Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupli...Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupling,and 1T-VTe_(2)monolayer theoretically predicted to host an intrinsic magnetism as experimentally suggested.In this work,we successfully constructed a vertical heterostructure composed of the two-dimensional Bi(110)monolayer and 1T-VTe_(2)monolayer by using molecular beam epitaxy(MBE).Scanning tunneling microscopy(STM)measurements revealed that the growth of Bi preferably occurs along the step edges of the VTe_(2)monolayer,forming a Bi(110)monolayer on top of the VTe_(2)monolayer next to a peripheral Bi bilayer.The Bi(100)/VTe_(2)heterostructure exhibits a specific lattice registry with a well-defined moiréperiodicity.Scanning tunneling spectroscopy(STS)measurements further unveiled an universal suppression in the local density-of-states at the boundary of the Bi(110)/VTe_(2)bilayer.By examining the atomic structures of Bi(110)boundaries,we found this effect does not originate from the previously proposed atomic reconstruction at the step edge of Bi(110),but is likely related to the magnetic properties of the VTe_(2)monolayer.展开更多
在遥感海浪数据质量控制研究中,由于数据的复杂与不规则性,传统质量控制方法对海浪数据单点异常值的检测具有一定局限性。深度学习具有强大的特征学习能力,在解决非线性复杂问题方面具有一定优势,将其应用在数据质量控制领域可以提高异...在遥感海浪数据质量控制研究中,由于数据的复杂与不规则性,传统质量控制方法对海浪数据单点异常值的检测具有一定局限性。深度学习具有强大的特征学习能力,在解决非线性复杂问题方面具有一定优势,将其应用在数据质量控制领域可以提高异常值检测能力。本研究采用遥感海浪有效波高数据,构建双向长短期记忆网络(bi-directional long short term memory,Bi-LSTM)模型对有效波高进行预测,结合阈值方法进行异常检测,与3σ准则法、孤立森林模型法、 LSTM模型法以及VAE-LSTM模型法进行异常检测精度比较,探究基于Bi-LSTM的质量控制模型在遥感海浪数据异常值检测方面的能力。试验结果表明,Bi-LSTM质量控制模型具有良好的异常值检测效果,其精准率、召回率、 F1分数和运行时间分别为91%、 93%、 92和3.35 s,综合评价效果最佳,可有效对遥感海浪数据进行质量控制。展开更多
Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-k...Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.展开更多
目的:探讨传统开颅手术与神经内镜微创手术对脑出血患者美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale Score,NIHSS)及巴塞尔指数评分(Barthel Index Score,BI)的影响。方法:回顾性收集2022年1月至2023年...目的:探讨传统开颅手术与神经内镜微创手术对脑出血患者美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale Score,NIHSS)及巴塞尔指数评分(Barthel Index Score,BI)的影响。方法:回顾性收集2022年1月至2023年1月期间本院收治的200例脑出血患者的临床资料。根据治疗方式不同将患者分为对照组(实施传统开颅手术,150例)和观察组(实施神经内镜微创手术,50例)。收集并比较两组术后神经功能恢复情况、术后日常生活活动能力、手术相关指标、术后并发症发生情况。结果:随着术后时间增长,两组NIHSS评分均降低;术后2、3、6、12 m,观察组NIHSS评分均低于对照组(P<0.05)。随着术后时间增长,两组BI评分均提高;术后2、3、6、12 m,观察组BI评分均高于对照组(P<0.05)。观察组手术时间、术后住院时间均短于对照组,术中出血量少于对照组(P<0.05)。观察组术后并发症发生率低于对照组(P<0.05)。结论:与传统开颅手术比较,神经内镜微创手术更有利于促进脑出血患者神经功能恢复、提升日常生活活动能力,且兼具操作时间短、出血量少、住院时间短、并发症发生率低等优势,预后情况良好,值得临床推广应用。展开更多
基金financially supported by the National Key Research and Development Program of China(Grant No.2021YFA1400403)the National Natural Science Foundation of China(Grant Nos.12374183,92165205)+2 种基金the Natural Science Foundation of Jiangsu Province(Grant No.BK20233001)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0302800)the Fundamental Research Funds for the Central Universities(Grant No.020414380207).
