Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system w...Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.展开更多
Mg and its alloys show high potential to be applied as implant materials due to their superior properties like biodegradability,bioactivity,biocompatibility,and suitable mechanical behaviors.Nevertheless,the fast and ...Mg and its alloys show high potential to be applied as implant materials due to their superior properties like biodegradability,bioactivity,biocompatibility,and suitable mechanical behaviors.Nevertheless,the fast and uncontrolled degradation of Mg alloys in biological environment severely restricts their wide applications as biomedical materials.In comparison with alloying,surface coatings can not only improve corrosion resistance but also impart other bio-functional properties to achieve diverse clinical requirements.This review analyzes and summarizes the most recent developments in popular coating technologies,including micro-arc oxidation,electrophoretic deposition,chemical conversion,anodic oxidation,layered double hydroxide,and sol-gel coatings.Considering inevitable damages under complex service conditions,smart self-healing coatings are also introduced in each coating technology.The existing issues and future perspectives are finally discussed to facilitate applications of Mg alloys as biomedical materials in the medical industry.展开更多
Over the past two decades,the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic materials based on calcium phosphates and alkali-free bioactive glasses.A key focus has been thedeli...Over the past two decades,the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic materials based on calcium phosphates and alkali-free bioactive glasses.A key focus has been thedeliberate incorporation of therapeutic ions like Mg,Sr,Zn,Mn,or Ga to enhance osteointegration and vascularization,confer antioxidant properties,and impart antimicrobial effects,marking significant contributions tothe field of biomaterials and bone tissue engineering.Such an approach is expected to circumvent the uncertaintiesposed by methods relying on growth factors,such as bone morphogenetic proteins,parathyroidhormone,and platelet-rich plasma,along with their associated high costs and potential adverse side effects.Thiscomprehensive overview of CICECO-hub’s significant contributions to the forefront inorganic biomaterials acrossall research aspects and dimensionalities(powders,granules,thin films,bulk materials,and porous structures),follows a unified approach rooted in a cohesive conceptual framework,including synthesis,characterization,andtesting protocols.Tangible outcomes[injectable cements,durable implant coatings,and bone graft substitutes(scaffolds)featuring customized porous architectures for implant fixation,osteointegration,accelerated boneregeneration in critical-sized bone defects]were achieved.The manuscript showcases specific biofunctionalexamples of successful biomedical applications and effective translations to the market of bone grafts foradvanced therapies.展开更多
Probiotic has gained a lot of attention pertaining to their potential health benefits in the last decades.Moreover,the growing demands for probiotic-based dietary supplements,food products and pharmaceuticals,have fur...Probiotic has gained a lot of attention pertaining to their potential health benefits in the last decades.Moreover,the growing demands for probiotic-based dietary supplements,food products and pharmaceuticals,have further affirmed its role as a prophylactic and therapeutic agent.Although considered safe,the increasing incidence of allergic sensitization and autoimmune disorders further limits the use of live probiotics.Recent,mechanistic evaluation behind the probiotic benefits has unraveled the role of surface effector molecules as primary mediators of the probiotic action.This review initially introduces the structural-functional aspects of surface-associated molecules(surface proteins,cell-bound exopolysaccharide,lipoteichoic acid,pilli and peptidoglycan complex)of probiotic lactic acid bacteria involved in host-microbe interactions.Later,the recent findings involving the role of these effector molecules in various host-associated bio-functional attributes such as intestinal adhesion,immunomodulation,restoration of gut barrier integrity,anti-pathogenic and anti-biofilm,anti-oxidative,anti-tumor,anti-obesity,anti-diabetic potentials were discussed elaborately.Mostly,interactions of bacterial surface components with host-derived factors occur in the gastrointestinal tract which ensure the successful exertion of the beneficial effects of probiotic bacteria.Thus,the direct evidence of the applicability of the effector molecules in imparting bio-functional attributes possibly indicates a safer alternative to classical probiotics.Complete knowledge of chemical structures,targets and validated dosages of these natural molecules further expands the area of pharmabiotics.展开更多
