Purpose: The present research was performed to evaluate the effect of food thickeners on the bitterness and dissolution of bitter drugs when co-administered to patients with dysphagia. Methods: Amlodipine besilate (AM...Purpose: The present research was performed to evaluate the effect of food thickeners on the bitterness and dissolution of bitter drugs when co-administered to patients with dysphagia. Methods: Amlodipine besilate (AMPB) powder was used as a model drug. Starch- and xanthan gum-based food thickeners were examined, with swallowing-aid jelly as a reference. The line-spread test (LST), texture prolife analysis (TPA) were done firstly. In related to AMPB powder mixed with food thickeners solution, a conventional dissolution test simulating the oral cavity was performed, the amlodipine (AMP) concentration and taste sensor output for dissolved medium versus time profiles were developed. The dissolution test at pH 1.2 and 4.5, representing typical gastric conditions for younger or elderly people, was performed in two kinds of thickener solution and swallowing-aid jelly those were mixed with AMPB powder. Results: LST demonstrated that xanthan gum-based food thickeners fulfilled the requirements for patients with dysphagia but that starch-based food thickeners did not. In TPA, hardness and adhesiveness decreased proportionally as the concentration increased for both kinds of food thickener. Conventional dissolution test simulating oral cavity demonstrated the following bitterness ranking: xanthan gum-based food thickener Conclusion: Although xanthan gum-based food thickeners were successful in masking the bitterness of AMP, they may reduce its bioavailability in humans. The 7.1 and 4.7 (w/v) % starch-based thickener show bitterness inhibition under simulated oral cavity conditions and complete dissolution of AMP under simulated gastric conditions.展开更多
Kush-Nāme,authored by Hakim Iranshan Ibn Abi al-Khair,offers information on Iran,its features,and even its neighbors,as other classical Persian literary works do.Although some of this historical information may need ...Kush-Nāme,authored by Hakim Iranshan Ibn Abi al-Khair,offers information on Iran,its features,and even its neighbors,as other classical Persian literary works do.Although some of this historical information may need to be more accurate due to the legendary nature of the work,it is important and worth studying.Aside from China,lands such as Makrān,Saqlab,Māchin,Besilā,and others are mentioned in Kush-Nāme.Besilāis the same as Korea based on the dynasty’s name,other details,and other references.The translation of Kush-Nāme into Korean has piqued the interest of many South Koreans.This study seeks to extract and,to some extent,examine Besilā’s many political,economic,geographical,and cultural representations in Kush-Nāme,not just to gain a better understanding of this country but this study serves as a foundation for future studies.According to the research,Besilāwas a remote and prosperous land with a monotheistic people and kingdom,a profitable and prosperous business,a huge army,and beautiful people who sheltered Abtin from the Chinese army and later married Abtin and Farārang,the daughter of BesilāKing and mother of Fereidun,and were somehow involved in Fereidun’s killing of Zahhāk.展开更多
Using 20.3 fb^(-1)of e^(+)e^(-)annihilation data collected at a center-of-mass energy of 3.773 GeV with the BESⅢdetector,we report on an improved search for the radiative leptonic decay D^(+)→γe^(+)ve.An upper limi...Using 20.3 fb^(-1)of e^(+)e^(-)annihilation data collected at a center-of-mass energy of 3.773 GeV with the BESⅢdetector,we report on an improved search for the radiative leptonic decay D^(+)→γe^(+)ve.An upper limit on its partial branching fraction for photon energies E_(γ)>10 MeV was determined to be 1.2×10^(-5)at a 90%confidence level;this excludes most current theoretical predictions.A sophisticated deep learning approach,which includes thorough validation and is based on the Transformer architecture,was implemented to efficiently distinguish the signal from massive backgrounds.展开更多
We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected ...We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682 and 4.699 GeV with the BESIII detector.The Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ c.c.We find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(4123.5±0.7_(sat)±4.7_(syst.))MeV/c^(2).As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.120 to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass energies.The upper limits of σ^(Born).B are found to be at the level of O(1)pb at each energy.Larger data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.展开更多
文摘Purpose: The present research was performed to evaluate the effect of food thickeners on the bitterness and dissolution of bitter drugs when co-administered to patients with dysphagia. Methods: Amlodipine besilate (AMPB) powder was used as a model drug. Starch- and xanthan gum-based food thickeners were examined, with swallowing-aid jelly as a reference. The line-spread test (LST), texture prolife analysis (TPA) were done firstly. In related to AMPB powder mixed with food thickeners solution, a conventional dissolution test simulating the oral cavity was performed, the amlodipine (AMP) concentration and taste sensor output for dissolved medium versus time profiles were developed. The dissolution test at pH 1.2 and 4.5, representing typical gastric conditions for younger or elderly people, was performed in two kinds of thickener solution and swallowing-aid jelly those were mixed with AMPB powder. Results: LST demonstrated that xanthan gum-based food thickeners fulfilled the requirements for patients with dysphagia but that starch-based food thickeners did not. In TPA, hardness and adhesiveness decreased proportionally as the concentration increased for both kinds of food thickener. Conventional dissolution test simulating oral cavity demonstrated the following bitterness ranking: xanthan gum-based food thickener Conclusion: Although xanthan gum-based food thickeners were successful in masking the bitterness of AMP, they may reduce its bioavailability in humans. The 7.1 and 4.7 (w/v) % starch-based thickener show bitterness inhibition under simulated oral cavity conditions and complete dissolution of AMP under simulated gastric conditions.
