Curriculum system construction is the core of talent training plan and the key to school operations.This article carried on a more in-depth study and discussion to biological curriculum system construction project,des...Curriculum system construction is the core of talent training plan and the key to school operations.This article carried on a more in-depth study and discussion to biological curriculum system construction project,described the four aspects characteristics of the curriculum,and discussed in the course of system integration, comprehensive and updated curriculum, bilingual education and the strengthening of the four areas to carry out comprehensive, innovative experiments.展开更多
Calcium phosphate cements(CPCs)are frequently used to repair bone defects.Since their discovery in the 1980s,extensive research has been conducted to improve their properties,and emerging evidence supports their incre...Calcium phosphate cements(CPCs)are frequently used to repair bone defects.Since their discovery in the 1980s,extensive research has been conducted to improve their properties,and emerging evidence supports their increased application in bone tissue engineering.Much effort has been made to enhance the biological performance of CPCs,including their biocompatibility,osteoconductivity,osteoinductivity,biodegradability,bioactivity,and interactions with cells.This review article focuses on the major recent developments in CPCs,including 3D printing,injectability,stem cell delivery,growth factor and drug delivery,and pre-vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis.展开更多
In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of d...In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of death from coronavirus disease 2019(COVID-19).In 2024,Kavli Prize recognizes the pioneering work of integrating engineered nanocarriers with biological functions for biomedical applications.The development of nanomedicine has changed the ways we approach the fundamental understand-ing,diagnosis,treatment,and prevention of diseases.These suc-cessful cases brought great excitement to the field of nanomedicine;however,many challenges still remain.In particular,it is critical to optimize nanocarriers to improve delivery effi-ciency and selectivity as well as reduce toxic side effects.展开更多
By enhancing surface interaction between metal oxide particles and carbon-based materials,it can effectively improve Faraday capacitance and conductivity,ultimately achieving high energy density with sufficient redox ...By enhancing surface interaction between metal oxide particles and carbon-based materials,it can effectively improve Faraday capacitance and conductivity,ultimately achieving high energy density with sufficient redox reactions in supercapacitors.Through a gentle biomineralization process and subsequent thermal reduction strategy,we successfully prepared the graphene oxide(GO)wrapping mixed-valence manganese oxides(MnO_(x))and S,P self-codoped carbon matrix porous composite(MnO_(x)@SPC@reduced graphene oxide(RGO)).During the biomineralization process of engineered Pseudomonas sp.(Ml)cells,GO nanosheets functioned as the'soil'to adsorb Mn^(2+)ion and uniformly disperse biogenic Mn oxides(BMO).After undergoing annealing,the MnO_(x) nanoparticles were evenly wrapped with graphene,resulting in the creation of the MnO_(x)@SPC@RGO3 composite.This composite possesses strong C—O—Mn bond interfaces,numerous electroactive sites,and a uniform pore structure.By optimizing the synergistic interaction between the highly conductive graphene and the remarkable surface capacitance of MnO_(x),the MnO_(x)@SPC@RGO3 electrode,with its intercalation Faraday reactions mechanism of■transformations,exhibits an outstanding specific capacity(448.3 F·g^(-1)at 0.5 A·g^(-1)),multiplying performance(340.5 F·g^(-1)at10 A·g^(-1)),and cycling stability(93.8%retention after 5000 cycles).Moreover,the asymmetric all-solidstate supercapacitors of MnO_(x)@SPC@RGO3//PC exhibit an exceptional energy density of 64.8 W·h·kg^(-1)and power density of 350 W·kg^(-1),as well as a long lifespan with capacitance retention of 92.5%after10000 cycles.In conclusion,the synthetic route utilizing biomineralization and thermal reduction exhibits significant potential for exploiting high-performance electrode materials in all-solid-state supercapacitor applications.展开更多
Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantifi...Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding.展开更多
Mixed strains Delftia sp.YH01 and Acidovorax sp.YH02,with capability of heterotrophic nitrification-aerobic denitrification,were introduced into a two-stage aerobic sequencing batch reactor to enhance NO3^--N removal....Mixed strains Delftia sp.YH01 and Acidovorax sp.YH02,with capability of heterotrophic nitrification-aerobic denitrification,were introduced into a two-stage aerobic sequencing batch reactor to enhance NO3^--N removal.With optimal C/N of 8,efficient NO3^--N removal was achieved at initial NO3^--N concentration of 2000 mg·L−1.Meanwhile,the massive accumulation of NO2^--N was avoided during the long operation.Compared to the one-stage aerobic sequencing batch reactor,the removal efficiency of NO3^--N and TN in the two-stage aerobic sequencing batch reactor was increased by 36.5% and 42.7%,which respectively was 93.8% and 88.4%.Microbial community study showed that the mixed strains have the stronger viability and can synergistically denitrify with the indigenous microorganisms in system,such as Azoarcus,Uncultured Saprospiraceae,Thauera,Paracocccus,which could be major contributors for aerobic denitrification.The proposed technology was shown to achieve high-efficiency treatment of high NO3^--N wastewater through aerobic denitrification.展开更多
