A weakly coupled data assimilation system was established for a coupled physical–biological model for the northeastern South China Sea（NSCS）. The physical model used was the Regional Ocean Modeling System; the biol...A weakly coupled data assimilation system was established for a coupled physical–biological model for the northeastern South China Sea（NSCS）. The physical model used was the Regional Ocean Modeling System; the biological component was a seven-compartment nitrogen–phytoplankton–zooplankton–detritus ecosystem model; and the data assimilation method was Ensemble Optical Interpolation. To test the performance of the weakly coupled data assimilation system, two numerical experiments（i.e. control and assimilation runs） based on a process-oriented idealized case were conducted, and climatological SST was assimilated in the assimilation run. Only physical variables were adjusted in the weakly coupled data assimilation. The results showed that both the assimilated SST and other unassimilated physical variables had reasonable process responses. Due to the warmer SST observation, the water temperature（salinity） in the assimilation run increased（decreased） in coastal upwelling regions. Both the alongshore and bottom cross-shore currents were reduced, jointly demonstrating the weakening of the upwelling system. Meanwhile, ecosystem variables were also affected to some extent by the SST assimilation through the coupled model. For example, larger phytoplankton（chlorophyll） productivity was found in the upwelling region within the shallow layer due to the warmer waters in the assimilation run. Hence, the application of this data assimilation system could reasonably modify both physical and biological variables for the NSCS by SST assimilation.展开更多
Changes in soil quality of sugarcane plantation as a result of changes in land management can not be measured directly, but must be demonstrated by measuring the change in the properties of the ecosystem as an indicat...Changes in soil quality of sugarcane plantation as a result of changes in land management can not be measured directly, but must be demonstrated by measuring the change in the properties of the ecosystem as an indicator. This research aimed to study the effect of the addition of various quality and quantity of organic matter on soil biology （earthworms） and physical quality （aggregate stability, macroporosity and infiltration rate）. There were i 5 treatment combinations tested. The first factor is the type of organic matter： （1） cattle manure （CM）, （2） filter cake （FC）, （3） sugarcane trash （ST）, （4） a mixture ofCM ＋ FC and （5） a mixture of CM ＋ ST. The second factor is the application dose of organic matter, which consists of three levels-5, l0 and 15 Mg/ha. The treatments were arranged in a factorial randomized block design with three replicates and one control treatment （without organic matter input）. The result of this research showed that the highest population density of earthworms was found in the treatment of ST （78 individuals/m2） and a mixture of CM ＋ ST （84 individuals/m2）. The type of organic matter with C/N ratio ranged from 15.5 to 34.7 and cellulose content in 33.3%-40.1% gave better growth of earthworm. The effect of increase in earthworm growth on soil physical improvement is more apparent in the treatment of mixture of low quality and high quality organic matter. The increase of earthworm density and biomass enhanced soil macroporosity （from r = 0.683 to r = 0.606） and infiltration rate （from r = 0.669 to r = 0.756）. The results of this study suggest a mixture of CM ＋ ST or ST alone as organic matters, which is recommended to improve soil physical and biological quality of sugarcane land, with the dose application ranged from 10 Mg/ha to 15 Mg/ha.展开更多
The omnidirectional character is one of important requirements for the sound source used in near-field head- related transfer function （HRTF） measurements. Based on the analysis on the radiation sound pressure and d...The omnidirectional character is one of important requirements for the sound source used in near-field head- related transfer function （HRTF） measurements. Based on the analysis on the radiation sound pressure and directivity character of various spherical polyhedron sound sources, a spherical dodecahedral sound source with radius of O. 035 m is proposed and manufactured. Theoretical and measured results indicate that the sound source is approximately omnidirectional below the frequency of 8 kHz. In addition, the sound source has reasonable magnitude response from 350Hz to 20 kHz and linear phase characteristics. Therefore, it is suitable for the near-field HRTF measurements.展开更多
