or functional brain regions.They can partially mimic brain physiological activities and diseased processes.Owing to their operability and sample accessibility,brain organoids serve as a bridge between in vitro monolayer cell culture models and in vivo animal models.An increasing number of induction protocols for brain organoids have been developed over the preceding decade.A key future research direction will focus on ensuring the complexity and quality of brain organoids.The integration of powerful technologies,such as the CRISP R/Cas9 genome editing and lineage tra cing systems,shall precipitate practical and broad applications of brain organoids.In this review,we discuss the generation and application of brain organoids,as well as their integration with genome editing technologies,in the study of neural development,disease modeling,and mechanistic investigations.The innovative combination of these two technologies may offer a fresh perspective for exploring the fundamental aspects of the human nervous system and related diseases.
基金supported by the National Key R&D Program of China (Grant No.2023YFA1406400)the National Natural Science Foundation of China (Grant Nos.12534005 and 12325402)。
文摘Superconducting diodes,which enable dissipationless supercurrent flow in one direction while blocking it in the reverse direction,are emerging as pivotal components for superconducting electronics.The development of editable superconducting diodes could unlock transformative applications,including dynamically reconfigurable quantum circuits that adapt to operational requirements.Here,we report the first observation of the superconducting diode effect(SDE)in LaAlO_(3)/KTaO_(3) heterostructures—a two-dimensional oxide interface superconductor with exceptional tunability.We observe a strong SDE in Hall-bar(or strip-shaped)devices under perpendicular magnetic fields(<15 Oe),with efficiencies above 40%and rectification signals exceeding 10 mV.Through conductive atomic force microscope lithography,we demonstrate reversible nanoscale editing of the SDE’s polarity and efficiency by locally modifying the superconducting channel edges.This approach enables multiple nonvolatile configurations within a single device,realizing an editable superconducting diode.Our work establishes LaAlO_(3)/KTaO_(3) as a platform for vortex-based nonreciprocal transport and provides a pathway toward designer quantum circuits with on-demand functionalities.
基金supported by the Jilin Science and Technology Development Program,China (20240602032RC)the Jilin Agricultural Science and Technology Innovation Project,China (CXGC2024ZD001)+1 种基金the Jilin Agricultural Science and Technology Innovation Project,China (CXGC2024ZY012)the Jilin Province Development and Reform Commission-Project for Improving the Independent Innovation Capacity of Major Grain Crops,China (2024C002)。
文摘Emerging and powerful genome editing tools,particularly CRISPR/Cas9,are facilitating functional genomics research and accelerating crop improvement(Jiang et al.2021;Cao et al.2023;Chen C et al.2023;Liu et al.2023a).However,the detection and screening of transgenic lines remain major bottlenecks,being time-consuming,labor-intensive,and inefficient during transformation and subsequent mutation identification.A simple and efficient visual marker system plays a critical role in addressing these challenges.Recent studies demonstrated that the GmW1 and RUBY reporter systems were used to obtain visual transgenic soybean(Glycine max) plants(Chen L et al.2023;Chen et al.2024).
基金the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(RS-2024-00344633)HYC acknowledges the financial support from the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(RS-2023-00211360)Biomaterials Specialized Graduate Program through the Korea Environmental Industry&Technology Institute(KEITI)funded by the Ministry of Environment(MOE).
文摘Genomic disorders affecting the central nervous system(CNS)are among the most complex and devastating conditions in human health.Moreover,these disorders,such as Rett syndrome,spinal muscular atrophy,and Fragile X syndrome,are typically caused by mutations in genes essential for neural development,synaptic function,or cellular homeostasis.Despite the genetic diversity involved,these diseases share key pathological features,including progressive neurodegeneration,disruption of neural circuits,and loss of cognitive or motor function.Meanwhile,one of the significant clinical challenges in treating CNS disorders is the limited regenerative capacity of the adult nervous system,which makes reversing disease progression extremely difficult once symptoms appear.In addition,the blood-brain barrier(BBB)restricts the passage of most systemically administered therapeutics,further complicating effective intervention.Consequently,current treatment options remain largely palliative,and effective cures remain elusive.
基金Research into Wolfram syndrome in the De Groef team has been supported by the Eye Hope Foundation(Belgium),Wolfram UK(UK)and The Snow Foundation(USA).
文摘Wolfram syndrome(WS)is a rare autosomal rece s s i ve disease characte r i zed by the development of diabetes insipidus,diabetes mellitus,optic atrophy,and deafness(often referred to as DIDMOAD),and overall severe neurodegenerative fallback.The global prevalence of this disease is estimated at 1 in 770,000(Lee et al.,2023).It is most commonly caused by biallelic(point)mutations in the Wolframin endoplasmic reticulum(ER)transmembrane glycoprotein(WFS1)gene(in case of WS type 1),but mutations in the CDGSH Iron Sulfur Domain 2(CISD2)are also linked to WS(type 2).The latter,however,often present with less severe pathological manifestations(Lee et al.,2023).WFS1 is located on chromosome 4p16.1 and spans over 33 kilobases.Many mutation variants have been identified in WFS1,encompassing missense,nonsense,and frameshift mutations.These mutations are spread across the coding region of WFS1,but certain regions,such as exon 8,the largest exon,appear particularly mutation-prone and associated with the classical WS type 1 phenotype(Lee et al.,2023).
文摘移动设备从服务器下载数据,在本地进行数据查询、更改、插入等操作,再与服务器进行数据同步,这是企业应用当中的一种模式。在基于SQL Server 2005 Compact Edition的环境下,可以通过数据库复制及远程数据存取实现。通过对移动设备与数据库服务器同步机制的研究,论述了复制及远程数据存取的编程思想,并通过示例给出程序实现方法。
文摘The Wild Flowers of Japan,Revised Edition.Field Version.Ohashi H,Kadota Y,Murata J,Yonekura K and Kihara H(eds),Vols.1‒2,25 June 2021.Heibonsha Ltd.,Publisher,Tokyo.第一卷:苏铁科-叶下珠科.共717页+图版668幅;第二卷:沟繁缕科-忍冬科.共741页+图版664幅。1982年日本首发3卷版《日本野生植物·草本》,深受读者欢迎,考虑到野外携带的方便性,1985年出版了简易版本。
文摘The twenty years history of Journal of Southeast University (English Edition) and its significant achievements are briefly reviewed. Based on the experiences accumulated over its twenty years, some suggestions for improving the quality of this English-language academic journal are proposed, including focusing on the report of the excellent disciplines of its sponsoring university, attracting high-level papers by giving the priority of publication, publishing special issues for experts and scholars at home and abroad, shortening publication period, and realizing the internationalization of the members of the editorial committee, etc.
文摘Richard T.Le Gates,Frederic Stout编著自1996年第一次印刷以来,《The City Reader》英文版已经在2000、2003、2007、2011和2015年经过了6次修订和重印。作为一本城市研究、城市规划、城市地理学和城市社会学经典文献的集锦,《The City Reader》已经在北美、欧洲以及其他英语国家畅销了近20年;而如今,我们相关领域学者也都熟悉此书,在城市规划或城市研究类的推荐文献中都会将其列入。然而,
