An investigation into the corrosion behavior of pure Mo50Re and rare earth oxide-doped Mo50Re,produced by spark plasma sintering,was performed in Ringer's physiologic solution at a temperature of 37°C.Potenti...An investigation into the corrosion behavior of pure Mo50Re and rare earth oxide-doped Mo50Re,produced by spark plasma sintering,was performed in Ringer's physiologic solution at a temperature of 37°C.Potentiodynamic polarization testing indicated a reduction in corrosion current density from 3.1μA·cm^(^(-2))for the pure Mo50Re to 1.6μA·cm^(-2)for Y-doped,1.5μA·cm^(-2)for La-doped,and 2.1μA·cm^(-2)for Y-La co-doped variants.Furthermore,electrochemical impedance spectroscopy revealed that the charge transfer resistance for the rare earth-doped alloys was higher,with values reaching up to 2.4×10^(4)Ω·cm2for Y-doped,3.4×10^(4)Ω·cm2for La-doped,and 2.9×10^(4)Ω·cm2for Y-La co-doped materials,in contrast to the 1.7×10^(3)Ω·cm2resistance observed for the pure Mo50Re.The research highlights the significant enhancement in corrosion resistance conferred by the incorporation of rare earth elements,ascribed to their ability to refine the grain size and purify the grain boundaries.展开更多
In the realm of biomedical materials,biomedical magnesium(Mg)alloy materials are progressively emerging as a highly salient research focal point,capitalizing on their distinctive advantages.Mg,as a unique metallic ele...In the realm of biomedical materials,biomedical magnesium(Mg)alloy materials are progressively emerging as a highly salient research focal point,capitalizing on their distinctive advantages.Mg,as a unique metallic element,by virtue of its specific properties,has ushered in novel development opportunities for the biomedical domain[1-3].Firstly,Mg manifests outstanding biodegradability.展开更多
Wound healing is a long-term,multi-stage biological process that mainly includes haemostatic,inflammatory,proliferative and tissue remodelling phases.Controlling infection and inflammation and promoting tissue regener...Wound healing is a long-term,multi-stage biological process that mainly includes haemostatic,inflammatory,proliferative and tissue remodelling phases.Controlling infection and inflammation and promoting tissue regeneration can contribute well to wound healing.Smart biomaterials offer significant advantages in wound healing because of their ability to control wound healing in time and space.Understanding how biomaterials are designed for different stages of wound healing will facilitate future personalized material tailoring for different wounds,making them beneficial for wound therapy.This review summarizes the design approaches of biomaterials in the field of anti-inflammatory,antimicrobial and tissue regeneration,highlights the advanced precise control achieved by biomaterials in different stages of wound healing and outlines the clinical and practical applications of biomaterials in wound healing.展开更多
The results of 31 cases of sutureless esophagogastrostomy by intraluminal elastic circular ligation (IECL) with the biodegradable supporting tube were reported. The fate of the supporting tube could be tracked satisfa...The results of 31 cases of sutureless esophagogastrostomy by intraluminal elastic circular ligation (IECL) with the biodegradable supporting tube were reported. The fate of the supporting tube could be tracked satisfactorily by X-ray, The tube-dislodge time was 15.03 +/- 2.23 days and unaffected by the size of supporting tube or the site of anastomosis, The supporting tube could be safely absorbed or partially discharged through the alimentary tract. IECL, with the merits of saving time, anastomosing tightly and leaving no suture materials in the anastomotic site, can be expected to further reduce the incidence of anastomotic leakage and provide references for other gastrointestinal anastomosis.展开更多
The tribological behaviour of Ti-30Zr, Ti-20Zr-10Nb and Ti-19Zr-10Nb-1Fe alloys was investigated using reciprocating friction and wear tests. X-ray diffraction（XRD） results indicate that Ti-30Zr, Ti-20Zr-10Nb and Ti...The tribological behaviour of Ti-30Zr, Ti-20Zr-10Nb and Ti-19Zr-10Nb-1Fe alloys was investigated using reciprocating friction and wear tests. X-ray diffraction（XRD） results indicate that Ti-30Zr, Ti-20Zr-10Nb and Ti-19Zr-10Nb-1Fe alloys are composed of hexagonal a＇-martensite, orthorhombic a＇＇-martensite and bcc β phases,respectively. Ti-30Zr alloy has the highest hardness of HV（273.1 ± 9.3）, while Ti-20Zr-10Nb alloy exhibits the lowest hardness of HV（235.2 ± 20.4） among all the alloys.The tribological results indicate that Ti-30Zr alloy shows the best wear resistance among these alloys, corresponding to the minimum average friction coefficient of 0.052 and the lowest wear rate of 6.4x10^-4mm3·N^-1·m^-1. Ti-20Zr-10Nb alloy displays better wear resistance than Ti-19Zr-10Nb-1Fe alloy, because the iron oxide is easy to fall off and less Nb2O5 films form on the worn surface of the latter.Delamination and abrasive wear in association with adhesive wear are the main wear mechanism of these alloys.展开更多
Biodegradable wires,able to provide load-bearing support for various biomedical applications,are the novel trends in current biomaterial research.A thin 99.92%Mg wire with a diameter of 250μm was prepared via direct ...Biodegradable wires,able to provide load-bearing support for various biomedical applications,are the novel trends in current biomaterial research.A thin 99.92%Mg wire with a diameter of 250μm was prepared via direct extrusion with an extreme reduction ratio of 1:576.The total imposed strain in a single processing step was 6.36.Extrusion was carried out at elevated temperatures in the range from 230 to 310℃and with various ram speeds ranging from^0.2 to^0.5 mm/s.The resulting wires show very good mechanical properties which vary with extrusion parameters.Maximum true tensile stress at room temperature reaches^228 MPa and ductility reaches^13%.The proposed single-step direct extrusion can be an effective method for the production of Mg wires in sufficient quantities for bioapplications.The fractographic analysis revealed that failure of the wires may be closely connected with inclusions(e.g.,Mg O particles).The results are essential for determining the optimal processing conditions of hot extrusion for thin Mg wire.The smaller grain size,as the outcome of the lower extrusion temperature,is identified as the main parameter affecting the tensile properties of the wires.展开更多