Development of minimally invasive dry electrodes for recording biopotentials is presented. The detailed fabrication process is outlined. A dry electrode is formed by a number of microneedles. The lengths of the micron...Development of minimally invasive dry electrodes for recording biopotentials is presented. The detailed fabrication process is outlined. A dry electrode is formed by a number of microneedles. The lengths of the microneedles are about 150μm and the diameters are about 50μm. The tips of the microneedles are sharp enough to penetrate into the skin. The silver/silver chloride is grown on microneedle arrays and demonstrates good character. The electrocardiogram shows that the dry electrode is suitable for recording biopotentials.展开更多
The mutant strains of aspergillus oryzae （HP300a） are screened under 300 MPa for 20min. Compared with the control strains, the screened mutant strains have unique properties such as genetic stability, rapid growth, ...The mutant strains of aspergillus oryzae （HP300a） are screened under 300 MPa for 20min. Compared with the control strains, the screened mutant strains have unique properties such as genetic stability, rapid growth, lots of spores, and high protease activity. Random amplified polymorphic DNA （RAPD） and inter simple sequence repeats （ISSR） are used to analyze the DNA fingerprinting of HP300a and the control strains. There are 67.9% and 51.3% polymorphic bands obtained by these two markers, respectively, indicating significant genetic variations between HP300a and the control strains. In addition, comparison of HP300a arid the control strains, the genetic distances of random sequence and simple sequence repeat of DNA are 0.51 and 0.34, respectively.展开更多
Neck linker （NL） is one of the most important mechanical elements of kinesin motors. The zipping up process of the neck-zipper （NZ） formed by NL and the related secondary structure elements is one of the major par...Neck linker （NL） is one of the most important mechanical elements of kinesin motors. The zipping up process of the neck-zipper （NZ） formed by NL and the related secondary structure elements is one of the major parts of kinesin＇s power stroke. All the weak interactions that are responsible for the formation of NZ are sensitive to or dependent on water. To investigate the role of water in the NZ region, a molecular dynamics （MD） model is set up with a crystal structure of kinesin 2KIN surrounded by a 10 A water layer, and minimization is performed to determine the positions of hydrogen atoms and other atoms. It is revealed that water molecules can assist the docking process of NL by forming hydrogen bonds at those positions where direct hydrogen bonding between the two sides of NZ is hindered and then acts as a constructive component of NZ at the docked state of NL. This result may improve the understanding of the mechanism for the docking of NL of kinesin wherein the function of water has not been comprehended sufficiently.展开更多
Zipping-and-assembly mechanism （ZAM） is a new mechanism describing the kinetics of protein folding. To dissect the validity of this mechanism for various protein-like systems, a prediction test based on three-dimens...Zipping-and-assembly mechanism （ZAM） is a new mechanism describing the kinetics of protein folding. To dissect the validity of this mechanism for various protein-like systems, a prediction test based on three-dimensional HP lattice models is carried out. It is found that only the native structures of a part of protein-like models could be predicted with a ZAM-based method. The detailed comparisons between the model proteins which are predicted or failed with the ZAM-based method suggest that the ZAM is likely to be applicable for the model proteins with the weak hydrophobicity, the low contact order for native conformations, and the large separation between the energies of native state and denatured states. These observations bring us more information about the protein-like systems for which the ZAM could be applied.展开更多
A worm-like chain model based on a spectrin network is employed to study the biomechanics of red blood cells. Coarse-grained molecular dynamics simulations are performed to obtain a stable configuration free of extern...A worm-like chain model based on a spectrin network is employed to study the biomechanics of red blood cells. Coarse-grained molecular dynamics simulations are performed to obtain a stable configuration free of external loadings. We also discuss the influence of two parameters： the average bending modulus and the persistence length. The change in shape of a malaria-infected red blood cell can contribute to the change in its molecular-based structure. As the persistence length of the membrane network in the infected red blood cell decreases, the deformability decreases and the biconcave shape is destroyed. The numerical results are comparable with previously reported experimental results. The coarse-grained model can be used to study the relationship between macro-mechanical properties and molecular-scale structures of cells.展开更多
Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization（EAD）-like rhythm in cultured cardiac myocytes and reproduced the exp...Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization（EAD）-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.展开更多
