Objective:This observational study deciphered the dynamic remodeling of gastrointestinal functional homeostasis during Daoist fasting(Bigu)through convergent analysis of physiometric biomarkers and psychosomatic perce...Objective:This observational study deciphered the dynamic remodeling of gastrointestinal functional homeostasis during Daoist fasting(Bigu)through convergent analysis of physiometric biomarkers and psychosomatic perception profiles,thereby unmasking the neuro-endocrine-immune regulatory mechanisms underlying the Traditional Chinese Medicine(TCM)doctrine of“Yang hyperactivity conjoined with Yin hypoactivity.”Methods:This is an observational study with 36 subjects involved from March 15 to 22,2020.The data from 3 tests before,during,and after the fasting were analyzed.Body composition,such as body weight and bone mass,physiological indexes,such as blood pressure,pulse beat,oxygen saturation,and blood perfusion,and subjective sensation,such as quality of sleep,energy evaluation,and fatigue,were analyzed.Results:There were significant differences in body weight,body mass index,systolic blood pressure,diastolic blood pressure,heart rate,basal metabolic rate,bone mass,and visceral fat index(P<0.01)before,during,and after fasting.Blood oxygen saturation,blood perfusion,and body water content before,during,and after fasting were not statistically significant.Conclusions:Combined with literature research and modern physiological testing instruments,this paper explains the traditional Chinese medicine theory of“excess in Yang and deficiency in Yin”from a new aspect.That is,when the contents of the gastrointestinal tract are full,the overall state of the body is in the hyperactive“Yangming”state characterized by full energy and absence of fatigue.When the gastrointestinal tract contents are near empty,the overall state of the body is in the weak“Taiyin”condition,characterized by lack of energy and fatigue.展开更多
Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ke...Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ketogenesis is induced during ketogenic diet therapy,we hypothesize that ketogenesis is detectable and related body weight loss would occur during the first week of Qigong Bigu practice.Methods:During the prospective observational study,34 healthy adult participants attended the Qigong Bigu practice for one week.The blood pressure,body weight,calorie consumption,blood glucose and beta-hydroxybutyrate level were measured.Results:The body weight and body mass index decreased by 2.39±1.34 kg(95%CI 1.92–2.85)and 0.94±0.57(95%CI 0.73–1.15),respectively,after five days of practice(P<0.001).The systolic and diastolic blood pressure decreased by 17.86±14.17 mmHg(95%CI 12.36–23.35)and 9.75±7.45 mmHg(95%CI 6.86–12.64),respectively(P<0.001).The average five-day calorie consumption was 1197.47±569.97 kcal(95%CI 998.60–1396.35).Meanwhile,no symptomatic hypoglycemia or other significant side effects were observed.The blood beta-hydroxybutyrate level increased to a nutritional level of 1.15±1.12 mmol/L(95%CI 0.76–1.62).The calorie consumption negatively correlated to the beta-hydroxybutyrate level in the blood.The loss of body weight and the decrease of body mass index were positively correlated to the blood beta-hydroxybutyrate level.Conclusions:Qigong Bigu can decrease the blood pressure,the body weight and the body mass index in healthy adult participants.The fasting stage of Qigong Bigu is accompanied by ketogenesis.Clinical trial of Qigong Bigu in hypertension and epilepsy patients might be worthwhile.The blood beta-hydroxybutyrate might be used as a biomarker to evaluate the effect of Qigong Bigu practice during fasting.展开更多
Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ke...Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ketogenesis is induced during ketogenic diet therapy,we hypothesize that ketogenesis is detectable and related body weight loss would occur during the first week of Qigong Bigu practice.Methods:During the prospective observational study,34 healthy adult participants attended the Qigong Bigu practice for one week.The blood pressure,body weight,calorie consumption,blood glucose and beta-hydroxy butyrate level were measured.Results:The body weight and body mass index decreased by 2.39±1.34 kg(95%CI1.92-2.85)and 0.94±0.57(95%CI 0.73-1.15),respectively,after five days of practice(P<0.001).The systolic and diastolic blood pressure decreased by 17.86±14.17 mmHg(95%Ci 12.36-23.35)and 9.75±7.45 mmHg(95%CI 6.86-12.64),respectively(P<0.001).The average five-day calorie consumption was 1197.47±569.97 kcal(95%CI 998.60-1396.35).Meanwhile,no symptomatic hypoglycemia or other significant side effects were observed.The blood beta-hydroxy butyrate level increased to a nutritional level of 1.15±1.12 mmol/L(95%CI 0.76-1.62).The calorie consumption negatively correlated to the beta-hydroxy butyrate level in the blood.The loss of body weight and the decrease of body mass index were positively correlated to the blood beta-hydroxy butyrate level.Conclusions:Qigong Bigu can decrease the blood pressure,the body weight and the body mass index in healthy adult participants.The fasting stage of Qigong Bigu is accompanied by ketogenesis.Clinical trial of Qigong Bigu in hypertension and epilepsy patients might be worthwhile.The blood beta-hydroxy butyrate might be used as a biomarker to evaluate the effect of Qigong Bigu practice during fasting.展开更多
基金Central Level Public Welfare Scientific Research Institution Basic Scientific Research Business Expense Personal Project(YZX-202345):Objectified study of the diagnosis of chronic atrophic gastritis by Fuyang pulse Doppler flow imagingCentral Level Public Welfare Scientific Research Institution Basic Scientific Research Business Expense Personal Project(ZZ18-XRZ-072):A Study on the Theoretical System of Traditional Chinese Medicine’s Diagnosis and Treatment Under the Time Philosophy of Four Seasons and Yin-Yang in Pre-Qin and Han Dynasties。
文摘Objective:This observational study deciphered the dynamic remodeling of gastrointestinal functional homeostasis during Daoist fasting(Bigu)through convergent analysis of physiometric biomarkers and psychosomatic perception profiles,thereby unmasking the neuro-endocrine-immune regulatory mechanisms underlying the Traditional Chinese Medicine(TCM)doctrine of“Yang hyperactivity conjoined with Yin hypoactivity.”Methods:This is an observational study with 36 subjects involved from March 15 to 22,2020.The data from 3 tests before,during,and after the fasting were analyzed.Body composition,such as body weight and bone mass,physiological indexes,such as blood pressure,pulse beat,oxygen saturation,and blood perfusion,and subjective sensation,such as quality of sleep,energy evaluation,and fatigue,were analyzed.Results:There were significant differences in body weight,body mass index,systolic blood pressure,diastolic blood pressure,heart rate,basal metabolic rate,bone mass,and visceral fat index(P<0.01)before,during,and after fasting.Blood oxygen saturation,blood perfusion,and body water content before,during,and after fasting were not statistically significant.Conclusions:Combined with literature research and modern physiological testing instruments,this paper explains the traditional Chinese medicine theory of“excess in Yang and deficiency in Yin”from a new aspect.That is,when the contents of the gastrointestinal tract are full,the overall state of the body is in the hyperactive“Yangming”state characterized by full energy and absence of fatigue.When the gastrointestinal tract contents are near empty,the overall state of the body is in the weak“Taiyin”condition,characterized by lack of energy and fatigue.
