Nanoparticles(NPs)formulation in biopolymers is an attractive process for the researcher to decrease the disadvantages of NPs application alone.Bimetallic NPs are a promising formula of two NPs that usually act as syn...Nanoparticles(NPs)formulation in biopolymers is an attractive process for the researcher to decrease the disadvantages of NPs application alone.Bimetallic NPs are a promising formula of two NPs that usually act as synergetic phenomena.Zinc oxide and gold NPs(ZnO@AuNPs)biosynthesis as a bimetallic was prepared via the eco-friendly manner currently.Carboxymethylcellulose(CMC)was employed for the formulation of ZnO@AuNPs as a nanocomposite via a green method.Physicochemical and topographical characterization was assigned to ZnO@AuNPs and nanocomposite features.The nanostructure of bimetallic NPs and nanocomposite were affirmed with sizes around 15 and 25 nm,respectively.Indeed,the DLS measurements affirmed the more reasonable size and stability of the prepared samples as 27 and 93 nm for bimetallic NPs and nanocomposite,respectively.The inhibitory potential of nanocomposite was more than ZnO@AuNPs against Staphylococcus aureus,Escherichia coli,Salmonella typhi,Enterococcus faecalis,Mucor albicans,Aspergillus flavus,and Mucor circinelloid.ZnO@AuNPs and nanocomposite exhibited antioxidant activity via DPPH with IC50 of 71.38 and 32.4μg/mL,correspondingly.Excellent anti-diabetic potential of nanocomposite with IC50 of 7.4μg/mL,and ZnO@AuNPs with IC50 of 9.7μg/mL was reported compared with the standard acarbose with the IC50 of 50.93μg/mL for amylase inhibition(%).Photocatalytic degradation of RR195 and RB dyes was performed by ZnO@AuNPs and nanocomposite,where maximum degradation was 85.7±1.53 and 88.7±0.58%,respectively using ZnO@AuNPs,90.3±0.28 and 91.8±0.27%,respectively using nanocomposite at 100 min.展开更多
Copper is a trace element that is required by almost all forms of life.Acting as cofactors for various key metabolism enzymes,copper takes part in many vital biological processes.Previous studies have found the concen...Copper is a trace element that is required by almost all forms of life.Acting as cofactors for various key metabolism enzymes,copper takes part in many vital biological processes.Previous studies have found the concentration of copper is significantly higher in tumor cells than in normal cells.In addition,copper can promote angiogenesis by activating VEGF and FGF signaling.展开更多
A biological molecule,e.g.,an enzyme,tends to interact with its many cognate substrates,targets,or partners differentially.Such a property is termed relative specificity and has been proposed to regulate important phy...A biological molecule,e.g.,an enzyme,tends to interact with its many cognate substrates,targets,or partners differentially.Such a property is termed relative specificity and has been proposed to regulate important physiological functions,even though it has not been examined explicitly in most complex biochemical systems.This essay reviews several recent large-scale studies that investigate protein folding,signal transduction,RNA binding,translation and transcription in the context of relative specificity.These results and others support a pervasive role of relative specificity in diverse biological processes.It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems,which has significant implications in disease processes as well.展开更多
基金The author extend their appreciation to the Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia for funding this research work through project number ISP23-62.
文摘Nanoparticles(NPs)formulation in biopolymers is an attractive process for the researcher to decrease the disadvantages of NPs application alone.Bimetallic NPs are a promising formula of two NPs that usually act as synergetic phenomena.Zinc oxide and gold NPs(ZnO@AuNPs)biosynthesis as a bimetallic was prepared via the eco-friendly manner currently.Carboxymethylcellulose(CMC)was employed for the formulation of ZnO@AuNPs as a nanocomposite via a green method.Physicochemical and topographical characterization was assigned to ZnO@AuNPs and nanocomposite features.The nanostructure of bimetallic NPs and nanocomposite were affirmed with sizes around 15 and 25 nm,respectively.Indeed,the DLS measurements affirmed the more reasonable size and stability of the prepared samples as 27 and 93 nm for bimetallic NPs and nanocomposite,respectively.The inhibitory potential of nanocomposite was more than ZnO@AuNPs against Staphylococcus aureus,Escherichia coli,Salmonella typhi,Enterococcus faecalis,Mucor albicans,Aspergillus flavus,and Mucor circinelloid.ZnO@AuNPs and nanocomposite exhibited antioxidant activity via DPPH with IC50 of 71.38 and 32.4μg/mL,correspondingly.Excellent anti-diabetic potential of nanocomposite with IC50 of 7.4μg/mL,and ZnO@AuNPs with IC50 of 9.7μg/mL was reported compared with the standard acarbose with the IC50 of 50.93μg/mL for amylase inhibition(%).Photocatalytic degradation of RR195 and RB dyes was performed by ZnO@AuNPs and nanocomposite,where maximum degradation was 85.7±1.53 and 88.7±0.58%,respectively using ZnO@AuNPs,90.3±0.28 and 91.8±0.27%,respectively using nanocomposite at 100 min.
文摘Copper is a trace element that is required by almost all forms of life.Acting as cofactors for various key metabolism enzymes,copper takes part in many vital biological processes.Previous studies have found the concentration of copper is significantly higher in tumor cells than in normal cells.In addition,copper can promote angiogenesis by activating VEGF and FGF signaling.
基金partly supported by the National Institutes of Health(Grant Nos.5P50-DA011806-12 and R01DA031202)
文摘A biological molecule,e.g.,an enzyme,tends to interact with its many cognate substrates,targets,or partners differentially.Such a property is termed relative specificity and has been proposed to regulate important physiological functions,even though it has not been examined explicitly in most complex biochemical systems.This essay reviews several recent large-scale studies that investigate protein folding,signal transduction,RNA binding,translation and transcription in the context of relative specificity.These results and others support a pervasive role of relative specificity in diverse biological processes.It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems,which has significant implications in disease processes as well.
