Objective:To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer(LS-SCLC).We conducted this retrospective study to evaluate whether immunotherapy can achieve bette...Objective:To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer(LS-SCLC).We conducted this retrospective study to evaluate whether immunotherapy can achieve better efficacy in LS-SCLC patients.Methods:We evaluated 122 LS-SCLC patients who received concurrent chemoradiotherapy(CCRT)or sequential chemoradiotherapy(SCRT)(Group A)and immunotherapy combined with CCRT/SCRT followed by immunotherapy(Group B),to assess the objective response rate(ORR),disease control rate(DCR),and progression-free survival(PFS).Factors affecting prognosis were also explored using Cox analysis.The prognosis of patients with type 2 diabetes and patients with different TNM stages was compared to guide the selection of clinical regimens.Results:The overall ORR was 55.93%.The overall DCR was 98.31%.The DCR was 100%in Group A and 96.61%in Group B.There was no statistical difference in ORR and DCR.The overall median PFS was 9.86 months(95%CI,8.62-11.10),and the difference in median PFS between the two groups was statistically significant(8.94 vs.11.89 months,p=0.03).The Cox regression analysis showed type 2 diabetes was associated with the survival prognosis.Patients with type 2 diabetes tended to choose immunotherapy combined with CCRT/SCRT.Patients in TNM stage IIIB had a significantly worse prognosis than those in stage I+II+IIIA.Conclusion:We suggest that LS-SCLC patients who receive immunotherapy combined with CCRT/SCRT can achieve longer PFS than those with CCRT/SCRT.Type 2 diabetes and TNM stage affect the survival prognosis.Patients with type 2 diabetes may benefit from immunotherapy combination treatments.展开更多
This paper proposes a single channel, 6-bit 230-MS/s asynchronous successive approximation register analog-to-digital converter （ADC） in an SMIC 65 nm CMOS technology. Through adopting the modified 2 bits/stage asyn...This paper proposes a single channel, 6-bit 230-MS/s asynchronous successive approximation register analog-to-digital converter （ADC） in an SMIC 65 nm CMOS technology. Through adopting the modified 2 bits/stage asynchronous control logic, the presented ADC actualizes a peak 40.90-dB spurious-free dynamic range and 29.05-dB signal-to-noise and distortion ratio at 230-MS/s sampling rate. Utilizing the dynamic comparator without the preamplifier, this work attains low-power design with only 0.93 mW power consumption and accomplishes a figure of merit of 174.67 fJ/step at 1 V supply voltage.展开更多
Based on the finite-discrete element method,a three-dimensional numerical model for axial impact rock breaking was established and validated.A computational method for energy conversion during impact rock breaking was...Based on the finite-discrete element method,a three-dimensional numerical model for axial impact rock breaking was established and validated.A computational method for energy conversion during impact rock breaking was proposed,and the effects of conical tooth forward rake angle,rock temperature,and impact velocity on rock breaking characteristics and energy transfer laws were analyzed.The results show that during single impact rock breaking with conical tooth bits,merely 7.52%to 12.51%of the energy is utilized for rock breaking,while a significant 57.26%to 78.10%is dissipated as frictional loss.An insufficient forward rake angle increases tooth penetration depth and frictional loss,whereas an excessive forward rake angle reduces penetration capability,causing bit rebound and greater energy absorption by the drill rod.Thus,an optimal forward rake angle exists.Regarding environmental factors,high temperatures significantly enhance impact-induced rock breaking.Thermal damage from high temperatures reduces rock strength and inhibits its energy absorption.Finally,higher impact velocities intensify rock damage,yet excessively high velocities increase frictional loss and reduce the proportion of energy absorbed by the rock,thereby failing to substantially improve rock breaking efficiency.An optimal impact velocity exists.展开更多
