Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelect...Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelectronic devices are now utilized as independent therapeutic interventions or as adjunct treatments,and their applications continue to expand.This article briefly outlines the discovery process of several common electrophysiological signals in the human body and focuses on diverse electrical stimulation technologies.Their applications in the nervous system,cancer treatment,tissue regeneration and repair,and cardiovascular therapy are discussed,along with the underlying mechanisms of action.Furthermore,the rapid development of artificial intelligence and technological innovation has significantly broadened the scope and application of bioelectronic medicine.Finally,the current limitations and future prospects of bioelectronic medicine are explored.展开更多
The currently reported conductive hydrogels are mainly used to detect the mechanical signals of human movement,whereas the application of detecting weak electrophysiological signals in epidermal electrodes is still li...The currently reported conductive hydrogels are mainly used to detect the mechanical signals of human movement,whereas the application of detecting weak electrophysiological signals in epidermal electrodes is still limited by a low signal-to-noise ratio and motion artifacts.In this study,a one-pot method was used to prepare a hydrogel conductor with excellent flexibility,self-adhesiveness,and compliance by introducing chitosan quaternary ammonium salt(HAAC)and 2-acrylamide-2-methylpropanesulfonic acid(AMPS)into the polyacrylamide(PAAm)hydrogel network.By adjusting the AMPS and HAAC contents,the hydrogel showed skin-like mechanical properties and surface adhesion,successfully eliminating the gap with the skin surface.The self-adhesive hydrogel showed a lower impedance(approximately 190 kΩ)than commercial Ag/AgCl electrodes.Notably,the hydrogel electrodes exhibited a significantly higher signal-to-noise ratio(SNR)than the commercial electrodes at the same level of muscle contraction.The hydrogel electrodes could accurately detect dynamic weak EMG signals and successfully drive the prosthetic hand to grasp without errors.Importantly,the combination of hydrogel strain sensors and epidermal electrodes can quantify the mode,frequency,and intensity of human movement,which has broad application prospects in data acquisition for daily exercise,fitness,and rehabilitation.展开更多
The development of non-invasive brain-computer interfaces(BCIs)relies on multidisciplinary integration across neuroscience,artificial intelligence,flexible electronics,and systems engineering.Recent advances in deep l...The development of non-invasive brain-computer interfaces(BCIs)relies on multidisciplinary integration across neuroscience,artificial intelligence,flexible electronics,and systems engineering.Recent advances in deep learning have significantly improved the accuracy and robustness of neural signal decoding.Parallel progress in electrode design—particularly through the use of flexible and stretchable materials like nanostructured conductors and novel fabrication strategies—has enhanced wearability and operational stability.Nevertheless,key challenges persist,including individual variability,biocompatibility limitations,and susceptibility to interference in complex environments.Further validation and optimization are needed to address gaps in generalization capability,long-term reliability,and real-world operational robustness.This review systematically examines the representative progress in neural decoding algorithms and flexible bioelectronic platforms over the past decade,highlighting key design principles,material innovations,and integration strategies that are poised to advance non-invasive BCI capabilities.It also discusses the importance of multimodal data fusion,hardware-software co-optimization,and closed-loop control strategies.Furthermore,the review discusses the application potential and associated engineering challenges of this technology in clinical rehabilitation and industrial translation,aiming to provide a reference for advancing non-invasive BCIs toward practical and scalable deployment.展开更多
The inherent complexities of excitable cardiac,nervous,and skeletal muscle tissues pose great challenges in constructing artificial counterparts that closely resemble their natural bioelectrical,structural,and mechani...The inherent complexities of excitable cardiac,nervous,and skeletal muscle tissues pose great challenges in constructing artificial counterparts that closely resemble their natural bioelectrical,structural,and mechanical properties.Recent advances have increasingly revealed the beneficial impact of bioelectrical microenvironments on cellular behaviors,tissue regeneration,and therapeutic efficacy for excitable tissues.This review aims to unveil the mechanisms by which electrical microenvironments enhance the regeneration and functionality of excitable cells and tissues,considering both endogenous electrical cues from electroactive biomaterials and exogenous electrical stimuli from external electronic systems.We explore the synergistic effects of these electrical microenvironments,combined with structural and mechanical guidance,on the regeneration of excitable tissues using tissue engineering scaffolds.Additionally,the emergence of micro/nanoscale bioelectronics has significantly broadened this field,facilitating intimate interactions between implantable bioelectronics and excitable tissues across cellular,tissue,and organ levels.These interactions enable precise data acquisition and localized modulation of cell and tissue functionalities through intricately designed electronic components according to physiological needs.The integration of tissue engineering and bioelectronics promises optimal outcomes,highlighting a growing trend in developing living tissue construct-bioelectronic hybrids for restoring and monitoring damaged excitable tissues.Furthermore,we envision critical challenges in engineering the next-generation hybrids,focusing on integrated fabrication strategies,the development of ionic conductive biomaterials,and their convergence with biosensors.展开更多
Despite the promising progress in conductive hydrogels made with pure conducting polymer,great challenges remain in the interface adhesion and robustness in longterm monitoring.To address these challenges,Prof.Seung H...Despite the promising progress in conductive hydrogels made with pure conducting polymer,great challenges remain in the interface adhesion and robustness in longterm monitoring.To address these challenges,Prof.Seung Hwan Ko and Taek-Soo Kim’s team introduced a laserinduced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer substrates.The laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm^(−1) with a spatial resolution down to 5μm.Moreover,they maintain impedance and charge-storage capacity even after 1 h of sonication.The micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings,highlighting their promising role in the field of bioelectronics.展开更多
