Preterm birth and suboptimal fetal growth remain significant perinatal challenges worldwide.Recent data indicate that China's perinatal profile has improved due to reductions in preterm birth rates.However,the cou...Preterm birth and suboptimal fetal growth remain significant perinatal challenges worldwide.Recent data indicate that China's perinatal profile has improved due to reductions in preterm birth rates.However,the country has a 6.5%prevalence of small-for-gestational-age(SGA),ranking fifth globally in total SGA birth numbers^([1,2]).展开更多
BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and...BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes status.METHODS Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant mortality.Confounders included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm birth.Bivariate and multivariate logistic regression assessed differences in outcomes by diabetes status.RESULTS Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic women.Women with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic women.CONCLUSION Diabetes is associated with the poor birth outcomes.Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes.展开更多
Several reviews have assessed the relationship between exposure to ambient air pollution and adverse birth outcomes during pregnancy,but the results remain controversial.The objective of this study was to assess this ...Several reviews have assessed the relationship between exposure to ambient air pollution and adverse birth outcomes during pregnancy,but the results remain controversial.The objective of this study was to assess this correlation quantitatively and to explore sources of heterogeneity.We included all published case-control or cohort studies that evaluated the correlation between ambient air pollution and low birth weight(LBW),preterm birth(PTB),and small for gestational age(SGA).Analytical methods and inclusion criteria were provided on the PROSPERO website(CRD42018085816).We evaluated pooled effects and heterogeneity.Subgroup analyses(grouped by exposure period,study settings,study design,exposure types,data source,Newcastle-Ottawa quality score(NOS),and adjustment for smoking or meteorological factors)were also conducted and publication bias was examined.The risk of bias in systematic reviews(ROBIS)tool was used to evaluate the overall risk of bias in this review.Forty studies met the inclusion criteria.We observed pooled odds ratios(ORs)of 1.03–1.21 for LBW and 0.97–1.06 for PTB when mothers were exposed to CO,NO2,NOx,O3,PM2.5,PM10,or SO2 throughout their pregnancy.For SGA,the pooled estimate was 1.02 in relation to NO2 concentrations.Subgroup analysis and sensitivity analysis decreased the heterogeneity to some extent,such as the subgroups of continuous measures(OR=0.98(0.97–0.99),I2=0.0%)and NOS>7(OR=0.98(0.97–0.99),I2=0.0%)in evaluating the association between PTB and NO2.This review was completed with a low risk of bias.High concentrations of air pollution were significantly related to the higher risk of adverse birth outcomes.However,the sources of heterogeneity among studies should be further explored.展开更多
Objective:To examine the effect of upright and ambulant positions versus lying down during the active first stage of labor on birth outcomes for nulliparous women.Methods:This is a randomized controlled clinical trial...Objective:To examine the effect of upright and ambulant positions versus lying down during the active first stage of labor on birth outcomes for nulliparous women.Methods:This is a randomized controlled clinical trial conducted at the delivery department of Damanhour Educational Institute,El Behira Governorate,Egypt.The study sample involved 150 parturient women equally divided into intervention and control groups using randomization block technique.The researchers used four tools for data collection:Demographic data interview schedule,World Health Organization Partograph,Apgar’s score,to evaluate neonatal outcomes,and visual analogue pain intensity scale.For the study group,the parturient women were encouraged to assume one of the upright positions or ambulating around the bed so as to maintain the pelvis in vertical plane as far as possible for 20-25 min for every 1 h.The control group received routine hospital care,which includes lying down in bed.IBM SPSS 23.0 was used to analyze the data.Results:Significant differences(P<0.05)were observed between the study and control groups in relation to cervical dilation,fetal head descent,uterine contractions interval,and frequency.The duration of the first stage of labor significantly reduced(P=0.018)in the intervention group compared with control group.No significant differences(P>0.05)were observed between both groups in term of emergency cesarean birth rates,oxytocin use,and neonatal outcomes.Conclusions:This study proves that upright and ambulant positions significantly enhance uterine contractility,cervical dilatation,and fetal head descent and reduce the first stage duration.展开更多
