Objective:To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo(PCI).Methods:Eighty-two patients with PCI who visited...Objective:To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo(PCI).Methods:Eighty-two patients with PCI who visited the hospital from February 2024 to February 2025 were selected as samples and randomly divided into two groups.Group A received Tianma Gouteng Decoction combined with Betahistine Mesylate,while Group B received only Betahistine Mesylate.The efficacy,syndrome scores,hemodynamics,and quality of life indicators were compared between the two groups.Results:The efficacy of PCI treatment in Group A was higher than that in Group B(P<0.05).The syndrome scores in Group A were lower than those in Group B(P<0.05).The peak systolic velocity(PSV)of the basilar artery and left and right vertebral arteries in Group A were higher than those in Group B(P<0.05).The quality of life(SF-36)score in Group A was higher than that in Group B(P<0.05).Conclusion:Tianma Gouteng Decoction combined with Betahistine Mesylate is effective and feasible in the treatment of PCI,with improved hemodynamic indicators and reduced disease scores.展开更多
To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VB...To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VBIV were randomly divided into two groups; 45 patients （the treated group） were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients （control group） were treated with Xueshuantong （血栓通） and BHI intravenous dripping, once daily for 14 days. The clinical syndromes and the index of the transcranial Doppler （TCD） and hemorheology were observed. Results： The total effective rate was 100% in the treated group, which was better than that in the control group 90.5%, （P〈0. 05）. The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, （P〈0.01）. Conclusion： YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.展开更多
Betahistine drugs are widely used in vestibular compensation process. For theunderstanding of drugs＇ structural feature, two betahistine drugs＇ （betahistine hydrochloride andbetahistine methanesulfonate） structure...Betahistine drugs are widely used in vestibular compensation process. For theunderstanding of drugs＇ structural feature, two betahistine drugs＇ （betahistine hydrochloride andbetahistine methanesulfonate） structure and vibrational spectra were calculated within densityfunctional theory （DFT） method and comparisons have been made with histamine. The drugs＇interactions with the receptors were revealed by using the molecular docking methods. The resultsshow that the discrepancies of pharmacodynamic property would be resulted from minor molecularstructure difference, and the vibrational spectra can be used for monitoring the drugs＇metabolization. Generally, betahistine drugs have better performance in the docking patterns withreceptors, like stronger interactions, forming more hydrogen bonds with receptors than histamine,and the betahistine methanesulfonate is found out to be the best for body recovery as it did inclinical presentation.展开更多
Objective:Epley maneuver is the most effective treatment for benign paroxysmal positional vertigo(BPPV).Betahistine has been shown to be effective in treating BPPV.This systematic review aims to compare the effectiven...Objective:Epley maneuver is the most effective treatment for benign paroxysmal positional vertigo(BPPV).Betahistine has been shown to be effective in treating BPPV.This systematic review aims to compare the effectiveness of Epley maneuver with betahistine to Epley maneuver alone in reducing residual dizziness in BPPV.Data Sources:Medline,Embase,and CENTRAL.Methods:We included randomized controlled trials(RCTs)that compared Epley maneuver with betahistine to Epley maneuver alone for treating BPPV.We evaluated the effectiveness of this intervention using Dizziness Handicap Inventory(DHI),Visual Analog Scale(VAS)for vertigo,and provocation maneuvers.We used the standardized mean difference(SMD)for continuous outcomes and the odds ratio(OR)for the dichotomous outcomes.Results:A total of eight RCTs that enrolled 516 participants were deemed eligible.Administration of betahistine with Epley maneuver showed no clinically significant difference over Epley maneuver alone in DHI score(SMD:−0.11,95%confidence interval[CI],−0.57 to 0.34,p=0.63,I^(2)=79%),VAS scores(SMD:−0.57,95%CI,−1.57 to 0.43,p=0.26,I^(2)=89%),or on provocation maneuvers(OR:1.84,95%CI,0.92 to 3.68,p=0.08,I^(2)=0%)after 1 week of betahistine administration.However,participants who received betahistine combined with Epley maneuver showed a statistically significant reduction in VAS scores after 4 weeks of betahistine administration(SMD:−0.89,95%CI,−1.30 to−0.49,p<0.0001,I^(2)=33%).Conclusion:Combining betahistine with Epley maneuver could improve the outcomes of BPPV in the long term.However,clinical trials with longer follow-up periods are needed to unravel its efficacy.展开更多
文摘Objective:To evaluate the therapeutic effect of Tianma Gouteng Decoction combined with Betahistine Mesylate in patients with posterior circulation ischemic vertigo(PCI).Methods:Eighty-two patients with PCI who visited the hospital from February 2024 to February 2025 were selected as samples and randomly divided into two groups.Group A received Tianma Gouteng Decoction combined with Betahistine Mesylate,while Group B received only Betahistine Mesylate.The efficacy,syndrome scores,hemodynamics,and quality of life indicators were compared between the two groups.Results:The efficacy of PCI treatment in Group A was higher than that in Group B(P<0.05).The syndrome scores in Group A were lower than those in Group B(P<0.05).The peak systolic velocity(PSV)of the basilar artery and left and right vertebral arteries in Group A were higher than those in Group B(P<0.05).The quality of life(SF-36)score in Group A was higher than that in Group B(P<0.05).Conclusion:Tianma Gouteng Decoction combined with Betahistine Mesylate is effective and feasible in the treatment of PCI,with improved hemodynamic indicators and reduced disease scores.