Bionic hydrogels offer significant advantages over conventional counterparts,boasting superior properties like enhanced adhesion,stretchability,conductivity,biocompatibility and versatile functionalities.Their physico...Bionic hydrogels offer significant advantages over conventional counterparts,boasting superior properties like enhanced adhesion,stretchability,conductivity,biocompatibility and versatile functionalities.Their physicochemical resemblance to biological tissues makes bionic hydrogels ideal interfaces for bioelectronic devices.In contrast,conventional hydrogels often exhibit inadequate performance,such as easy detachment,lack of good skin compliance,and inadequate conductivity,failing to meet the rigorous demands of bioelectronic applications.Bionic hydrogels,inspired by biological designs,exhibit exceptional physicochemical characteristics that fulfill diverse criteria for bioelectronic applications,driving the advancement of bioelectronic devices.This review first introduces a variety of materials used in the fabrication of bionic hydrogels,including natural polymers,synthetic polymers,and other materials.Then different mechanisms of hydrogel bionics,are categorized into material bionics,structural bionics,and functional bionics based on their bionic approaches.Subsequently,various applications of bionic hydrogels in the field of bioelectronics were introduced,including physiological signal monitoring,tissue engineering,and human-machine interactions.Lastly,the current development and future prospects of bionic hydrogels in bioelectronic devices are summarized.Hopefully,this comprehensive review could inspire advancements in bionic hydrogels for applications in bioelectronic devices.展开更多
Ultra-thin crystalline silicon stands as a cornerstone material in the foundation of modern micro and nano electronics.Despite the proliferation of various materials including oxide-based,polymer-based,carbon-based,an...Ultra-thin crystalline silicon stands as a cornerstone material in the foundation of modern micro and nano electronics.Despite the proliferation of various materials including oxide-based,polymer-based,carbon-based,and two-dimensional(2D)materials,crystal silicon continues to maintain its stronghold,owing to its superior functionality,scalability,stability,reliability,and uniformity.Nonetheless,the inherent rigidity of the bulk silicon leads to incompatibility with soft tissues,hindering the utilization amid biomedical applications.Because of such issues,decades of research have enabled successful utilization of various techniques to precisely control the thickness and morphology of silicon layers at the scale of several nanometres.This review provides a comprehensive exploration on the features of ultra-thin single crystalline silicon as a semiconducting material,and its role especially among the frontier of advanced bioelectronics.Key processes that enable the transition of rigid silicon to flexible form factors are exhibited,in accordance with their chronological sequence.The inspected stages span both prior and subsequent to transferring the silicon membrane,categorized respectively as on-wafer manufacturing and rigid-to-soft integration.Extensive guidelines to unlock the full potential of flexible electronics are provided through ordered analysis of each manufacturing procedure,the latest findings of biomedical applications,along with practical perspectives for researchers and manufacturers.展开更多
Neuromorphic computing has the potential to overcome limitations of traditional silicon technology in machine learning tasks.Recent advancements in large crossbar arrays and silicon-based asynchronous spiking neural n...Neuromorphic computing has the potential to overcome limitations of traditional silicon technology in machine learning tasks.Recent advancements in large crossbar arrays and silicon-based asynchronous spiking neural networks have led to promising neuromorphic systems.However,developing compact parallel computing technology for integrating artificial neural networks into traditional hardware remains a challenge.Organic computational materials offer affordable,biocompatible neuromorphic devices with exceptional adjustability and energy-efficient switching.Here,the review investigates the advancements made in the development of organic neuromorphic devices.This review explores resistive switching mechanisms such as interface-regulated filament growth,molecular-electronic dynamics,nanowire-confined filament growth,and vacancy-assisted ion migration,while proposing methodologies to enhance state retention and conductance adjustment.The survey examines the challenges faced in implementing low-power neuromorphic computing,e.g.,reducing device size and improving switching time.The review analyses the potential of these materials in adjustable,flexible,and low-power consumption applications,viz.biohybrid spiking circuits interacting with biological systems,systems that respond to specific events,robotics,intelligent agents,neuromorphic computing,neuromorphic bioelectronics,neuroscience,and other applications,and prospects of this technology.展开更多
Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanopar...Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles(CP NPs),while endowing the CP NPs with redox activity and biocompatibility.This is a universal strategy applicable for a series of CPs,including polyaniline,polypyrrole,and poly(3,4-ethylenedioxythiophene).The catechol/quinone contained sulfonated lignin(LS)was doped into various CPs to form CP/LS NPs with hydrophilicity,conductivity,and redox activity.These CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term adhesiveness.The CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network,forming a well-connected electric path.The hydrogel exhibits long-term adhesiveness,which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS NPs.This conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics.展开更多