Objective: to analyze the effect on the blood glucose control level. Methods: 100 patients with gestational diabetes treated during March 2021 in March 2020 were selected, and the patients were divided into two groups...Objective: to analyze the effect on the blood glucose control level. Methods: 100 patients with gestational diabetes treated during March 2021 in March 2020 were selected, and the patients were divided into two groups: 50 patients in the study group and 50 patients in the comparison group. The contrast group used routine intervention, and the study group used dietary intervention, exercise guidance, and used insulin to control blood glucose levels. After admission, blood glucose levels and delivery outcomes were compared between the two groups. Results: the blood glucose level of the study group was lower than that of the comparison group, and the difference was significant (P 0.05). Conclusion: blood glucose control level during pregnancy has a very significant impact on delivery outcome in patients with gestational diabetes mellitus. Effective control of blood glucose level can improve delivery outcome, which has a positive significance for both pregnant women and newborns.展开更多
Background Distinct characteristics of maternal inflammation at midgestation related to fetal and neonatal health are not clear.This study aims to explore the associations between the maternal circulating inflammatory...Background Distinct characteristics of maternal inflammation at midgestation related to fetal and neonatal health are not clear.This study aims to explore the associations between the maternal circulating inflammatory profile during the second trimester of pregnancy and a series of adverse birth outcomes.Methods The present study was a prospective cohort study based on the Born in Guangzhou Cohort Study conducted in Guangzhou,China.Peripheral blood samples from women were obtained during the second trimester.Adverse newborn outcomes were collected through electronic medical records at birth and within the first week after birth.We used logistic,Poisson and generalized linear regressions to assess the impact of inflammatory indicators during pregnancy on different outcomes.Results A total of 1567 singleton pregnant women were included.The proportions of preterm birth,small for gestational age(SGA),low birth weight(LBW),neonatal asphyxia and hyperbilirubinemia cases were 4.3%,6.6%,3.9%,1.1%and 12.6%,respectively.The maternal circulating level of log2-transformed interleukin(IL)-7 was positively associated with preterm birth[adjusted odds ratio(OR)=1.58,95%confidence interval(CI)=1.03–2.41].A higher level of log2-transformed IL-2 was correlated with increased LBW risk(adjusted OR=1.48,95%CI=1.09–2.02)and a decreased birth weight Z-score(adjustedβ=−0.06,95%CI=−0.11,−0.01).IL-7 was associated with an increased risk of LBW(adjusted OR=1.80,95%CI=1.14–2.86),whereas log2-transformed IL-15 was positively related to SGA(adjusted OR=1.39,95%CI=1.02–1.91).There were no significant associations of maternal inflammatory indicators with neonatal asphyxia or hyperbilirubinemia.Conclusion Maternal circulating IL-2,IL-7 and IL-15 levels during the second trimester of pregnancy were associated with preterm birth or birth weight.展开更多