Growth of Antibody-Antigen complexes in a multivalent Antibody-Antigen system is studied by the Monte Carlo simulation method. The validity of the algorithm is first demonstrated for the case of the equal reactivity, ...Growth of Antibody-Antigen complexes in a multivalent Antibody-Antigen system is studied by the Monte Carlo simulation method. The validity of the algorithm is first demonstrated for the case of the equal reactivity, then the simulation is presented for the case of unequal reactivity. It is shown that the influence of the unequal reactivity on the critical point, size distribution and the weight-average binding degree is significant. Especially, the gelation regions for the cases of unequal reactivity are studied, which can provide some useful clues for the immunological experiments.展开更多
We examine how noise interacts with encoding mechanisms of neuronal stimulus in a cold receptor. From ISI series and bifurcation diagrams it is shown that there are considerable differences in interval distributions a...We examine how noise interacts with encoding mechanisms of neuronal stimulus in a cold receptor. From ISI series and bifurcation diagrams it is shown that there are considerable differences in interval distributions and impulse patterns caused by purely deterministic simulations and noisy simulations. The ISI-distance can be used as an effective and powerful way to measure the noise effects on spike trains of the cold receptor quantitatively. It is also found that spike trains observed in cold receptors can be more strongly affected by noise for low temperatures than for high temperatures in some aspects; meanwhile, the spike train has greater variability with increasing noise intensity.展开更多
We study the dynamics of tumor cell growth with time-delayed feedback driven by multiplicative noise in an asymmetrical bistable potential well. For a small delay time, the analytical solutions of the probability dist...We study the dynamics of tumor cell growth with time-delayed feedback driven by multiplicative noise in an asymmetrical bistable potential well. For a small delay time, the analytical solutions of the probability distribution and the first passage time show that, with the increasing delay time, the peak of the probability distribution in a lower population state would increase, but in a higher population state it decreases. It is shown that the multiplicative noise and the time delay play opposite roles in the tumor cell growth.展开更多
Binding of methylene blue （MB） and DNA, photosensitization of MB in DNA, and correlation of photosensiti- zation and binding mode are studied at different concentration ratios of DNA and MB. The absorption spectra i...Binding of methylene blue （MB） and DNA, photosensitization of MB in DNA, and correlation of photosensiti- zation and binding mode are studied at different concentration ratios of DNA and MB. The absorption spectra indicate that the electrostatic binding is the main mode at low γ ratios （γ≤ 2）, while at high γ ratios （γ 〉 2） the intercalative binding is dominated. Mudies on dynamics of photosensitization formation of singlet oxygen （102） for MB in DNA are carried out by using＂ time-resolved technology. There are no obvious changes of the singlet oxygen lifetime and the triplet state MB molecule （MB3＋＊） lifetime at low ratios, they are about 4 μs and 1 μs, respectively. However, we could not obtain the 1 O2 lifetime and MB3＋＊ lifetime due to the great decrease of 1 O2 phosphorescence signals at high ratios. These results show that the photosensitization and binding mode of MB in DNA possess high correlation. When MB binds with DNA by electrostatic interaction, type-lI photosen- sitization of MB plays a major role in photodynamic effect, the damage of DNA probably could be ascribed to 1 O2. However, at high ratios, binding mode between MB and DNA turns to intercalative binding, which greatly weakens the type-Ⅱ photosensitization process. Charge transfer between MB and DNA possibly becomes the main damage mechanism.展开更多
The possibility of formation of complexes between glycine and boron doped C60 （C59B） fullerene is investigated and compared with that of C60 fullerene by using the density functional theory calculations. It has been...The possibility of formation of complexes between glycine and boron doped C60 （C59B） fullerene is investigated and compared with that of C60 fullerene by using the density functional theory calculations. It has been found that the binding of glycine to C59B generated the most stable complexes via its carbonyl oxygen active site, with a binding energy of-37.89 kcal/mol, while the glycine molecule prefers to bind to the pure C60 cage via its amino nitrogen active site, consistent with the recent experimental and theoretical studies. We have also tested the stability of the most stable Gly-C59B complex with ab initio molecular dynamics simulation, carried out at room temperature. These indicate that the B-doped C60 fullerenes seem to be more suitable materials for bindings to proteins than pure C60 fullerenes.展开更多