The relative dispersion of cloud and fog droplets has significant impacts on aerosol indirect effects,radiative transfer,and microphysical processes.However,previous studies have been mostly concerned with clouds,with...The relative dispersion of cloud and fog droplets has significant impacts on aerosol indirect effects,radiative transfer,and microphysical processes.However,previous studies have been mostly concerned with clouds,with limited studies on fog,particularly those that examine the combined influences of all key physical processes and their roles during fog evolution.As such,this study aims to conduct a comprehensive investigation by examining the relationships between relative dispersion and other microphysical variables,as well as the underlying microphysical and dynamic processes,based on field fog campaigns in polluted and clean conditions.In polluted fog,droplet concentrations are higher,leading to smaller droplets and increased dispersion.The correlation between dispersion and droplet volume-mean radius is positive in the polluted fog,but shifts to negative in clean fog.We attribute the difference to various microphysical processes like aerosol activation,condensation,collision-coalescence,and entrainment-mixing.In polluted fog,high aerosol concentrations,low supersaturations,and strong turbulence(entrainment-mixing)provide suitable conditions for the simultaneous occurrence of droplet condensation and aerosol activation,resulting in a positive correlation between dispersion and volume-mean radius,especially during the fog formation stage.In contrast,during the mature stage in clean fog,condensation is dominant with weak aerosol activation leading to a negative correlation between relative dispersion and volume-mean radius.The collision-coalescence process is more active in the mature stage,increasing radii and leading to the negative correlation between dispersion and volume-mean radius.This result sheds new light on understanding the relative dispersion and mechanisms in fog under different aerosol backgrounds.展开更多
Grouting is an essential technique for reinforcing tunnel rock masses following deformation and failure.However,the mechanisms and effectiveness evaluation of grouting in fractured rock masses that have experienced su...Grouting is an essential technique for reinforcing tunnel rock masses following deformation and failure.However,the mechanisms and effectiveness evaluation of grouting in fractured rock masses that have experienced substantial deformation and transition into the residual stage remain insufficiently understood.To elucidate the relationship between grouting effectiveness and pre-cracking strain,grouting and subsequent re-fracturing tests were conducted on sandy mudstone specimens with varying levels of pre-cracking strain.Additionally,a model was developed to determine the optimal grouting timing during the residual stage.The results indicate that the failure mode of specimens in the residual stage exhibits banded and localized distribution patterns.As pre-cracking strain increases,both the maximum fracture aperture and the relative grout injection ratio increase,with the increases becoming more pronounced at higher strain levels.After grouting,the consolidation coefficient and strength enhancement coefficient exhibit a positive correlation with pre-cracking strain,although the rate of increase gradually decreases.Grouting does not alter the initial failure mode of residual-stage fractured specimens but effectively suppresses secondary crack propagation in regions distant from primary fractures.At the microscale,grout bonds within the rock matrix form cavity structures that delay tensile failure and generate an interconnected network,thereby enhancing crack resistance.Based on the evolution of rock damage and the efficiency of grouting materials utilization,a method is proposed to determine the optimal grouting timing for fractured specimens in the residual stage.At the optimal timing,specimens exhibit moderate damage while maintaining high reinforcement efficiency per unit mass of grout.展开更多
The root-to-shoot(R/S)ratio is a critical indicator of the balance between root biomass and shoot biomass,representing the ecological strategies and adaptive responses of plants to environmental conditions.However,the...The root-to-shoot(R/S)ratio is a critical indicator of the balance between root biomass and shoot biomass,representing the ecological strategies and adaptive responses of plants to environmental conditions.However,the patterns of change in community R/S ratios during forest succession and their response to moisture levels across broad geographic gradients remains unclear.Based on forest biomass data from a national field inventory of 5,825 plots conducted across China between 2011 and 2015,this study looked into allocating biomass shoots and roots at the early,middle,and late stages of growth in plantations and succession in natural forests,and evaluated how moisture availability influences this allocation.The results revealed a significant decline in R/S ratios from early to late