Killing bacteria,eliminating biofilm and building soft tissue integration are very important for percutaneous implants which service in a complicated environment.In order to endow Ti implants with above abilities,mult...Killing bacteria,eliminating biofilm and building soft tissue integration are very important for percutaneous implants which service in a complicated environment.In order to endow Ti implants with above abilities,multifunctional coatings consisted of Fe_(2)O_(3)-FeOOH nanograins as an outer layer and Zn doped microporous TiO2 as an inner layer were fabricated by micro-arc oxidation,hydrothermal treatment and annealing treatment.The microstructures,physicochemical properties and photothermal response of the coatings were observed;their antibacterial efficiencies and cell response in vitro as well as biofilm elimination and soft tissue integration in vivo were evaluated.The results show that with the increased annealing temperature,coating morphologies didn’t change obviously,but lattices of β-FeOOH gradually disorganized into amorphous state and rearranged to form Fe_(2)O_(3).The coating annealed at 450℃(MA450)had nanocrystallized Fe_(2)O_(3) and β-FeOOH.With a proper NIR irradiation strategy,MA450 killed adhered bacteria efficiently and increased fibroblast behaviors via up-regulating fibrogenic-related genes in vitro;in an infected model,MA450 eliminated biofilm,reduced inflammatory response and improved biointegration with soft tissue.The good performance of MA450 was due to a synergic effect of photothermal response and released ions(Zn^(2+)and Fe^(3+)).展开更多
In this paper,the surface of zirconium implant was improved by growing zirconium oxide nanotubes using a simple chemical method to increase the surface porosity and thus increase the effectiveness of bone fusion.Histo...In this paper,the surface of zirconium implant was improved by growing zirconium oxide nanotubes using a simple chemical method to increase the surface porosity and thus increase the effectiveness of bone fusion.Histopathological examinations showed the filling of the bone lakes at the implant site with live bone cells and the penetration of Haversian canals into the blood vessels.EDXS profile confirmed the signal characteristic of zirconium and oxygen.EDXS profile is another evidence of pure ZrO_(2) nanotubes formation.EDXS presents peaks between 0.525 and 2.044 kV,which indicate the presence of ZrO_(2) nanotubes.SEM result showed that homogeneous nanotubes are less in diameter with increasing concentration of glycerine.展开更多
3D printed polyether-ether-ketone(PEEK)implant has become a popular clinical alternative to implants made of titanium alloy for cranial bone substitutes due to its bone-match properties,however its biological inert hi...3D printed polyether-ether-ketone(PEEK)implant has become a popular clinical alternative to implants made of titanium alloy for cranial bone substitutes due to its bone-match properties,however its biological inert hin-dered the progress of clinical applications of such material.To enhance the tissue integration capability of PEEK implants and promote their long-term stability,cranial implants of gradient porous structures were designed and manufactured via fused filament fabrication(FFF)3D printing technology in both PEEK and PEEK/HA com-posites materials,then functionally evaluation of the implants on the tissue in-growth and the osteointegration mechanisms was conducted via animal tests.The 3D printed PEEK scaffold was found to have 2-5 folds of the compressive strength to those of the natural cranial bone.The in vivo studies verified that the porous PEEK/HA scaffold could effectively induce the bone ingrowth to form a stable biointegration boundary surrounding the host bone tissue after 4 weeks of implantation.Moreover,the PEEK/HA scaffold showed no significant advantages in improving the soft tissue in-growth,only making its distribution more evenly.It is also interestingly to find out that the vertically connective pores throughout the implant did not enhance the tissue binding force even though it did promote the nutrient transportation.In conclusion,the use of PEEK/HA composite material and a well-designed porous structure was proved to be an effective approach to improve the biointegration between the implant and host tissues.展开更多