The introduction of poly（ether urethane） （PEUR） into polymer electrolyte based on poly（ethylene oxide）, LiI and I2, has significantly increased the ionic conductivity by nearly two orders of magnitudes. An incre...The introduction of poly（ether urethane） （PEUR） into polymer electrolyte based on poly（ethylene oxide）, LiI and I2, has significantly increased the ionic conductivity by nearly two orders of magnitudes. An increment of I3- diffusion coefficient is also observed. All-solid-state dye-sensitized solar cells are constructed using the polymer electrolytes. It was found that PEUR incorporation has a beneficial effect on the enhancement of open circuit voltage VOC by shifting the band edge of TiO2 to a negative value. Scanningelectron microscope images indicate the perfect interfacial contact between the TiO2 electrode and the blend electrolyte.展开更多
We study the interaction between holes and molecular vibrations on dry DNA by using the extended Firsov＇s model. The ground state energy, calculated by using two Hilbert spaces, Fock state space and coherent state sp...We study the interaction between holes and molecular vibrations on dry DNA by using the extended Firsov＇s model. The ground state energy, calculated by using two Hilbert spaces, Fock state space and coherent state space, is confirmed. The polaron binding energy, defined with the ground state energy, is 0.014eV, much less than the thermal energy 0.026eV at room temperature 300K, which means that polarons are difficult to form self-trapping at room temperature and Anderson localization will prevent a metallic state on dry DNA. The results are consistent with the available experiments.展开更多
We study the relation between the magnetic field structure and the induced electric-current distribution based on a cylindrical model composed of a uniform electrically conductive medium. When the time-varying magneti...We study the relation between the magnetic field structure and the induced electric-current distribution based on a cylindrical model composed of a uniform electrically conductive medium. When the time-varying magnetic fields are axisymmetrically applied in the axial direction of the model, the electric fields are induced around the central axis in accordance with Faradays law. We examine the eddy-current distributions generated by loop-coils with various geometries carrying an alternating electric current. It is shown that the radial structure of the induced fields can significantly be controlled by the loop coil geometry, which will be suitable for practical use especially in magnetic nerve stimulation on bioelectromagneties, if we appropriately p/ace the exciting coil with optimum geometry.展开更多
Water confined into the interior channels of narrow carbon nanotubes or transmembrane proteins can form collectively oriented molecular chains held together by tight hydrogen bonds. We develop a quasi-one-dimensional ...Water confined into the interior channels of narrow carbon nanotubes or transmembrane proteins can form collectively oriented molecular chains held together by tight hydrogen bonds. We develop a quasi-one-dimensional model for a chain of water molecules which interact with each other via the Coulomb and power-like repulsive interactions. We explore the equilibrium property of the water chain and derive an exact analytical expression for the total interaction energy of the water chain, denoted by W（0）int. It is found that W（0）int is minimal when the distance between the two neighboring water molecules in a hydrogen-bonded chain is equal to 0.265 nm. The model is expected to be useful for studying analytically the properties of single-file water molecules inside water channels, such as the concerted motion of water molecules.展开更多
A drug delivery system via multi-walled carbon nanotube （MWNT） vehicle was synthesized in aqueous solution. MWNTs were first noncovalently functionalized with chitosan oligomers （CS） with a molecule weight of 4000...A drug delivery system via multi-walled carbon nanotube （MWNT） vehicle was synthesized in aqueous solution. MWNTs were first noncovalently functionalized with chitosan oligomers （CS） with a molecule weight of 4000-6000, making MWNTs water-soluble, and then a cancer ancillary drug tea polyphenols （TP） was conjugated mainly via the hydrogen bond between CS and TP molecules, making MWNTs efficient vehicle for drug delivering. The release of drug molecules can be realized by pH variation and γ-radiation, leading to new methods for controlling drug release from carbon nanotubes carrier. Due to the high penetrability of γ-rays, γ-radiation shows up new opportunities in controlled drug release, possibly facilitating the future cancer treatment in vivo.展开更多