stages for both plantations and natural forests.Shoot and root biomass in plantations grew isometrically during the early and middle succession stages but shifted to allometric growth in the late stage,with the slope of the log-transformed shoot-root biomass relationship differing significantly across growth stages.Natural forests,in contrast,maintained isometric growth across successional stages,showing no significant variation in the slope of the log-transformed shoot-root biomass relationship.Environmental factors,particularly moisture levels,strongly influenced R/S ratios.Moisture levels significantly affected size-corrected R/S ratios,particularly in the middle stage of plantations and the early and middle stages of natural forests,supporting the hypothesis of optimal allocation.These findings suggest that in water-limited regions,forest management should prioritize drought-tolerant,deep-rooted native species,encourage mixed-species planting in the early stage,and reduce logging intensity in mature plantations.Conserving natural forests to maintain successional dynamics is essential for long-term ecological resilience.These findings emphasize the importance of balancing productivity with ecological sustainability by adapting practices to specific environments and forest types under climate change.展开更多
Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hyperten...Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P<0.001),and fewer postoperative complications(33.9%vs.57.6%,P<0.001),including lower rates of postoperative liver decompensation(16.9%vs.28.0%,P=0.043),postoperative ascites(18.6%vs.31.4%,P=0.024)and pulmonary infections(12.7%vs.29.7%,P=0.001).The long-term follow-up showed that overall survival(P=0.154)and recurrence-free survival(P=0.376)were comparable between the two groups.In subgroup analysis,patients with PLT≤75×10^(9)/L suffered more postoperative liver decompensation(PLD)and ascites than patiens with PLT>75×10^(9)/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.展开更多
The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspective...The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspectives on the ore-forming process during this critical transition,focusing on the Hongyuan porphyry Mo(Cu) deposit(PMCD) in West Junggar,China.We find that sulfide-quartz-rich miarolitic cavities(MCs),characterized by micrographic quartz and feldspar,indicate the formation of initial mineralizing fluids from magmatic fluids.This conclusion is supported by three key observations: the simultaneous formation of feldspar and sulfides in the micrographic zones of MCs,the high formation temperatures(approaching 750 ℃) suggested by the sectorzoned bright CL cores of quartz phenocrysts,and the magmatic sulfur source indicated by the narrow sulfur isotopic composition ranges(+0.18‰ to +4.63‰).LA-ICP-MS analyses reveal distinct trace element distribution patterns between the early magmatic and transition stages and the later hydrothermal stage.Chalcopyrite from the early stages has higher Cd and lower Zn contents,while molybdenite has higher Re contents,and pyrite has higher Co and Ni contents than its counterparts in the hydrothermal stage.The decrease in sulfur concentrations at sulfide saturation from granite porphyry to micrographic quartz-feldspar melts(from 200 ppm to 100 ppm) suggests that nearly half of the sulfur was exsolved during the formation of feldspar and quartz intergrowths from fractionated granitic magma.These findings indicate that the initial mineralizing fluids of the porphyry deposit were high-temperature,melt-bearing,and ore-rich and originated from magma.The transition from initial melt-bearing,metal-rich fluids to hydrothermal ore-forming fluids is marked by decreasing temperatures and logf_(S2) values,underscoring the critical role of sulfide formation during the magmatic-hydrothermal transition in the development of porphyry deposits.展开更多
Alzheimer’s disease(AD)remains an incurable neurodegenerative disorder with devastating societal and personal impacts.Despite decades of intensive research,therapeutic efforts targeting the clinical stages of AD have...Alzheimer’s disease(AD)remains an incurable neurodegenerative disorder with devastating societal and personal impacts.Despite decades of intensive research,therapeutic efforts targeting the clinical stages of AD have largely failed to halt or reverse disease progression.This has prompted a critical shift in focus toward the earlier,preclinical stages of AD,where interventions may hold greater promise for altering the disease trajectory.展开更多