The Ti-35Nb-2Zr-0.3O(mass fraction,%)alloy was melted under a high-purity argon atmosphere in a high vacuumnon-consumable arc melting furnace,followed by cold deformation.The effects of cold deformation process on mic...The Ti-35Nb-2Zr-0.3O(mass fraction,%)alloy was melted under a high-purity argon atmosphere in a high vacuumnon-consumable arc melting furnace,followed by cold deformation.The effects of cold deformation process on microstructure andmechanical properties were investigated using the OM,XRD,TEM,Vicker hardness tester and universal material testing machine.Results indicated that the alloy showed multiple plastic deformation mechanisms,including stress-inducedα'martensite(SIMα')transformation,dislocation slipping and deformation twins.With the increase of cold deformation reduction,the tensile strength andhardness increased owing to the increase of dislocation density and grain refinement,and the elastic modulus slightly increasedowing to the increase of SIMα'phase.The90%cold deformed alloy exhibited a great potential to become a new candidate forbiomedical applications since it possessed low elastic modulus(56.2GPa),high tensile strength(1260MPa)and highstrength-to-modulus ratio(22.4×10-3),which are superior than those of Ti-6Al-4V alloy.展开更多
A series of Zr_(63.5-x)Ti_(x)Al_(9)Fe_(4.5)Cu_(23)(x=0,1.5,3.0,4.5,6.0;at%) bulk metallic glasses(BMGs) were designed and produced by means of copper mold suction casting.The effect of Ti addition on the glass-forming...A series of Zr_(63.5-x)Ti_(x)Al_(9)Fe_(4.5)Cu_(23)(x=0,1.5,3.0,4.5,6.0;at%) bulk metallic glasses(BMGs) were designed and produced by means of copper mold suction casting.The effect of Ti addition on the glass-forming ability(GFA) and mechanical properties of Zr_(63.5-x)Ti_(x)Al_(9)Fe_(4.5)Cu_(23) alloys was first investigated.The glassforming ability and room-temperature plasticity of BMGs increase first and then reduced with Ti content increasing.At x=3.0,the Zr_(60.5)Ti_(3)Al_(9)Fe_(4.5)Cu_(23) BMG showed a critical glass formation diameter of 10 mm and excellent room-temperature compressive plasticity(εP=4.7%) by using the samples with dimensions of Φ3 mm × 6 mm.Meanwhile,the BMG also showed better biocompatibility and biocorrosion resistance compared with Ti6 A14 V alloy.Under the imitated human body condition,the corrosion current density(Icorr) of BMG was 6.61 × 10^(-10) A·cm^(-2),which is two orders of magnitude lower than that of conventional Ti6Al4V alloy.Moreover,the CCD-986 sk cell viabilities are,respectively,65.4% and 46.6% on the BMG and Ti6 A14 V alloy,indicating better biocompatibility of BMG.The Zr_(60.5)Ti_(3)Al_(9)Fe_(4.5)Cu_(23) BMG with larger GFA,excellent mechanical properties,biocompatibility and biocorrosion resistance is considered as a potential material in biomedical device fields.展开更多
The corrosion behaviors of SUS316L stainless steel, Co Cr alloy and Ti 6Al 4V alloy in Ringer’s, PBS(-) and Hank’s solutions have been investigated. The results indicate that the corrosion of Ringer’s solution is t...The corrosion behaviors of SUS316L stainless steel, Co Cr alloy and Ti 6Al 4V alloy in Ringer’s, PBS(-) and Hank’s solutions have been investigated. The results indicate that the corrosion of Ringer’s solution is the strongest, then followed by PBS(-) and Hank’s solution. The presence of HPO 2- 4, H 2PO - 4, SO 2- 4 and glucose in the PBS(-)and Hank’s solution probably reduces the corrosion inhibitor and corrosion current. The decrease of the solution’s pH significantly increases the corrosion rate and susceptibility to localized corrosion of SUS316L SS and Co Cr alloy. However, Ti 6Al 4V alloy exhibits an exceptional stability and has only a slight increase of corrosion rate with decreasing pH.展开更多
Four Zr–Cu–Fe–Al-based bulk metallic glasses（BMGs） with Zr contents greater than 65at% and minor additions of Nb were designed and prepared. The glass forming abilities, thermal stabilities, mechanical properties...Four Zr–Cu–Fe–Al-based bulk metallic glasses（BMGs） with Zr contents greater than 65at% and minor additions of Nb were designed and prepared. The glass forming abilities, thermal stabilities, mechanical properties, and corrosion resistance properties of the prepared BMGs were investigated. These BMGs exhibit moderate glass forming abilities along with superior fracture and yield strengths compared to previously reported Zr–Cu–Fe–Al BMGs. Specifically, the addition of Nb into this quaternary system remarkably increases the plastic strain to 27.5%, which is related to the high Poisson＇s ratio and low Young＇s and shear moduli. The Nb-bearing BMGs also exhibit a lower corrosion current density by about one order of magnitude and a wider passive region than 316 L steel in phosphate buffer solution（PBS, pH 7.4）. The combination of the optimized composition with high deformation ability, low Young＇s modulus, and excellent corrosion resistance properties indicates that this kind of BMG is promising for biomedical applications.展开更多
Biodegradable metals such as magnesium(Mg)and its alloys have attracted extensive attention in biomedical research due to their excellent mechanical properties and biodegradability.However,traditional casting,extrusio...Biodegradable metals such as magnesium(Mg)and its alloys have attracted extensive attention in biomedical research due to their excellent mechanical properties and biodegradability.However,traditional casting,extrusion,and commercial processing have limitations in manufacturing components with a complex shape/structure,and these processes may produce defects such as cavities and gas pores which can degrade the properties and usefulness of the products.Compared to conventional techniques,additive manufacturing(AM)can be used to precisely control the geometry of workpieces made of different Mg-based materials with multiple geometric scales and produce desirable medical products for orthopedics,dentistry,and other fields.However,a detailed and thorough understanding of the raw materials,manufacturing processes,properties,and applications is required to foster the production of commercial Mg-based biomedical components by AM.This review summarizes recent advances and important issues pertaining to AM of Mg-based biomedical products and discusses future development and application trends.展开更多