文摘To evaluate the therapeutic efficacy of Yinxing Damo （银杏达莫, YXDM） combined with Betahistine Hydrochloride Injection （BHI） on vertebra basilar artery ischemic vertigo （VBIV）. Methods： Ninety patients with VBIV were randomly divided into two groups; 45 patients （the treated group） were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients （control group） were treated with Xueshuantong （血栓通） and BHI intravenous dripping, once daily for 14 days. The clinical syndromes and the index of the transcranial Doppler （TCD） and hemorheology were observed. Results： The total effective rate was 100% in the treated group, which was better than that in the control group 90.5%, （P〈0. 05）. The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, （P〈0.01）. Conclusion： YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.
基金financially supported by the Natural Science Foundation of Fujian Province(2017Y0040)New Century Excellent Talent Project in University of Fujian Province,Educational Department of Fujian Province(JAT170151)+2 种基金Fujian Province University Key Laboratory of Green Energy and Environment Catalysis(FJ-GEEC201703)Research Fund for Industry-university Cooperation of Fujian Province(2014H6003)Beijing National Laboratory for Molecular Sciences(BNLMS20160101)
文摘Betahistine drugs are widely used in vestibular compensation process. For theunderstanding of drugs＇ structural feature, two betahistine drugs＇ （betahistine hydrochloride andbetahistine methanesulfonate） structure and vibrational spectra were calculated within densityfunctional theory （DFT） method and comparisons have been made with histamine. The drugs＇interactions with the receptors were revealed by using the molecular docking methods. The resultsshow that the discrepancies of pharmacodynamic property would be resulted from minor molecularstructure difference, and the vibrational spectra can be used for monitoring the drugs＇metabolization. Generally, betahistine drugs have better performance in the docking patterns withreceptors, like stronger interactions, forming more hydrogen bonds with receptors than histamine,and the betahistine methanesulfonate is found out to be the best for body recovery as it did inclinical presentation.
基金Received:16 October 2023|Accepted:12 December 2023。
文摘Objective:Epley maneuver is the most effective treatment for benign paroxysmal positional vertigo(BPPV).Betahistine has been shown to be effective in treating BPPV.This systematic review aims to compare the effectiveness of Epley maneuver with betahistine to Epley maneuver alone in reducing residual dizziness in BPPV.Data Sources:Medline,Embase,and CENTRAL.Methods:We included randomized controlled trials(RCTs)that compared Epley maneuver with betahistine to Epley maneuver alone for treating BPPV.We evaluated the effectiveness of this intervention using Dizziness Handicap Inventory(DHI),Visual Analog Scale(VAS)for vertigo,and provocation maneuvers.We used the standardized mean difference(SMD)for continuous outcomes and the odds ratio(OR)for the dichotomous outcomes.Results:A total of eight RCTs that enrolled 516 participants were deemed eligible.Administration of betahistine with Epley maneuver showed no clinically significant difference over Epley maneuver alone in DHI score(SMD:−0.11,95%confidence interval[CI],−0.57 to 0.34,p=0.63,I^(2)=79%),VAS scores(SMD:−0.57,95%CI,−1.57 to 0.43,p=0.26,I^(2)=89%),or on provocation maneuvers(OR:1.84,95%CI,0.92 to 3.68,p=0.08,I^(2)=0%)after 1 week of betahistine administration.However,participants who received betahistine combined with Epley maneuver showed a statistically significant reduction in VAS scores after 4 weeks of betahistine administration(SMD:−0.89,95%CI,−1.30 to−0.49,p<0.0001,I^(2)=33%).Conclusion:Combining betahistine with Epley maneuver could improve the outcomes of BPPV in the long term.However,clinical trials with longer follow-up periods are needed to unravel its efficacy.