Mycotoxin exposure during pregnancy has been associated with adverse birth outcomes and poor infant growth in low-and middle-income countries.We assessed multiple biomarkers and metabolites of exposure to mycotoxins d...Mycotoxin exposure during pregnancy has been associated with adverse birth outcomes and poor infant growth in low-and middle-income countries.We assessed multiple biomarkers and metabolites of exposure to mycotoxins during pregnancy and their associations with birth outcomes and infant growth in 305 pregnant participants,between 30 and 34 completed weeks of gestation,in rural Burkina Faso.In this study,whole blood microsamples were analyzed for mycotoxin concentrations using ultra-performance liquid chromatography coupled to tandem mass spectrometry.Unadjusted and adjusted associations between mycotoxin exposure,and birth outcomes and infant growth at 6 months were estimated using linear regression models for continuous outcomes and linear probability models with robust variance estimation for binary outcomes.Infant growth trajectories from birth to 6 months were compared by exposure status using mixed-effects models with random intercept for the individual infant and random slope for the infant's age.Ochratoxin A(OTA)exposure was detected in 50.8%of the study participants,with aflatoxin G1,aflatoxin M1,cyclopiazonic acid,deoxynivalenol and T-2-toxin being detected in the range of 0.33%and 2.31%of the population.We found no statistically significant(p≥0.05)associations between OTA exposure,and birth outcomes and infant growth.Despite this,the findings indicate a significant presence of ochratoxin A among pregnant participants.Public health policies and nutrition-sensitive interventions must ensure that OTA exposure is reduced in Burkina Faso.展开更多
Objective: to study the effect of a midwife-led comprehensive intervention in late pregnancy on maternal self-efficacy and delivery outcomes.Methods: the samples were selected from August 2021 to December 2021, and a ...Objective: to study the effect of a midwife-led comprehensive intervention in late pregnancy on maternal self-efficacy and delivery outcomes.Methods: the samples were selected from August 2021 to December 2021, and a total of 100 samples were randomly divided into the control group and the observation group. The application value of the third-pregnancy comprehensive intervention led by midwives was analyzed.Results: the natural delivery rate was higher than the control group (P <0.05);lower (P <0.05);Lower self-efficacy and social support scores in the control group (P <0.05): lower GAD-7 and PHQ-9 (P <0.05);lower GQOL-74 scores than the control group (P <0.05). Conclusion: the comprehensive nursing intervention in the field, improve the cognition of natural delivery, improve the natural delivery rate, promote the effective improvement of maternal self-efficacy and social support evaluation, reduce the influence of postpartum bad mood, optimize the overall quality of life, has high clinical application value.展开更多
To study maternal and perinatal outcomes after cervical cerclage in both singleton and twin pregnancies,we retrospectively reviewed women undergoing cervical cerclage for cervical insufficiency at Tongji Hospital,Wuha...To study maternal and perinatal outcomes after cervical cerclage in both singleton and twin pregnancies,we retrospectively reviewed women undergoing cervical cerclage for cervical insufficiency at Tongji Hospital,Wuhan,China from January 1,2010 to July 31,2015 to evaluate primary and secondary outcomes for subgroups with cervical length（CL） ≤15,〉15 to 〈25,and ≥25 mm.Of 166 patients who underwent cervical cerclage,after exclusion of patients with missed abortion and continuing pregnancy,141 patients（121 singleton and 20 twin pregnancies） were included in the analysis.Mean gestational age at birth was 34.22 and 28.27 weeks for singleton and twin pregnancies,respectively.There were 17（14.05%） and 13（33.33%） neonatal deaths in singleton and twin pregnancies,respectively.Mean age（31.60±4.62 vs.31.22±4.63 years,P=0.39） and gestational weeks at cerclage（18.50±4.62 vs.19.31±4.99,P=0.47） were similar for both groups.Mean gestational weeks at delivery（34.22±5.77 vs.28.27±6.17,P〈0.001） and the suture to delivery interval（15.72±7.15 vs.8.96±6.70,P〈0.001） were significantly longer in the singleton group.These variables indicate a linear negative correlation with the degree of CL shortening,with better outcomes in patients with CL ≥25 mm who underwent cerclage,both in singleton and twin pregnancies.No difference in mode of delivery existed between the singleton group and twin group.Our results indicate a high risk of preterm delivery in both groups,especially in the twin group.Patients with a history of preterm labor and CL 〉25 mm in the current pregnancy,possibly in a twin pregnancy,could benefit from elective cervical cerclage;however,cervical cerclage was inadvisable for twin pregnancies with a CL 〉15 and 〈25 mm.Our data emphasize the importance of re-evaluating the efficacy of cervical cerclage for twin pregnancies in well-designed clinical trials.展开更多