出版物的结构化处理是语义出版发展的基础。图书交换标签集(Book Interchange Tag Suite,BITS)是一套面向科技类图书的结构化表示模型。本文通过分析BITS模型的元素和结构,比较BITS与期刊标签集JATS以及电子书标准Docbook和DITA的异同,...出版物的结构化处理是语义出版发展的基础。图书交换标签集(Book Interchange Tag Suite,BITS)是一套面向科技类图书的结构化表示模型。本文通过分析BITS模型的元素和结构,比较BITS与期刊标签集JATS以及电子书标准Docbook和DITA的异同,并结合中文科技类图书的特点,以探讨BITS对中文图书的适用性和改进方向。展开更多
基金funded by the National Natural Science Foundation of China(grant no.82273162)the National Natural Science Foundation of China(grant no.82203272)the Science and Technology Development Foundation of Nanjing Medical University(grant NMUB20240119)。
文摘Objective:To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer(LS-SCLC).We conducted this retrospective study to evaluate whether immunotherapy can achieve better efficacy in LS-SCLC patients.Methods:We evaluated 122 LS-SCLC patients who received concurrent chemoradiotherapy(CCRT)or sequential chemoradiotherapy(SCRT)(Group A)and immunotherapy combined with CCRT/SCRT followed by immunotherapy(Group B),to assess the objective response rate(ORR),disease control rate(DCR),and progression-free survival(PFS).Factors affecting prognosis were also explored using Cox analysis.The prognosis of patients with type 2 diabetes and patients with different TNM stages was compared to guide the selection of clinical regimens.Results:The overall ORR was 55.93%.The overall DCR was 98.31%.The DCR was 100%in Group A and 96.61%in Group B.There was no statistical difference in ORR and DCR.The overall median PFS was 9.86 months(95%CI,8.62-11.10),and the difference in median PFS between the two groups was statistically significant(8.94 vs.11.89 months,p=0.03).The Cox regression analysis showed type 2 diabetes was associated with the survival prognosis.Patients with type 2 diabetes tended to choose immunotherapy combined with CCRT/SCRT.Patients in TNM stage IIIB had a significantly worse prognosis than those in stage I+II+IIIA.Conclusion:We suggest that LS-SCLC patients who receive immunotherapy combined with CCRT/SCRT can achieve longer PFS than those with CCRT/SCRT.Type 2 diabetes and TNM stage affect the survival prognosis.Patients with type 2 diabetes may benefit from immunotherapy combination treatments.
基金supported by the National Science Foundation for Young Scientists of China(No.61306029)the National High Technology Research and Development Program of China(No.2013AA014103)
文摘This paper proposes a single channel, 6-bit 230-MS/s asynchronous successive approximation register analog-to-digital converter （ADC） in an SMIC 65 nm CMOS technology. Through adopting the modified 2 bits/stage asynchronous control logic, the presented ADC actualizes a peak 40.90-dB spurious-free dynamic range and 29.05-dB signal-to-noise and distortion ratio at 230-MS/s sampling rate. Utilizing the dynamic comparator without the preamplifier, this work attains low-power design with only 0.93 mW power consumption and accomplishes a figure of merit of 174.67 fJ/step at 1 V supply voltage.
基金Supported by Major Instrument Project of National Natural Science Foundation of China(52327803)Major Project of National Natural Science Foundation of China(52192622).
文摘Based on the finite-discrete element method,a three-dimensional numerical model for axial impact rock breaking was established and validated.A computational method for energy conversion during impact rock breaking was proposed,and the effects of conical tooth forward rake angle,rock temperature,and impact velocity on rock breaking characteristics and energy transfer laws were analyzed.The results show that during single impact rock breaking with conical tooth bits,merely 7.52%to 12.51%of the energy is utilized for rock breaking,while a significant 57.26%to 78.10%is dissipated as frictional loss.An insufficient forward rake angle increases tooth penetration depth and frictional loss,whereas an excessive forward rake angle reduces penetration capability,causing bit rebound and greater energy absorption by the drill rod.Thus,an optimal forward rake angle exists.Regarding environmental factors,high temperatures significantly enhance impact-induced rock breaking.Thermal damage from high temperatures reduces rock strength and inhibits its energy absorption.Finally,higher impact velocities intensify rock damage,yet excessively high velocities increase frictional loss and reduce the proportion of energy absorbed by the rock,thereby failing to substantially improve rock breaking efficiency.An optimal impact velocity exists.
基金supported by the Chinese National Natural Science Foundation under Grant Nos.(41975181,42325503,42375197,42575207,42205090)Y.LIU is supported by the U.S.Department of Energy’s Atmospheric System Research(ASR)program.