With the prevalence of cardiovascular disease,it is imperative that medical monitoring and treatment become more instantaneous and comfortable for patients.Recently,wearable and implantable optoelectronic devices can ...With the prevalence of cardiovascular disease,it is imperative that medical monitoring and treatment become more instantaneous and comfortable for patients.Recently,wearable and implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological monitoring and treatment in an imperceptible and spatiotemporally unconstrained manner,opening countless possibilities for the intelligent healthcare paradigm.To achieve biointegrated cardiac healthcare,researchers have focused on novel strategies for the construction of flexible/stretchable optoelectronic devices and systems.Here,we overview the progress of biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare devices.Firstly,the device design is addressed,including the mechanical design,interface adhesion,and encapsulation strategies.Next,the practical applications of optoelectronic devices for cardiac physiological monitoring,cardiac optogenetics,and nongenetic stimulation are presented.Finally,an outlook on biointegrated flexible and stretchable optoelectronic devices and systems for intelligent cardiac healthcare is discussed.展开更多
Next-generation electronics that are fused into the human body can play a key role in future intelligent communication,smart healthcare,and human enhancement applications.As a promising energy supply component for sma...Next-generation electronics that are fused into the human body can play a key role in future intelligent communication,smart healthcare,and human enhancement applications.As a promising energy supply component for smart biointegrated electronics,environment-adaptive electrochemical energy storage(EES)devices with complementary adaptability and functions have garnered huge interest in the past decade.Owing to the advancements in autonomous chemistry,which regulate the constitutional dynamic networks in materials,EES devices have witnessed higher freedom of autonomous adaptability in terms of mechano-adaptable,biocompatibility,and stimuli-response properties for biointegrated and smart applications.In this mini-review,we summarize the recent progress in emerging environmentadaptive EES devices enabled by the constitutional dynamic network of mechanical adaptable materials,biocompatible materials,and stimuli-responsive supramolecular polymer materials.Finally,the challenges and perspectives of autonomous chemistry on the environment-adaptive EES devices are discussed.展开更多
基金the National Natural Science Foundation of China(Grant No.51771142,51631007,51971171,82072075)National Key Research and Development Program of China No.2016YFC1100600(sub-project.2016YFC1100604)Natural Science Foundation of Shaanxi Province(No.2020JM-024,2021JC-07,2019TD-020)for financially supporting this work.
文摘Killing bacteria,eliminating biofilm and building soft tissue integration are very important for percutaneous implants which service in a complicated environment.In order to endow Ti implants with above abilities,multifunctional coatings consisted of Fe_(2)O_(3)-FeOOH nanograins as an outer layer and Zn doped microporous TiO2 as an inner layer were fabricated by micro-arc oxidation,hydrothermal treatment and annealing treatment.The microstructures,physicochemical properties and photothermal response of the coatings were observed;their antibacterial efficiencies and cell response in vitro as well as biofilm elimination and soft tissue integration in vivo were evaluated.The results show that with the increased annealing temperature,coating morphologies didn’t change obviously,but lattices of β-FeOOH gradually disorganized into amorphous state and rearranged to form Fe_(2)O_(3).The coating annealed at 450℃(MA450)had nanocrystallized Fe_(2)O_(3) and β-FeOOH.With a proper NIR irradiation strategy,MA450 killed adhered bacteria efficiently and increased fibroblast behaviors via up-regulating fibrogenic-related genes in vitro;in an infected model,MA450 eliminated biofilm,reduced inflammatory response and improved biointegration with soft tissue.The good performance of MA450 was due to a synergic effect of photothermal response and released ions(Zn^(2+)and Fe^(3+)).
文摘In this paper,the surface of zirconium implant was improved by growing zirconium oxide nanotubes using a simple chemical method to increase the surface porosity and thus increase the effectiveness of bone fusion.Histopathological examinations showed the filling of the bone lakes at the implant site with live bone cells and the penetration of Haversian canals into the blood vessels.EDXS profile confirmed the signal characteristic of zirconium and oxygen.EDXS profile is another evidence of pure ZrO_(2) nanotubes formation.EDXS presents peaks between 0.525 and 2.044 kV,which indicate the presence of ZrO_(2) nanotubes.SEM result showed that homogeneous nanotubes are less in diameter with increasing concentration of glycerine.
