Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and dru...Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped CQDs.Lipo/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.展开更多
The electronic and crystal structural properties of Bi-doped Sr3Ti2O7 are studied using the first principles density functional theory（DFT）based on pseudopotentials basis and plane-wave method.Our results show that ...The electronic and crystal structural properties of Bi-doped Sr3Ti2O7 are studied using the first principles density functional theory（DFT）based on pseudopotentials basis and plane-wave method.Our results show that the formation energy of Bi doping in Site-1 and Site-2 of Sr3Ti2O7 increases with increasing doping concentration.And at the same doping concentration,the formation energy of Bi doping in Site-2 is lower than that in Site-1.The undoped Sr3Ti2O7is found to be an insulator and its Fermi level stays at the top of the valence band.While the Fermi level of the Bi-doped Sr3Ti2O7moves into the bottom of conduction band,the system undergoes an insulator-to-metal phase transition.Furthermore,our calculation results demonstrated that the Fermi level of the Bi-doped Sr3Ti2O7goes deeper into the bottom of conduction band with increasing doping concentration.展开更多
Bi-doped glass fibers with controllable optical response are essential for next-generation broadband amplifiers and tunable lasers.However,achieving broad wavelength tunability and stable near-infrared(NIR)emission re...Bi-doped glass fibers with controllable optical response are essential for next-generation broadband amplifiers and tunable lasers.However,achieving broad wavelength tunability and stable near-infrared(NIR)emission remains challenging due to limited structural modification of conventional silica glasses and variability of Bi active centers(BACs).Here,we propose a cation hybridization strategy to overcome these issues,demonstrating an enhanced ultra-broadband,multi-band NIR optical response in Bi-doped photonic glasses.Alkaline earth metal ions,such as Mg^(2+)and Ba^(2+),were employed as the hybrid cations to“repair”(Mg^(2+))and“tailor”(Ba^(2+))the flexible glass network of germanate glasses,enabling precise customization of the local environment to stabilize different BACs.Impressively,this enables a tunable optical response,ranging from one main peak emission at 1142 nm to a stable multi-band emission spanning 920,1142,1265,and 1516 nm,with an emission bandwidth of 526 nm,which is distinct from conventional rare-earth ions doped glasses.Furthermore,Bi-doped hybrid germanate glass fibers were fabricated and a positive on-off gain in multiple communication bands(O+E+S+C bands)was successfully achieved.The results offer new insights into the Bi NIR luminescence behavior and introduce a promising strategy for developing advanced photonic glass materials.展开更多
Bi-doped TiO2 nanotubes with variable Bi/Ti ratios were synthesized by hydrothermal treatment in 10 mol·L^-1 NaOH （aq.） through using Bi-doped TiO2 particles derived from conventional sol-gel method as starting...Bi-doped TiO2 nanotubes with variable Bi/Ti ratios were synthesized by hydrothermal treatment in 10 mol·L^-1 NaOH （aq.） through using Bi-doped TiO2 particles derived from conventional sol-gel method as starting materials. The effects of Bi content on the morphology, textural properties, photo absorption and photocatalytic activity of TiO2 nanotubes were investigated. The scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS） observations of the obtained samples revealed the formation of titanate nanotube structure doped with Bi, which exists as a higher oxidation state than Bi3＋. Bi-doping TiO2 nanotubes exhibited an extension of light absorption into the visible region and improved photocatalytic activities for hydrogen production from a glycerol/water mixed solution as compared with pure TiO2 nanotubes. There was an optimal Bi-doped content for the photocatalytic hydrogen production, and high content of Bi would retard the phase transition of titanate to anatase and result in morphology change from nanotube to nano- belt, which in turn decreases the photocatlytic activity for hydrogen evolution.展开更多
基金funded by Beijing Natural Science Foundation (Nos.L222109, 3222018)Military Health Care Project(No.22BJZ22)+6 种基金Science Foundation of China University of Petroleum (Nos.2462019QNXZ02, 2462019BJRC007)National Natural Science Foundation of China (Nos.52211530034, 82273236)Guangdong Provincial Basic and Applied Basic Research Foundation (Nos.2022A151522004, 2022A1515220042)Science and Technology Innovation Commission of Shenzhen (Nos.JSGG20210802153410031, JCYJ20220530141609021)Science and Technology Plan of Shenzhen Nanshan District (No.NS016)Discipline Leader Foundation of Huazhong University of Science and Technology Union Shenzhen Hospital (No.YN2021002)Crosswise Project of Daan Gene (No.HXKY2022002)。
文摘Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped CQDs.Lipo/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.
