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丝素基微纳米涂层调控巨噬细胞极化促进钛表面成骨分化的研究
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作者 冯靖 王璐 武峰 《实用口腔医学杂志》 北大核心 2026年第2期179-186,共8页
目的:研究利用聚多巴胺(PDA)将丝素蛋白(SF)及丝素蛋白衍生肽(Cs肽)固定在化学二氧化钛上,主要目的是探讨该微纳米仿生涂层能否通过改变巨噬细胞的极化表型和行为来调节炎症反应,促进早期成骨分化。方法:通过两步酸蚀法在钛表面构建了... 目的:研究利用聚多巴胺(PDA)将丝素蛋白(SF)及丝素蛋白衍生肽(Cs肽)固定在化学二氧化钛上,主要目的是探讨该微纳米仿生涂层能否通过改变巨噬细胞的极化表型和行为来调节炎症反应,促进早期成骨分化。方法:通过两步酸蚀法在钛表面构建了微米级TiO2结构,然后利用PDA的共价结合作用将SF及Cs肽黏附固定在钛表面。研究不同钛片表面Raw264.7黏附、炎症因子与基因表达水平、表面标记分子。此外,在巨噬细胞-骨髓间充质干细胞(BMSCs)共培养环境中,研究涂层表面的体外成骨分化活性。结果:在钛表面成功构建了丝素基微纳米仿生复合涂层。掺入Cs肽后M2相关分子IL-10、Arg-1、CD206等表达增加,M1相关分子TNF-α、IL-6、CD86等表达降低。此外,ALP活性、体外矿化程度、成骨相关基因表达水平均有所提升。结论:基于SF-Cs的亲水性微纳米复合涂层能够调控钛表面巨噬细胞黏附和极化。并且可能通过旁分泌信号发挥炎症调节作用,为BMSCs成骨分化创造有利的骨免疫微环境。 展开更多
关键词 丝素蛋白衍生肽 骨免疫 微纳米结构 仿生
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Liquid-metal microgrid stretchable electronics based on bionic leaf veins with ultra-stretchability and high conductivity
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作者 Xi-Di Sun Jun-Yang An +6 位作者 Yi-Qi Sun Xin Guo Jing Wu Jiang-Bo Hua Meng-Rui Su Yi Shi Li-Jia Pan 《Rare Metals》 SCIE EI CAS CSCD 2024年第6期2747-2757,共11页
Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare applications.Such devices can be seamlessly integrated with human skin.Howeve... Stretchable electronics that monitor joint activity and treat diseases based on liquid metal could be used in the development of healthcare applications.Such devices can be seamlessly integrated with human skin.However,most high-precision microstructures and complex patterns are difficult to fabricate due to the limitations of conventional fabrication solutions,resulting in suboptimal performance under practical conditions.Here,a liquid-metal stretchable system utilizing natural leaf veins was reported as microstructures,which was based on a biomimetic concept and utilized an all-solution process for the preparation of complex microstructures.The systems are ultra-high tensile(800%tensile strain),environmentally stable(20 days)and mechanically durable(300-cycle).The system can accurately recognize the wearer's finger bending level as well as simple gesture signals.At the same time,the system acts as a wearable heater,which can realize the fast heating behavior of heating up to 50℃in 3 min under the human body-safe voltage(1.5 V).The tensile stability is demonstrated by the heterogeneous integration of lasers(405 nm)with the system interconnects for a stretchable and wearable light source. 展开更多
关键词 Stretchable electronics Liquid metal Stretchable conductor VEIN bionicist electronics
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