Mg and its alloys show high potential to be applied as implant materials due to their superior properties like biodegradability,bioactivity,biocompatibility,and suitable mechanical behaviors.Nevertheless,the fast and ...Mg and its alloys show high potential to be applied as implant materials due to their superior properties like biodegradability,bioactivity,biocompatibility,and suitable mechanical behaviors.Nevertheless,the fast and uncontrolled degradation of Mg alloys in biological environment severely restricts their wide applications as biomedical materials.In comparison with alloying,surface coatings can not only improve corrosion resistance but also impart other bio-functional properties to achieve diverse clinical requirements.This review analyzes and summarizes the most recent developments in popular coating technologies,including micro-arc oxidation,electrophoretic deposition,chemical conversion,anodic oxidation,layered double hydroxide,and sol-gel coatings.Considering inevitable damages under complex service conditions,smart self-healing coatings are also introduced in each coating technology.The existing issues and future perspectives are finally discussed to facilitate applications of Mg alloys as biomedical materials in the medical industry.展开更多
A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,conf...A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,confocal laser microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,transmission electron microscopy,and electrochemical analysis,are employed to characterize MAO coatings at different stages of preparation.MAO has MgO,hydroxyapatite,Ca_(3)(PO_(4))_(2),and Mg2SiO4 phases.Its microstructure of the coating is characterized by"multiple breakdowns,pores within pores",and"repaired blind pores".The porosity and the uniformity of MAO coating first declines in the constant voltage mode,then augments while the discharge phenomenon takes place,and finally decreases in the repair stage.These analyses reveal a four-stage growth pattern for MAO coatings:anodic oxidation stage,micro-arc oxidation stage,breakdown stage,and repairing stage.During anodic oxidation and MAO stages,inward growth prevails,while the breakdown stage sees outward and accelerated growth.Simultaneous inward and outward growth in the repair stage results in a denser,more uniform coating with increased thickness and improved corrosion resistance.展开更多
Ce-incorporated apatite（Ce-HA） nano-scale particles with different Ce percentage contents（atomic ratio of Ce to Ce ＋ Ca is 5%,10%and 20%,respectively） were synthesized via a simple wet chemical method in this stu...Ce-incorporated apatite（Ce-HA） nano-scale particles with different Ce percentage contents（atomic ratio of Ce to Ce ＋ Ca is 5%,10%and 20%,respectively） were synthesized via a simple wet chemical method in this study.The crystal structure,chemical groups,thermal stability,crystal morphologies and crystal sizes of the Ce-HA nano-particles were characterized by X-ray diffraction（XRD）,Fourier transform infrared spectroscopy（FTIR）,and transmission electron microscopy（TEM）.The influences of reaction temperature,reaction time,pH value,and the atomic ratio of Ce to Ce ＋ Ca on the structure and performance of Ce-HA particles were studied.The results show that the lattice constants,particle sizes,crystallinity and thermal stability of Ce-HA vary with the doped Ce contents.With the increase of Ce content,the lattice constants of the Ce-HA nano-particles remarkably increase but the particle size,crystallinity and thermal stability gradually decrease.The reaction temperature as well as the reaction time has no significant effect on the properties of the final products,while the pH value has a direct relationship with their final chemical composition.The obtained Ce-HA nanosize particles possess potential application in preparing artificial bone implants,bone tissue engineering scaffold and other bioactive coatings.展开更多
Nano-scale Tb-incorporated apatite （nano-Tb-AP） particles with different Tb contents （Tb/（Tb＋Ca）） of 0%, 5%, 10% and 20% were synthesized through a simple wet chemical method in this study. The crystal structur...Nano-scale Tb-incorporated apatite （nano-Tb-AP） particles with different Tb contents （Tb/（Tb＋Ca）） of 0%, 5%, 10% and 20% were synthesized through a simple wet chemical method in this study. The crystal structure, thermal stabilities, chemical groups, crystal morphologies and crystal sizes of the nano--Tb-AP particles were characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, and transmission electron microscopy （TEM）, respectively. It was found that lattice constants, particle sizes, crystalline and thermal stability varied with the doped Tb contents. With the increasing of Tb content, the lattice constants, particle size, length/diameter ratio, crystalline and thermal stability of nano-Tb-AP gradually decrease. Especially, almost all the 20%Tb-AP nano particles had been decomposed at 1200 ℃ while only a few of the decomposed products （β-TCP） were detected in the Tb-free nano apatite powders： This kind of nano-scale Tb-incorporated apatite exhibits an extremely potential clinic application because it integrates both the excellent biological functions of Tb element and apatite in human body.展开更多
TiO2 nanotubes(NT)has been demonstrated its potential in orthopaedic applications due to its enhanced surface wettability and bio-osteointegration.However,the fretting biocorrosion is the main concern that limited its...TiO2 nanotubes(NT)has been demonstrated its potential in orthopaedic applications due to its enhanced surface wettability and bio-osteointegration.However,the fretting biocorrosion is the main concern that limited its successfully application in orthopaedic application.In this study,a structure optimised thin TiO2 nanotube(SONT)layer was successfully created on Ti6Al4V bone screw,and its fretting corrosion performance was investigated and compared to the pristine Ti6Al4V bone screws and NT decorated screw in a bone-screw fretting simulation rig.The results have shown that the debonding TiO2 nanotube from the bone screw reduced significantly,as a result of structure optimisation.The SONT layer also exhibited enhanced bio-corrosion resistance compared pristine bone screw and conventionally NT modified bone screw.It is postulated that interfacial layer between TiO2 nanotube and Ti6Al4V substrate,generated during structure optimisation process,enhanced bonding of TiO2 nanotube layer to the Ti6Al4V bone screws that leading to the improvement in fretting corrosion resistance.The results highlighted the potential SONT in orthopaedic application as bone fracture fixation devices.展开更多
