目的分析1例Blake’s陷窝囊肿合并小脑蚓部发育不良的遗传学病因。方法收集胎儿B超、MRI、尸检、染色体核型分析、CNV-seq检查以及全外显子组测序结果,并利用Sanger测序对致病变异位点进行确认。检索The Human Protein Atlas数据库、Mon...目的分析1例Blake’s陷窝囊肿合并小脑蚓部发育不良的遗传学病因。方法收集胎儿B超、MRI、尸检、染色体核型分析、CNV-seq检查以及全外显子组测序结果,并利用Sanger测序对致病变异位点进行确认。检索The Human Protein Atlas数据库、Monarch数据库以及Simple ClinVar数据库,分析候选致病基因与疾病的关系。构建致病基因野生型以及变异型蛋白3D结构,利用Gromacs软件对野生型和变异型致病基因蛋白进行分子动力学模拟。结果胎儿在23周、25周以及28周依次出现Blake’s囊肿、小脑发育不良、双侧侧脑室室管膜下囊肿。羊水染色体核型分析以及CNV-seq结果未见异常。全外显子组测序显示胎儿VLDLR复合杂合变异:c.262C>T(p.R88*)和c.670G>A(p.E224K)。这两个未见报道的可能致病性变异分别遗传自父、母亲,且均位于VLDLR的LDL受体A家族结构域。c.670G>A(p.E224K)可以影响VLDLR的RMSD、Gyrate、蛋白内氢键数量以及第225氨基酸位置的二级结构。结论VLDLR基因c.262C>T(p.R88*)和c.670G>A(p.E224K)复合杂合变异是导致Blake’s陷窝囊肿合并小脑蚓部发育不良的病因。展开更多
William Blake(1757-1827) is a renowned British poet in the 18th centrury. His lyric poems displays the characteristics of romantic spirit, and he is regarded as the forefather of the British Romanticism. His London is...William Blake(1757-1827) is a renowned British poet in the 18th centrury. His lyric poems displays the characteristics of romantic spirit, and he is regarded as the forefather of the British Romanticism. His London is a well-known lyric poetry, which is thought to be the best versicle in the West. Now let's analyse this poem in terms of its theme, image and form and then draw a brief conclusion for the Characteristics of William Blake's poem.展开更多
William Blake utilized ingenious language in his creation of the poem London.Foregrounding and deviation are well practised in this poem.In rhyme pattern,the poem takes end rhyme,consonance,alliteration and internal r...William Blake utilized ingenious language in his creation of the poem London.Foregrounding and deviation are well practised in this poem.In rhyme pattern,the poem takes end rhyme,consonance,alliteration and internal rhyme.In rhythm pattern,the poem mainly uses iambic tetrameter along with the variation of three troches and one single stress at the end of lines which produces a shocking atmosphere.Among syntax features,emphatic pattern and anticipatory structure are used.Among lexical features,the reiteration of specific words makes neat euphonious parallelism while the subtle pun word create a far-reaching artistry.展开更多
This paper is an exploration of how London is portrayed differently in two poems--William Wordsworth＇s Composed upon Westminster bridge and William Blake＇s London. In Wordsworth＇s poem Composed upon Westminster bri...This paper is an exploration of how London is portrayed differently in two poems--William Wordsworth＇s Composed upon Westminster bridge and William Blake＇s London. In Wordsworth＇s poem Composed upon Westminster bridge, the natural beauty of London is impressed deeply upon every reader. On the contrary, William Blake describes a dark, inactive and suffering city of London. With detailed analysis of the texts of the two poems, this paper shows how the two poets express different views of London.展开更多
Writer＇s imagination does not only provide inspiration for literary creation, but also contribute literature works with more dazzling brilliance. As a representative of the British Romantic Poetry--William Blake, who...Writer＇s imagination does not only provide inspiration for literary creation, but also contribute literature works with more dazzling brilliance. As a representative of the British Romantic Poetry--William Blake, whose poems are full of imagination, always concedes his emotion and thoughts in a variety of imageries, exposing the reality of his times within his poetry writing. However. William Blake＇s imagination is no castles in the air, but based on the religious mythology, historical background, and the poet＇s life experience and dream pursuit. Only with in-depth understanding of the imagination in William Blake＇s poems can those hidden emotions and thoughts be grasped and appreciated.展开更多
Bowen Wang Trinity College Dublin,Dublin,From ut pictura poesis to intermediality,the close,interactive,and complicated relationship between poetry and painting has been an inevitable subject under discussion througho...Bowen Wang Trinity College Dublin,Dublin,From ut pictura poesis to intermediality,the close,interactive,and complicated relationship between poetry and painting has been an inevitable subject under discussion throughout the historiography of literature and fine art.Different approaches and interpretations to/on their sisterhood could come to a broad spectrum of interartistic ideas and practices.William Blake,an English Romantic poet,painter,and printmaker,links word and image by his invention of relief etching,or more understandably,the illuminated painting which juxtaposes his verse with in-text illustrations simultaneously on the same page.His technical strategy has already implied a dynamic and dialectical interrelation between word and image,like the treatment of earlier medieval manuscripts,yet in a more innovative rather than decorative manner.This article,therefore,through a comparative analysis of both Blake’s verbal and visual representations,will first attempt to clarify two distinct modes of combining poetic language with visualisation vis-à-vis form and content,and then critically investigate how this word-image interaction can be used to reflect the poet’s Romantic thought about sociocultural changes and provide new possibilities of reading,interpretation,and aesthetic complexity in that specific epoch.展开更多