Wool textile industry is now facing serious market environment. Ways to breakthrough may be: exerting special virtues of wool, e.g. degradable, ecological,comfortable etc.; inoculating of biological engineering, seeki...Wool textile industry is now facing serious market environment. Ways to breakthrough may be: exerting special virtues of wool, e.g. degradable, ecological,comfortable etc.; inoculating of biological engineering, seeking for clean production, producing green commodities; creating new market through innovations.展开更多
4-Hydroxyphenylpyruvic acid （4-HPPA）, a kind of α-keto acid, is an intermediate in the metabolism of tyrosine and has a wide range of application in food, pharmaceutical and chemical industry. Using amino acids as ...4-Hydroxyphenylpyruvic acid （4-HPPA）, a kind of α-keto acid, is an intermediate in the metabolism of tyrosine and has a wide range of application in food, pharmaceutical and chemical industry. Using amino acids as raw material to prod uce the corresponding α-keto acid is thought to be both economic and efficient. Among the enzymes that convert amino acid to α-keto acid, membrane bound L-amino acid deaminase （mL-AAD）, which is anchored to the outer side of the cytomembrane, becomes an ideal enzyme to prepare α-keto acid since there is no cofactors needed and H2O2 production during the reaction. In this study, the mL-AAD from Proteus vulgaris was used to prepare whole-cell catalysts to produce 4-HPPA from L-tyrosine. The secretory efficiency of mL-AAD conducted by its own twin-arginine signal peptide （twin-arginine translocation pathway, Tat） and integrated pelB （the general secretory pathway, Sec）-Tat signal peptide was determined and compared firstly, using two pET systems （pET28a and pET20b）. It was found that the Tat pathway （pET28a-mlaad） resulted in higher cell-associated mL-AAD activity and cell biomass, and was more beneficial to prepare biocatalyst. In addition, expression hosts BI21 （DE3） and 0.05 mmol. L- 1 IPTG were found to be suitable for mL-AAD expression. The reaction conditions for mL-AAD were optimized and 72.72 mmol,L 1 4-HPPA was obtained from 100 mmol.L 1 tyrosine in 10 h under the optimized conditions. This bioprocess, which is more eco-friendly and economical than the traditional chemical synthesis ways, has great potential for industrial application.展开更多
The school consists of four first-level interdisciplines： chemistry, biological science, chemical engineering and technology, and food science and engineering. There are three basic teaching divisions： chemistry, bi...The school consists of four first-level interdisciplines： chemistry, biological science, chemical engineering and technology, and food science and engineering. There are three basic teaching divisions： chemistry, biological science and chemical engineering; four research institutes： biological science and technology, food science and technology, chemical materials, and applied chemistry; four basic experimental teaching centers： biology, chemistry, chemical engineering and technique, and food science and engineering; and one food quality and safety testing and detecting center.展开更多
Aquatic viruses are naturally present in the aquatic environment and the number of viruses is staggering.Various multicellular organisms in aquatic ecosystems may be infected,cross-species transmitted,manipulated,and ...Aquatic viruses are naturally present in the aquatic environment and the number of viruses is staggering.Various multicellular organisms in aquatic ecosystems may be infected,cross-species transmitted,manipulated,and killed by aquatic viruses,which can lead to cascading ecological effects.The viruses in unicellular aquatic organisms can alter interactions between host individuals,and are essential in effecting or maintaining the dynamics of aquatic microbial communities,horizontal gene transfer,biodiversity,and modulating ecological processes globally.Meanwhile,hosts also impact viral abundance and diversity.Microbial diversity drives multifunctionality in ecosystems,while viruses shape complex microbial communities and are crucial for ecosystem functioning.This review focuses on molecular,genetic,evolutionary,and ecosystemic advances related to emerging and reemerging aquatic viruses,presents the contexts,novel tools,and investigative approaches pertaining to the study of aquatic virology,and discusses the mechanisms by which viruses affect aquatic ecosystems.The paper provides an efficient and broadly-based blueprint for improving understanding of aquatic viruses.展开更多