Zr-Al-Co-Cu bulk metallic glasses （BMGs） are promising surgical materials. By using the electron concentration criterion for BMG composition design, a series of Zr55.8Al19.a（Co1-xCux）24.8 （x = 0-0.8 at.%） alloys...Zr-Al-Co-Cu bulk metallic glasses （BMGs） are promising surgical materials. By using the electron concentration criterion for BMG composition design, a series of Zr55.8Al19.a（Co1-xCux）24.8 （x = 0-0.8 at.%） alloys were produced, of which BMG rod samples with different diameters were made by copper mold casting. Among these alloys, the Zr55.8A119.4Co17.36Cu7.44 BMG exhibited a centimeter-scale glass formation size （dmax = 12 mm）, an ultrahigh strength （δy = 2.04 GPa）, a large room-temperature plasticity （εp = 4.0%）, and a fracture toughness （KQ = 120 MPa m^l/2）, as well as good corrosion resistance in phosphate-buffered solution. The attAlnment of the combination of properties as large glass-forming ability with excellent mechanical and corrosion stability would suit the surgical devices applications.展开更多
Biomanufacturing(BM)is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors,including medicine,energy,and the enviro...Biomanufacturing(BM)is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors,including medicine,energy,and the environment.BM has undergone a remarkable transformation in the last two decades,entering the era of BM4.0 and becoming a pivotal driver of the sustainable revolution.Notably,Japan has made significant advances in BM,contributing to its development through the creation of innovative materials,advanced processes,and interdisciplinary applications.However,because of certain development policies,this research has not been widely recognized on an international level.This paper provides a comprehensive summary of the research progress made by renowned Japanese laboratories and researchers in biomedical materials,bio-three-dimensional(3D)printing,and biomedical applications in the last five years.Their unique contributions are introduced and analyzed,illuminating the distinctive approaches and breakthroughs within each domain.Additionally,this review highlights the current challenges and prospects of BM.The viewpoints presented in this paper are intended to serve as a valuable reference for scholars studying BM in Japan.展开更多
Donor shortages for organ transplantations are a major clinical challenge worldwide. Potential risks that are inevitably encountered with traditional methods include complications, secondary injuries, and limited sour...Donor shortages for organ transplantations are a major clinical challenge worldwide. Potential risks that are inevitably encountered with traditional methods include complications, secondary injuries, and limited source donors. Three-dimensional （3D） printing technology holds the potential to solve these limitations; it can he used to rapidly manufacture personalized tissue engineering scaffolds, repair tissue defects in situ with cells, and even directly print tissue and organs. Such printed implants and organs not only perfectly match the patient＇s damaged tissue, hut can also have engineered material microstructures and cell arrangements to promote cell growth and differentiation. Thus, such implants allow the desired tissue repair to he achieved, and could eventually solve the donor-shortage problem. This review summarizes relevant studies and recent progress on four levels, introduces different types of biomedical materials, and discusses existing problems and development issues with 3D printing that are related to materials and to the construction of extracellular matrix in vitro for medical applications.展开更多
This study proposes a novel strategy for the design of a new family of metastable Zr alloys.These al-loys offer improved mechanical properties for implants,particularly in applications where conventional stainless ste...This study proposes a novel strategy for the design of a new family of metastable Zr alloys.These al-loys offer improved mechanical properties for implants,particularly in applications where conventional stainless steels and Co-Cr alloys are currently used but lack suitability.The design approach is based on the controlled twinning-induced plasticity(TWIP)effect,significantly enhancing the ductility and strain-hardenability of the Zr alloys.In order to draw a“blueprint”for the compositional design of biomedical T WIP(Bio-T WIP)Zr alloys-using only non-toxic elements,the study combines D-electron phase stability calculations(specifically bond order(Bo)and mean d-orbital energy(Md))with a systematic experimental screening of active deformation mechanisms within the Zr-Nb-Sn alloy system.This research aids in ac-curately identifying the TWIP line,which signifies the mechanism shift between TWIP and classic slip as the primary deformation mechanism.To demonstrate the efficacy of the TWIP mechanism in enhancing mechanical properties,Zr-12Nb-2Sn,Zr-13Nb-1Sn,and Zr-14Nb-3Sn alloys are selected.Results indicate that the TWIP mechanism leads to a significant improvement of strain-hardening rate and a uniform elongation of∼20%in Zr-12Nb-2Sn,which displays both{332}<113>mechanical twinning and disloca-tion slip as the primary deformation mechanisms.Conversely,Zr-14Nb-3Sn exhibits the typical mechan-ical properties found in stable body-centered cubic(BCC)alloys,characterized by the sole occurrence of dislocation slip.Cell viability tests confirm the superior biocompatibility of Zr-Nb-based alloys with deformation twins on the surface,in line with existing literature.Based on the whole set of results,a comprehensive design diagram is proposed.展开更多
基金financial supported by the National Natural Science Foundation of China(No.52164043)Jiangxi Province Key Laboratory of Ultra-high Temperature Metal Material(2024SSY05011)。
文摘An investigation into the corrosion behavior of pure Mo50Re and rare earth oxide-doped Mo50Re,produced by spark plasma sintering,was performed in Ringer's physiologic solution at a temperature of 37°C.Potentiodynamic polarization testing indicated a reduction in corrosion current density from 3.1μA·cm^(^(-2))for the pure Mo50Re to 1.6μA·cm^(-2)for Y-doped,1.5μA·cm^(-2)for La-doped,and 2.1μA·cm^(-2)for Y-La co-doped variants.Furthermore,electrochemical impedance spectroscopy revealed that the charge transfer resistance for the rare earth-doped alloys was higher,with values reaching up to 2.4×10^(4)Ω·cm2for Y-doped,3.4×10^(4)Ω·cm2for La-doped,and 2.9×10^(4)Ω·cm2for Y-La co-doped materials,in contrast to the 1.7×10^(3)Ω·cm2resistance observed for the pure Mo50Re.The research highlights the significant enhancement in corrosion resistance conferred by the incorporation of rare earth elements,ascribed to their ability to refine the grain size and purify the grain boundaries.