文摘The relative dispersion of cloud and fog droplets has significant impacts on aerosol indirect effects,radiative transfer,and microphysical processes.However,previous studies have been mostly concerned with clouds,with limited studies on fog,particularly those that examine the combined influences of all key physical processes and their roles during fog evolution.As such,this study aims to conduct a comprehensive investigation by examining the relationships between relative dispersion and other microphysical variables,as well as the underlying microphysical and dynamic processes,based on field fog campaigns in polluted and clean conditions.In polluted fog,droplet concentrations are higher,leading to smaller droplets and increased dispersion.The correlation between dispersion and droplet volume-mean radius is positive in the polluted fog,but shifts to negative in clean fog.We attribute the difference to various microphysical processes like aerosol activation,condensation,collision-coalescence,and entrainment-mixing.In polluted fog,high aerosol concentrations,low supersaturations,and strong turbulence(entrainment-mixing)provide suitable conditions for the simultaneous occurrence of droplet condensation and aerosol activation,resulting in a positive correlation between dispersion and volume-mean radius,especially during the fog formation stage.In contrast,during the mature stage in clean fog,condensation is dominant with weak aerosol activation leading to a negative correlation between relative dispersion and volume-mean radius.The collision-coalescence process is more active in the mature stage,increasing radii and leading to the negative correlation between dispersion and volume-mean radius.This result sheds new light on understanding the relative dispersion and mechanisms in fog under different aerosol backgrounds.
基金supported by the National Natural Science Foundation of China(Grant Nos.52274091 and 51974193).
文摘Grouting is an essential technique for reinforcing tunnel rock masses following deformation and failure.However,the mechanisms and effectiveness evaluation of grouting in fractured rock masses that have experienced substantial deformation and transition into the residual stage remain insufficiently understood.To elucidate the relationship between grouting effectiveness and pre-cracking strain,grouting and subsequent re-fracturing tests were conducted on sandy mudstone specimens with varying levels of pre-cracking strain.Additionally,a model was developed to determine the optimal grouting timing during the residual stage.The results indicate that the failure mode of specimens in the residual stage exhibits banded and localized distribution patterns.As pre-cracking strain increases,both the maximum fracture aperture and the relative grout injection ratio increase,with the increases becoming more pronounced at higher strain levels.After grouting,the consolidation coefficient and strength enhancement coefficient exhibit a positive correlation with pre-cracking strain,although the rate of increase gradually decreases.Grouting does not alter the initial failure mode of residual-stage fractured specimens but effectively suppresses secondary crack propagation in regions distant from primary fractures.At the microscale,grout bonds within the rock matrix form cavity structures that delay tensile failure and generate an interconnected network,thereby enhancing crack resistance.Based on the evolution of rock damage and the efficiency of grouting materials utilization,a method is proposed to determine the optimal grouting timing for fractured specimens in the residual stage.At the optimal timing,specimens exhibit moderate damage while maintaining high reinforcement efficiency per unit mass of grout.
基金supported by the China National Science Foundation(No.42130506,42071031)the Special Technology Innovation Fund of Carbon Peak and Carbon Neutrality in Jiangsu Province(BK20231515)+1 种基金the Spanish Government grant PID2022-140808NB-I00 funded by MICIU/AEI/https://doi.org/10.13039/501100011033the Catalan Government grants SGR 2021-1333 and AGAUR2023 CLIMA 00118.
文摘The root-to-shoot(R/S)ratio is a critical indicator of the balance between root biomass and shoot biomass,representing the ecological strategies and adaptive responses of plants to environmental conditions.However,the patterns of change in community R/S ratios during forest succession and their response to moisture levels across broad geographic gradients remains unclear.Based on forest biomass data from a national field inventory of 5,825 plots conducted across China between 2011 and 2015,this study looked into allocating biomass shoots and roots at the early,middle,and late stages of growth in plantations and succession in natural forests,and evaluated how moisture availability influences this allocation.The results revealed a significant decline in R/S ratios from early to late stages for both plantations and natural forests.Shoot and root biomass in plantations grew isometrically during the early and middle succession stages but shifted to allometric growth in the late stage,with the slope of the log-transformed shoot-root biomass relationship differing significantly across growth stages.Natural forests,in contrast,maintained isometric growth across successional stages,showing no significant variation in the slope of the log-transformed shoot-root biomass relationship.Environmental factors,particularly moisture levels,strongly influenced R/S ratios.Moisture levels significantly affected size-corrected R/S ratios,particularly in the middle stage of plantations and the early and middle stages of natural forests,supporting the hypothesis of optimal allocation.These findings suggest that in water-limited regions,forest management should prioritize drought-tolerant,deep-rooted native species,encourage mixed-species planting in the early stage,and reduce logging intensity in mature plantations.Conserving natural forests to maintain successional dynamics is essential for long-term ecological resilience.These findings emphasize the importance of balancing productivity with ecological sustainability by adapting practices to specific environments and forest types under climate change.
