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Predictors of Successful Radiofrequency Ablation of Benign Thyroid Nodules: A Single Centre Analysis
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作者 Waswa Edgar Jiangyuan Cheng +2 位作者 Esraa Atef Saad Mwale Paul Wu Meng 《International Journal of Clinical Medicine》 2025年第1期16-28,共13页
Objective: To assess the predictors of successful inactivation of benign thyroid nodules using radiofrequency ablation (RFA) and the hormonal responses thereafter. Methods: A retrospective study conducted at Zhongnan ... Objective: To assess the predictors of successful inactivation of benign thyroid nodules using radiofrequency ablation (RFA) and the hormonal responses thereafter. Methods: A retrospective study conducted at Zhongnan Hospital of Wuhan University (January 2022 to January 2024) analysed thyroid tumor characteristics using B-mode ultrasound, colour Doppler imaging, and CEUS post-RFA. Thyroid hormone levels were also assessed before RFA and at 1, 3, and 6 months after the procedure. Results: The study involved 72 patients with benign thyroid nodules, comprising 13 males and 59 females, with a mean age of 45.8 ± 12.1 years. Complete inactivation was achieved in 70.8% of nodules, while 29.2% showed partial inactivation. Nodules with complete inactivation exhibited more calcification (p = 0.040), whereas those with partial inactivation demonstrated higher vascularity (p Conclusion: In conclusion, this study found that therapeutic RFA effectively achieves high rates of complete inactivation in benign thyroid nodules, with the degree of inactivation mainly influenced by nodule vascularity and calcifications. 展开更多
关键词 PREDICTORS Radiofrequency Ablation benign thyroid Nodules
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Perithyroidal hemorrhage caused by hydrodissection during radiofrequency ablation for benign thyroid nodules:Two case reports 被引量:5
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作者 Bo-Wen Zheng Tao Wu +2 位作者 Zhi-Cheng Yao Yan-Ping Ma Jie Ren 《World Journal of Clinical Cases》 SCIE 2022年第29期10755-10762,共8页
BACKGROUND Hydrodissection is a widely used technique during radiofrequency ablation(RFA)for benign thyroid nodules.Although it could effectively avoid thermal injury to the surrounding critical structures and achieve... BACKGROUND Hydrodissection is a widely used technique during radiofrequency ablation(RFA)for benign thyroid nodules.Although it could effectively avoid thermal injury to the surrounding critical structures and achieve complete treatment,routine operation of the remaining needle could cause perithyroidal hemorrhage.In this report,we present 2 cases of perithyroidal hemorrhage during RFA caused by a hydrodissection needle,which have not been reported before.CASE SUMMARY A 21-year-old female and a 45-year-old male were admitted for RFA for benign thyroid nodules.Considering that their nodules were adjacent to the recurrent laryngeal nerve,the needle used for hydrodissection was placed and remained between the dorsal capsule of the lateral