文摘In the realm of biomedical materials,biomedical magnesium(Mg)alloy materials are progressively emerging as a highly salient research focal point,capitalizing on their distinctive advantages.Mg,as a unique metallic element,by virtue of its specific properties,has ushered in novel development opportunities for the biomedical domain[1-3].Firstly,Mg manifests outstanding biodegradability.
基金supported by the National Natural Science Youth Foundation of China(Grant 82001975)The Innovation Fund on Medicine and Education Connection of Jiangsu University(KYCX23_3759).
文摘Wound healing is a long-term,multi-stage biological process that mainly includes haemostatic,inflammatory,proliferative and tissue remodelling phases.Controlling infection and inflammation and promoting tissue regeneration can contribute well to wound healing.Smart biomaterials offer significant advantages in wound healing because of their ability to control wound healing in time and space.Understanding how biomaterials are designed for different stages of wound healing will facilitate future personalized material tailoring for different wounds,making them beneficial for wound therapy.This review summarizes the design approaches of biomaterials in the field of anti-inflammatory,antimicrobial and tissue regeneration,highlights the advanced precise control achieved by biomaterials in different stages of wound healing and outlines the clinical and practical applications of biomaterials in wound healing.
文摘The results of 31 cases of sutureless esophagogastrostomy by intraluminal elastic circular ligation (IECL) with the biodegradable supporting tube were reported. The fate of the supporting tube could be tracked satisfactorily by X-ray, The tube-dislodge time was 15.03 +/- 2.23 days and unaffected by the size of supporting tube or the site of anastomosis, The supporting tube could be safely absorbed or partially discharged through the alimentary tract. IECL, with the merits of saving time, anastomosing tightly and leaving no suture materials in the anastomotic site, can be expected to further reduce the incidence of anastomotic leakage and provide references for other gastrointestinal anastomosis.
基金financially supported by the National Natural Science Foundation of China (Nos. 51371016 and 51401027)the China Postdoctoral Science Foundation Funded Project (No.2016M591040)
文摘The tribological behaviour of Ti-30Zr, Ti-20Zr-10Nb and Ti-19Zr-10Nb-1Fe alloys was investigated using reciprocating friction and wear tests. X-ray diffraction（XRD） results indicate that Ti-30Zr, Ti-20Zr-10Nb and Ti-19Zr-10Nb-1Fe alloys are composed of hexagonal a＇-martensite, orthorhombic a＇＇-martensite and bcc β phases,respectively. Ti-30Zr alloy has the highest hardness of HV（273.1 ± 9.3）, while Ti-20Zr-10Nb alloy exhibits the lowest hardness of HV（235.2 ± 20.4） among all the alloys.The tribological results indicate that Ti-30Zr alloy shows the best wear resistance among these alloys, corresponding to the minimum average friction coefficient of 0.052 and the lowest wear rate of 6.4x10^-4mm3·N^-1·m^-1. Ti-20Zr-10Nb alloy displays better wear resistance than Ti-19Zr-10Nb-1Fe alloy, because the iron oxide is easy to fall off and less Nb2O5 films form on the worn surface of the latter.Delamination and abrasive wear in association with adhesive wear are the main wear mechanism of these alloys.
基金Financial support of the Czech Technical University in Prague in the frame of the project SGS18/191/OHK4/3T/14financial support of the European Regional Development Fund (project CZ.02.1.01/0.0/0.0/16-019/0000778)
文摘Biodegradable wires,able to provide load-bearing support for various biomedical applications,are the novel trends in current biomaterial research.A thin 99.92%Mg wire with a diameter of 250μm was prepared via direct extrusion with an extreme reduction ratio of 1:576.The total imposed strain in a single processing step was 6.36.Extrusion was carried out at elevated temperatures in the range from 230 to 310℃and with various ram speeds ranging from^0.2 to^0.5 mm/s.The resulting wires show very good mechanical properties which vary with extrusion parameters.Maximum true tensile stress at room temperature reaches^228 MPa and ductility reaches^13%.The proposed single-step direct extrusion can be an effective method for the production of Mg wires in sufficient quantities for bioapplications.The fractographic analysis revealed that failure of the wires may be closely connected with inclusions(e.g.,Mg O particles).The results are essential for determining the optimal processing conditions of hot extrusion for thin Mg wire.The smaller grain size,as the outcome of the lower extrusion temperature,is identified as the main parameter affecting the tensile properties of the wires.