The polarizabilities of DNA in transverse direction and CdSe semiconductor quantum dots （QDs） deposited on mica surface are compared by means of electrostatic force microscopy （EFM）. We observe clear EFM-phase shi...The polarizabilities of DNA in transverse direction and CdSe semiconductor quantum dots （QDs） deposited on mica surface are compared by means of electrostatic force microscopy （EFM）. We observe clear EFM-phase shift over CdSe QDs, while no obvious signal on DNA is detected, suggesting that DNA molecules is an electrical insulator.展开更多
文摘A weakly coupled data assimilation system was established for a coupled physical–biological model for the northeastern South China Sea（NSCS）. The physical model used was the Regional Ocean Modeling System; the biological component was a seven-compartment nitrogen–phytoplankton–zooplankton–detritus ecosystem model; and the data assimilation method was Ensemble Optical Interpolation. To test the performance of the weakly coupled data assimilation system, two numerical experiments（i.e. control and assimilation runs） based on a process-oriented idealized case were conducted, and climatological SST was assimilated in the assimilation run. Only physical variables were adjusted in the weakly coupled data assimilation. The results showed that both the assimilated SST and other unassimilated physical variables had reasonable process responses. Due to the warmer SST observation, the water temperature（salinity） in the assimilation run increased（decreased） in coastal upwelling regions. Both the alongshore and bottom cross-shore currents were reduced, jointly demonstrating the weakening of the upwelling system. Meanwhile, ecosystem variables were also affected to some extent by the SST assimilation through the coupled model. For example, larger phytoplankton（chlorophyll） productivity was found in the upwelling region within the shallow layer due to the warmer waters in the assimilation run. Hence, the application of this data assimilation system could reasonably modify both physical and biological variables for the NSCS by SST assimilation.
文摘Changes in soil quality of sugarcane plantation as a result of changes in land management can not be measured directly, but must be demonstrated by measuring the change in the properties of the ecosystem as an indicator. This research aimed to study the effect of the addition of various quality and quantity of organic matter on soil biology （earthworms） and physical quality （aggregate stability, macroporosity and infiltration rate）. There were i 5 treatment combinations tested. The first factor is the type of organic matter： （1） cattle manure （CM）, （2） filter cake （FC）, （3） sugarcane trash （ST）, （4） a mixture ofCM ＋ FC and （5） a mixture of CM ＋ ST. The second factor is the application dose of organic matter, which consists of three levels-5, l0 and 15 Mg/ha. The treatments were arranged in a factorial randomized block design with three replicates and one control treatment （without organic matter input）. The result of this research showed that the highest population density of earthworms was found in the treatment of ST （78 individuals/m2） and a mixture of CM ＋ ST （84 individuals/m2）. The type of organic matter with C/N ratio ranged from 15.5 to 34.7 and cellulose content in 33.3%-40.1% gave better growth of earthworm. The effect of increase in earthworm growth on soil physical improvement is more apparent in the treatment of mixture of low quality and high quality organic matter. The increase of earthworm density and biomass enhanced soil macroporosity （from r = 0.683 to r = 0.606） and infiltration rate （from r = 0.669 to r = 0.756）. The results of this study suggest a mixture of CM ＋ ST or ST alone as organic matters, which is recommended to improve soil physical and biological quality of sugarcane land, with the dose application ranged from 10 Mg/ha to 15 Mg/ha.
基金Supported by the National Natural Science Foundation of China under Grant No 10774049, State Key Lab of Subtropical Building Science, South China University of Technology, and Guangdong Natural Science Foundation of China （Dr Startup Items）
文摘The omnidirectional character is one of important requirements for the sound source used in near-field head- related transfer function （HRTF） measurements. Based on the analysis on the radiation sound pressure and directivity character of various spherical polyhedron sound sources, a spherical dodecahedral sound source with radius of O. 035 m is proposed and manufactured. Theoretical and measured results indicate that the sound source is approximately omnidirectional below the frequency of 8 kHz. In addition, the sound source has reasonable magnitude response from 350Hz to 20 kHz and linear phase characteristics. Therefore, it is suitable for the near-field HRTF measurements.
基金Supported by the National Natural Science Foundation of China under Grant Nos 60776024, 60877035 and 90820002, tile National High-Technology Research and Development Program of China under Grant Nos 2007AA03Z427, 2007AA04Z329 and 2007AA04Z254.