lobe and the recurrent laryngeal nerve.During the procedure,active bleeding near the needle appeared on ultrasonography(US).Although moderate pressure was quickly applied to the neck for several minutes,contrast-enhanced US(CEUS)still showed an active hemorrhage.A radiofrequency electrode was placed at the bleeding point under the guidance of CEUS to stop the bleeding,and the procedure was finally confirmed to be successful by CEUS,without other complications.CONCLUSION Hydrodissection during RFA of benign thyroid nodules was associated with a risk of perithyroidal hemorrhage.The timely recognition of this acute hemorrhage could help in the timely control of the bleeding,and CEUS-guided ablation of the bleeding point could be useful. 展开更多
关键词 COMPLICATION HEMORRHAGE HYDRODISSECTION Radiofrequency ablation benign thyroid nodules Case report
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Perioperative Quality Care for Thoracoscopic Lumpectomy for Benign Thyroid Disease
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作者 CAIYan 《外文科技期刊数据库(文摘版)医药卫生》 2022年第1期110-113,共4页
Objective: to explore the effect of using quality nursing concept during peritreatment of patients with benign thyroid disease. Methods: the study was conducted from October 2019 to October 2020, and the study subject... Objective: to explore the effect of using quality nursing concept during peritreatment of patients with benign thyroid disease. Methods: the study was conducted from October 2019 to October 2020, and the study subjects selected patients with benign thyroid disease and required thoracectomy. The total number of study cases was 60.Before the formal study, with the consent of the study subjects and their family members, the above 60 study subjects were randomly divided into the two research groups, among which the routine care group was called the control group, and the quality care group during perisurgery was known as the observation group. Comparative analysis of the effects of the two groups under different modes of care was conducted. Results: the time of surgery, intraoperative bleeding, incision flow and hospital time in the perioperative care with quality care were better than the control group, and the difference between groups was large, and the obtained P-value was lower than 0.05.Patients in the observation group had higher quality of life scores in all dimensions after intervention compared with the control group, and showed large differences between groups, and the obtained P-value was lower than 0.05.The comparison of pain scores at admission was quite different, and the P-value was higher than 0.05. After perinatal care, both patients were lower, but the observation group was significantly lower than the control group, and the difference was large, and the P-value was lower than 0.05.The observation group had more satisfaction with the care services they had received than in the control group, and the comparison between the groups varied greatly, and the obtained P-value was lower than 0.05.Conclusion: in the implementation of thoracoscopic resection of benign thyroid disease patients with perioperative nursing reference high quality nursing concept is of important significance, can not only to ensure the smooth operation, optimize the surgical index, but also can enhance the prognostic effect, promote patient recovery speed, is worth actively quoted in clinical practice. 展开更多