基金Project(20133069014)supported by the National Aerospace Science Foundation of China
文摘The Ti-35Nb-2Zr-0.3O(mass fraction,%)alloy was melted under a high-purity argon atmosphere in a high vacuumnon-consumable arc melting furnace,followed by cold deformation.The effects of cold deformation process on microstructure andmechanical properties were investigated using the OM,XRD,TEM,Vicker hardness tester and universal material testing machine.Results indicated that the alloy showed multiple plastic deformation mechanisms,including stress-inducedα'martensite(SIMα')transformation,dislocation slipping and deformation twins.With the increase of cold deformation reduction,the tensile strength andhardness increased owing to the increase of dislocation density and grain refinement,and the elastic modulus slightly increasedowing to the increase of SIMα'phase.The90%cold deformed alloy exhibited a great potential to become a new candidate forbiomedical applications since it possessed low elastic modulus(56.2GPa),high tensile strength(1260MPa)and highstrength-to-modulus ratio(22.4×10-3),which are superior than those of Ti-6Al-4V alloy.
基金supported by the National Natural Science Foundation of China (Nos.51901116 and 51671045)the Science Challenge Project (No.TZ2016004)+1 种基金the Fundamental Research Funds for the Central Universities (Nos.DUT16ZD209 and DUT18GF112)the National Magnetic-Confinement Fusion Science Program (Nos.2013GB107003 and 2015GB105003)。
文摘A series of Zr_(63.5-x)Ti_(x)Al_(9)Fe_(4.5)Cu_(23)(x=0,1.5,3.0,4.5,6.0;at%) bulk metallic glasses(BMGs) were designed and produced by means of copper mold suction casting.The effect of Ti addition on the glass-forming ability(GFA) and mechanical properties of Zr_(63.5-x)Ti_(x)Al_(9)Fe_(4.5)Cu_(23) alloys was first investigated.The glassforming ability and room-temperature plasticity of BMGs increase first and then reduced with Ti content increasing.At x=3.0,the Zr_(60.5)Ti_(3)Al_(9)Fe_(4.5)Cu_(23) BMG showed a critical glass formation diameter of 10 mm and excellent room-temperature compressive plasticity(εP=4.7%) by using the samples with dimensions of Φ3 mm × 6 mm.Meanwhile,the BMG also showed better biocompatibility and biocorrosion resistance compared with Ti6 A14 V alloy.Under the imitated human body condition,the corrosion current density(Icorr) of BMG was 6.61 × 10^(-10) A·cm^(-2),which is two orders of magnitude lower than that of conventional Ti6Al4V alloy.Moreover,the CCD-986 sk cell viabilities are,respectively,65.4% and 46.6% on the BMG and Ti6 A14 V alloy,indicating better biocompatibility of BMG.The Zr_(60.5)Ti_(3)Al_(9)Fe_(4.5)Cu_(23) BMG with larger GFA,excellent mechanical properties,biocompatibility and biocorrosion resistance is considered as a potential material in biomedical device fields.
文摘The corrosion behaviors of SUS316L stainless steel, Co Cr alloy and Ti 6Al 4V alloy in Ringer’s, PBS(-) and Hank’s solutions have been investigated. The results indicate that the corrosion of Ringer’s solution is the strongest, then followed by PBS(-) and Hank’s solution. The presence of HPO 2- 4, H 2PO - 4, SO 2- 4 and glucose in the PBS(-)and Hank’s solution probably reduces the corrosion inhibitor and corrosion current. The decrease of the solution’s pH significantly increases the corrosion rate and susceptibility to localized corrosion of SUS316L SS and Co Cr alloy. However, Ti 6Al 4V alloy exhibits an exceptional stability and has only a slight increase of corrosion rate with decreasing pH.
基金financially supported by the National Natural Science Foundation of China (No. 51271018)the Proprietary Program of the State Key Laboratory for Advanced Metals and Materials,University of Science and Technology Beijing (Nos.2011Z-01 and 2012Z-01)
文摘Four Zr–Cu–Fe–Al-based bulk metallic glasses（BMGs） with Zr contents greater than 65at% and minor additions of Nb were designed and prepared. The glass forming abilities, thermal stabilities, mechanical properties, and corrosion resistance properties of the prepared BMGs were investigated. These BMGs exhibit moderate glass forming abilities along with superior fracture and yield strengths compared to previously reported Zr–Cu–Fe–Al BMGs. Specifically, the addition of Nb into this quaternary system remarkably increases the plastic strain to 27.5%, which is related to the high Poisson＇s ratio and low Young＇s and shear moduli. The Nb-bearing BMGs also exhibit a lower corrosion current density by about one order of magnitude and a wider passive region than 316 L steel in phosphate buffer solution（PBS, pH 7.4）. The combination of the optimized composition with high deformation ability, low Young＇s modulus, and excellent corrosion resistance properties indicates that this kind of BMG is promising for biomedical applications.
基金This work was financially supported by the Guangdong Basic and Applied Basic Research Foundation(No.2020B1515120078,2021A1515111140,and 2021B1515120059)National Key Research and Development Project of China(No.2020YFC1107202)+3 种基金Science Research Cultivation Program(PY2022002)Science and Technology Planning Project of Guangzhou(No.202206010030)City University of Hong Kong Donation Research Grants[DONRMG No.9229021 and 9220061]as well as City University of Hong Kong Strategic Research Grant[SRG 7005505].
文摘Biodegradable metals such as magnesium(Mg)and its alloys have attracted extensive attention in biomedical research due to their excellent mechanical properties and biodegradability.However,traditional casting,extrusion,and commercial processing have limitations in manufacturing components with a complex shape/structure,and these processes may produce defects such as cavities and gas pores which can degrade the properties and usefulness of the products.Compared to conventional techniques,additive manufacturing(AM)can be used to precisely control the geometry of workpieces made of different Mg-based materials with multiple geometric scales and produce desirable medical products for orthopedics,dentistry,and other fields.However,a detailed and thorough understanding of the raw materials,manufacturing processes,properties,and applications is required to foster the production of commercial Mg-based biomedical components by AM.This review summarizes recent advances and important issues pertaining to AM of Mg-based biomedical products and discusses future development and application trends.