Developing techniques to effectively and real-time monitor and regulate the interior environment of biological objects is significantly important for many biomedical engineering and scientific applications, including ...Developing techniques to effectively and real-time monitor and regulate the interior environment of biological objects is significantly important for many biomedical engineering and scientific applications, including drug delivery, electrophysiological recording and regulation of intracellular activities. Semi-implantable bioelectronics is currently a hot spot in biomedical engineering research area, because it not only meets the increasing technical demands for precise detection or regulation of biological activities, but also provides a desirable platform for externally incorporating complex functionalities and electronic integration. Although there is less definition and summary to distinguish it from the well-reviewed non-invasive bioelectronics and fully implantable bioelectronics, semi-implantable bioelectronics have emerged as highly unique technology to boost the development of biochips and smart wearable device. Here, we reviewed the recent progress in this field and raised the concept of “Semi-implantable bioelectronics”, summarizing the principle and strategies of semi-implantable device for cell applications and in vivo applications, discussing the typical methodologies to access to intracellular environment or in vivo environment, biosafety aspects and typical applications. This review is meaningful for understanding in-depth the design principles, materials fabrication techniques, device integration processes, cell/tissue penetration methodologies, biosafety aspects, and applications strategies that are essential to the development of future minimally invasive bioelectronics.展开更多
An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management.Nevertheless,conventional dressings ...An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management.Nevertheless,conventional dressings and skin bioelectronics with single function,mechanical mismatches,and impracticality severely limit their widespread applications in clinical.Herein,we explore a gelling mechanism,fabrication method,and functionalization for broadly applicable food biopolymers-based biogels that unite the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single system.We combine our biogels with functional nanomaterials,such as cuttlefish ink nanoparticles and silver nanowires,to endow the biogels with reactive oxygen species scavenging capacity and electrical conductivity,and finally realized the improvement in diabetic wound microenvironment and the monitoring of electrophysiological signals on skin.This line of research work sheds light on preparing food biopolymers-based biogels with multifunctional integration of wound treatment and smart medical treatment.展开更多
With the growing market of wearable devices for smart sensing and personalized healthcare applications,energy storage devices that ensure stable power supply and can be constructed in flexible platforms have attracted...With the growing market of wearable devices for smart sensing and personalized healthcare applications,energy storage devices that ensure stable power supply and can be constructed in flexible platforms have attracted tremendous research interests.A variety of active materials and fabrication strategies of flexible energy storage devices have been intensively studied in recent years,especially for integrated self-powered systems and biosensing.A series of materials and applications for flexible energy storage devices have been studied in recent years.In this review,the commonly adopted fabrication methods of flexible energy storage devices are introduced.Besides,recent advances in integrating these energy devices into flexible self-powered systems are presented.Furthermore,the applications of flexible energy storage devices for biosensing are summarized.Finally,the prospects and challenges of the self-powered sensing system for wearable electronics are discussed.展开更多
The peripheral nervous system plays a major role in the maintenance of our physiology. Several peripheral nerves intimately regulate the state of the brain, spinal cord, and visceral systems. A new class of therapeuti...The peripheral nervous system plays a major role in the maintenance of our physiology. Several peripheral nerves intimately regulate the state of the brain, spinal cord, and visceral systems. A new class of therapeutics, called bioelectronic medicines, are being developed to precisely regulate physiology and treat dysfunction using peripheral nerve stimulation. In this review, we first discuss new work using closed-loop bioelectronic medicine to treat upper limb paralysis. In contrast to open-loop bioelectronic medicines, closed-loop approaches trigger ‘on demand' peripheral nerve stimulation due to a change in function(e.g., during an upper limb movement or a change in cardiopulmonary state). We also outline our perspective on timing rules for closedloop bioelectronic stimulation, interface features for non-invasively stimulating peripheral nerves, and machine learning algorithms to recognize disease events for closed-loop stimulation control. Although there will be several challenges for this emerging field, we look forward to future bioelectronic medicines that can autonomously sense changes in the body, to provide closed-loop peripheral nerve stimulation and treat disease.展开更多
The integration of electronics and biology has spawned bioelectronics and opened exciting opportunities to fulfill the unmet needs of therapeutic treatments.Recent developments in nanoelectronics and soft and biocompa...The integration of electronics and biology has spawned bioelectronics and opened exciting opportunities to fulfill the unmet needs of therapeutic treatments.Recent developments in nanoelectronics and soft and biocompatible materials have shown potential applicability to clinical practices,including physiological sensing,drug delivery,cardiovascular monitoring,and brain stimulation.To date,most bioelectronic devices require wired connections for electrical control,making their implantation complicated and inconvenient for patients.As an alternative,wireless technology is proliferating to create bioelectronics that offer noninvasive control,biotelemetry,and wireless power transfer(WPT).This review paper provides a comprehensive overview of wireless bioelectronics and ongoing developments in their applications for organ-specific treatments,including disorders and dysfunctions.The main emphasis is on delineating the key features of antennas,namely their radiation characteristics,materials,integration with rest of the electronics,and experimental setup.Although the recent progress in wireless mediated bioelectronics is expected to enhance the control of its functionalities,there are still numerous challenges that need to be addressed for commercialization,as well as to address everexpanding and evolving future therapeutic targets.展开更多
The development of precise and sensitive electrophysiological recording platforms holds the utmost importance for research in the fields of cardiology and neuroscience.In recent years,active micro/nano-bioelectronic d...The development of precise and sensitive electrophysiological recording platforms holds the utmost importance for research in the fields of cardiology and neuroscience.In recent years,active micro/nano-bioelectronic devices have undergone significant advancements,thereby facilitating the study of electrophysiology.The distinctive configuration and exceptional functionality of these active micro-nano-collaborative bioelectronic devices offer the potential for the recording of high-fidelity action potential signals on a large scale.In this paper,we review three-dimensional active nano-transistors and planar active micro-transistors in terms of their applications in electroexcitable cells,focusing on the evaluation of the effects of active micro/nano-bioelectronic devices on electrophysiological signals.Looking forward to the possibilities,challenges,and wide prospects of active micro-nano-devices,we expect to advance their progress to satisfy the demands of theoretical investigations and medical implementations within the domains of cardiology and neuroscience research.展开更多
