Natural products have provided numerous lead compounds for drug discovery.However,the traditional analytical methods cannot detect most of these active components,especially at their usual low concentrations,from comp...Natural products have provided numerous lead compounds for drug discovery.However,the traditional analytical methods cannot detect most of these active components,especially at their usual low concentrations,from complex natural products.Herein,we reviewed the recent technological advances(2015-2019)related to the separation and screening bioactive components from natural resources,especially the emerging screening methods based on the bioaffinity techniques,including biological chromatography,affinity electrophoresis,affinity mass spectroscopy,and the latest magnetic and optical methods.These screening methods are uniquely advanced compared to other traditional methods,and they can fish out the active components from complex natural products because of the affinity between target and components,without tedious separation works.Therefore,these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents.展开更多
基金supported by the National Natural Science Foundation of China(No.81673398)the“the World-Class Universities(Disciplines)and the Characteristic Development Guidance Funds for the Central Universities(No.PY3A012,China)”+1 种基金the China Postdoctoral Science Foundation(2018M643681)the Natural Science Foundation of Shaanxi Province(No.2017JQ8024,China)
文摘Natural products have provided numerous lead compounds for drug discovery.However,the traditional analytical methods cannot detect most of these active components,especially at their usual low concentrations,from complex natural products.Herein,we reviewed the recent technological advances(2015-2019)related to the separation and screening bioactive components from natural resources,especially the emerging screening methods based on the bioaffinity techniques,including biological chromatography,affinity electrophoresis,affinity mass spectroscopy,and the latest magnetic and optical methods.These screening methods are uniquely advanced compared to other traditional methods,and they can fish out the active components from complex natural products because of the affinity between target and components,without tedious separation works.Therefore,these new tools can reduce the time and cost of the drug discovery process and accelerate the development of more effective and better-targeted therapeutic agents.