基金supported by the National Natural Science Foundation of China (NSFC) (Grant Nos.51575452,51475378 and 51474176)the Fundamental Research Funds for the Central Universities (No.3102015ZY025)+2 种基金the Research Fund of the State Key Laboratory of Solidification Processing,Northwestern Polytechnic University (Grant No.161-QP-2016)NSFC-Guangdong mutual funds (phase ii) supercomputing science and applied research under special fundingNational supercomputing center in Guangzhou
文摘The electronic and crystal structural properties of Bi-doped Sr3Ti2O7 are studied using the first principles density functional theory（DFT）based on pseudopotentials basis and plane-wave method.Our results show that the formation energy of Bi doping in Site-1 and Site-2 of Sr3Ti2O7 increases with increasing doping concentration.And at the same doping concentration,the formation energy of Bi doping in Site-2 is lower than that in Site-1.The undoped Sr3Ti2O7is found to be an insulator and its Fermi level stays at the top of the valence band.While the Fermi level of the Bi-doped Sr3Ti2O7moves into the bottom of conduction band,the system undergoes an insulator-to-metal phase transition.Furthermore,our calculation results demonstrated that the Fermi level of the Bi-doped Sr3Ti2O7goes deeper into the bottom of conduction band with increasing doping concentration.
基金supported by the National Natural Science Foundation of China(62405092,62122027,62075063,62205109)the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZC20230852)the Guangdong Basic and Applied Basic Research Foundation(2025A1515010444).
文摘Bi-doped glass fibers with controllable optical response are essential for next-generation broadband amplifiers and tunable lasers.However,achieving broad wavelength tunability and stable near-infrared(NIR)emission remains challenging due to limited structural modification of conventional silica glasses and variability of Bi active centers(BACs).Here,we propose a cation hybridization strategy to overcome these issues,demonstrating an enhanced ultra-broadband,multi-band NIR optical response in Bi-doped photonic glasses.Alkaline earth metal ions,such as Mg^(2+)and Ba^(2+),were employed as the hybrid cations to“repair”(Mg^(2+))and“tailor”(Ba^(2+))the flexible glass network of germanate glasses,enabling precise customization of the local environment to stabilize different BACs.Impressively,this enables a tunable optical response,ranging from one main peak emission at 1142 nm to a stable multi-band emission spanning 920,1142,1265,and 1516 nm,with an emission bandwidth of 526 nm,which is distinct from conventional rare-earth ions doped glasses.Furthermore,Bi-doped hybrid germanate glass fibers were fabricated and a positive on-off gain in multiple communication bands(O+E+S+C bands)was successfully achieved.The results offer new insights into the Bi NIR luminescence behavior and introduce a promising strategy for developing advanced photonic glass materials.
基金We acknowledge the financial supports from the Na-tional Natural Science Foundation of China （Nos. 21276190 and 20806059）.
文摘Bi-doped TiO2 nanotubes with variable Bi/Ti ratios were synthesized by hydrothermal treatment in 10 mol·L^-1 NaOH （aq.） through using Bi-doped TiO2 particles derived from conventional sol-gel method as starting materials. The effects of Bi content on the morphology, textural properties, photo absorption and photocatalytic activity of TiO2 nanotubes were investigated. The scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS） observations of the obtained samples revealed the formation of titanate nanotube structure doped with Bi, which exists as a higher oxidation state than Bi3＋. Bi-doping TiO2 nanotubes exhibited an extension of light absorption into the visible region and improved photocatalytic activities for hydrogen production from a glycerol/water mixed solution as compared with pure TiO2 nanotubes. There was an optimal Bi-doped content for the photocatalytic hydrogen production, and high content of Bi would retard the phase transition of titanate to anatase and result in morphology change from nanotube to nano- belt, which in turn decreases the photocatlytic activity for hydrogen evolution.
