在遥感海浪数据质量控制研究中,由于数据的复杂与不规则性,传统质量控制方法对海浪数据单点异常值的检测具有一定局限性。深度学习具有强大的特征学习能力,在解决非线性复杂问题方面具有一定优势,将其应用在数据质量控制领域可以提高异...在遥感海浪数据质量控制研究中,由于数据的复杂与不规则性,传统质量控制方法对海浪数据单点异常值的检测具有一定局限性。深度学习具有强大的特征学习能力,在解决非线性复杂问题方面具有一定优势,将其应用在数据质量控制领域可以提高异常值检测能力。本研究采用遥感海浪有效波高数据,构建双向长短期记忆网络(bi-directional long short term memory,Bi-LSTM)模型对有效波高进行预测,结合阈值方法进行异常检测,与3σ准则法、孤立森林模型法、 LSTM模型法以及VAE-LSTM模型法进行异常检测精度比较,探究基于Bi-LSTM的质量控制模型在遥感海浪数据异常值检测方面的能力。试验结果表明,Bi-LSTM质量控制模型具有良好的异常值检测效果,其精准率、召回率、 F1分数和运行时间分别为91%、 93%、 92和3.35 s,综合评价效果最佳,可有效对遥感海浪数据进行质量控制。展开更多
Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-k...Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.展开更多
By measuring scanning tunneling spectroscopy on some large Bi islands deposited on FeTe_(0.55)Se_(0.45)superconductors,we observe clear in-gap edge states with double peaks at about±1.0 me V on the spectra measur...By measuring scanning tunneling spectroscopy on some large Bi islands deposited on FeTe_(0.55)Se_(0.45)superconductors,we observe clear in-gap edge states with double peaks at about±1.0 me V on the spectra measured near the perimeter of the islands.This feature is very different from the single zero-energy peak observed on some other small Bi islands.The edge states spread towards the inner side of the islands over a width of 2-3 nm.The two edge-state peaks at positive and negative energies move to higher values with the increase of the magnetic field,and they disappear near the transition temperature of FeTe_(0.55)Se_(0.45).Meanwhile,enhanced superconducting gaps are observed in the central regions of these Bi islands,which may be induced by the enhanced pair potential of the topological surface state.Our observations provide a valuable message for the edge state and the proximity-induced superconductivity on specific Bi islands grown on FeTe_(0.55)Se_(0.45)substrate.展开更多
短期预测在智能电网建设中扮演着重要角色,深刻影响电网发输变配用各个环节的智能化改造。短期预测一般基于系统实测数据,而传感器故障,数据传输错误等原因会导致数据质量下降,严重影响短期预测的精确性。为建立数据质量受损情况下的精...短期预测在智能电网建设中扮演着重要角色,深刻影响电网发输变配用各个环节的智能化改造。短期预测一般基于系统实测数据,而传感器故障,数据传输错误等原因会导致数据质量下降,严重影响短期预测的精确性。为建立数据质量受损情况下的精确短期预测模型,提出了结合数据预处理和双向长短期记忆(bi-directional long short-term memory,Bi-LSTM)的短期预测框架Bi-LSTM-DP(bi-directional long short-term memory data preprocessing)。在Bi-LSTM-DP中,采集的数据首先通过均值填补缺失值,进而基于Savitzky-Golay滤波器对数据降噪,最后采用Bi-LSTM提取时间序列的信息,实现短期预测。为了评估所提方法的性能,文中使用实测的公开数据集分别预测风电发电量和负荷需求,与其他参考方法对比表明了所述方法的有效性和鲁棒性。展开更多
Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). Th...Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). The reaction of 2 with hydrazine hydrate followed by diazotization reaction af-forded the 1,1’-(1,4-phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(e-than-1-one) (3) and 1,1’-(1,4-phenylenebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3,4-b]-pyridine-4,5-diyl))bis(ethan-1-one) (4) respectively. On the other hand, reaction of 4 with malononitrile, 2-cyanoethanethioamide, ethyl acetoacetate, acetyl acetone, ethyl benzoylacetate, diethylmalonate, ethyl cyanoacetate and phenacylbromide aiming to build up pyrazolotriazine or pyrazole ring on the ring system of 4. Structures of all newly synthesized heterocyclic compounds in the present study were confirmed by considering the data of IR, 1H NMR, mass spectra as well as that of elemental analyses.展开更多
The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum glazing.Under the condition of constant boron content,how the structure and properties vary with B...The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum glazing.Under the condition of constant boron content,how the structure and properties vary with Bi/Si ratio in low-melting glass was investigated.In addition,the relationships between laser power,low-melting glass solder with different Bi/Si ratios and laser sealing shear strength were revealed.The results show that a decrease in the Bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal expansion.During laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the Bi/Si ratio will affect the valence state transition of the copper ions in the low-melting glass.The absorbance of the low-melting glass does not follow the expected correlation with the Bi/Si ratio,but shows a linear correlation with the content of divalent copper ions.The greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser sealing.The shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.展开更多
文摘在遥感海浪数据质量控制研究中,由于数据的复杂与不规则性,传统质量控制方法对海浪数据单点异常值的检测具有一定局限性。深度学习具有强大的特征学习能力,在解决非线性复杂问题方面具有一定优势,将其应用在数据质量控制领域可以提高异常值检测能力。本研究采用遥感海浪有效波高数据,构建双向长短期记忆网络(bi-directional long short term memory,Bi-LSTM)模型对有效波高进行预测,结合阈值方法进行异常检测,与3σ准则法、孤立森林模型法、 LSTM模型法以及VAE-LSTM模型法进行异常检测精度比较,探究基于Bi-LSTM的质量控制模型在遥感海浪数据异常值检测方面的能力。试验结果表明,Bi-LSTM质量控制模型具有良好的异常值检测效果,其精准率、召回率、 F1分数和运行时间分别为91%、 93%、 92和3.35 s,综合评价效果最佳,可有效对遥感海浪数据进行质量控制。
基金funded by grants from the Suzhou Gusu Health Talents Project(grant No.GSWS2024050 to Liu W)Natural Science Foundation Project of Nanjing University of Chinese Medicine(grant No.XZR2021043 to Liu W and grant No.XZR2023021 to Huang F)+1 种基金Suzhou Science Education Health Youth Project(grant No.KJXW2021046 to Liu W)Suzhou Major Disease Multi-center Clinical Research Project(grant No.DZXYJ202410 to Huang F).