文摘Development of minimally invasive dry electrodes for recording biopotentials is presented. The detailed fabrication process is outlined. A dry electrode is formed by a number of microneedles. The lengths of the microneedles are about 150μm and the diameters are about 50μm. The tips of the microneedles are sharp enough to penetrate into the skin. The silver/silver chloride is grown on microneedle arrays and demonstrates good character. The electrocardiogram shows that the dry electrode is suitable for recording biopotentials.
基金Supported by the National Natural Science Foundation of China under Grant Nos 20773043, 21073071 and 10979001, and the National Basic Research Program of China under Grant Nos 2005CB724400 and 2007CB808000.
文摘The mutant strains of aspergillus oryzae （HP300a） are screened under 300 MPa for 20min. Compared with the control strains, the screened mutant strains have unique properties such as genetic stability, rapid growth, lots of spores, and high protease activity. Random amplified polymorphic DNA （RAPD） and inter simple sequence repeats （ISSR） are used to analyze the DNA fingerprinting of HP300a and the control strains. There are 67.9% and 51.3% polymorphic bands obtained by these two markers, respectively, indicating significant genetic variations between HP300a and the control strains. In addition, comparison of HP300a arid the control strains, the genetic distances of random sequence and simple sequence repeat of DNA are 0.51 and 0.34, respectively.
基金Supported by the National Natural Science Foundation of China under Grant No 90403007.
文摘Neck linker （NL） is one of the most important mechanical elements of kinesin motors. The zipping up process of the neck-zipper （NZ） formed by NL and the related secondary structure elements is one of the major parts of kinesin＇s power stroke. All the weak interactions that are responsible for the formation of NZ are sensitive to or dependent on water. To investigate the role of water in the NZ region, a molecular dynamics （MD） model is set up with a crystal structure of kinesin 2KIN surrounded by a 10 A water layer, and minimization is performed to determine the positions of hydrogen atoms and other atoms. It is revealed that water molecules can assist the docking process of NL by forming hydrogen bonds at those positions where direct hydrogen bonding between the two sides of NZ is hindered and then acts as a constructive component of NZ at the docked state of NL. This result may improve the understanding of the mechanism for the docking of NL of kinesin wherein the function of water has not been comprehended sufficiently.
基金Supported by the National Basic Research Program under Grant Nos 2006CB910302 and 2007CB814806, the National Natural Science Foundation under Grant Nos 10834002 and 10774069, the Foundation for the Author of National Excellent Doctoral Dissertation of China, and the Fund of Jiangsu Province （BK2009008）.
文摘Zipping-and-assembly mechanism （ZAM） is a new mechanism describing the kinetics of protein folding. To dissect the validity of this mechanism for various protein-like systems, a prediction test based on three-dimensional HP lattice models is carried out. It is found that only the native structures of a part of protein-like models could be predicted with a ZAM-based method. The detailed comparisons between the model proteins which are predicted or failed with the ZAM-based method suggest that the ZAM is likely to be applicable for the model proteins with the weak hydrophobicity, the low contact order for native conformations, and the large separation between the energies of native state and denatured states. These observations bring us more information about the protein-like systems for which the ZAM could be applied.
基金Supported by the National Basic Research Program of China under Grant No 2006CB300404 and by the National Natural Science Foundation of China under Grant No 10502046.
文摘A worm-like chain model based on a spectrin network is employed to study the biomechanics of red blood cells. Coarse-grained molecular dynamics simulations are performed to obtain a stable configuration free of external loadings. We also discuss the influence of two parameters： the average bending modulus and the persistence length. The change in shape of a malaria-infected red blood cell can contribute to the change in its molecular-based structure. As the persistence length of the membrane network in the infected red blood cell decreases, the deformability decreases and the biconcave shape is destroyed. The numerical results are comparable with previously reported experimental results. The coarse-grained model can be used to study the relationship between macro-mechanical properties and molecular-scale structures of cells.
基金Supported by the National Natural Science Foundation of China under Grant Nos 30670533 and 10772101, and the National High Technology Research and Development Program under Grant No 2007AA02Z310.