Organic electrochemical transistors(OECTs) exhibit significant potential for applications in healthcare and human-machine interfaces, due to their tunable synthesis, facile deposition, and excellent biocompatibility. ...Organic electrochemical transistors(OECTs) exhibit significant potential for applications in healthcare and human-machine interfaces, due to their tunable synthesis, facile deposition, and excellent biocompatibility. Expanding OECTs to the fexible devices will significantly facilitate stable contact with the skin and enable more possible bioelectronic applications. In this work,we summarize the device physics of fexible OECTs, aiming to offer a foundational understanding and guidelines for material selection and device architecture. Particular attention is paid to the advanced manufacturing approaches, including photolithography and printing techniques, which establish a robust foundation for the commercialization and large-scale fabrication. And abundantly demonstrated examples ranging from biosensors, artificial synapses/neurons, to bioinspired nervous systems are summarized to highlight the considerable prospects of smart healthcare. In the end, the challenges and opportunities are proposed for fexible OECTs. The purpose of this review is not only to elaborate on the basic design principles of fexible OECTs, but also to act as a roadmap for further exploration of wearable OECTs in advanced bio-applications.展开更多
Benefiting from the unique advantages of superior biocompatibility,strong stability,good biodegradability,and adjustable mechanical properties,hydrogels have attracted extensive research interests in bioelectronics.Ho...Benefiting from the unique advantages of superior biocompatibility,strong stability,good biodegradability,and adjustable mechanical properties,hydrogels have attracted extensive research interests in bioelectronics.However,due to the existence of an interface between hydrogels and human tissues,the transmission of electrical signals from the human tissues to the hydrogel electronic devices will be hindered.The adhesive hydrogels with adhesive properties can tightly combine with the human tissue,which can enhance the contact between the electronic devices and human tissues and reduce the contact resistance,thereby improving the performance of hydrogel electronic devices.In this review,we will discuss in detail the adhesion mechanism of adhesive hydrogels and elaborate on the design principles of adhesive hydrogels.After that,we will introduce some methods of performance evaluation for adhesive hydrogels.Finally,we will provide a perspective on the development of adhesive hydrogel bioelectronics.展开更多
Advanced biological systems are characterized by dynamic,complex,and functional biointerfaces.Human skin,for example,exemplifies such a biointerface,featuring diverse micro-and nano-scale surface structures.It serves ...Advanced biological systems are characterized by dynamic,complex,and functional biointerfaces.Human skin,for example,exemplifies such a biointerface,featuring diverse micro-and nano-scale surface structures.It serves as an ideal window for bioelectronic devices to acquire vital physiological information,enabling continuous health monitoring,and disease intervention.展开更多
Wearable and implantable devices mark a major advancement in biomedical engineering,enabling continuous bio-signal monitoring and treatment based on precise feedback.However,traditional rigid bioelectronic devices fac...Wearable and implantable devices mark a major advancement in biomedical engineering,enabling continuous bio-signal monitoring and treatment based on precise feedback.However,traditional rigid bioelectronic devices face challenges in seamlessly interfacing with soft organs,often leading to tissue damage and inflammation.To address these issues,soft bioelectronics that better conform to the body while maintaining performance accuracy have been developed.Despite these advancements,the dynamic nature of body movements and the complex chemical environment in the body can compromise the stability of devices over time.Therefore,recent innovations have focused on ultrathin and stretchable designs that enhance conformal contact through van der Waals forces,as well as the incorporation of adhesive hydrogels,to improve adhesion,even in the presence of biofluids.This review provides a comprehensive overview of the advancements in wearable and implantable bioelectronics aimed at achieving conformal tissue adhesion and long-term stability,covering structural modifications to bilayer designs.Finally,the integration of bioelectronics with closed-loop therapies to significantly enhance treatment efficacy is explored.展开更多
Launched in 2023,Med-X is an international journal published by Springer Nature,dedicated to showcasing groundbreaking research in biomedical engineering to transform modern medicine.Our mission is to establish Med-X ...Launched in 2023,Med-X is an international journal published by Springer Nature,dedicated to showcasing groundbreaking research in biomedical engineering to transform modern medicine.Our mission is to establish Med-X as a leading publication—alongside Nature Biomedical Engineering—and to serve as a premier platform for communicating interdisciplinary breakthroughs and innovations in the field.展开更多
基金supported by the National Natural Science Foundation of China[grant numbers 82350003 and 92049201].
文摘Bioelectronic medicine is a discipline that employs various electronic devices and technologies to diagnose,treat,and monitor biological systems and diseases.With continuous technological advancement,numerous bioelectronic devices are now utilized as independent therapeutic interventions or as adjunct treatments,and their applications continue to expand.This article briefly outlines the discovery process of several common electrophysiological signals in the human body and focuses on diverse electrical stimulation technologies.Their applications in the nervous system,cancer treatment,tissue regeneration and repair,and cardiovascular therapy are discussed,along with the underlying mechanisms of action.Furthermore,the rapid development of artificial intelligence and technological innovation has significantly broadened the scope and application of bioelectronic medicine.Finally,the current limitations and future prospects of bioelectronic medicine are explored.
基金financially supported by the Science and Technology Plan Project of the Jilin Province(No.YDZJ202401546ZYTS).