In 2024,all 186 papers published in the International Jourmal of Agricultural and Biological Engineering(UJABE)have been indexed and abstracted by the Web of Science Core Collection and other famous indexing databases...In 2024,all 186 papers published in the International Jourmal of Agricultural and Biological Engineering(UJABE)have been indexed and abstracted by the Web of Science Core Collection and other famous indexing databases in a timely manner.The total number of DOI resolutions of IJABE papers in the past 12 months from January 2024 to January 2025 reached 135958,with increasing international availability,visibility,and impact.The Fourth Term IJABE International Editorial Board was updated,and more outstanding young researchers,scientists,and scholars were recruited to be included in the editorial board.IJABE keeps bursting with new vitality.展开更多
The global“PhD glut”has emerged as a critical issue with the rapid expansion of doctoral education.This oversupply has caused challenges such as intense competition for academic positions and a decline in the percei...The global“PhD glut”has emerged as a critical issue with the rapid expansion of doctoral education.This oversupply has caused challenges such as intense competition for academic positions and a decline in the perceived value of doctoral degrees.To address these issues,a shift in the definition of the PhD is needed,moving towards a more versatile qualification that meets the evolving needs of society and the labor market.In the field of Agricultural and Biological Engineering(ABE),a“Solution-Driven PhD”model is proposed,integrating doctoral training with agricultural engineering enterprises and modern agricultural industry clusters.This paper explores the multifaceted challenges of the PhD glut,the need for redefining doctoral education,and the specific opportunities and strategies for transforming ABE doctoral programs to better align with global demands and future development needs.展开更多
The past 50 years have witnessed a massive expansion in the demand and application of pesticides.However,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a...The past 50 years have witnessed a massive expansion in the demand and application of pesticides.However,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many aspects.To aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment,chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a pollution.In recent years,bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide degradation.Combining the customized design strategy and standardized assembly mode,the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue degradation.This review introduces the mechanisms and hazards of different pesticides,summarizes the methods applied in the degradation of pesticide residues,and discusses the advantages,applications,and prospects of synthetic biology in degrading pesticide residues.展开更多
文摘Curriculum system construction is the core of talent training plan and the key to school operations.This article carried on a more in-depth study and discussion to biological curriculum system construction project,described the four aspects characteristics of the curriculum,and discussed in the course of system integration, comprehensive and updated curriculum, bilingual education and the strengthening of the four areas to carry out comprehensive, innovative experiments.
基金supported by NIH R01 DE14190 and R21 DE22625(HX)the National Science Foundation of China 81401794(PW)and 81400487(LW)+2 种基金the Youth Fund of Science and Technology of Jilin Province 20150520043JH(LW)the China Postdoctoral Science Foundation 2015M581405(LW)the University of Maryland School of Dentistry bridge fund(HX)
文摘Calcium phosphate cements(CPCs)are frequently used to repair bone defects.Since their discovery in the 1980s,extensive research has been conducted to improve their properties,and emerging evidence supports their increased application in bone tissue engineering.Much effort has been made to enhance the biological performance of CPCs,including their biocompatibility,osteoconductivity,osteoinductivity,biodegradability,bioactivity,and interactions with cells.This review article focuses on the major recent developments in CPCs,including 3D printing,injectability,stem cell delivery,growth factor and drug delivery,and pre-vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis.
文摘In 2023,Nobel Prize in Physiology/Medicine awarded the mRNA vaccine technology.The synthetic vaccine prepared by encapsu-lating the modified mRNA within cationic lipid nanocarriers signif-icantly reduces the risk of death from coronavirus disease 2019(COVID-19).In 2024,Kavli Prize recognizes the pioneering work of integrating engineered nanocarriers with biological functions for biomedical applications.The development of nanomedicine has changed the ways we approach the fundamental understand-ing,diagnosis,treatment,and prevention of diseases.These suc-cessful cases brought great excitement to the field of nanomedicine;however,many challenges still remain.In particular,it is critical to optimize nanocarriers to improve delivery effi-ciency and selectivity as well as reduce toxic side effects.