There is considerable research interest and vigorous debate about the DNA binding of polypyridyl complexes including the electron transfer involving DNA. In this review, based on the fluorescence quenching experiments...There is considerable research interest and vigorous debate about the DNA binding of polypyridyl complexes including the electron transfer involving DNA. In this review, based on the fluorescence quenching experiments, it was proposed that DNA might serve as a conductor. From the time-interval CD spectra, the different binding rates of Δ- and Λ-enantiomer to calf thymus DNA were observed. The factors influencing the DNA-binding of polypyridyl complexes, and the potential bio-functions of the complexes are also discussed.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.31500777)the Research Start-up Funds of DGUT(Grant No.GC300501-082)the Characteristic Innovation Project of University in Guangdong(Grant No.2020KTSCX148)。
文摘Magnesium was considered as a revolutionary biodegradable implant material for orthopedic application. Concerning the weakness of intrinsic strength and corrosion behavior, a novel strategy of Mg/metal hybrid system was proposed for extension of orthopedic application, especially at load-bearing site. In this work, an Mg and HA composite layered coating was constructed on titanium by means of chemical conversion and vapor deposition. The HA transition interlayer was introduced to enhance the bonding between Mg film and Ti substrate. Compared with the bare Mg coating, the Mg/HA coating presented good interface bonding, which avoided the occurrence of Mg film peeling off from the substrate. The Mg/HA coating showed a uniform degradation and kept integrity after immersion of 14 d. The Mg ions release by degradation played a crucial role in osteopromotion and antibacterial effect. Incubation of MC3T3-E1 osteoblasts with the Mg/HA coating showed significant promotion on osteogenic differentiation according to ALP activity and Alizarin Red staining assays. Meanwhile the degradation of Mg exhibited strong suppression of bacteria proliferation. It was believed that this novel Mg/HA composite layered coating could be potentially applied in further development of bio-functional hybrid orthopedic implants.
基金supported by the Chongqing Natural Science Foundation(No.CSTB2023NSCQ-MSX0512)Municipal Human Resources and Social Security Bureau(No.cx2022098)China Postdoctoral Science Foundation(Nos.2022T150767 and 2021M693708).
文摘Mg and its alloys show high potential to be applied as implant materials due to their superior properties like biodegradability,bioactivity,biocompatibility,and suitable mechanical behaviors.Nevertheless,the fast and uncontrolled degradation of Mg alloys in biological environment severely restricts their wide applications as biomedical materials.In comparison with alloying,surface coatings can not only improve corrosion resistance but also impart other bio-functional properties to achieve diverse clinical requirements.This review analyzes and summarizes the most recent developments in popular coating technologies,including micro-arc oxidation,electrophoretic deposition,chemical conversion,anodic oxidation,layered double hydroxide,and sol-gel coatings.Considering inevitable damages under complex service conditions,smart self-healing coatings are also introduced in each coating technology.The existing issues and future perspectives are finally discussed to facilitate applications of Mg alloys as biomedical materials in the medical industry.
基金the project No.2021/43/P/ST7/02418 cofunded by the National Science Centre and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 945339JMFF,RB,PG gratefully acknowledge the financial support provided by the Polish National Science Centre for the POLONEZ BIS 1“BAGBONE”,Project no.536651.JMFF would like to thank all the national and international research collaborators for their valuable contributions,especially for the papers covered in this review article+2 种基金the scope of the project CICECOAveiro Institute of Materials,UIDB/50011/2020,UIDP/50011/2020&LA/P/0006/2020,financed by national funds through the FCT/MCTES(PIDDAC)the Department of Health Research–Indian Council of Medical Research[DHR-ICMR]India[Reference:R.11013/28/2021-GIA/HR dated November 25,2021]is recognized by SK and MA.GES and ACP are thankful to the Core Program of the National Institute of Materials Physics within the National Research Development and Innovation Plan 2022–2027,carried out with the support of the Romanian Ministry of Research,Innovation and Digitalization under the project PC2-PN23080101.