文摘The currently reported conductive hydrogels are mainly used to detect the mechanical signals of human movement,whereas the application of detecting weak electrophysiological signals in epidermal electrodes is still limited by a low signal-to-noise ratio and motion artifacts.In this study,a one-pot method was used to prepare a hydrogel conductor with excellent flexibility,self-adhesiveness,and compliance by introducing chitosan quaternary ammonium salt(HAAC)and 2-acrylamide-2-methylpropanesulfonic acid(AMPS)into the polyacrylamide(PAAm)hydrogel network.By adjusting the AMPS and HAAC contents,the hydrogel showed skin-like mechanical properties and surface adhesion,successfully eliminating the gap with the skin surface.The self-adhesive hydrogel showed a lower impedance(approximately 190 kΩ)than commercial Ag/AgCl electrodes.Notably,the hydrogel electrodes exhibited a significantly higher signal-to-noise ratio(SNR)than the commercial electrodes at the same level of muscle contraction.The hydrogel electrodes could accurately detect dynamic weak EMG signals and successfully drive the prosthetic hand to grasp without errors.Importantly,the combination of hydrogel strain sensors and epidermal electrodes can quantify the mode,frequency,and intensity of human movement,which has broad application prospects in data acquisition for daily exercise,fitness,and rehabilitation.
基金the National Natural Science Foundation of China for Distinguished Young Scholars(62325403)the National Natural Science Foundation of China(62504103 and 82002454)+4 种基金the Basic Research Program of Jiangsu(BK20251214)the Natural Science Foundation of Jiangsu Province(BK20230498)the China Postdoctoral Science Foundation under Grant Number 2025T180143 and 2025M770547the Medical Scientific Research Project of Jiangsu Health Commission(ZD2021011)the Jiangsu Funding Program for Excellent Postdoctoral Talent(2024ZB427)。
文摘The development of non-invasive brain-computer interfaces(BCIs)relies on multidisciplinary integration across neuroscience,artificial intelligence,flexible electronics,and systems engineering.Recent advances in deep learning have significantly improved the accuracy and robustness of neural signal decoding.Parallel progress in electrode design—particularly through the use of flexible and stretchable materials like nanostructured conductors and novel fabrication strategies—has enhanced wearability and operational stability.Nevertheless,key challenges persist,including individual variability,biocompatibility limitations,and susceptibility to interference in complex environments.Further validation and optimization are needed to address gaps in generalization capability,long-term reliability,and real-world operational robustness.This review systematically examines the representative progress in neural decoding algorithms and flexible bioelectronic platforms over the past decade,highlighting key design principles,material innovations,and integration strategies that are poised to advance non-invasive BCI capabilities.It also discusses the importance of multimodal data fusion,hardware-software co-optimization,and closed-loop control strategies.Furthermore,the review discusses the application potential and associated engineering challenges of this technology in clinical rehabilitation and industrial translation,aiming to provide a reference for advancing non-invasive BCIs toward practical and scalable deployment.
基金financially supported by the National Natural Science Foundation of China(Nos.52125501,52405325)the Key Research Project of Shaanxi Province(Nos.2021LLRH-08,2024SF2-GJHX-34)+5 种基金the Program for Innovation Team of Shaanxi Province(No.2023-CX-TD17)the Postdoctoral Fellowship Program of CPSF(No.GZB20230573)the Postdoctoral Project of Shaanxi Province(No.2023BSHYDZZ30)the Basic Research Program of Natural Science in Shaanxi Province(No.2021JQ-906)the China Postdoctoral Science Foundationthe Fundamental Research Funds for the Central Universities。
文摘The inherent complexities of excitable cardiac,nervous,and skeletal muscle tissues pose great challenges in constructing artificial counterparts that closely resemble their natural bioelectrical,structural,and mechanical properties.Recent advances have increasingly revealed the beneficial impact of bioelectrical microenvironments on cellular behaviors,tissue regeneration,and therapeutic efficacy for excitable tissues.This review aims to unveil the mechanisms by which electrical microenvironments enhance the regeneration and functionality of excitable cells and tissues,considering both endogenous electrical cues from electroactive biomaterials and exogenous electrical stimuli from external electronic systems.We explore the synergistic effects of these electrical microenvironments,combined with structural and mechanical guidance,on the regeneration of excitable tissues using tissue engineering scaffolds.Additionally,the emergence of micro/nanoscale bioelectronics has significantly broadened this field,facilitating intimate interactions between implantable bioelectronics and excitable tissues across cellular,tissue,and organ levels.These interactions enable precise data acquisition and localized modulation of cell and tissue functionalities through intricately designed electronic components according to physiological needs.The integration of tissue engineering and bioelectronics promises optimal outcomes,highlighting a growing trend in developing living tissue construct-bioelectronic hybrids for restoring and monitoring damaged excitable tissues.Furthermore,we envision critical challenges in engineering the next-generation hybrids,focusing on integrated fabrication strategies,the development of ionic conductive biomaterials,and their convergence with biosensors.
基金supported by the National Natural Science Foundation of China(52475610)Zhejiang Provincial Natural Science Foundation of China(LDQ24E050001).
文摘Despite the promising progress in conductive hydrogels made with pure conducting polymer,great challenges remain in the interface adhesion and robustness in longterm monitoring.To address these challenges,Prof.Seung Hwan Ko and Taek-Soo Kim’s team introduced a laserinduced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer substrates.The laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm^(−1) with a spatial resolution down to 5μm.Moreover,they maintain impedance and charge-storage capacity even after 1 h of sonication.The micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings,highlighting their promising role in the field of bioelectronics.
基金supported by the Scientific and Technological Project in Henan Province(242102231002)Henan Province Science and Technology Research and Development Program Joint Fund Advantageous Discipline Cultivation Project(No.232301420033)the Foundation for Outstanding Young Teachers in Universities of Henan Province(2021GGJS014).
