Anthranilic diamides are fasting growing class insecticides in modern crop protection for their high activity, low ecotoxicity, and broad insecticidal spectra. However. the bioactive conformations of anthranilic diami...Anthranilic diamides are fasting growing class insecticides in modern crop protection for their high activity, low ecotoxicity, and broad insecticidal spectra. However. the bioactive conformations of anthranilic diamides are still unclear until now. In the present study, DFT-based potential energy surface scanning was used to detect the low energy conformations of chlorantraniliprole, then were used respectively in the structure alignment for a series of anthranilic diamide compounds followed by detailed CoMFA and CoMSIA analyses. Finally, the bioactive conformations of anthranilic diamide insecticides were revealed from a series of low energy conformations, which might provide some clues for future insecticide design.展开更多
A new reactive graft copolymer, poly(tetramethylene glycol)-graft-omega-propyl sodium sulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesized by the cationic polymerization of alpha-omega-bifunc...A new reactive graft copolymer, poly(tetramethylene glycol)-graft-omega-propyl sodium sulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesized by the cationic polymerization of alpha-omega-bifunctional PEG macromonomer ((sic)CH2-PEG-CH2CH2CH2SO3Na) and THF. The obtained copolymer exhibits the expected structure as indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine) were covalently attached to the copolymer after converting the sulfonate group, to sulfonyl chloride. So the new reactive graft copolymer (PTMG-g-PEG-CH2CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer.展开更多
Dietary plant polysaccharides,which are natural,biocompatible,and functional macromolecules derived from plants,mushrooms,algae,and agri-food byproducts,have thus emerged as a focal point in the fields of food science...Dietary plant polysaccharides,which are natural,biocompatible,and functional macromolecules derived from plants,mushrooms,algae,and agri-food byproducts,have thus emerged as a focal point in the fields of food science,nutrition,and biomedical research.Driven by the global consumer demand for clean-label functional foods,natural nutraceut-icals,and sustainable health solutions,there has been a growing interest in these polysaccharides has surged,largely due to their diverse bio-logical activities and their potential to address pressing public health challenges,such as metabolic disorders,gut dysbiosis,and age-related diseases(Qin et al.,2021;Wang et al.,2024;Yang et al.,2025).展开更多
Medicinal plants are acknowledged as vital resources for human health,given their therapeutic efficacy in addressing numerous diseases.Due to their antioxidant,antimicrobial,antitumor,and anti-inflammatory properties,...Medicinal plants are acknowledged as vital resources for human health,given their therapeutic efficacy in addressing numerous diseases.Due to their antioxidant,antimicrobial,antitumor,and anti-inflammatory properties,medicinal plants find extensive use in food,beverages,pharmaceuticals,cosmetics,animal feed,and other industries.Medicinal plants are the primary source of the richest bio-resources for drugs in both traditional and modern medical systems.Statistics indicate that around 45,000 plants are utilized for medicinal purposes,providing a rich reservoir for discovering active ingredients and novel drugs.Medicinal plants may be utilized in raw or processed form.Effective processing techniques can maximize their nutraceutical and therapeutic potential and are vital for fully valorizing these potential natural resources.Fermentation,a highly traditional,natural,and cost-effective process and a pioneer in modern biotechnology,presents a promising strategy to enhance the nutritional,bioactive,and health potential of medicinal plants.Therefore,the purpose of this comprehensive review is to highlight recent advances in the effects of fermentation on nutritional/functional characteristics,phytochemical properties,therapeutic effects,antimicrobial activity,and flavor profile of medicinal plants.Furthermore,it presents the fermentation effect as an emerging extraction technology for bioactive compounds and a promising tool for the reclamation of medicinal plant waste and residues.The application of fermented medicinal plants in animal feed is also discussed.In conclusion,this bioprocessing turns raw medicinal plants and their waste into promising functional ingredients for food,beverage,pharmaceutical,cosmetic,and feed industries that promote health and well-being.展开更多
The potentially bioactive 2-aryl-thiazolo[4,5-b]pyridines were synthesized via palladium-catalyzed desulfitative cross-coupling reaction between multisubstituted thiazolo[4,5-b]pyridine thioethers and boronic acids. Y...The potentially bioactive 2-aryl-thiazolo[4,5-b]pyridines were synthesized via palladium-catalyzed desulfitative cross-coupling reaction between multisubstituted thiazolo[4,5-b]pyridine thioethers and boronic acids. Yields of 48%–94% were obtained with copper（I） thiophene-2-carboxylate in the system.展开更多
基金the financial support from the National Key Technology R&D Program of China (No.2011BAE06B05)
文摘Anthranilic diamides are fasting growing class insecticides in modern crop protection for their high activity, low ecotoxicity, and broad insecticidal spectra. However. the bioactive conformations of anthranilic diamides are still unclear until now. In the present study, DFT-based potential energy surface scanning was used to detect the low energy conformations of chlorantraniliprole, then were used respectively in the structure alignment for a series of anthranilic diamide compounds followed by detailed CoMFA and CoMSIA analyses. Finally, the bioactive conformations of anthranilic diamide insecticides were revealed from a series of low energy conformations, which might provide some clues for future insecticide design.