文摘Background:Inflammation,caused by prolonged hyperglycemia,plays a substantially more important part in the progression of diabetic peripheral neuropathy(DPN).Notably,the MAPK pathway that mediates the Nuclear Factor-kappa B(NF-κB)pathway contributes to inflammation-induced peripheral nerve damage,affecting cell survival.Juan Bi Tong Luo(JBTL),a traditional Chinese medicine(TCM),has demonstrated favorable results in alleviating pain and numbness in patients with DPN;however,whether JBTL exerts its effect through the MAPK mediating NF-κB pathway remains unclear.Methods:This study investigated whether JBTL modulates apoptosis in DPN models and Schwann cells cultured in 100 mM of glucose by MAPK/NF-κB.Results:The JBTL altered inflammation,reduced peripheral nerve tissue damage,and improved cell survival rates by down-regulating MAPK/NF-κB.Conclusion:Our findings demonstrate that the effect of JBTL on DPN is likely mediated by suppressing inflammation induced by the MAPK/NF-κB pathway,thus providing evidence for the clinical efficacy of JBTL in treating DPN.
基金supported by the National Key R&D Program of China(Grant Nos.2022YFA1403201 and 2024YFA1408104)the National Natural Science Foundation of China(Grant Nos.11927809 and 12434004)the Natural Science Foundation of Jiangsu Province(Grant No.BK20233001)。
文摘By measuring scanning tunneling spectroscopy on some large Bi islands deposited on FeTe_(0.55)Se_(0.45)superconductors,we observe clear in-gap edge states with double peaks at about±1.0 me V on the spectra measured near the perimeter of the islands.This feature is very different from the single zero-energy peak observed on some other small Bi islands.The edge states spread towards the inner side of the islands over a width of 2-3 nm.The two edge-state peaks at positive and negative energies move to higher values with the increase of the magnetic field,and they disappear near the transition temperature of FeTe_(0.55)Se_(0.45).Meanwhile,enhanced superconducting gaps are observed in the central regions of these Bi islands,which may be induced by the enhanced pair potential of the topological surface state.Our observations provide a valuable message for the edge state and the proximity-induced superconductivity on specific Bi islands grown on FeTe_(0.55)Se_(0.45)substrate.
文摘短期预测在智能电网建设中扮演着重要角色,深刻影响电网发输变配用各个环节的智能化改造。短期预测一般基于系统实测数据,而传感器故障,数据传输错误等原因会导致数据质量下降,严重影响短期预测的精确性。为建立数据质量受损情况下的精确短期预测模型,提出了结合数据预处理和双向长短期记忆(bi-directional long short-term memory,Bi-LSTM)的短期预测框架Bi-LSTM-DP(bi-directional long short-term memory data preprocessing)。在Bi-LSTM-DP中,采集的数据首先通过均值填补缺失值,进而基于Savitzky-Golay滤波器对数据降噪,最后采用Bi-LSTM提取时间序列的信息,实现短期预测。为了评估所提方法的性能,文中使用实测的公开数据集分别预测风电发电量和负荷需求,与其他参考方法对比表明了所述方法的有效性和鲁棒性。
文摘Reaction of 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile) (1) with methyl iodide afforded the 4,4’-(1,4-phenylene)bis(5-acetyl-6-methyl-2-(methylthio)nicotinonitrile) (2). The reaction of 2 with hydrazine hydrate followed by diazotization reaction af-forded the 1,1’-(1,4-phenylenebis(3-amino-6-methyl-1H-pyrazolo[3,4-b]pyridine-4,5-diyl))bis(e-than-1-one) (3) and 1,1’-(1,4-phenylenebis(3-(chlorodiazenyl)-6-methyl-1H-pyrazolo[3,4-b]-pyridine-4,5-diyl))bis(ethan-1-one) (4) respectively. On the other hand, reaction of 4 with malononitrile, 2-cyanoethanethioamide, ethyl acetoacetate, acetyl acetone, ethyl benzoylacetate, diethylmalonate, ethyl cyanoacetate and phenacylbromide aiming to build up pyrazolotriazine or pyrazole ring on the ring system of 4. Structures of all newly synthesized heterocyclic compounds in the present study were confirmed by considering the data of IR, 1H NMR, mass spectra as well as that of elemental analyses.
基金Funded by the National Natural Science Foundation of China(No.52472012)Opening Project of State Silica-Based Materials Laboratory of Anhui Province(No.2022KF11)the Research and Development of Glass Powder for Laser Sealing and Its Sealing Technology(No.K24556)。
文摘The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum glazing.Under the condition of constant boron content,how the structure and properties vary with Bi/Si ratio in low-melting glass was investigated.In addition,the relationships between laser power,low-melting glass solder with different Bi/Si ratios and laser sealing shear strength were revealed.The results show that a decrease in the Bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal expansion.During laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the Bi/Si ratio will affect the valence state transition of the copper ions in the low-melting glass.The absorbance of the low-melting glass does not follow the expected correlation with the Bi/Si ratio,but shows a linear correlation with the content of divalent copper ions.The greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser sealing.The shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.