Objective: TO assess the effects of zinc supplementation to Chinese rural pregnant with cereal-based diet and their pregnancy outcome. Methods A total of 156 women were given randomly in double blind 5mg/d (group A, G...Objective: TO assess the effects of zinc supplementation to Chinese rural pregnant with cereal-based diet and their pregnancy outcome. Methods A total of 156 women were given randomly in double blind 5mg/d (group A, GPA, n=37),10mg/d (group B, GPB, n=40), 30mg (group C, GpC, n = 39) Of zinc supplement or placebo (group D, GpD, n = 40 ) starting from, the first visit at the prenatal clinic (average 9-week gestation ) till the delivery. Results Mean dietary zinc intake of these women was about 10mg/d, and more than 65% of dietary zinc were taken from cereals, grains and vegetables. Serum zinc concentrations at 25-and 32-gestation in GpC and in the umbilical cord blood of their babies at birth significantly increased. Infants in GpC had a significantly heavier birth weight (283. 079, P = 0. 016 ) and larger head circumference(0. 63cm, P = 0. 035) than infants in GpD. The incidence of low birth weight, preterm and intrauterine growth retardation infants was significantly reduced in GpC. As compared to GpD (38. 34 ± 1. 34 weeks), the duration of gestation in GpD(39. 12± 1. 11 weeks) was prolonged (P= 0. 032). Serum zinc concentration at 25-weeks gestation was negatively correlated with duration of gestation (P = 0. 009 ). Apgar score of the infants in GpC was significantly higher than that in GpD, and serum zinc concentration at 32-weeks gestation was positively associated with infant Apgar score (P = 0. 015 ). Conclusion Zinc supplementation in 30mg/d to Chinese rural women during pregnancy could significantly improve their pregnancy outcome. Both 5mg/d and 10mg/d of zinc supplementation had no detected benefits to them.展开更多
Objective To explore the effects of prenatal exposure to polybrominated diphenyl ethers(PBDEs)on placental size and birth outcomes.Methods Based on the perspective Wenzhou Birth Cohort,this nested case-control study i...Objective To explore the effects of prenatal exposure to polybrominated diphenyl ethers(PBDEs)on placental size and birth outcomes.Methods Based on the perspective Wenzhou Birth Cohort,this nested case-control study included 101 fetal growth restriction(FGR)and 101 healthy newborns.Maternal serum samples were collected during the third trimester and measured for PBDEs by gas chromatography tandem mass spectrometry.The basic information of mother-newborn pairs was collected from questionnaires,whereas the placental size and birth outcomes of newborns were obtained from hospital records.Results A total of 19 brominated diphenyle ether(BDE)congeners were detected in maternal serum samples.Higher concentrations of BDE-207,-208,-209,and∑19PBDEs were detected in FGR cases than in controls.Increased BDE-207,-208,-209,and∑19PBDEs levels in maternal serum were related to decreased placental length,breadth,surface area,birth weight,birth length,gestational age,and Quetelet index of newborns.After adjusting for confounders,BDE-207 and∑19PBDE concentrations in maternal serum were significantly associated with an increased risk of FGR.Conclusion A negative association was found between PBDE levels in maternal serum and placental size and birth outcomes.Prenatal PBDE exposure may be associated with elevated risk of the incidence of FGR birth.展开更多
基金funded by the Natural Science Foundation of Hunan Province(grant number 2024JJ5283 to XH)。
文摘Preterm birth and suboptimal fetal growth remain significant perinatal challenges worldwide.Recent data indicate that China's perinatal profile has improved due to reductions in preterm birth rates.However,the country has a 6.5%prevalence of small-for-gestational-age(SGA),ranking fifth globally in total SGA birth numbers^([1,2]).
文摘BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes status.METHODS Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant mortality.Confounders included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm birth.Bivariate and multivariate logistic regression assessed differences in outcomes by diabetes status.RESULTS Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic women.Women with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic women.CONCLUSION Diabetes is associated with the poor birth outcomes.Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes.