文摘Kush-Nāme,authored by Hakim Iranshan Ibn Abi al-Khair,offers information on Iran,its features,and even its neighbors,as other classical Persian literary works do.Although some of this historical information may need to be more accurate due to the legendary nature of the work,it is important and worth studying.Aside from China,lands such as Makrān,Saqlab,Māchin,Besilā,and others are mentioned in Kush-Nāme.Besilāis the same as Korea based on the dynasty’s name,other details,and other references.The translation of Kush-Nāme into Korean has piqued the interest of many South Koreans.This study seeks to extract and,to some extent,examine Besilā’s many political,economic,geographical,and cultural representations in Kush-Nāme,not just to gain a better understanding of this country but this study serves as a foundation for future studies.According to the research,Besilāwas a remote and prosperous land with a monotheistic people and kingdom,a profitable and prosperous business,a huge army,and beautiful people who sheltered Abtin from the Chinese army and later married Abtin and Farārang,the daughter of BesilāKing and mother of Fereidun,and were somehow involved in Fereidun’s killing of Zahhāk.
基金supported in part by National Key R&D Program of China(2020YFA0406400,2023YFA1606000,2020YFA0406300)National Natural Science Foundation of China(NSFC)(11635010,11735014,11935015,11935016,11935018,12025502,12035009,12035013,12061131003,12192260,12192261,12192262,12192263,12192264,12192265,12221005,12225509,12235017,12361141819)+18 种基金the Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility Programthe CAS Center for Excellence in Particle Physics(CCEPP)Joint Large-Scale Scientific Facility Funds of the NSFC and CAS(U1832207)CAS(YSBR-101)100 Talents Program of CASCAS Project for Young Scientists in Basic Research(YSBR-117)The Institute of Nuclear and Particle Physics(INPAC)and Shanghai Key Laboratory for Particle Physics and CosmologyAgencia Nacional de Investigación y Desarrollo de Chile(ANID),Chile(ANID PIA/APOYO AFB230003)German Research Foundation DFG(FOR5327)Istituto Nazionale di Fisica Nucleare,ItalyKnut and Alice Wallenberg Foundation(2021.0174,2021.0299)Ministry of Development of Turkey(DPT2006K-120470)National Research Foundation of Korea(NRF-2022R1A2C1092335)National Science and Technology fund of MongoliaNational Science Research and Innovation Fund(NSRF)via the Program Management Unit for Human Resources&Institutional Development,Research and Innovation of Thailand(B50G670107)Polish National Science Centre(2019/35/O/ST2/02907)Swedish Research Council(2019.04595)The Swedish Foundation for International Cooperation in Research and Higher Education(CH2018-7756)U.S.Department of Energy(DE-FG02-05ER41374)。
文摘Using 20.3 fb^(-1)of e^(+)e^(-)annihilation data collected at a center-of-mass energy of 3.773 GeV with the BESⅢdetector,we report on an improved search for the radiative leptonic decay D^(+)→γe^(+)ve.An upper limit on its partial branching fraction for photon energies E_(γ)>10 MeV was determined to be 1.2×10^(-5)at a 90%confidence level;this excludes most current theoretical predictions.A sophisticated deep learning approach,which includes thorough validation and is based on the Transformer architecture,was implemented to efficiently distinguish the signal from massive backgrounds.
基金Supported in part by National Key R&D Program of China(Grant Nos.2020YFA0406400,2020YFA0406300)National Natural Science Foundation of China(NSFC)(Grant Nos.11635010,11735014,11805086,11835012,11935015,11935016,11935018,11961141012,12022510,12025502,12035009,12035013,12192260,12192261,12192262,12192263,12192264,12192265)+18 种基金the Chinese Academy of Sciences(CAS)Large-Scale Scientific Facility ProgramJoint Large-Scale Scientific Facility Funds of the NSFC and CAS(Grant No.U1832207)the CAS Center for Excellence in Particle Physics(CCEPP)100 Talents Program of CASFundamental Research Funds for the Central Universities,Lanzhou University,University of Chinese Academy of SciencesThe Institute of Nuclear and Particle Physics(INPAC)and Shanghai Key Laboratory for Particle Physics and CosmologyERC(Grant No.758462)European Union's Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement(Grant No.894790)German Research Foundation DFG(Grant No.443159800),Collaborative Research Center CRC 1044,GRK 2149Istituto Nazionale di Fisica Nucleare,ItalyMinistry of Development of Turkey(Grant No.DPT2006K-120470)National Science and Technology fundNational Science Research and Innovation Fund(NSRF)via the Program Management Unit for Human Resources&Institutional Development,Research and Innovation(Grant No.B16F640076)Olle Engkvist Foundation(Grant No.200-0605)STFC(United Kingdom)Suranaree University of Technology(SUT),Thailand Science Research and Innovation(TSRI),and National Science Research and Innovation Fund(NSRF)(Grant No.160355)The Royal Society,UK(Grant Nos.DH140054,DH160214)The Swedish Research CouncilU.S.Department of Energy(Grant No.DE-FG02-05ER41374)。
文摘We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682 and 4.699 GeV with the BESIII detector.The Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ c.c.We find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(4123.5±0.7_(sat)±4.7_(syst.))MeV/c^(2).As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.120 to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass energies.The upper limits of σ^(Born).B are found to be at the level of O(1)pb at each energy.Larger data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.