基金supported by National Natural Science Foundation of China(Grant.Nos.51835010,12202347)Natural Science Basic Research Program of Shaanxi Province of China(Grant.No.2022JQ-378)+1 种基金Fundamental Research Funds for the Central Universities and the Program for Innovation Team of Shaanxi Province of China(Grant.No.2023-CX-TD-17)Natural Science Foundation of Guangdong Province of China(Grant.No.2022A1515012552).
文摘3D printed polyether-ether-ketone(PEEK)implant has become a popular clinical alternative to implants made of titanium alloy for cranial bone substitutes due to its bone-match properties,however its biological inert hin-dered the progress of clinical applications of such material.To enhance the tissue integration capability of PEEK implants and promote their long-term stability,cranial implants of gradient porous structures were designed and manufactured via fused filament fabrication(FFF)3D printing technology in both PEEK and PEEK/HA com-posites materials,then functionally evaluation of the implants on the tissue in-growth and the osteointegration mechanisms was conducted via animal tests.The 3D printed PEEK scaffold was found to have 2-5 folds of the compressive strength to those of the natural cranial bone.The in vivo studies verified that the porous PEEK/HA scaffold could effectively induce the bone ingrowth to form a stable biointegration boundary surrounding the host bone tissue after 4 weeks of implantation.Moreover,the PEEK/HA scaffold showed no significant advantages in improving the soft tissue in-growth,only making its distribution more evenly.It is also interestingly to find out that the vertically connective pores throughout the implant did not enhance the tissue binding force even though it did promote the nutrient transportation.In conclusion,the use of PEEK/HA composite material and a well-designed porous structure was proved to be an effective approach to improve the biointegration between the implant and host tissues.
基金financially supported by the National Key R&D Program of China(2023YFB3609000)the Strategic Priority Research Program of CAS(XDB0520101)+3 种基金the National Natural Science Foundation of China(U22A6002 and 22173109)the CAS Project for Young Scientists in Basic Research(YSBR-053)the CAS-Croucher Scheme for Joint Laboratoriesthe CAS Cooperation Project(121111KYSB20200036).
文摘With the prevalence of cardiovascular disease,it is imperative that medical monitoring and treatment become more instantaneous and comfortable for patients.Recently,wearable and implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological monitoring and treatment in an imperceptible and spatiotemporally unconstrained manner,opening countless possibilities for the intelligent healthcare paradigm.To achieve biointegrated cardiac healthcare,researchers have focused on novel strategies for the construction of flexible/stretchable optoelectronic devices and systems.Here,we overview the progress of biointegrated flexible and stretchable optoelectronics for wearable and implantable cardiac healthcare devices.Firstly,the device design is addressed,including the mechanical design,interface adhesion,and encapsulation strategies.Next,the practical applications of optoelectronic devices for cardiac physiological monitoring,cardiac optogenetics,and nongenetic stimulation are presented.Finally,an outlook on biointegrated flexible and stretchable optoelectronic devices and systems for intelligent cardiac healthcare is discussed.
基金This work was financially supported by the Agency for Science,Technology and Research(A*STAR)under its AME Programmatic Funding Scheme of CyberPhysiochemical Interfaces Programme(Project No.A18A1b0045)。
文摘Next-generation electronics that are fused into the human body can play a key role in future intelligent communication,smart healthcare,and human enhancement applications.As a promising energy supply component for smart biointegrated electronics,environment-adaptive electrochemical energy storage(EES)devices with complementary adaptability and functions have garnered huge interest in the past decade.Owing to the advancements in autonomous chemistry,which regulate the constitutional dynamic networks in materials,EES devices have witnessed higher freedom of autonomous adaptability in terms of mechano-adaptable,biocompatibility,and stimuli-response properties for biointegrated and smart applications.In this mini-review,we summarize the recent progress in emerging environmentadaptive EES devices enabled by the constitutional dynamic network of mechanical adaptable materials,biocompatible materials,and stimuli-responsive supramolecular polymer materials.Finally,the challenges and perspectives of autonomous chemistry on the environment-adaptive EES devices are discussed.