关键词 benign thyroid disease transthoracoscopic endoscopic resection perioperative care quality nursing
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Efficacy and Safety Analysis of Modified Miccoli Operation through Isthmus Approach and Upper Lateral Approach for the Treatment of Benign Thyroid Tumors
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作者 FU Rong 《外文科技期刊数据库(文摘版)医药卫生》 2021年第2期277-281,共5页
Objective: to explore the treatment of benign thyroid tumors. Methods: the patients in our hospital were selected to compare the therapeutic effects of modified Miccoli operation through isthmus approach and upper lat... Objective: to explore the treatment of benign thyroid tumors. Methods: the patients in our hospital were selected to compare the therapeutic effects of modified Miccoli operation through isthmus approach and upper lateral approach. Results: the patients in the observation group had better drainage volume, operation time, thyroid function, and fewer complications (P < 0.05). There was little difference in hospitalization time and thyroid function before treatment between the two groups (P > 0.05). Conclusion: the upper isthmus approach modified Miccoli operation can improve the therapeutic effect and has high safety in patients with benign thyroid tumor. 展开更多
关键词 isthmus approach upper lateral approach Miccoli surgery benign thyroid tumor
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Comparative Study on the Effect of Endoscopic Assisted Neck Small Incision Surgery and Traditional Thyroid Surgery in the Treatment of Benign Thyroid Tumors
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作者 YU Xuechao YU Fangyuan 《外文科技期刊数据库(文摘版)医药卫生》 2021年第3期097-101,共5页
Objective: to compare the clinical value of endoscopic assisted small cervical incision surgery and traditional thyroid surgery in the treatment of thyroid benign tumors. Methods: a total of 100 patients who were admi... Objective: to compare the clinical value of endoscopic assisted small cervical incision surgery and traditional thyroid surgery in the treatment of thyroid benign tumors. Methods: a total of 100 patients who were admitted to our hospital from January 2017 to March 2020 were randomly divided into observation group (endoscopic assisted small incision surgery in the neck) and control group (traditional thyroid surgery), 50 cases in each group. Results: in the observation group, the satisfaction rate of incision scar (94%) was high, and the complication rate (8%) was low (P < 0.05). In addition, the scores of VAS, VRS and PPI after operation in the observation group were all lower (P < 0.05). Conclusion: endoscopic-assisted cervical small incision surgery for benign thyroid tumors is more effective. 展开更多