基金supported by the National Natural Science Foundation of China(31900005)the Fund of Science and Technology Department of Henan Province(242102231001,242102320362,242102320157)+1 种基金the Fund of Program for Innovative Research Team(in Science and Technology)in University of Henan Province(23IRTSTHN009)Fund of Key Scientific Research Projects of Higher Education Institutions in Henan Province(22A150048)。
文摘By enhancing surface interaction between metal oxide particles and carbon-based materials,it can effectively improve Faraday capacitance and conductivity,ultimately achieving high energy density with sufficient redox reactions in supercapacitors.Through a gentle biomineralization process and subsequent thermal reduction strategy,we successfully prepared the graphene oxide(GO)wrapping mixed-valence manganese oxides(MnO_(x))and S,P self-codoped carbon matrix porous composite(MnO_(x)@SPC@reduced graphene oxide(RGO)).During the biomineralization process of engineered Pseudomonas sp.(Ml)cells,GO nanosheets functioned as the'soil'to adsorb Mn^(2+)ion and uniformly disperse biogenic Mn oxides(BMO).After undergoing annealing,the MnO_(x) nanoparticles were evenly wrapped with graphene,resulting in the creation of the MnO_(x)@SPC@RGO3 composite.This composite possesses strong C—O—Mn bond interfaces,numerous electroactive sites,and a uniform pore structure.By optimizing the synergistic interaction between the highly conductive graphene and the remarkable surface capacitance of MnO_(x),the MnO_(x)@SPC@RGO3 electrode,with its intercalation Faraday reactions mechanism of■transformations,exhibits an outstanding specific capacity(448.3 F·g^(-1)at 0.5 A·g^(-1)),multiplying performance(340.5 F·g^(-1)at10 A·g^(-1)),and cycling stability(93.8%retention after 5000 cycles).Moreover,the asymmetric all-solidstate supercapacitors of MnO_(x)@SPC@RGO3//PC exhibit an exceptional energy density of 64.8 W·h·kg^(-1)and power density of 350 W·kg^(-1),as well as a long lifespan with capacitance retention of 92.5%after10000 cycles.In conclusion,the synthetic route utilizing biomineralization and thermal reduction exhibits significant potential for exploiting high-performance electrode materials in all-solid-state supercapacitor applications.
基金National Key Research and Development Project of China(2016YFD0102106)National Key Scientific Instrument and Equipment Project of National Natural Science Foundation of China(21627812).
文摘Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding.
基金supported by grants fromthe Science and Technology Planning Project of Guangzhou City,China(201903010031)the Natural Science Foundation Research Team Project of Guangdong Province,China(2016A030312009).
文摘Mixed strains Delftia sp.YH01 and Acidovorax sp.YH02,with capability of heterotrophic nitrification-aerobic denitrification,were introduced into a two-stage aerobic sequencing batch reactor to enhance NO3^--N removal.With optimal C/N of 8,efficient NO3^--N removal was achieved at initial NO3^--N concentration of 2000 mg·L−1.Meanwhile,the massive accumulation of NO2^--N was avoided during the long operation.Compared to the one-stage aerobic sequencing batch reactor,the removal efficiency of NO3^--N and TN in the two-stage aerobic sequencing batch reactor was increased by 36.5% and 42.7%,which respectively was 93.8% and 88.4%.Microbial community study showed that the mixed strains have the stronger viability and can synergistically denitrify with the indigenous microorganisms in system,such as Azoarcus,Uncultured Saprospiraceae,Thauera,Paracocccus,which could be major contributors for aerobic denitrification.The proposed technology was shown to achieve high-efficiency treatment of high NO3^--N wastewater through aerobic denitrification.
文摘Wool textile industry is now facing serious market environment. Ways to breakthrough may be: exerting special virtues of wool, e.g. degradable, ecological,comfortable etc.; inoculating of biological engineering, seeking for clean production, producing green commodities; creating new market through innovations.
基金Supported by the National Natural Science Foundation of China(31470793,31670804)China Postdoctoral Science Foundation(2016M592003)+1 种基金the Natural Science Foundation of Zhejiang Province(LZ13B060002)the General Scientific Research Project of Zhejiang Provincial Education Department(Y201432760)
文摘4-Hydroxyphenylpyruvic acid （4-HPPA）, a kind of α-keto acid, is an intermediate in the metabolism of tyrosine and has a wide range of application in food, pharmaceutical and chemical industry. Using amino acids as raw material to prod uce the corresponding α-keto acid is thought to be both economic and efficient. Among the enzymes that convert amino acid to α-keto acid, membrane bound L-amino acid deaminase （mL-AAD）, which is anchored to the outer side of the cytomembrane, becomes an ideal enzyme to prepare α-keto acid since there is no cofactors needed and H2O2 production during the reaction. In this study, the mL-AAD from Proteus vulgaris was used to prepare whole-cell catalysts to produce 4-HPPA from L-tyrosine. The secretory efficiency of mL-AAD conducted by its own twin-arginine signal peptide （twin-arginine translocation pathway, Tat） and integrated pelB （the general secretory pathway, Sec）-Tat signal peptide was determined and compared firstly, using two pET systems （pET28a and pET20b）. It was found that the Tat pathway （pET28a-mlaad） resulted in higher cell-associated mL-AAD activity and cell biomass, and was more beneficial to prepare biocatalyst. In addition, expression hosts BI21 （DE3） and 0.05 mmol. L- 1 IPTG were found to be suitable for mL-AAD expression. The reaction conditions for mL-AAD were optimized and 72.72 mmol,L 1 4-HPPA was obtained from 100 mmol.L 1 tyrosine in 10 h under the optimized conditions. This bioprocess, which is more eco-friendly and economical than the traditional chemical synthesis ways, has great potential for industrial application.
