Polymer mechanochemistry has rapidly evolved since the mid-20o0s.Recent advancements highlight the development of mechanophore platforms for the controlled release of bioactive payloads and the exploration of biocompa...Polymer mechanochemistry has rapidly evolved since the mid-20o0s.Recent advancements highlight the development of mechanophore platforms for the controlled release of bioactive payloads and the exploration of biocompatible activation strategies.These platforms,ranging from furan-maleimide Diels-Alder adducts to disulfide motifs withβ-carbonate linkages,demonstrate promising prospects in targeted drug delivery.Additionally,supramolecular assemblies and free radical-generating mechanophores present innovative avenues for potential therapeutic applications.Biocompatible activation methods,notably high-intensity and/or low-intensity focused ultrasound,hold potential for in vivo applications.However,challenges persist in comprehending the fundamental physics of ultrasound and its utilization for activation.展开更多
基金financially supported by the National Natural Science Foundation of China(22271061)the startup funds from State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science at Fudan University。
文摘Polymer mechanochemistry has rapidly evolved since the mid-20o0s.Recent advancements highlight the development of mechanophore platforms for the controlled release of bioactive payloads and the exploration of biocompatible activation strategies.These platforms,ranging from furan-maleimide Diels-Alder adducts to disulfide motifs withβ-carbonate linkages,demonstrate promising prospects in targeted drug delivery.Additionally,supramolecular assemblies and free radical-generating mechanophores present innovative avenues for potential therapeutic applications.Biocompatible activation methods,notably high-intensity and/or low-intensity focused ultrasound,hold potential for in vivo applications.However,challenges persist in comprehending the fundamental physics of ultrasound and its utilization for activation.