关键词 benign thyroid tumor ENDOSCOPIC small incision neck surgery
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Subcutaneous implantation of benign thyroid tissue: a rare complication after thyroidectomy
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作者 LIU Ying LI Zhi-yu DU Ya-ping 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第7期1111-1113,共3页
Subcutaneous implantation of benign thyroid tissue is a rare complication of thyroid surgery. Here the authors report two cases of subcutaneous implantation of benign thyroid tissue following conventional thyroid surg... Subcutaneous implantation of benign thyroid tissue is a rare complication of thyroid surgery. Here the authors report two cases of subcutaneous implantation of benign thyroid tissue following conventional thyroid surgery. The diagnosis and differential diagnosis of cervical subcutaneous thyroid tissue implantation, and their clinical pathological characteristics are retrospectively investigated. The mechanism of the implantation process is analyzed. The management of patient with cervical subcutaneous soft tissue implantation is also discussed. 展开更多
关键词 thyroid subcutaneous tissue IMPLANTATION ECTOPIC benign
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Diagnostic Value of Ultrasonography in Benign and Malignant Thyroid Lesions
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作者 GUO Zhifang 《外文科技期刊数据库(文摘版)医药卫生》 2021年第6期253-254,共3页
Objective: to analyze the diagnostic value of ultrasonography in benign and malignant thyroid lesions. Methods: retrospective analysis was performed on 70 patients with pathologically confirmed thyroid lesions admitte... Objective: to analyze the diagnostic value of ultrasonography in benign and malignant thyroid lesions. Methods: retrospective analysis was performed on 70 patients with pathologically confirmed thyroid lesions admitted to our hospital from March 2019 to March 2020. According to the benign and malignant lesions, they were divided into benign group (n = 38) and malignant group (n = 32). Ultrasound examination was performed on all patients, and ultrasound signs, blood flow signals and hemodynamic indexes of patients in both groups were observed. Results: the ultrasonographic signs of malignant group were as follows: very low echo, blurred boundary and irregular lesion. Benign group: usually hyperechoic, its boundary is clear, the lesion is regular. The incidence of grade III blood signals in the malignant group was higher than that in the benign group and the incidence of grade I signals in the benign group was higher than that in the malignant group. Meanwhile, the peak systolic and end-diastolic blood flow velocity in the malignant group were also higher than that in the benign group, respectively, with statistical significance (P < 0.05). Conclusion: ultrasound has a good application effect in the diagnosis of benign and malignant thyroid lesions, and its ratio of blood flow signal level and hemodynamic indexes are significantly different, which is worth popularizing. 展开更多