基金supported by the Chongqing Natural Science Foundation(No.CSTB2023NSCQ-MSX0512)Municipal Human Resources and Social Security Bureau(No.cx2022098)China Postdoctoral Science Foundation(Nos.2022T150767 and 2021M693708).
文摘Mg and its alloys show high potential to be applied as implant materials due to their superior properties like biodegradability,bioactivity,biocompatibility,and suitable mechanical behaviors.Nevertheless,the fast and uncontrolled degradation of Mg alloys in biological environment severely restricts their wide applications as biomedical materials.In comparison with alloying,surface coatings can not only improve corrosion resistance but also impart other bio-functional properties to achieve diverse clinical requirements.This review analyzes and summarizes the most recent developments in popular coating technologies,including micro-arc oxidation,electrophoretic deposition,chemical conversion,anodic oxidation,layered double hydroxide,and sol-gel coatings.Considering inevitable damages under complex service conditions,smart self-healing coatings are also introduced in each coating technology.The existing issues and future perspectives are finally discussed to facilitate applications of Mg alloys as biomedical materials in the medical industry.
文摘A custom micro-arc oxidation(MAO)apparatus is employed to produce coatings under optimized constant voltage–current two-step power supply mode.Various analytical techniques,including scanning electron microscopy,confocal laser microscopy,X-ray diffraction,X-ray photoelectron spectroscopy,transmission electron microscopy,and electrochemical analysis,are employed to characterize MAO coatings at different stages of preparation.MAO has MgO,hydroxyapatite,Ca_(3)(PO_(4))_(2),and Mg2SiO4 phases.Its microstructure of the coating is characterized by"multiple breakdowns,pores within pores",and"repaired blind pores".The porosity and the uniformity of MAO coating first declines in the constant voltage mode,then augments while the discharge phenomenon takes place,and finally decreases in the repair stage.These analyses reveal a four-stage growth pattern for MAO coatings:anodic oxidation stage,micro-arc oxidation stage,breakdown stage,and repairing stage.During anodic oxidation and MAO stages,inward growth prevails,while the breakdown stage sees outward and accelerated growth.Simultaneous inward and outward growth in the repair stage results in a denser,more uniform coating with increased thickness and improved corrosion resistance.
基金supported by the National Natural Science Foundation of China(Nos.51072159 and 51273159)the Fundamental Research Funds for the Central University and Program for New Century Excellent Talents in Universities(Chinese Ministry of Education,NCET-08-0444(2301G107aaa))
文摘Ce-incorporated apatite（Ce-HA） nano-scale particles with different Ce percentage contents（atomic ratio of Ce to Ce ＋ Ca is 5%,10%and 20%,respectively） were synthesized via a simple wet chemical method in this study.The crystal structure,chemical groups,thermal stability,crystal morphologies and crystal sizes of the Ce-HA nano-particles were characterized by X-ray diffraction（XRD）,Fourier transform infrared spectroscopy（FTIR）,and transmission electron microscopy（TEM）.The influences of reaction temperature,reaction time,pH value,and the atomic ratio of Ce to Ce ＋ Ca on the structure and performance of Ce-HA particles were studied.The results show that the lattice constants,particle sizes,crystallinity and thermal stability of Ce-HA vary with the doped Ce contents.With the increase of Ce content,the lattice constants of the Ce-HA nano-particles remarkably increase but the particle size,crystallinity and thermal stability gradually decrease.The reaction temperature as well as the reaction time has no significant effect on the properties of the final products,while the pH value has a direct relationship with their final chemical composition.The obtained Ce-HA nanosize particles possess potential application in preparing artificial bone implants,bone tissue engineering scaffold and other bioactive coatings.
基金supported by the Fundamental Research Funds for the Central Universitythe National Natural Science Foundation of China (No. 51072159+1 种基金51273159)Program for New Century Excellent Talents in Universities (Chinese Ministry of Education,NCET-08-0444)
文摘Nano-scale Tb-incorporated apatite （nano-Tb-AP） particles with different Tb contents （Tb/（Tb＋Ca）） of 0%, 5%, 10% and 20% were synthesized through a simple wet chemical method in this study. The crystal structure, thermal stabilities, chemical groups, crystal morphologies and crystal sizes of the nano--Tb-AP particles were characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, and transmission electron microscopy （TEM）, respectively. It was found that lattice constants, particle sizes, crystalline and thermal stability varied with the doped Tb contents. With the increasing of Tb content, the lattice constants, particle size, length/diameter ratio, crystalline and thermal stability of nano-Tb-AP gradually decrease. Especially, almost all the 20%Tb-AP nano particles had been decomposed at 1200 ℃ while only a few of the decomposed products （β-TCP） were detected in the Tb-free nano apatite powders： This kind of nano-scale Tb-incorporated apatite exhibits an extremely potential clinic application because it integrates both the excellent biological functions of Tb element and apatite in human body.