文摘Bionic hydrogels offer significant advantages over conventional counterparts,boasting superior properties like enhanced adhesion,stretchability,conductivity,biocompatibility and versatile functionalities.Their physicochemical resemblance to biological tissues makes bionic hydrogels ideal interfaces for bioelectronic devices.In contrast,conventional hydrogels often exhibit inadequate performance,such as easy detachment,lack of good skin compliance,and inadequate conductivity,failing to meet the rigorous demands of bioelectronic applications.Bionic hydrogels,inspired by biological designs,exhibit exceptional physicochemical characteristics that fulfill diverse criteria for bioelectronic applications,driving the advancement of bioelectronic devices.This review first introduces a variety of materials used in the fabrication of bionic hydrogels,including natural polymers,synthetic polymers,and other materials.Then different mechanisms of hydrogel bionics,are categorized into material bionics,structural bionics,and functional bionics based on their bionic approaches.Subsequently,various applications of bionic hydrogels in the field of bioelectronics were introduced,including physiological signal monitoring,tissue engineering,and human-machine interactions.Lastly,the current development and future prospects of bionic hydrogels in bioelectronic devices are summarized.Hopefully,this comprehensive review could inspire advancements in bionic hydrogels for applications in bioelectronic devices.
基金support received from National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT)(RS-2024-00353768)the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT)(RS-2025-02217919)+1 种基金funded by the Yonsei Fellowshipfunded by Lee Youn Jae and the KIST Institutional Program Project No.2E31603-22-140 (KJY).
文摘Ultra-thin crystalline silicon stands as a cornerstone material in the foundation of modern micro and nano electronics.Despite the proliferation of various materials including oxide-based,polymer-based,carbon-based,and two-dimensional(2D)materials,crystal silicon continues to maintain its stronghold,owing to its superior functionality,scalability,stability,reliability,and uniformity.Nonetheless,the inherent rigidity of the bulk silicon leads to incompatibility with soft tissues,hindering the utilization amid biomedical applications.Because of such issues,decades of research have enabled successful utilization of various techniques to precisely control the thickness and morphology of silicon layers at the scale of several nanometres.This review provides a comprehensive exploration on the features of ultra-thin single crystalline silicon as a semiconducting material,and its role especially among the frontier of advanced bioelectronics.Key processes that enable the transition of rigid silicon to flexible form factors are exhibited,in accordance with their chronological sequence.The inspected stages span both prior and subsequent to transferring the silicon membrane,categorized respectively as on-wafer manufacturing and rigid-to-soft integration.Extensive guidelines to unlock the full potential of flexible electronics are provided through ordered analysis of each manufacturing procedure,the latest findings of biomedical applications,along with practical perspectives for researchers and manufacturers.
基金financially supported by the Ministry of Education(Singapore)(MOE-T2EP50220-0022)SUTD-MIT International Design Center(Singapore)+3 种基金SUTD-ZJU IDEA Grant Program(SUTD-ZJU(VP)201903)SUTD Kickstarter Initiative(SKI 2021_02_03,SKI 2021_02_17,SKI 2021_01_04)Agency of Science,Technology and Research(Singapore)(A20G9b0135)National Supercomputing Centre(Singapore)(15001618)。
文摘Neuromorphic computing has the potential to overcome limitations of traditional silicon technology in machine learning tasks.Recent advancements in large crossbar arrays and silicon-based asynchronous spiking neural networks have led to promising neuromorphic systems.However,developing compact parallel computing technology for integrating artificial neural networks into traditional hardware remains a challenge.Organic computational materials offer affordable,biocompatible neuromorphic devices with exceptional adjustability and energy-efficient switching.Here,the review investigates the advancements made in the development of organic neuromorphic devices.This review explores resistive switching mechanisms such as interface-regulated filament growth,molecular-electronic dynamics,nanowire-confined filament growth,and vacancy-assisted ion migration,while proposing methodologies to enhance state retention and conductance adjustment.The survey examines the challenges faced in implementing low-power neuromorphic computing,e.g.,reducing device size and improving switching time.The review analyses the potential of these materials in adjustable,flexible,and low-power consumption applications,viz.biohybrid spiking circuits interacting with biological systems,systems that respond to specific events,robotics,intelligent agents,neuromorphic computing,neuromorphic bioelectronics,neuroscience,and other applications,and prospects of this technology.
基金This work was financially supported by the R&D Program in Key Areas of Guangdong(2019B010941002)National Key Research and Development Program of China(2016YFB0700802),NSFC(81671824,31700841)Fundamental Research Funds for the Central Universities(2682019JQ03).
文摘Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles(CP NPs),while endowing the CP NPs with redox activity and biocompatibility.This is a universal strategy applicable for a series of CPs,including polyaniline,polypyrrole,and poly(3,4-ethylenedioxythiophene).The catechol/quinone contained sulfonated lignin(LS)was doped into various CPs to form CP/LS NPs with hydrophilicity,conductivity,and redox activity.These CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term adhesiveness.The CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network,forming a well-connected electric path.The hydrogel exhibits long-term adhesiveness,which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS NPs.This conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics.