关键词 ultrasound examination benign and malignant thyroid lesions diagnostic value
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二维超声联合人工智能对甲状腺结节良恶性的预测价值 被引量:1
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作者 杨燕 丁治国 +3 位作者 祁烁 王琪琪 张肖梅 张武平 《机器人外科学杂志(中英文)》 2025年第6期899-903,共5页
目的:探究二维超声联合人工智能对甲状腺结节良恶性的预测价值。方法:回顾性分析2021年10月—2024年9月北京中医药大学孙思邈医院收治的甲状腺结节患者212例,以手术病理为金标准,分析二维超声、人工智能以及两项联合诊断甲状腺结节良恶... 目的:探究二维超声联合人工智能对甲状腺结节良恶性的预测价值。方法:回顾性分析2021年10月—2024年9月北京中医药大学孙思邈医院收治的甲状腺结节患者212例,以手术病理为金标准,分析二维超声、人工智能以及两项联合诊断甲状腺结节良恶性的价值、与金标准的一致性、诊断的准确性。结果:在260个甲状腺结节中,手术病理确诊105个恶性结节,155个良性结节。ROC曲线分析显示,二维超声、人工智能诊断甲状腺结节良恶性的AUC值分别为0.830、0.745,敏感度分别为86.67%、83.81%,特异性分别为81.94%、69.03%。两项联合诊断甲状腺结节良恶性的AUC值为0.872,敏感度为95.24%,特异性为81.94%。以手术病理结果为金标准,二维超声、人工智能诊断甲状腺结节良恶性Kappa值分别为0.672、0.511,一致性一般;两项联合的Kappa值为0.765,一致性良好。两项联合诊断甲状腺结节良恶性的敏感度、阴性预测值高于二维超声、人工智能;特异性、准确率、阳性预测值高于人工智能;漏检率低于二维超声、人工智能;误诊率低于人工智能(P<0.05)。结论:基于二维超声、人工智能诊断甲状腺结节的良恶性均具有一定价值,两项联合诊断价值更高。 展开更多
关键词 甲状腺结节 良恶性 二维超声 人工智能 预测价值
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超声AI联合C-TIRADS在甲状腺结节良恶性鉴别中的效果分析 被引量:1
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作者 董明华 孟芳 《中国实验诊断学》 2025年第8期910-915,共6页
目的分析超声人工智能(AI)联合C-TIRADS在甲状腺结节(TNS)良恶性鉴别中的效果。方法回顾性分析2023年6月至2024年5月收治的87例(96个结节)TNS患者的临床资料,均行超声检查,并按照手术病理检查结果分为良性和恶性。比较两组的基线资料及... 目的分析超声人工智能(AI)联合C-TIRADS在甲状腺结节(TNS)良恶性鉴别中的效果。方法回顾性分析2023年6月至2024年5月收治的87例(96个结节)TNS患者的临床资料,均行超声检查,并按照手术病理检查结果分为良性和恶性。比较两组的基线资料及超声AI指标、C-TIRADS评分。分析甲状腺恶性结节的影响因素及超声AI联合C-TIRADS对甲状腺恶性结节的诊断价值。结果87例患者中,32例为恶性,55例为良性。恶性组形态不规则、边界模糊、声晕不完整或中断、低回声、钙化、血流1~2级、纵横比<1及C-TIRADS≥2分的占比分别为75.00%、87.50%、87.50%、68.75%、68.75%、62.50%、68.75%、75.00%,高于良性组的21.82%、9.09%、47.27%、43.64%、25.45%、12.73%、45.45%、5.45%(P<0.05)。多因素Logistic回归分析可得出:形态不规则[OR=10.750(95%CI:3.859,29.948)]、边界模糊[OR=14.126(95%CI:4.828,41.328)]、声晕不完整或中断[OR=7.808(95%CI:2.414,25.252)]、内部低回声[OR=2.842(95%CI:1.135,7.116)]、钙化[OR=6.443(95%CI:2.460,16.873)]、血流1~2级[OR=11.429(95%CI:3.927,33.258)]、纵横比<1[OR=2.640(95%CI:1.055,6.603)]、C-TIRADS评分≥2分[OR=19.125(95%CI:6.537,55.954)]均为甲状腺恶性结节的危险因素(P<0.05)。ROC曲线可得出:超声AI联合C-TIRADS诊断甲状腺恶性结节的AUC值为0.983(95%CI:0.961,1.000),敏感度为100.00%,特异度为83.50%,具有较高的诊断价值。结论超声AI联合C-TIRADS可更好的鉴别TNS的良恶性。 展开更多
关键词 超声AI C-TIRADS 甲状腺结节 良恶性 鉴别诊断
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甲状腺良恶性病变患者SPECT-CT定量参数表达差异与血管生成的相关性
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作者 李唯 蔡淑云 +3 位作者 宣建新 赵明 郑义 滕伟 《影像科学与光化学》 2025年第6期114-119,共6页
目的:探究甲状腺良恶性病变患者SPECT-CT定量参数与血管生成的相关性。方法:选取2022年1月至2023年12月于本院就诊的甲状腺良恶性病变患者121例,分为良性病变组(n=91)和恶性病变组(n=30)。对比两组的SPECT-CT定量参数(甲状腺体积、SUVm... 目的:探究甲状腺良恶性病变患者SPECT-CT定量参数与血管生成的相关性。方法:选取2022年1月至2023年12月于本院就诊的甲状腺良恶性病变患者121例,分为良性病变组(n=91)和恶性病变组(n=30)。对比两组的SPECT-CT定量参数(甲状腺体积、SUVmean、SUVmax、锝摄取功率、FTM)及血管生成指标(VEGF、EGFR、Ang-2)。采用Pearson相关分析两者之间的相关性。结果:恶性病变组的各项SPECT-CT定量参数及血管生成指标均显著高于良性病变组(P<0.05,通过t检验得出)。SPECT-CT定量参数与血管生成呈正相关。结论:SPECT-CT定量参数的异常升高与血管生成有显著相关性。 展开更多
关键词 甲状腺良恶性病变 SPECT-CT定量参数 血管生成 相关性分析
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综合护理在甲状腺良性肿瘤切除术患者中的应用效果分析
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作者 骆媛媛 《中国社区医师》 2025年第17期143-145,共3页