基金financially supported by the European Union via the H2020-MSCA-RISE-2016 program(BAMOS Project,734156)Royal Society via the International Exchange Program(IE161349)+2 种基金Key Research Project from the National Key Research and Development Program of China(2016YFC1100401)National Natural Science Foundation of China(51705507)Young Elite Scientists Sponsorship Program by CAST(2017QNRC0181)。
文摘TiO2 nanotubes(NT)has been demonstrated its potential in orthopaedic applications due to its enhanced surface wettability and bio-osteointegration.However,the fretting biocorrosion is the main concern that limited its successfully application in orthopaedic application.In this study,a structure optimised thin TiO2 nanotube(SONT)layer was successfully created on Ti6Al4V bone screw,and its fretting corrosion performance was investigated and compared to the pristine Ti6Al4V bone screws and NT decorated screw in a bone-screw fretting simulation rig.The results have shown that the debonding TiO2 nanotube from the bone screw reduced significantly,as a result of structure optimisation.The SONT layer also exhibited enhanced bio-corrosion resistance compared pristine bone screw and conventionally NT modified bone screw.It is postulated that interfacial layer between TiO2 nanotube and Ti6Al4V substrate,generated during structure optimisation process,enhanced bonding of TiO2 nanotube layer to the Ti6Al4V bone screws that leading to the improvement in fretting corrosion resistance.The results highlighted the potential SONT in orthopaedic application as bone fracture fixation devices.
基金This work was supported by the National Natural Science Foundation of China （51671045）, the Science Challenge Project （TZ2016004）, the Fundamental Research Funds for the Cen- tral Universities （DUT16ZD209）, the National Magnetic-Confine-ment Fusion Science Program of China （2013GB107003 and 2015GB105003）, and the Nuclear Energy Development Project （H660003-13-02）.
文摘Zr-Al-Co-Cu bulk metallic glasses （BMGs） are promising surgical materials. By using the electron concentration criterion for BMG composition design, a series of Zr55.8Al19.a（Co1-xCux）24.8 （x = 0-0.8 at.%） alloys were produced, of which BMG rod samples with different diameters were made by copper mold casting. Among these alloys, the Zr55.8A119.4Co17.36Cu7.44 BMG exhibited a centimeter-scale glass formation size （dmax = 12 mm）, an ultrahigh strength （δy = 2.04 GPa）, a large room-temperature plasticity （εp = 4.0%）, and a fracture toughness （KQ = 120 MPa m^l/2）, as well as good corrosion resistance in phosphate-buffered solution. The attAlnment of the combination of properties as large glass-forming ability with excellent mechanical and corrosion stability would suit the surgical devices applications.
基金This work was supported by the National Natural Science Foundation of China(No.52105072).
文摘Biomanufacturing(BM)is a multidisciplinary area incorporating the characteristics of living organisms and engineering principles to create valuable products for various sectors,including medicine,energy,and the environment.BM has undergone a remarkable transformation in the last two decades,entering the era of BM4.0 and becoming a pivotal driver of the sustainable revolution.Notably,Japan has made significant advances in BM,contributing to its development through the creation of innovative materials,advanced processes,and interdisciplinary applications.However,because of certain development policies,this research has not been widely recognized on an international level.This paper provides a comprehensive summary of the research progress made by renowned Japanese laboratories and researchers in biomedical materials,bio-three-dimensional(3D)printing,and biomedical applications in the last five years.Their unique contributions are introduced and analyzed,illuminating the distinctive approaches and breakthroughs within each domain.Additionally,this review highlights the current challenges and prospects of BM.The viewpoints presented in this paper are intended to serve as a valuable reference for scholars studying BM in Japan.
文摘Donor shortages for organ transplantations are a major clinical challenge worldwide. Potential risks that are inevitably encountered with traditional methods include complications, secondary injuries, and limited source donors. Three-dimensional （3D） printing technology holds the potential to solve these limitations; it can he used to rapidly manufacture personalized tissue engineering scaffolds, repair tissue defects in situ with cells, and even directly print tissue and organs. Such printed implants and organs not only perfectly match the patient＇s damaged tissue, hut can also have engineered material microstructures and cell arrangements to promote cell growth and differentiation. Thus, such implants allow the desired tissue repair to he achieved, and could eventually solve the donor-shortage problem. This review summarizes relevant studies and recent progress on four levels, introduces different types of biomedical materials, and discusses existing problems and development issues with 3D printing that are related to materials and to the construction of extracellular matrix in vitro for medical applications.
基金the support of the French Agence Nationale de la Recherche(ANR),under grant ANR-21-CE08-0022(project ISANAMI)Junhui TANG is sponsored by the China Scholarship Council.
文摘This study proposes a novel strategy for the design of a new family of metastable Zr alloys.These al-loys offer improved mechanical properties for implants,particularly in applications where conventional stainless steels and Co-Cr alloys are currently used but lack suitability.The design approach is based on the controlled twinning-induced plasticity(TWIP)effect,significantly enhancing the ductility and strain-hardenability of the Zr alloys.In order to draw a“blueprint”for the compositional design of biomedical T WIP(Bio-T WIP)Zr alloys-using only non-toxic elements,the study combines D-electron phase stability calculations(specifically bond order(Bo)and mean d-orbital energy(Md))with a systematic experimental screening of active deformation mechanisms within the Zr-Nb-Sn alloy system.This research aids in ac-curately identifying the TWIP line,which signifies the mechanism shift between TWIP and classic slip as the primary deformation mechanism.To demonstrate the efficacy of the TWIP mechanism in enhancing mechanical properties,Zr-12Nb-2Sn,Zr-13Nb-1Sn,and Zr-14Nb-3Sn alloys are selected.Results indicate that the TWIP mechanism leads to a significant improvement of strain-hardening rate and a uniform elongation of∼20%in Zr-12Nb-2Sn,which displays both{332}<113>mechanical twinning and disloca-tion slip as the primary deformation mechanisms.Conversely,Zr-14Nb-3Sn exhibits the typical mechan-ical properties found in stable body-centered cubic(BCC)alloys,characterized by the sole occurrence of dislocation slip.Cell viability tests confirm the superior biocompatibility of Zr-Nb-based alloys with deformation twins on the surface,in line with existing literature.Based on the whole set of results,a comprehensive design diagram is proposed.