基金financial support from the National Natural Science Foundation of China(Grant Nos.32171399)the National Key R&D Program of China(Grant Nos.2021YFF1200700,2021YFA0911100)+1 种基金the National Natural Science Foundation of China(Grant Nos.32171456,32171335,61901535,31900954,62104264)。
文摘Developing techniques to effectively and real-time monitor and regulate the interior environment of biological objects is significantly important for many biomedical engineering and scientific applications, including drug delivery, electrophysiological recording and regulation of intracellular activities. Semi-implantable bioelectronics is currently a hot spot in biomedical engineering research area, because it not only meets the increasing technical demands for precise detection or regulation of biological activities, but also provides a desirable platform for externally incorporating complex functionalities and electronic integration. Although there is less definition and summary to distinguish it from the well-reviewed non-invasive bioelectronics and fully implantable bioelectronics, semi-implantable bioelectronics have emerged as highly unique technology to boost the development of biochips and smart wearable device. Here, we reviewed the recent progress in this field and raised the concept of “Semi-implantable bioelectronics”, summarizing the principle and strategies of semi-implantable device for cell applications and in vivo applications, discussing the typical methodologies to access to intracellular environment or in vivo environment, biosafety aspects and typical applications. This review is meaningful for understanding in-depth the design principles, materials fabrication techniques, device integration processes, cell/tissue penetration methodologies, biosafety aspects, and applications strategies that are essential to the development of future minimally invasive bioelectronics.
基金supported by the National Natural Science Foundation of China(22274053,22274051)the director fund of Shanghai Key Lab for Urban Ecological Processes and Eco-Restoration(SHUES2022C03)+2 种基金the Shanghai Municipal Science and Technology Major Project(“Beyond Limits manufacture”),and the Fundamental Research Funds for the Central UniversitiesAll experiments with human research participants were approved by the Human Research Protection Committee of East China Normal University(approved number:HR 805-2022)Study Participation:Prior to participation in the experiments,informed consent was obtained from the volunteer in all experiments.All animal experiments were approved by the Animal Ethics Committee of East China Normal University(approved number:ARXM2022163).
文摘An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management.Nevertheless,conventional dressings and skin bioelectronics with single function,mechanical mismatches,and impracticality severely limit their widespread applications in clinical.Herein,we explore a gelling mechanism,fabrication method,and functionalization for broadly applicable food biopolymers-based biogels that unite the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single system.We combine our biogels with functional nanomaterials,such as cuttlefish ink nanoparticles and silver nanowires,to endow the biogels with reactive oxygen species scavenging capacity and electrical conductivity,and finally realized the improvement in diabetic wound microenvironment and the monitoring of electrophysiological signals on skin.This line of research work sheds light on preparing food biopolymers-based biogels with multifunctional integration of wound treatment and smart medical treatment.
基金the Engineering Research Center of Integrated Circuits for Next-Generation Communications Grant(Y01796303)Southern University of Science and Technology Grant(Y01796108,Y01796208).
文摘With the growing market of wearable devices for smart sensing and personalized healthcare applications,energy storage devices that ensure stable power supply and can be constructed in flexible platforms have attracted tremendous research interests.A variety of active materials and fabrication strategies of flexible energy storage devices have been intensively studied in recent years,especially for integrated self-powered systems and biosensing.A series of materials and applications for flexible energy storage devices have been studied in recent years.In this review,the commonly adopted fabrication methods of flexible energy storage devices are introduced.Besides,recent advances in integrating these energy devices into flexible self-powered systems are presented.Furthermore,the applications of flexible energy storage devices for biosensing are summarized.Finally,the prospects and challenges of the self-powered sensing system for wearable electronics are discussed.
文摘The peripheral nervous system plays a major role in the maintenance of our physiology. Several peripheral nerves intimately regulate the state of the brain, spinal cord, and visceral systems. A new class of therapeutics, called bioelectronic medicines, are being developed to precisely regulate physiology and treat dysfunction using peripheral nerve stimulation. In this review, we first discuss new work using closed-loop bioelectronic medicine to treat upper limb paralysis. In contrast to open-loop bioelectronic medicines, closed-loop approaches trigger ‘on demand' peripheral nerve stimulation due to a change in function(e.g., during an upper limb movement or a change in cardiopulmonary state). We also outline our perspective on timing rules for closedloop bioelectronic stimulation, interface features for non-invasively stimulating peripheral nerves, and machine learning algorithms to recognize disease events for closed-loop stimulation control. Although there will be several challenges for this emerging field, we look forward to future bioelectronic medicines that can autonomously sense changes in the body, to provide closed-loop peripheral nerve stimulation and treat disease.
文摘The integration of electronics and biology has spawned bioelectronics and opened exciting opportunities to fulfill the unmet needs of therapeutic treatments.Recent developments in nanoelectronics and soft and biocompatible materials have shown potential applicability to clinical practices,including physiological sensing,drug delivery,cardiovascular monitoring,and brain stimulation.To date,most bioelectronic devices require wired connections for electrical control,making their implantation complicated and inconvenient for patients.As an alternative,wireless technology is proliferating to create bioelectronics that offer noninvasive control,biotelemetry,and wireless power transfer(WPT).This review paper provides a comprehensive overview of wireless bioelectronics and ongoing developments in their applications for organ-specific treatments,including disorders and dysfunctions.The main emphasis is on delineating the key features of antennas,namely their radiation characteristics,materials,integration with rest of the electronics,and experimental setup.Although the recent progress in wireless mediated bioelectronics is expected to enhance the control of its functionalities,there are still numerous challenges that need to be addressed for commercialization,as well as to address everexpanding and evolving future therapeutic targets.
基金The work is supported in part by the National Natural Science Foundation of China(Grant Nos.62171483,82061148011)Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ23F010004)+1 种基金Hangzhou Agricultural and Social Development Research Key Project(Grant No.20231203A08)Doctoral Initiation Program of the Tenth Affiliated Hospital,Southern Medical University(Grant No.K202308).