文摘Over the past two decades,the CICECO-hub scientists have devoted substantial efforts to advancing bioactiveinorganic materials based on calcium phosphates and alkali-free bioactive glasses.A key focus has been thedeliberate incorporation of therapeutic ions like Mg,Sr,Zn,Mn,or Ga to enhance osteointegration and vascularization,confer antioxidant properties,and impart antimicrobial effects,marking significant contributions tothe field of biomaterials and bone tissue engineering.Such an approach is expected to circumvent the uncertaintiesposed by methods relying on growth factors,such as bone morphogenetic proteins,parathyroidhormone,and platelet-rich plasma,along with their associated high costs and potential adverse side effects.Thiscomprehensive overview of CICECO-hub’s significant contributions to the forefront inorganic biomaterials acrossall research aspects and dimensionalities(powders,granules,thin films,bulk materials,and porous structures),follows a unified approach rooted in a cohesive conceptual framework,including synthesis,characterization,andtesting protocols.Tangible outcomes[injectable cements,durable implant coatings,and bone graft substitutes(scaffolds)featuring customized porous architectures for implant fixation,osteointegration,accelerated boneregeneration in critical-sized bone defects]were achieved.The manuscript showcases specific biofunctionalexamples of successful biomedical applications and effective translations to the market of bone grafts foradvanced therapies.
基金The financial assistance provided by Science and Engineering Research Board(SERB)under Department of Science and Technology(DST),New Delhi(File No.CRG/2021/001310 dated:December 29,2021)India is also duly acknowledged.
文摘Probiotic has gained a lot of attention pertaining to their potential health benefits in the last decades.Moreover,the growing demands for probiotic-based dietary supplements,food products and pharmaceuticals,have further affirmed its role as a prophylactic and therapeutic agent.Although considered safe,the increasing incidence of allergic sensitization and autoimmune disorders further limits the use of live probiotics.Recent,mechanistic evaluation behind the probiotic benefits has unraveled the role of surface effector molecules as primary mediators of the probiotic action.This review initially introduces the structural-functional aspects of surface-associated molecules(surface proteins,cell-bound exopolysaccharide,lipoteichoic acid,pilli and peptidoglycan complex)of probiotic lactic acid bacteria involved in host-microbe interactions.Later,the recent findings involving the role of these effector molecules in various host-associated bio-functional attributes such as intestinal adhesion,immunomodulation,restoration of gut barrier integrity,anti-pathogenic and anti-biofilm,anti-oxidative,anti-tumor,anti-obesity,anti-diabetic potentials were discussed elaborately.Mostly,interactions of bacterial surface components with host-derived factors occur in the gastrointestinal tract which ensure the successful exertion of the beneficial effects of probiotic bacteria.Thus,the direct evidence of the applicability of the effector molecules in imparting bio-functional attributes possibly indicates a safer alternative to classical probiotics.Complete knowledge of chemical structures,targets and validated dosages of these natural molecules further expands the area of pharmabiotics.
基金Acknowledgements We are grateful to the State Key Laboratory of Coordination Chemistry in Nanjing University, the State Key Laboratory of Bio-organic and Natural Products Chemistry in Shanghai Institute of Organic Chemistry for their financial support. T
文摘There is considerable research interest and vigorous debate about the DNA binding of polypyridyl complexes including the electron transfer involving DNA. In this review, based on the fluorescence quenching experiments, it was proposed that DNA might serve as a conductor. From the time-interval CD spectra, the different binding rates of Δ- and Λ-enantiomer to calf thymus DNA were observed. The factors influencing the DNA-binding of polypyridyl complexes, and the potential bio-functions of the complexes are also discussed.