基金Supported by the National Natural Science Foundation of China and Huoyindong Education Foundation
文摘A new reactive graft copolymer, poly(tetramethylene glycol)-graft-omega-propyl sodium sulfonate-poly(ethylene glycol) (PTMG-g-PEG-CH2CH2CH2SO3-Na+), was synthesized by the cationic polymerization of alpha-omega-bifunctional PEG macromonomer ((sic)CH2-PEG-CH2CH2CH2SO3Na) and THF. The obtained copolymer exhibits the expected structure as indicated by the result of characterization. Two amino acids (L-arginine, L-tyrosine) were covalently attached to the copolymer after converting the sulfonate group, to sulfonyl chloride. So the new reactive graft copolymer (PTMG-g-PEG-CH2CH2CH2SO3-Na+) is expected to be very useful in attachment of potentially bioactive moieties to polymer via a hydrophilic PEG spacer.
文摘Dietary plant polysaccharides,which are natural,biocompatible,and functional macromolecules derived from plants,mushrooms,algae,and agri-food byproducts,have thus emerged as a focal point in the fields of food science,nutrition,and biomedical research.Driven by the global consumer demand for clean-label functional foods,natural nutraceut-icals,and sustainable health solutions,there has been a growing interest in these polysaccharides has surged,largely due to their diverse bio-logical activities and their potential to address pressing public health challenges,such as metabolic disorders,gut dysbiosis,and age-related diseases(Qin et al.,2021;Wang et al.,2024;Yang et al.,2025).
文摘Medicinal plants are acknowledged as vital resources for human health,given their therapeutic efficacy in addressing numerous diseases.Due to their antioxidant,antimicrobial,antitumor,and anti-inflammatory properties,medicinal plants find extensive use in food,beverages,pharmaceuticals,cosmetics,animal feed,and other industries.Medicinal plants are the primary source of the richest bio-resources for drugs in both traditional and modern medical systems.Statistics indicate that around 45,000 plants are utilized for medicinal purposes,providing a rich reservoir for discovering active ingredients and novel drugs.Medicinal plants may be utilized in raw or processed form.Effective processing techniques can maximize their nutraceutical and therapeutic potential and are vital for fully valorizing these potential natural resources.Fermentation,a highly traditional,natural,and cost-effective process and a pioneer in modern biotechnology,presents a promising strategy to enhance the nutritional,bioactive,and health potential of medicinal plants.Therefore,the purpose of this comprehensive review is to highlight recent advances in the effects of fermentation on nutritional/functional characteristics,phytochemical properties,therapeutic effects,antimicrobial activity,and flavor profile of medicinal plants.Furthermore,it presents the fermentation effect as an emerging extraction technology for bioactive compounds and a promising tool for the reclamation of medicinal plant waste and residues.The application of fermented medicinal plants in animal feed is also discussed.In conclusion,this bioprocessing turns raw medicinal plants and their waste into promising functional ingredients for food,beverage,pharmaceutical,cosmetic,and feed industries that promote health and well-being.
基金supported by the National Natural Science Foundation of China(No.21272009)
文摘The potentially bioactive 2-aryl-thiazolo[4,5-b]pyridines were synthesized via palladium-catalyzed desulfitative cross-coupling reaction between multisubstituted thiazolo[4,5-b]pyridine thioethers and boronic acids. Yields of 48%–94% were obtained with copper（I） thiophene-2-carboxylate in the system.