文摘The school consists of four first-level interdisciplines： chemistry, biological science, chemical engineering and technology, and food science and engineering. There are three basic teaching divisions： chemistry, biological science and chemical engineering; four research institutes： biological science and technology, food science and technology, chemical materials, and applied chemistry; four basic experimental teaching centers： biology, chemistry, chemical engineering and technique, and food science and engineering; and one food quality and safety testing and detecting center.
基金supported by the National Key R&D Plan of the Ministry of Science and Technology,China(2018YFA0903101,2018YFD0900302)the Key Program of Frontier Sciences of the Chinese Academy of Sciences(KJZD-SW-L11).
文摘Aquatic viruses are naturally present in the aquatic environment and the number of viruses is staggering.Various multicellular organisms in aquatic ecosystems may be infected,cross-species transmitted,manipulated,and killed by aquatic viruses,which can lead to cascading ecological effects.The viruses in unicellular aquatic organisms can alter interactions between host individuals,and are essential in effecting or maintaining the dynamics of aquatic microbial communities,horizontal gene transfer,biodiversity,and modulating ecological processes globally.Meanwhile,hosts also impact viral abundance and diversity.Microbial diversity drives multifunctionality in ecosystems,while viruses shape complex microbial communities and are crucial for ecosystem functioning.This review focuses on molecular,genetic,evolutionary,and ecosystemic advances related to emerging and reemerging aquatic viruses,presents the contexts,novel tools,and investigative approaches pertaining to the study of aquatic virology,and discusses the mechanisms by which viruses affect aquatic ecosystems.The paper provides an efficient and broadly-based blueprint for improving understanding of aquatic viruses.
文摘In 2024,all 186 papers published in the International Jourmal of Agricultural and Biological Engineering(UJABE)have been indexed and abstracted by the Web of Science Core Collection and other famous indexing databases in a timely manner.The total number of DOI resolutions of IJABE papers in the past 12 months from January 2024 to January 2025 reached 135958,with increasing international availability,visibility,and impact.The Fourth Term IJABE International Editorial Board was updated,and more outstanding young researchers,scientists,and scholars were recruited to be included in the editorial board.IJABE keeps bursting with new vitality.
文摘The global“PhD glut”has emerged as a critical issue with the rapid expansion of doctoral education.This oversupply has caused challenges such as intense competition for academic positions and a decline in the perceived value of doctoral degrees.To address these issues,a shift in the definition of the PhD is needed,moving towards a more versatile qualification that meets the evolving needs of society and the labor market.In the field of Agricultural and Biological Engineering(ABE),a“Solution-Driven PhD”model is proposed,integrating doctoral training with agricultural engineering enterprises and modern agricultural industry clusters.This paper explores the multifaceted challenges of the PhD glut,the need for redefining doctoral education,and the specific opportunities and strategies for transforming ABE doctoral programs to better align with global demands and future development needs.
基金supported by the National Natural Science Foundation of China(No.22278343)Shenzhen Basic Research Project(JCYJ20190809160209449).
文摘The past 50 years have witnessed a massive expansion in the demand and application of pesticides.However,pesticides are difficult to be completely degraded without intervention hence the pesticide residue could pose a persistent threat to non-target organisms in many aspects.To aim at the problem of the abuse of pesticide products and excessive pesticide residues in the environment,chemical and biological degradation methods are widely developed but are scaled and insufficient to solve such a pollution.In recent years,bio-degradative tools instructed by synthetic biological principles have been further studied and have paved a way for pesticide degradation.Combining the customized design strategy and standardized assembly mode,the engineering bacteria for multi-dimensional degradation has become an effective tool for pesticide residue degradation.This review introduces the mechanisms and hazards of different pesticides,summarizes the methods applied in the degradation of pesticide residues,and discusses the advantages,applications,and prospects of synthetic biology in degrading pesticide residues.