基金Project supported by the National Natural Science Foundation of China(No.81230016)the Birth Defect Control and Prevention Project of Shaanxi Commission of Health and Family Planning(No.sxwsjs wzfcght2016-013),China
文摘Several reviews have assessed the relationship between exposure to ambient air pollution and adverse birth outcomes during pregnancy,but the results remain controversial.The objective of this study was to assess this correlation quantitatively and to explore sources of heterogeneity.We included all published case-control or cohort studies that evaluated the correlation between ambient air pollution and low birth weight(LBW),preterm birth(PTB),and small for gestational age(SGA).Analytical methods and inclusion criteria were provided on the PROSPERO website(CRD42018085816).We evaluated pooled effects and heterogeneity.Subgroup analyses(grouped by exposure period,study settings,study design,exposure types,data source,Newcastle-Ottawa quality score(NOS),and adjustment for smoking or meteorological factors)were also conducted and publication bias was examined.The risk of bias in systematic reviews(ROBIS)tool was used to evaluate the overall risk of bias in this review.Forty studies met the inclusion criteria.We observed pooled odds ratios(ORs)of 1.03–1.21 for LBW and 0.97–1.06 for PTB when mothers were exposed to CO,NO2,NOx,O3,PM2.5,PM10,or SO2 throughout their pregnancy.For SGA,the pooled estimate was 1.02 in relation to NO2 concentrations.Subgroup analysis and sensitivity analysis decreased the heterogeneity to some extent,such as the subgroups of continuous measures(OR=0.98(0.97–0.99),I2=0.0%)and NOS>7(OR=0.98(0.97–0.99),I2=0.0%)in evaluating the association between PTB and NO2.This review was completed with a low risk of bias.High concentrations of air pollution were significantly related to the higher risk of adverse birth outcomes.However,the sources of heterogeneity among studies should be further explored.
文摘Objective:To examine the effect of upright and ambulant positions versus lying down during the active first stage of labor on birth outcomes for nulliparous women.Methods:This is a randomized controlled clinical trial conducted at the delivery department of Damanhour Educational Institute,El Behira Governorate,Egypt.The study sample involved 150 parturient women equally divided into intervention and control groups using randomization block technique.The researchers used four tools for data collection:Demographic data interview schedule,World Health Organization Partograph,Apgar’s score,to evaluate neonatal outcomes,and visual analogue pain intensity scale.For the study group,the parturient women were encouraged to assume one of the upright positions or ambulating around the bed so as to maintain the pelvis in vertical plane as far as possible for 20-25 min for every 1 h.The control group received routine hospital care,which includes lying down in bed.IBM SPSS 23.0 was used to analyze the data.Results:Significant differences(P<0.05)were observed between the study and control groups in relation to cervical dilation,fetal head descent,uterine contractions interval,and frequency.The duration of the first stage of labor significantly reduced(P=0.018)in the intervention group compared with control group.No significant differences(P>0.05)were observed between both groups in term of emergency cesarean birth rates,oxytocin use,and neonatal outcomes.Conclusions:This study proves that upright and ambulant positions significantly enhance uterine contractility,cervical dilatation,and fetal head descent and reduce the first stage duration.
文摘Objective: to analyze the effect on the blood glucose control level. Methods: 100 patients with gestational diabetes treated during March 2021 in March 2020 were selected, and the patients were divided into two groups: 50 patients in the study group and 50 patients in the comparison group. The contrast group used routine intervention, and the study group used dietary intervention, exercise guidance, and used insulin to control blood glucose levels. After admission, blood glucose levels and delivery outcomes were compared between the two groups. Results: the blood glucose level of the study group was lower than that of the comparison group, and the difference was significant (P 0.05). Conclusion: blood glucose control level during pregnancy has a very significant impact on delivery outcome in patients with gestational diabetes mellitus. Effective control of blood glucose level can improve delivery outcome, which has a positive significance for both pregnant women and newborns.
基金supported by the Ministry of Science and Technology of the People’s Republic of China(2022YFC2704601)the National Natural Science Foundation of China(82173525)+1 种基金the Health Commission of Guangdong Province(A2023275)the Guangzhou Municipal Science and Technology Bureau(2024A03J1104 and 2024A03J1254).