文摘Dissolved cardiac myocytes can couple together and generate synchronous beatings in culture. We observed a synchronized early after-depolarization（EAD）-like rhythm in cultured cardiac myocytes and reproduced the experimental observation in a network mathematical model whose dynamics are close to a Hopf bifurcation. The mechanism for this EAD-like rhythm is attributed to noised-induced stochastic alternatings between the focus and the limit cycle. These results provide novel understandings for pathological heart rhythms like the early immature beatings.
基金Supported by the National Natural Science Foundation of China under Grant No 20873035.
文摘Growth of Antibody-Antigen complexes in a multivalent Antibody-Antigen system is studied by the Monte Carlo simulation method. The validity of the algorithm is first demonstrated for the case of the equal reactivity, then the simulation is presented for the case of unequal reactivity. It is shown that the influence of the unequal reactivity on the critical point, size distribution and the weight-average binding degree is significant. Especially, the gelation regions for the cases of unequal reactivity are studied, which can provide some useful clues for the immunological experiments.
基金Supported by the National Natural Science Foundation of China under Grant No 10872014.
文摘We examine how noise interacts with encoding mechanisms of neuronal stimulus in a cold receptor. From ISI series and bifurcation diagrams it is shown that there are considerable differences in interval distributions and impulse patterns caused by purely deterministic simulations and noisy simulations. The ISI-distance can be used as an effective and powerful way to measure the noise effects on spike trains of the cold receptor quantitatively. It is also found that spike trains observed in cold receptors can be more strongly affected by noise for low temperatures than for high temperatures in some aspects; meanwhile, the spike train has greater variability with increasing noise intensity.
基金Supported by the National Natural Science Foundation of China under Grant No 10975063, and the Fundamental Research Pund for Physics and Mathematics of Lanzhou University.
文摘We study the dynamics of tumor cell growth with time-delayed feedback driven by multiplicative noise in an asymmetrical bistable potential well. For a small delay time, the analytical solutions of the probability distribution and the first passage time show that, with the increasing delay time, the peak of the probability distribution in a lower population state would increase, but in a higher population state it decreases. It is shown that the multiplicative noise and the time delay play opposite roles in the tumor cell growth.
基金Supported by the National Natural Science Foundation of China under Grant Nos 60508004 and 60778043, and the Specialized Research Fund for the Doctoral Program of Higher Education of China under Grant No 20060055024.
文摘Binding of methylene blue （MB） and DNA, photosensitization of MB in DNA, and correlation of photosensiti- zation and binding mode are studied at different concentration ratios of DNA and MB. The absorption spectra indicate that the electrostatic binding is the main mode at low γ ratios （γ≤ 2）, while at high γ ratios （γ 〉 2） the intercalative binding is dominated. Mudies on dynamics of photosensitization formation of singlet oxygen （102） for MB in DNA are carried out by using＂ time-resolved technology. There are no obvious changes of the singlet oxygen lifetime and the triplet state MB molecule （MB3＋＊） lifetime at low ratios, they are about 4 μs and 1 μs, respectively. However, we could not obtain the 1 O2 lifetime and MB3＋＊ lifetime due to the great decrease of 1 O2 phosphorescence signals at high ratios. These results show that the photosensitization and binding mode of MB in DNA possess high correlation. When MB binds with DNA by electrostatic interaction, type-lI photosen- sitization of MB plays a major role in photodynamic effect, the damage of DNA probably could be ascribed to 1 O2. However, at high ratios, binding mode between MB and DNA turns to intercalative binding, which greatly weakens the type-Ⅱ photosensitization process. Charge transfer between MB and DNA possibly becomes the main damage mechanism.
文摘The possibility of formation of complexes between glycine and boron doped C60 （C59B） fullerene is investigated and compared with that of C60 fullerene by using the density functional theory calculations. It has been found that the binding of glycine to C59B generated the most stable complexes via its carbonyl oxygen active site, with a binding energy of-37.89 kcal/mol, while the glycine molecule prefers to bind to the pure C60 cage via its amino nitrogen active site, consistent with the recent experimental and theoretical studies. We have also tested the stability of the most stable Gly-C59B complex with ab initio molecular dynamics simulation, carried out at room temperature. These indicate that the B-doped C60 fullerenes seem to be more suitable materials for bindings to proteins than pure C60 fullerenes.