文摘The development of precise and sensitive electrophysiological recording platforms holds the utmost importance for research in the fields of cardiology and neuroscience.In recent years,active micro/nano-bioelectronic devices have undergone significant advancements,thereby facilitating the study of electrophysiology.The distinctive configuration and exceptional functionality of these active micro-nano-collaborative bioelectronic devices offer the potential for the recording of high-fidelity action potential signals on a large scale.In this paper,we review three-dimensional active nano-transistors and planar active micro-transistors in terms of their applications in electroexcitable cells,focusing on the evaluation of the effects of active micro/nano-bioelectronic devices on electrophysiological signals.Looking forward to the possibilities,challenges,and wide prospects of active micro-nano-devices,we expect to advance their progress to satisfy the demands of theoretical investigations and medical implementations within the domains of cardiology and neuroscience research.
基金sponsored by the Regional Joint Fund of the National Science Foundation of China via Grant No. U21A20492the National Natural Science Foundation of China (NSFC) via Grant No. 62275041+2 种基金the Sichuan Science and Technology Program via Grant Nos. 2022YFH0081, 2022YFG0012 and 2022YFG0013the Sichuan Youth Software Innovation Project Funding via Grant No. MZGC20230068the Sichuan Province Key Laboratory of Display Science and Technology。
文摘Organic electrochemical transistors(OECTs) exhibit significant potential for applications in healthcare and human-machine interfaces, due to their tunable synthesis, facile deposition, and excellent biocompatibility. Expanding OECTs to the fexible devices will significantly facilitate stable contact with the skin and enable more possible bioelectronic applications. In this work,we summarize the device physics of fexible OECTs, aiming to offer a foundational understanding and guidelines for material selection and device architecture. Particular attention is paid to the advanced manufacturing approaches, including photolithography and printing techniques, which establish a robust foundation for the commercialization and large-scale fabrication. And abundantly demonstrated examples ranging from biosensors, artificial synapses/neurons, to bioinspired nervous systems are summarized to highlight the considerable prospects of smart healthcare. In the end, the challenges and opportunities are proposed for fexible OECTs. The purpose of this review is not only to elaborate on the basic design principles of fexible OECTs, but also to act as a roadmap for further exploration of wearable OECTs in advanced bio-applications.
基金financially supported by the Natural Science Foundation of Shandong Province(ZR2022QB014)Higher Education Institutions Youth Innovation Team Plan of Shandong Province(2022KJ192)+3 种基金Academic Promotion Program of Shandong First Medical University(2019QL009)Science and Technology Funding from Jinan(2020GXRC018)Talent Introduction Project of Shandong First Medical University(003067)High-level University and High-level Discipline Construction Project of Shandong First Medical University(923002011).
文摘Benefiting from the unique advantages of superior biocompatibility,strong stability,good biodegradability,and adjustable mechanical properties,hydrogels have attracted extensive research interests in bioelectronics.However,due to the existence of an interface between hydrogels and human tissues,the transmission of electrical signals from the human tissues to the hydrogel electronic devices will be hindered.The adhesive hydrogels with adhesive properties can tightly combine with the human tissue,which can enhance the contact between the electronic devices and human tissues and reduce the contact resistance,thereby improving the performance of hydrogel electronic devices.In this review,we will discuss in detail the adhesion mechanism of adhesive hydrogels and elaborate on the design principles of adhesive hydrogels.After that,we will introduce some methods of performance evaluation for adhesive hydrogels.Finally,we will provide a perspective on the development of adhesive hydrogel bioelectronics.
文摘Advanced biological systems are characterized by dynamic,complex,and functional biointerfaces.Human skin,for example,exemplifies such a biointerface,featuring diverse micro-and nano-scale surface structures.It serves as an ideal window for bioelectronic devices to acquire vital physiological information,enabling continuous health monitoring,and disease intervention.
基金supported by the Institute for Basic Science(nos.IBS-R015-D1 and IBS-R015-D2)supported by the Korean Fund for Regenerative Medicine grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare)(23B0102L1)+2 种基金supported by the NAVER Digital Bio Innovation Research Fund,funded by NAVER Corporation(Grant No.[37-2023-0040])supported by the Korea-US Collaborative Research Fund(KUCRF)funded by the Ministry of Science and ICT and Ministry of Health&Welfare,Republic of Korea(no.RS-2024-00467213).
文摘Wearable and implantable devices mark a major advancement in biomedical engineering,enabling continuous bio-signal monitoring and treatment based on precise feedback.However,traditional rigid bioelectronic devices face challenges in seamlessly interfacing with soft organs,often leading to tissue damage and inflammation.To address these issues,soft bioelectronics that better conform to the body while maintaining performance accuracy have been developed.Despite these advancements,the dynamic nature of body movements and the complex chemical environment in the body can compromise the stability of devices over time.Therefore,recent innovations have focused on ultrathin and stretchable designs that enhance conformal contact through van der Waals forces,as well as the incorporation of adhesive hydrogels,to improve adhesion,even in the presence of biofluids.This review provides a comprehensive overview of the advancements in wearable and implantable bioelectronics aimed at achieving conformal tissue adhesion and long-term stability,covering structural modifications to bilayer designs.Finally,the integration of bioelectronics with closed-loop therapies to significantly enhance treatment efficacy is explored.
文摘Launched in 2023,Med-X is an international journal published by Springer Nature,dedicated to showcasing groundbreaking research in biomedical engineering to transform modern medicine.Our mission is to establish Med-X as a leading publication—alongside Nature Biomedical Engineering—and to serve as a premier platform for communicating interdisciplinary breakthroughs and innovations in the field.