文摘Background Distinct characteristics of maternal inflammation at midgestation related to fetal and neonatal health are not clear.This study aims to explore the associations between the maternal circulating inflammatory profile during the second trimester of pregnancy and a series of adverse birth outcomes.Methods The present study was a prospective cohort study based on the Born in Guangzhou Cohort Study conducted in Guangzhou,China.Peripheral blood samples from women were obtained during the second trimester.Adverse newborn outcomes were collected through electronic medical records at birth and within the first week after birth.We used logistic,Poisson and generalized linear regressions to assess the impact of inflammatory indicators during pregnancy on different outcomes.Results A total of 1567 singleton pregnant women were included.The proportions of preterm birth,small for gestational age(SGA),low birth weight(LBW),neonatal asphyxia and hyperbilirubinemia cases were 4.3%,6.6%,3.9%,1.1%and 12.6%,respectively.The maternal circulating level of log2-transformed interleukin(IL)-7 was positively associated with preterm birth[adjusted odds ratio(OR)=1.58,95%confidence interval(CI)=1.03–2.41].A higher level of log2-transformed IL-2 was correlated with increased LBW risk(adjusted OR=1.48,95%CI=1.09–2.02)and a decreased birth weight Z-score(adjustedβ=−0.06,95%CI=−0.11,−0.01).IL-7 was associated with an increased risk of LBW(adjusted OR=1.80,95%CI=1.14–2.86),whereas log2-transformed IL-15 was positively related to SGA(adjusted OR=1.39,95%CI=1.02–1.91).There were no significant associations of maternal inflammatory indicators with neonatal asphyxia or hyperbilirubinemia.Conclusion Maternal circulating IL-2,IL-7 and IL-15 levels during the second trimester of pregnancy were associated with preterm birth or birth weight.
基金supported by Fonds Wetenschappelijk Onderzoek(project No G085921 N).
文摘Mycotoxin exposure during pregnancy has been associated with adverse birth outcomes and poor infant growth in low-and middle-income countries.We assessed multiple biomarkers and metabolites of exposure to mycotoxins during pregnancy and their associations with birth outcomes and infant growth in 305 pregnant participants,between 30 and 34 completed weeks of gestation,in rural Burkina Faso.In this study,whole blood microsamples were analyzed for mycotoxin concentrations using ultra-performance liquid chromatography coupled to tandem mass spectrometry.Unadjusted and adjusted associations between mycotoxin exposure,and birth outcomes and infant growth at 6 months were estimated using linear regression models for continuous outcomes and linear probability models with robust variance estimation for binary outcomes.Infant growth trajectories from birth to 6 months were compared by exposure status using mixed-effects models with random intercept for the individual infant and random slope for the infant's age.Ochratoxin A(OTA)exposure was detected in 50.8%of the study participants,with aflatoxin G1,aflatoxin M1,cyclopiazonic acid,deoxynivalenol and T-2-toxin being detected in the range of 0.33%and 2.31%of the population.We found no statistically significant(p≥0.05)associations between OTA exposure,and birth outcomes and infant growth.Despite this,the findings indicate a significant presence of ochratoxin A among pregnant participants.Public health policies and nutrition-sensitive interventions must ensure that OTA exposure is reduced in Burkina Faso.
文摘Objective: to study the effect of a midwife-led comprehensive intervention in late pregnancy on maternal self-efficacy and delivery outcomes.Methods: the samples were selected from August 2021 to December 2021, and a total of 100 samples were randomly divided into the control group and the observation group. The application value of the third-pregnancy comprehensive intervention led by midwives was analyzed.Results: the natural delivery rate was higher than the control group (P <0.05);lower (P <0.05);Lower self-efficacy and social support scores in the control group (P <0.05): lower GAD-7 and PHQ-9 (P <0.05);lower GQOL-74 scores than the control group (P <0.05). Conclusion: the comprehensive nursing intervention in the field, improve the cognition of natural delivery, improve the natural delivery rate, promote the effective improvement of maternal self-efficacy and social support evaluation, reduce the influence of postpartum bad mood, optimize the overall quality of life, has high clinical application value.
