This letter discusses the findings of Pang et al retrospective study on omental patch repair as a balanced treatment for gastric ulcer perforation.We acknowledge its clinical value while highlighting a critical limita...This letter discusses the findings of Pang et al retrospective study on omental patch repair as a balanced treatment for gastric ulcer perforation.We acknowledge its clinical value while highlighting a critical limitation:Conventional mechanical closure often results in fibrotic scarring and functional impairment across the mucosal,muscular,and neurovascular layers.To address this,we propose the innovative concept of“multi-layer repair”and present a proof-ofconcept three-dimensional bioprinted functional biopatch.This patch features a multilayer structure:An inner layer laden with gastric mucosal organoids and an outer layer containing primary gastric muscle cells,both integrated onto a wetadhesive electrospun membrane.Preliminary animal studies have yielded encouraging results,supporting its potential to promote functional restoration beyond mechanical sealing.展开更多
基金Supported by Beijing Municipal Natural Science Foundation,No.7234387Chinese PLA General Hospital Young Independent Innovation Science Foundation,No.22QNFC004.
文摘This letter discusses the findings of Pang et al retrospective study on omental patch repair as a balanced treatment for gastric ulcer perforation.We acknowledge its clinical value while highlighting a critical limitation:Conventional mechanical closure often results in fibrotic scarring and functional impairment across the mucosal,muscular,and neurovascular layers.To address this,we propose the innovative concept of“multi-layer repair”and present a proof-ofconcept three-dimensional bioprinted functional biopatch.This patch features a multilayer structure:An inner layer laden with gastric mucosal organoids and an outer layer containing primary gastric muscle cells,both integrated onto a wetadhesive electrospun membrane.Preliminary animal studies have yielded encouraging results,supporting its potential to promote functional restoration beyond mechanical sealing.