文摘Interplay between topology and magnetism can give rise to exotic properties in topological materials.Two-dimensional bismuth has been extensively studied owing to its topological states with a strong spin-orbit coupling,and 1T-VTe_(2)monolayer theoretically predicted to host an intrinsic magnetism as experimentally suggested.In this work,we successfully constructed a vertical heterostructure composed of the two-dimensional Bi(110)monolayer and 1T-VTe_(2)monolayer by using molecular beam epitaxy(MBE).Scanning tunneling microscopy(STM)measurements revealed that the growth of Bi preferably occurs along the step edges of the VTe_(2)monolayer,forming a Bi(110)monolayer on top of the VTe_(2)monolayer next to a peripheral Bi bilayer.The Bi(100)/VTe_(2)heterostructure exhibits a specific lattice registry with a well-defined moiréperiodicity.Scanning tunneling spectroscopy(STS)measurements further unveiled an universal suppression in the local density-of-states at the boundary of the Bi(110)/VTe_(2)bilayer.By examining the atomic structures of Bi(110)boundaries,we found this effect does not originate from the previously proposed atomic reconstruction at the step edge of Bi(110),but is likely related to the magnetic properties of the VTe_(2)monolayer.
文摘在遥感海浪数据质量控制研究中,由于数据的复杂与不规则性,传统质量控制方法对海浪数据单点异常值的检测具有一定局限性。深度学习具有强大的特征学习能力,在解决非线性复杂问题方面具有一定优势,将其应用在数据质量控制领域可以提高异常值检测能力。本研究采用遥感海浪有效波高数据,构建双向长短期记忆网络(bi-directional long short term memory,Bi-LSTM)模型对有效波高进行预测,结合阈值方法进行异常检测,与3σ准则法、孤立森林模型法、 LSTM模型法以及VAE-LSTM模型法进行异常检测精度比较,探究基于Bi-LSTM的质量控制模型在遥感海浪数据异常值检测方面的能力。试验结果表明,Bi-LSTM质量控制模型具有良好的异常值检测效果,其精准率、召回率、 F1分数和运行时间分别为91%、 93%、 92和3.35 s,综合评价效果最佳,可有效对遥感海浪数据进行质量控制。
基金funded by grants from the Suzhou Gusu Health Talents Project(grant No.GSWS2024050 to Liu W)Natural Science Foundation Project of Nanjing University of Chinese Medicine(grant No.XZR2021043 to Liu W and grant No.XZR2023021 to Huang F)+1 种基金Suzhou Science Education Health Youth Project(grant No.KJXW2021046 to Liu W)Suzhou Major Disease Multi-center Clinical Research Project(grant No.DZXYJ202410 to Huang F).
文摘Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.
文摘目的:探讨传统开颅手术与神经内镜微创手术对脑出血患者美国国立卫生研究院卒中量表评分(National Institute of Health Stroke Scale Score,NIHSS)及巴塞尔指数评分(Barthel Index Score,BI)的影响。方法:回顾性收集2022年1月至2023年1月期间本院收治的200例脑出血患者的临床资料。根据治疗方式不同将患者分为对照组(实施传统开颅手术,150例)和观察组(实施神经内镜微创手术,50例)。收集并比较两组术后神经功能恢复情况、术后日常生活活动能力、手术相关指标、术后并发症发生情况。结果:随着术后时间增长,两组NIHSS评分均降低;术后2、3、6、12 m,观察组NIHSS评分均低于对照组(P<0.05)。随着术后时间增长,两组BI评分均提高;术后2、3、6、12 m,观察组BI评分均高于对照组(P<0.05)。观察组手术时间、术后住院时间均短于对照组,术中出血量少于对照组(P<0.05)。观察组术后并发症发生率低于对照组(P<0.05)。结论:与传统开颅手术比较,神经内镜微创手术更有利于促进脑出血患者神经功能恢复、提升日常生活活动能力,且兼具操作时间短、出血量少、住院时间短、并发症发生率低等优势,预后情况良好,值得临床推广应用。