文摘To study maternal and perinatal outcomes after cervical cerclage in both singleton and twin pregnancies,we retrospectively reviewed women undergoing cervical cerclage for cervical insufficiency at Tongji Hospital,Wuhan,China from January 1,2010 to July 31,2015 to evaluate primary and secondary outcomes for subgroups with cervical length（CL） ≤15,〉15 to 〈25,and ≥25 mm.Of 166 patients who underwent cervical cerclage,after exclusion of patients with missed abortion and continuing pregnancy,141 patients（121 singleton and 20 twin pregnancies） were included in the analysis.Mean gestational age at birth was 34.22 and 28.27 weeks for singleton and twin pregnancies,respectively.There were 17（14.05%） and 13（33.33%） neonatal deaths in singleton and twin pregnancies,respectively.Mean age（31.60±4.62 vs.31.22±4.63 years,P=0.39） and gestational weeks at cerclage（18.50±4.62 vs.19.31±4.99,P=0.47） were similar for both groups.Mean gestational weeks at delivery（34.22±5.77 vs.28.27±6.17,P〈0.001） and the suture to delivery interval（15.72±7.15 vs.8.96±6.70,P〈0.001） were significantly longer in the singleton group.These variables indicate a linear negative correlation with the degree of CL shortening,with better outcomes in patients with CL ≥25 mm who underwent cerclage,both in singleton and twin pregnancies.No difference in mode of delivery existed between the singleton group and twin group.Our results indicate a high risk of preterm delivery in both groups,especially in the twin group.Patients with a history of preterm labor and CL 〉25 mm in the current pregnancy,possibly in a twin pregnancy,could benefit from elective cervical cerclage;however,cervical cerclage was inadvisable for twin pregnancies with a CL 〉15 and 〈25 mm.Our data emphasize the importance of re-evaluating the efficacy of cervical cerclage for twin pregnancies in well-designed clinical trials.
文摘Objective: TO assess the effects of zinc supplementation to Chinese rural pregnant with cereal-based diet and their pregnancy outcome. Methods A total of 156 women were given randomly in double blind 5mg/d (group A, GPA, n=37),10mg/d (group B, GPB, n=40), 30mg (group C, GpC, n = 39) Of zinc supplement or placebo (group D, GpD, n = 40 ) starting from, the first visit at the prenatal clinic (average 9-week gestation ) till the delivery. Results Mean dietary zinc intake of these women was about 10mg/d, and more than 65% of dietary zinc were taken from cereals, grains and vegetables. Serum zinc concentrations at 25-and 32-gestation in GpC and in the umbilical cord blood of their babies at birth significantly increased. Infants in GpC had a significantly heavier birth weight (283. 079, P = 0. 016 ) and larger head circumference(0. 63cm, P = 0. 035) than infants in GpD. The incidence of low birth weight, preterm and intrauterine growth retardation infants was significantly reduced in GpC. As compared to GpD (38. 34 ± 1. 34 weeks), the duration of gestation in GpD(39. 12± 1. 11 weeks) was prolonged (P= 0. 032). Serum zinc concentration at 25-weeks gestation was negatively correlated with duration of gestation (P = 0. 009 ). Apgar score of the infants in GpC was significantly higher than that in GpD, and serum zinc concentration at 32-weeks gestation was positively associated with infant Apgar score (P = 0. 015 ). Conclusion Zinc supplementation in 30mg/d to Chinese rural women during pregnancy could significantly improve their pregnancy outcome. Both 5mg/d and 10mg/d of zinc supplementation had no detected benefits to them.
基金the National Natural Science Foundation of China[No.21577026]。
文摘Objective To explore the effects of prenatal exposure to polybrominated diphenyl ethers(PBDEs)on placental size and birth outcomes.Methods Based on the perspective Wenzhou Birth Cohort,this nested case-control study included 101 fetal growth restriction(FGR)and 101 healthy newborns.Maternal serum samples were collected during the third trimester and measured for PBDEs by gas chromatography tandem mass spectrometry.The basic information of mother-newborn pairs was collected from questionnaires,whereas the placental size and birth outcomes of newborns were obtained from hospital records.Results A total of 19 brominated diphenyle ether(BDE)congeners were detected in maternal serum samples.Higher concentrations of BDE-207,-208,-209,and∑19PBDEs were detected in FGR cases than in controls.Increased BDE-207,-208,-209,and∑19PBDEs levels in maternal serum were related to decreased placental length,breadth,surface area,birth weight,birth length,gestational age,and Quetelet index of newborns.After adjusting for confounders,BDE-207 and∑19PBDE concentrations in maternal serum were significantly associated with an increased risk of FGR.Conclusion A negative association was found between PBDE levels in maternal serum and placental size and birth outcomes.Prenatal PBDE exposure may be associated with elevated risk of the incidence of FGR birth.