基金supported by Sanming Project of Medicine in Shenzhen(SZSM201812005)Shenzhen Key Medical Discipline Construction Fund(No.SZXK033)Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties(No.SZGSP012).
文摘Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ketogenesis is induced during ketogenic diet therapy,we hypothesize that ketogenesis is detectable and related body weight loss would occur during the first week of Qigong Bigu practice.Methods:During the prospective observational study,34 healthy adult participants attended the Qigong Bigu practice for one week.The blood pressure,body weight,calorie consumption,blood glucose and beta-hydroxybutyrate level were measured.Results:The body weight and body mass index decreased by 2.39±1.34 kg(95%CI 1.92–2.85)and 0.94±0.57(95%CI 0.73–1.15),respectively,after five days of practice(P<0.001).The systolic and diastolic blood pressure decreased by 17.86±14.17 mmHg(95%CI 12.36–23.35)and 9.75±7.45 mmHg(95%CI 6.86–12.64),respectively(P<0.001).The average five-day calorie consumption was 1197.47±569.97 kcal(95%CI 998.60–1396.35).Meanwhile,no symptomatic hypoglycemia or other significant side effects were observed.The blood beta-hydroxybutyrate level increased to a nutritional level of 1.15±1.12 mmol/L(95%CI 0.76–1.62).The calorie consumption negatively correlated to the beta-hydroxybutyrate level in the blood.The loss of body weight and the decrease of body mass index were positively correlated to the blood beta-hydroxybutyrate level.Conclusions:Qigong Bigu can decrease the blood pressure,the body weight and the body mass index in healthy adult participants.The fasting stage of Qigong Bigu is accompanied by ketogenesis.Clinical trial of Qigong Bigu in hypertension and epilepsy patients might be worthwhile.The blood beta-hydroxybutyrate might be used as a biomarker to evaluate the effect of Qigong Bigu practice during fasting.
基金This work was supported by Sanming Project of Medicine in Shenzhen(SZSM201812005)Shenzhen Key Medical Discipline Construction Fund(No.SZXK033)Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties(No.SZGSP012).
文摘Background:Hypertension is one of the most common comorbid conditions of epilepsy.Hypertension and epilepsy may be related to each other.Qigong Bigu practice induces a similar effect as fasting in the first week.As ketogenesis is induced during ketogenic diet therapy,we hypothesize that ketogenesis is detectable and related body weight loss would occur during the first week of Qigong Bigu practice.Methods:During the prospective observational study,34 healthy adult participants attended the Qigong Bigu practice for one week.The blood pressure,body weight,calorie consumption,blood glucose and beta-hydroxy butyrate level were measured.Results:The body weight and body mass index decreased by 2.39±1.34 kg(95%CI1.92-2.85)and 0.94±0.57(95%CI 0.73-1.15),respectively,after five days of practice(P<0.001).The systolic and diastolic blood pressure decreased by 17.86±14.17 mmHg(95%Ci 12.36-23.35)and 9.75±7.45 mmHg(95%CI 6.86-12.64),respectively(P<0.001).The average five-day calorie consumption was 1197.47±569.97 kcal(95%CI 998.60-1396.35).Meanwhile,no symptomatic hypoglycemia or other significant side effects were observed.The blood beta-hydroxy butyrate level increased to a nutritional level of 1.15±1.12 mmol/L(95%CI 0.76-1.62).The calorie consumption negatively correlated to the beta-hydroxy butyrate level in the blood.The loss of body weight and the decrease of body mass index were positively correlated to the blood beta-hydroxy butyrate level.Conclusions:Qigong Bigu can decrease the blood pressure,the body weight and the body mass index in healthy adult participants.The fasting stage of Qigong Bigu is accompanied by ketogenesis.Clinical trial of Qigong Bigu in hypertension and epilepsy patients might be worthwhile.The blood beta-hydroxy butyrate might be used as a biomarker to evaluate the effect of Qigong Bigu practice during fasting.
