Purpose: To evaluate the feasibility of biweekly administration of cisplatin and vinorelbine as adjuvant chemotherapy for patients with completely resected non-small cell lung cancer (NSCLC). Patients and Methods: Thi...Purpose: To evaluate the feasibility of biweekly administration of cisplatin and vinorelbine as adjuvant chemotherapy for patients with completely resected non-small cell lung cancer (NSCLC). Patients and Methods: This was a single-arm, single-institutional study. Patients with completely resected NSCLC (p-Stage IB-IIIA) with no previous chemotherapy or radiotherapy were eligible. Simon’s optimal two-stage design was applied. Both cisplatin (50 mg/m2) and vinorelbine (25 mg/m2) were given on days 1 and 15, every 28 days. The primary endpoint of this study was the feasibility of this combination in the four cycles of treatment. Results: Twenty patients (19 lobectomies and 1 pneumonectomy) were enrolled in this study. 10 (50%) of patients had grade 3/4 neutropenia, and 3 (15%) had grade 3/4 anemia. Severe non-hematologic toxicities were uncommon in this series. No treatment-related death was encountered. 18 (90%) patients completed the planned 4 cycles of chemotherapy. The median intensity was 24.3 (range 18.1 to 25) mg/m2/week with an average of 23.6 (21 - 25) mg/m2/week cisplatin and 12.5 (range 10 to 12.5) mg/m2/week with an average of 12.3 (10 - 12.5) mg/m2/week vinorelbine. The median relative dose intensity of cisplatin was 97.5% (range 72.5% to 100%) with an average of 94.6% (72.5% - 100%) and that of vinorelbine was 100% (range 80% to 100%) with an average of 97.8% (80% - 100%). Conclusion: This regimen is feasible in the treatment of patients with completely resected NSCLC. A phase III trial is warranted to assess the efficacy of this regimen at promoting survival and preventing recurrence.展开更多
On February 4,"Happy Chinese New Year—China Film Biweekly Tour" hosted by China Cultural Center in Benin kicked off in Abomey-Calavi. The tour will then come to 15 important cities in Benin, including Ganvi...On February 4,"Happy Chinese New Year—China Film Biweekly Tour" hosted by China Cultural Center in Benin kicked off in Abomey-Calavi. The tour will then come to 15 important cities in Benin, including Ganvie, Cotonou, Porto-Novo, Bohicon, Dassa-Zoume and Savalou and it will last until February 20.展开更多
Intraseasonal Oscillation (ISO) which is the eastward-propagating disturbance with a period of 10 - 60 days has been the topic of interest since its discovery by Madden-Julian in 1972. Many researchers have published ...Intraseasonal Oscillation (ISO) which is the eastward-propagating disturbance with a period of 10 - 60 days has been the topic of interest since its discovery by Madden-Julian in 1972. Many researchers have published their work on ISO, yet they all agree that there is no clear understanding of this matter. By using daily observed surface temperature (T2m), this study reveals the presence of significant biweekly ISO over Tanzania, a period shorter than the anticipated Madden-Julian Oscillation (MJO) period of 30 to 60 days. It also reveals significant changes in wind direction when comparing the cold phase to the warm phase, highlighting a distinct atmospheric circulation pattern associated with each phase. Furthermore, the analysis reveals the presence of MJO-like eastward movement of pressure systems in the Subtropical High region, which is associated with this variability. This study presents a new analysis by providing a detailed analysis of the intraseasonal variability (ISV) of temperature over Tanzania, focusing on understanding the 2020 spatial-temporal patterns within the October-November-December (OND) season that may play a role in weather forecasting, agricultural planning, climate adaptation, reducing heat-related illnesses and contributing to the international effort to refine climate models and predictability.展开更多
文摘Purpose: To evaluate the feasibility of biweekly administration of cisplatin and vinorelbine as adjuvant chemotherapy for patients with completely resected non-small cell lung cancer (NSCLC). Patients and Methods: This was a single-arm, single-institutional study. Patients with completely resected NSCLC (p-Stage IB-IIIA) with no previous chemotherapy or radiotherapy were eligible. Simon’s optimal two-stage design was applied. Both cisplatin (50 mg/m2) and vinorelbine (25 mg/m2) were given on days 1 and 15, every 28 days. The primary endpoint of this study was the feasibility of this combination in the four cycles of treatment. Results: Twenty patients (19 lobectomies and 1 pneumonectomy) were enrolled in this study. 10 (50%) of patients had grade 3/4 neutropenia, and 3 (15%) had grade 3/4 anemia. Severe non-hematologic toxicities were uncommon in this series. No treatment-related death was encountered. 18 (90%) patients completed the planned 4 cycles of chemotherapy. The median intensity was 24.3 (range 18.1 to 25) mg/m2/week with an average of 23.6 (21 - 25) mg/m2/week cisplatin and 12.5 (range 10 to 12.5) mg/m2/week with an average of 12.3 (10 - 12.5) mg/m2/week vinorelbine. The median relative dose intensity of cisplatin was 97.5% (range 72.5% to 100%) with an average of 94.6% (72.5% - 100%) and that of vinorelbine was 100% (range 80% to 100%) with an average of 97.8% (80% - 100%). Conclusion: This regimen is feasible in the treatment of patients with completely resected NSCLC. A phase III trial is warranted to assess the efficacy of this regimen at promoting survival and preventing recurrence.
文摘On February 4,"Happy Chinese New Year—China Film Biweekly Tour" hosted by China Cultural Center in Benin kicked off in Abomey-Calavi. The tour will then come to 15 important cities in Benin, including Ganvie, Cotonou, Porto-Novo, Bohicon, Dassa-Zoume and Savalou and it will last until February 20.
文摘Intraseasonal Oscillation (ISO) which is the eastward-propagating disturbance with a period of 10 - 60 days has been the topic of interest since its discovery by Madden-Julian in 1972. Many researchers have published their work on ISO, yet they all agree that there is no clear understanding of this matter. By using daily observed surface temperature (T2m), this study reveals the presence of significant biweekly ISO over Tanzania, a period shorter than the anticipated Madden-Julian Oscillation (MJO) period of 30 to 60 days. It also reveals significant changes in wind direction when comparing the cold phase to the warm phase, highlighting a distinct atmospheric circulation pattern associated with each phase. Furthermore, the analysis reveals the presence of MJO-like eastward movement of pressure systems in the Subtropical High region, which is associated with this variability. This study presents a new analysis by providing a detailed analysis of the intraseasonal variability (ISV) of temperature over Tanzania, focusing on understanding the 2020 spatial-temporal patterns within the October-November-December (OND) season that may play a role in weather forecasting, agricultural planning, climate adaptation, reducing heat-related illnesses and contributing to the international effort to refine climate models and predictability.
