The present study concerns the lowlands of the Birnin Lokoyo watershed located in the Matankari Rural Commune (Southwestern borders of the large Iullemmeden basin in the Niger). Dominated by the Birnin Lokoyo pond, th...The present study concerns the lowlands of the Birnin Lokoyo watershed located in the Matankari Rural Commune (Southwestern borders of the large Iullemmeden basin in the Niger). Dominated by the Birnin Lokoyo pond, this watershed faced with the continuous silting up of the minor bed, dissipates further upstream in the east, so that it moves downstream to the west for the benefit of the populations of Matankari city. The main objective of this work is to analyze the representative elements of the new climatic and environmental situation as well as the various factors determining the surface conditions in the watershed. The methodological approach is based on documentary research, field observations, individual surveys and interviews with targeted groups. The results show that the silting up of the lowlands is the result of the concomitant degradation of the plant cover and the soils, which, as a result, triggered the development of crusting surfaces and area erosion on the slopes. The study underlined the importance of endogenous knowledge in the choice of remedies against the silting up of lowlands. In addition, rational land management practices on plateaus and structures (within the watershed) do not seem to be in phase with topographical factors and the tectonic framework. This work is part of the vision of better management of glacis on the banks, but also of sills subject to regressive erosion upstream and in order to guide the policies of resilience of the populations.展开更多
目的:探讨辛芷鼻敏胶囊对变应性鼻炎(Allergic rhinitis,AR)大鼠的血清中白介素13(Interleukin-13,IL-13)和鼻粘膜组织的信号转导和转录激活因子-6(Signaltransducers and activators of transcription-6,STAT6)mRNA及蛋白表达,明确药...目的:探讨辛芷鼻敏胶囊对变应性鼻炎(Allergic rhinitis,AR)大鼠的血清中白介素13(Interleukin-13,IL-13)和鼻粘膜组织的信号转导和转录激活因子-6(Signaltransducers and activators of transcription-6,STAT6)mRNA及蛋白表达,明确药效机制。方法:40只大鼠随机分为空白对照组、模型组、对照组、实验组,用卵清蛋白建立AR大鼠模型,通过对造模的大鼠灌服辛芷鼻敏胶囊及与同类药物对照,用酶联免疫吸附技术(Enzyme labeled immunosorbent assay,ELISA)定量测定各组大鼠血清IL-13水平,用原位杂交(ISH)、免疫组化方法半定量检测鼻粘膜中STAT6mRNA、STAT6蛋白含量的表达。结果:实验组大鼠血清的IL-13表达水平和鼻粘膜中STAT6mRNA、STAT6蛋白含量的表达比例明显低于模型组及对照组(P<0.05)。结论:辛芷鼻敏胶囊可能降低STAT6mRNA、STAT6蛋白含量表达,抑制大鼠AR发病过程中IL-13的表达水平,进而减少嗜酸性粒细胞浸润而控制症状。展开更多
文摘The present study concerns the lowlands of the Birnin Lokoyo watershed located in the Matankari Rural Commune (Southwestern borders of the large Iullemmeden basin in the Niger). Dominated by the Birnin Lokoyo pond, this watershed faced with the continuous silting up of the minor bed, dissipates further upstream in the east, so that it moves downstream to the west for the benefit of the populations of Matankari city. The main objective of this work is to analyze the representative elements of the new climatic and environmental situation as well as the various factors determining the surface conditions in the watershed. The methodological approach is based on documentary research, field observations, individual surveys and interviews with targeted groups. The results show that the silting up of the lowlands is the result of the concomitant degradation of the plant cover and the soils, which, as a result, triggered the development of crusting surfaces and area erosion on the slopes. The study underlined the importance of endogenous knowledge in the choice of remedies against the silting up of lowlands. In addition, rational land management practices on plateaus and structures (within the watershed) do not seem to be in phase with topographical factors and the tectonic framework. This work is part of the vision of better management of glacis on the banks, but also of sills subject to regressive erosion upstream and in order to guide the policies of resilience of the populations.
文摘目的:探讨辛芷鼻敏胶囊对变应性鼻炎(Allergic rhinitis,AR)大鼠的血清中白介素13(Interleukin-13,IL-13)和鼻粘膜组织的信号转导和转录激活因子-6(Signaltransducers and activators of transcription-6,STAT6)mRNA及蛋白表达,明确药效机制。方法:40只大鼠随机分为空白对照组、模型组、对照组、实验组,用卵清蛋白建立AR大鼠模型,通过对造模的大鼠灌服辛芷鼻敏胶囊及与同类药物对照,用酶联免疫吸附技术(Enzyme labeled immunosorbent assay,ELISA)定量测定各组大鼠血清IL-13水平,用原位杂交(ISH)、免疫组化方法半定量检测鼻粘膜中STAT6mRNA、STAT6蛋白含量的表达。结果:实验组大鼠血清的IL-13表达水平和鼻粘膜中STAT6mRNA、STAT6蛋白含量的表达比例明显低于模型组及对照组(P<0.05)。结论:辛芷鼻敏胶囊可能降低STAT6mRNA、STAT6蛋白含量表达,抑制大鼠AR发病过程中IL-13的表达水平,进而减少嗜酸性粒细胞浸润而控制症状。
