Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for ...Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for the management of urolithiasis.Objective:The study is carried out to scientifically validate the traditional formulation and to study the mechanism of ABC.Methods:In the present study,the antiurolithiatic activity of ABC was evaluated in Wister albino rats by using ethylene glycol through drinking water.Group I acted as the standard control group and was given unlimited access to conventional rat food and water.Group II-V was given ethylene glycol(0.75%)in water to induce renal calculi for 28 days.Group III got the typical anti-urolithiatic medication,Cystone(750 mg/kg),from the 15th day to the 28th day,whereas Group II functioned as the lithiatic control group and received the vehicle.Aavarai Bhavanai Chooranam(200 mg/kg)was administered to Group IV from the 15th to the 28th day as a curative regimen.From the first day to the 28th day,Group V received Aavarai Bhavanai Chooranam(200 mg/kg),which was administered as a preventative regimen.All groups'urine samples were taken,and using accepted techniques,their calcium,magnesium,oxalate,inorganic phosphate,protein,and creatinine levels were determined.ABC treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline condition in the urinary system which probably mediates the antilithiatic activity.Conclusion:ABC provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.展开更多
Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable diseases.With more than 62 million people in India already living with d...Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable diseases.With more than 62 million people in India already living with diabetes,the disease is quickly gaining the status of a possible epidemic.It has been demonstrated that this medical theory contains anti-diabetic substances.The goal of this work is to assess in silico computational investigations of the phytoconstituents in the traditional Siddha polyherbal preparation ABC,which is frequently used to treat diabetes.Method:Alpha-Glucosidase was used as the target enzyme in docking calculations for recovered phytocomponents.With the help of Auto Dock tools,necessary hydrogen atoms,Kollman unified atom type charges,and solvation parameters were added.The Lamarckian genetic algorithm and the Solis and Wets local search approach were used to simulate docking.Results:A total of 13 bioactive lead compounds were identified from the Siddha Formulation ABC.According to the herb’s stated data,the target enzyme Alpha-Glucosidase can interact with the phytochemicals Beta-Sitosterol,Amyrin,Lupeol,Arjunic acid,Arjungenin,Tinosporide,and Tembetarine up to four or five times.The second-placed substances,which had a maximum of two to three interactions with the target enzyme Alpha-Glucosidase,were betulonic acid,kaempferol,gallic acid,and barbaloin.Conclusion:The implementation of these formulations in future preclinical and clinical studies could result in the effective management of Type II Diabetes Mellitus.展开更多
文摘Background:Aavarai Bhavanai Chooranam(ABC)is a Siddha polyherbal formulation containing ten medicinal plants that have been used in the Siddha system of medicine,practiced in the Southern part of Tamil Nadu,India for the management of urolithiasis.Objective:The study is carried out to scientifically validate the traditional formulation and to study the mechanism of ABC.Methods:In the present study,the antiurolithiatic activity of ABC was evaluated in Wister albino rats by using ethylene glycol through drinking water.Group I acted as the standard control group and was given unlimited access to conventional rat food and water.Group II-V was given ethylene glycol(0.75%)in water to induce renal calculi for 28 days.Group III got the typical anti-urolithiatic medication,Cystone(750 mg/kg),from the 15th day to the 28th day,whereas Group II functioned as the lithiatic control group and received the vehicle.Aavarai Bhavanai Chooranam(200 mg/kg)was administered to Group IV from the 15th to the 28th day as a curative regimen.From the first day to the 28th day,Group V received Aavarai Bhavanai Chooranam(200 mg/kg),which was administered as a preventative regimen.All groups'urine samples were taken,and using accepted techniques,their calcium,magnesium,oxalate,inorganic phosphate,protein,and creatinine levels were determined.ABC treatment promotes diuresis which leads to flushing of the renal stones and maintains the alkaline condition in the urinary system which probably mediates the antilithiatic activity.Conclusion:ABC provides structural and functional protection to the kidneys by enhancing its physiological function against stone formation and validates its clinical use.
文摘Background:The Siddha system of traditional medicine has historically been utilized to treat a wide range of illnesses,including noncommunicable diseases.With more than 62 million people in India already living with diabetes,the disease is quickly gaining the status of a possible epidemic.It has been demonstrated that this medical theory contains anti-diabetic substances.The goal of this work is to assess in silico computational investigations of the phytoconstituents in the traditional Siddha polyherbal preparation ABC,which is frequently used to treat diabetes.Method:Alpha-Glucosidase was used as the target enzyme in docking calculations for recovered phytocomponents.With the help of Auto Dock tools,necessary hydrogen atoms,Kollman unified atom type charges,and solvation parameters were added.The Lamarckian genetic algorithm and the Solis and Wets local search approach were used to simulate docking.Results:A total of 13 bioactive lead compounds were identified from the Siddha Formulation ABC.According to the herb’s stated data,the target enzyme Alpha-Glucosidase can interact with the phytochemicals Beta-Sitosterol,Amyrin,Lupeol,Arjunic acid,Arjungenin,Tinosporide,and Tembetarine up to four or five times.The second-placed substances,which had a maximum of two to three interactions with the target enzyme Alpha-Glucosidase,were betulonic acid,kaempferol,gallic acid,and barbaloin.Conclusion:The implementation of these formulations in future preclinical and clinical studies could result in the effective management of Type II Diabetes Mellitus.