基金Supported by the High-Tech Research and Development Program of China under Grant No 2007AA05Z439, the National Basic Research Program of China under Grant No 2006CB202605, and the National Natural Science Foundation of China under Grant No 20873162.
文摘The introduction of poly（ether urethane） （PEUR） into polymer electrolyte based on poly（ethylene oxide）, LiI and I2, has significantly increased the ionic conductivity by nearly two orders of magnitudes. An increment of I3- diffusion coefficient is also observed. All-solid-state dye-sensitized solar cells are constructed using the polymer electrolytes. It was found that PEUR incorporation has a beneficial effect on the enhancement of open circuit voltage VOC by shifting the band edge of TiO2 to a negative value. Scanningelectron microscope images indicate the perfect interfacial contact between the TiO2 electrode and the blend electrolyte.
基金Supported by the National Natural Science Foundation of China under Grant Nos 10876032 and 10875099, Foundation of Sichuan Educational Committee under Grant No 08zb006, and the Research Fund of Southwest University of Science and Technology under Grant No 06ZX7113.
文摘We study the interaction between holes and molecular vibrations on dry DNA by using the extended Firsov＇s model. The ground state energy, calculated by using two Hilbert spaces, Fock state space and coherent state space, is confirmed. The polaron binding energy, defined with the ground state energy, is 0.014eV, much less than the thermal energy 0.026eV at room temperature 300K, which means that polarons are difficult to form self-trapping at room temperature and Anderson localization will prevent a metallic state on dry DNA. The results are consistent with the available experiments.
文摘We study the relation between the magnetic field structure and the induced electric-current distribution based on a cylindrical model composed of a uniform electrically conductive medium. When the time-varying magnetic fields are axisymmetrically applied in the axial direction of the model, the electric fields are induced around the central axis in accordance with Faradays law. We examine the eddy-current distributions generated by loop-coils with various geometries carrying an alternating electric current. It is shown that the radial structure of the induced fields can significantly be controlled by the loop coil geometry, which will be suitable for practical use especially in magnetic nerve stimulation on bioelectromagneties, if we appropriately p/ace the exciting coil with optimum geometry.
基金Supported by the National Natural Science Foundation of China under Grant No 10604060, and the Shanghai Supercomputer Center of China.
文摘Water confined into the interior channels of narrow carbon nanotubes or transmembrane proteins can form collectively oriented molecular chains held together by tight hydrogen bonds. We develop a quasi-one-dimensional model for a chain of water molecules which interact with each other via the Coulomb and power-like repulsive interactions. We explore the equilibrium property of the water chain and derive an exact analytical expression for the total interaction energy of the water chain, denoted by W（0）int. It is found that W（0）int is minimal when the distance between the two neighboring water molecules in a hydrogen-bonded chain is equal to 0.265 nm. The model is expected to be useful for studying analytically the properties of single-file water molecules inside water channels, such as the concerted motion of water molecules.
文摘A drug delivery system via multi-walled carbon nanotube （MWNT） vehicle was synthesized in aqueous solution. MWNTs were first noncovalently functionalized with chitosan oligomers （CS） with a molecule weight of 4000-6000, making MWNTs water-soluble, and then a cancer ancillary drug tea polyphenols （TP） was conjugated mainly via the hydrogen bond between CS and TP molecules, making MWNTs efficient vehicle for drug delivering. The release of drug molecules can be realized by pH variation and γ-radiation, leading to new methods for controlling drug release from carbon nanotubes carrier. Due to the high penetrability of γ-rays, γ-radiation shows up new opportunities in controlled drug release, possibly facilitating the future cancer treatment in vivo.
基金Supported by the National Natural Science Foundation under Grant No 10604034, the Natural Science Foundation of Zhejiang Province （Y606309）, Ningbo Natural Science Foundation （2006A610046）, and K. C. Wong Magna Fund in Ningbo University.
文摘The polarizabilities of DNA in transverse direction and CdSe semiconductor quantum dots （QDs） deposited on mica surface are compared by means of electrostatic force microscopy （EFM）. We observe clear EFM-phase shift over CdSe QDs, while no obvious signal on DNA is detected, suggesting that DNA molecules is an electrical insulator.