There are many"little boys"images in Blake's poems, which is worth further analyzing. Accordingly, by observing and analyzing the boy images in William Blake's poems, this essay will explore the poet...There are many"little boys"images in Blake's poems, which is worth further analyzing. Accordingly, by observing and analyzing the boy images in William Blake's poems, this essay will explore the poet's developing attitude towards the vulnerable group.展开更多
文摘目的分析1例Blake’s陷窝囊肿合并小脑蚓部发育不良的遗传学病因。方法收集胎儿B超、MRI、尸检、染色体核型分析、CNV-seq检查以及全外显子组测序结果,并利用Sanger测序对致病变异位点进行确认。检索The Human Protein Atlas数据库、Monarch数据库以及Simple ClinVar数据库,分析候选致病基因与疾病的关系。构建致病基因野生型以及变异型蛋白3D结构,利用Gromacs软件对野生型和变异型致病基因蛋白进行分子动力学模拟。结果胎儿在23周、25周以及28周依次出现Blake’s囊肿、小脑发育不良、双侧侧脑室室管膜下囊肿。羊水染色体核型分析以及CNV-seq结果未见异常。全外显子组测序显示胎儿VLDLR复合杂合变异:c.262C>T(p.R88*)和c.670G>A(p.E224K)。这两个未见报道的可能致病性变异分别遗传自父、母亲,且均位于VLDLR的LDL受体A家族结构域。c.670G>A(p.E224K)可以影响VLDLR的RMSD、Gyrate、蛋白内氢键数量以及第225氨基酸位置的二级结构。结论VLDLR基因c.262C>T(p.R88*)和c.670G>A(p.E224K)复合杂合变异是导致Blake’s陷窝囊肿合并小脑蚓部发育不良的病因。
文摘William Blake(1757-1827) is a renowned British poet in the 18th centrury. His lyric poems displays the characteristics of romantic spirit, and he is regarded as the forefather of the British Romanticism. His London is a well-known lyric poetry, which is thought to be the best versicle in the West. Now let's analyse this poem in terms of its theme, image and form and then draw a brief conclusion for the Characteristics of William Blake's poem.
文摘William Blake utilized ingenious language in his creation of the poem London.Foregrounding and deviation are well practised in this poem.In rhyme pattern,the poem takes end rhyme,consonance,alliteration and internal rhyme.In rhythm pattern,the poem mainly uses iambic tetrameter along with the variation of three troches and one single stress at the end of lines which produces a shocking atmosphere.Among syntax features,emphatic pattern and anticipatory structure are used.Among lexical features,the reiteration of specific words makes neat euphonious parallelism while the subtle pun word create a far-reaching artistry.
文摘This paper is an exploration of how London is portrayed differently in two poems--William Wordsworth＇s Composed upon Westminster bridge and William Blake＇s London. In Wordsworth＇s poem Composed upon Westminster bridge, the natural beauty of London is impressed deeply upon every reader. On the contrary, William Blake describes a dark, inactive and suffering city of London. With detailed analysis of the texts of the two poems, this paper shows how the two poets express different views of London.
文摘Writer＇s imagination does not only provide inspiration for literary creation, but also contribute literature works with more dazzling brilliance. As a representative of the British Romantic Poetry--William Blake, whose poems are full of imagination, always concedes his emotion and thoughts in a variety of imageries, exposing the reality of his times within his poetry writing. However. William Blake＇s imagination is no castles in the air, but based on the religious mythology, historical background, and the poet＇s life experience and dream pursuit. Only with in-depth understanding of the imagination in William Blake＇s poems can those hidden emotions and thoughts be grasped and appreciated.
文摘Bowen Wang Trinity College Dublin,Dublin,From ut pictura poesis to intermediality,the close,interactive,and complicated relationship between poetry and painting has been an inevitable subject under discussion throughout the historiography of literature and fine art.Different approaches and interpretations to/on their sisterhood could come to a broad spectrum of interartistic ideas and practices.William Blake,an English Romantic poet,painter,and printmaker,links word and image by his invention of relief etching,or more understandably,the illuminated painting which juxtaposes his verse with in-text illustrations simultaneously on the same page.His technical strategy has already implied a dynamic and dialectical interrelation between word and image,like the treatment of earlier medieval manuscripts,yet in a more innovative rather than decorative manner.This article,therefore,through a comparative analysis of both Blake’s verbal and visual representations,will first attempt to clarify two distinct modes of combining poetic language with visualisation vis-à-vis form and content,and then critically investigate how this word-image interaction can be used to reflect the poet’s Romantic thought about sociocultural changes and provide new possibilities of reading,interpretation,and aesthetic complexity in that specific epoch.
文摘There are many"little boys"images in Blake's poems, which is worth further analyzing. Accordingly, by observing and analyzing the boy images in William Blake's poems, this essay will explore the poet's developing attitude towards the vulnerable group.