基金supported by grants from the Sichuan Science and Technology Program(2023YFQ0094)the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(25HXJS028).
文摘Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P<0.001),and fewer postoperative complications(33.9%vs.57.6%,P<0.001),including lower rates of postoperative liver decompensation(16.9%vs.28.0%,P=0.043),postoperative ascites(18.6%vs.31.4%,P=0.024)and pulmonary infections(12.7%vs.29.7%,P=0.001).The long-term follow-up showed that overall survival(P=0.154)and recurrence-free survival(P=0.376)were comparable between the two groups.In subgroup analysis,patients with PLT≤75×10^(9)/L suffered more postoperative liver decompensation(PLD)and ascites than patiens with PLT>75×10^(9)/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.
基金jointly supported by the National Natural Science Foundation of China (Nos.42272075,42302083,and 92162323)Guangdong Province Introduced Innovative R&D Team of Big Data-Mathematical Earth Sciences and Extreme Geological Events Team (No.2021ZT09H399)+1 种基金the National Key R&D Program of China (Nos.2017YFC0601201,2018YFC0604002)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University (No.22qntd2101)。
文摘The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspectives on the ore-forming process during this critical transition,focusing on the Hongyuan porphyry Mo(Cu) deposit(PMCD) in West Junggar,China.We find that sulfide-quartz-rich miarolitic cavities(MCs),characterized by micrographic quartz and feldspar,indicate the formation of initial mineralizing fluids from magmatic fluids.This conclusion is supported by three key observations: the simultaneous formation of feldspar and sulfides in the micrographic zones of MCs,the high formation temperatures(approaching 750 ℃) suggested by the sectorzoned bright CL cores of quartz phenocrysts,and the magmatic sulfur source indicated by the narrow sulfur isotopic composition ranges(+0.18‰ to +4.63‰).LA-ICP-MS analyses reveal distinct trace element distribution patterns between the early magmatic and transition stages and the later hydrothermal stage.Chalcopyrite from the early stages has higher Cd and lower Zn contents,while molybdenite has higher Re contents,and pyrite has higher Co and Ni contents than its counterparts in the hydrothermal stage.The decrease in sulfur concentrations at sulfide saturation from granite porphyry to micrographic quartz-feldspar melts(from 200 ppm to 100 ppm) suggests that nearly half of the sulfur was exsolved during the formation of feldspar and quartz intergrowths from fractionated granitic magma.These findings indicate that the initial mineralizing fluids of the porphyry deposit were high-temperature,melt-bearing,and ore-rich and originated from magma.The transition from initial melt-bearing,metal-rich fluids to hydrothermal ore-forming fluids is marked by decreasing temperatures and logf_(S2) values,underscoring the critical role of sulfide formation during the magmatic-hydrothermal transition in the development of porphyry deposits.
基金supported by the Canadian Institutes of Health Research Project grant (PJT-169197) to QYsupported by a CGS-M fellowship from the Canadian Institutes of Health Research
文摘Alzheimer’s disease(AD)remains an incurable neurodegenerative disorder with devastating societal and personal impacts.Despite decades of intensive research,therapeutic efforts targeting the clinical stages of AD have largely failed to halt or reverse disease progression.This has prompted a critical shift in focus toward the earlier,preclinical stages of AD,where interventions may hold greater promise for altering the disease trajectory.
文摘出版物的结构化处理是语义出版发展的基础。图书交换标签集(Book Interchange Tag Suite,BITS)是一套面向科技类图书的结构化表示模型。本文通过分析BITS模型的元素和结构,比较BITS与期刊标签集JATS以及电子书标准Docbook和DITA的异同,并结合中文科技类图书的特点,以探讨BITS对中文图书的适用性和改进方向。