目的:观察对于甲状腺良性肿瘤切除术患者实施综合护理的效果。方法:将2023年11月—2024年11月于贵州航天医院接受甲状腺良性肿瘤切除术的患者74例按照随机数字表法分为对照组(n=37,接受常规护理)和观察组(n=37,接受综合护理)。对比两组... 目的:观察对于甲状腺良性肿瘤切除术患者实施综合护理的效果。方法:将2023年11月—2024年11月于贵州航天医院接受甲状腺良性肿瘤切除术的患者74例按照随机数字表法分为对照组(n=37,接受常规护理)和观察组(n=37,接受综合护理)。对比两组心理状态、疼痛程度、并发症发生情况、护理满意度及生活质量。结果:与干预前相比,两组干预后的焦虑、抑郁评分下降,且与对照组相比,观察组较低(P<0.001)。与术后1d相比,两组术后7d的疼痛评分下降,且与对照组相比,观察组较低(P<0.001)。观察组切口感染、喉返神经损伤、低钙血症抽搐等发生率低于对照组,护理满意度高于对照组(P<0.05)。与干预前相比,两组干预后的总体健康、躯体疼痛、社会功能、情绪角色、心理健康评分升高,且与对照组相比,观察组较高(P<0.001)。结论:综合护理能够减轻甲状腺良性肿瘤切除术患者的疼痛程度,调整患者不良心理,减少并发症,提高生活质量与护理满意度。 展开更多
关键词 甲状腺良性肿瘤 手术 综合护理 心理状态 并发症 生活质量
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超声引导下甲状腺结节射频消融术与传统开放手术的疗效及安全性对比分析
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作者 李晶 《首都食品与医药》 2025年第5期42-44,共3页
目的 探究超声引导下甲状腺结节射频消融术与传统开放手术的疗效及安全性.方法 选取本院自2022年8月-2023年2月收治的良性甲状腺结节患者98例,采用随机数表法分成两组,每组各49例,对照组采取传统开放手术治疗,观察组采取超声引导下射频... 目的 探究超声引导下甲状腺结节射频消融术与传统开放手术的疗效及安全性.方法 选取本院自2022年8月-2023年2月收治的良性甲状腺结节患者98例,采用随机数表法分成两组,每组各49例,对照组采取传统开放手术治疗,观察组采取超声引导下射频消融术治疗,对比两组临床疗效、甲状腺结节体积缩小率、治疗前后甲状腺激素指标,同时观察并发症情况.结果 观察组与对照组相比,临床总有效率较高,甲状腺结节体积缩小率较高(P<0.05).两组治疗后与治疗前相比,FT3、FT4及TSH水平均较低,但观察组FT3、FT4及TSH水平高于对照组(P<0.05).两组患者的并发症发生率比较,差异无统计学意义(P>0.05).结论 超声引导下甲状腺结节射频消融术与传统开放手术的应用均可获得显著临床疗效,但前者疗效更加突出,尽管两种方法均会对甲状腺激素指标造成影响,但前者造成的影响较小,整体安全性也较高. 展开更多
关键词 超声引导下射频消融术 传统开放手术 良性甲状腺结节 甲状腺激素指标 安全性
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超声引导下甲状腺结节射频消融术治疗甲状腺良性结节效果与安全性探讨
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作者 李杰 樊婷婷 王朋飞 《四川生理科学杂志》 2025年第6期1273-1276,共4页
目的:分析甲状腺良性结节应用超声引导下甲状腺结节射频消融术治疗的效果及手术安全性.方法:选取2022年1月~2024年6月期间本院收治的82例甲状腺良性结节患者作为研究对象.采用随机数字表法将患者分为对照组和观察组,每组各41例.对照组... 目的:分析甲状腺良性结节应用超声引导下甲状腺结节射频消融术治疗的效果及手术安全性.方法:选取2022年1月~2024年6月期间本院收治的82例甲状腺良性结节患者作为研究对象.采用随机数字表法将患者分为对照组和观察组,每组各41例.对照组采取常规甲状腺结节切除术治疗;观察组采取超声引导下甲状腺结节射频消融术治疗.分析比较两组的手术效果、手术并发症、手术相关指标(手术时间与手术切口长度、出血量)、甲状腺激素[促甲状腺激素(Thyroid stimulating hormone,TSH)、游离三碘甲腺原氨酸(Free triiodothyronine,FT3)、游离甲状腺素(Free Thyroxine,FT4)]水平.结果:观察组的手术治疗总有效率显著高于对照组(P<0.05).观察组的并发症总发生率显著低于对照组(P<0.05).观察组的手术时间、手术切口长度、出血量均显著低于对照组(P<0.05).术后1 m,两组的TSH、FT3、FT4各项甲状腺激素指标均比术前显著改善,且观察组术后1 m的TSH、FT3、FT4各项甲状腺激素指标均显著优于对照组(P<0.05).结论:甲状腺良性结节应用超声引导下甲状腺结节射频消融术治疗,能提高治疗效果,减少并发症,减少手术时间与手术切口长度,降低出血量,促进甲状腺功能恢复. 展开更多
关键词 甲状腺良性结节 常规甲状腺结节切除术 超声引导下甲状腺结节射频消融术 手术效果 并发症 甲状腺功能
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对比良恶性甲状腺结节的超声影像学特征
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作者 程丽 席丽娟 《医学研究前沿》 2025年第10期75-77,共3页
目的分析超声检查良恶性甲状腺结节的影像学特征。方法选取2023年1月—2025年1月因甲状腺结节入院的20例患者进行回顾性分析,对其实施超声检查。结果20例患者内恶性结节人数为1例,占比5%。19例为良性结节,占比95%。恶性肿瘤边界不清晰... 目的分析超声检查良恶性甲状腺结节的影像学特征。方法选取2023年1月—2025年1月因甲状腺结节入院的20例患者进行回顾性分析,对其实施超声检查。结果20例患者内恶性结节人数为1例,占比5%。19例为良性结节,占比95%。恶性肿瘤边界不清晰、形态不规则、内部回声低、微钙化数量均高于良性结节。同时,恶性结节的超声检查参数高于良性,P<0.05。结论对甲状腺结节患者进行检查时,可采用超声检查,可帮助医生分辨患者的良恶性,为后续治疗提供支持。 展开更多
关键词 良恶性 甲状腺结节 超声 影像学特征
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甲状腺结节与乳腺肿瘤之间的因果关系:双向两样本孟德尔随机化研究
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作者 李君毅 李释心 +6 位作者 宋奥林 张东坡 朱熠冰 邢潇潇 莫爵飞 廖代祥 李杰 《中国循证医学杂志》 北大核心 2025年第6期653-658,共6页
目的甲状腺结节是一种常见的甲状腺疾病。既往研究表明,甲状腺疾病和乳腺肿瘤之间可能存在联系。然而,很少有研究深入探讨甲状腺结节和乳腺肿瘤之间的因果关系。本研究进行了孟德尔随机化(MR)分析,以进一步探讨它们之间的因果关系。方... 目的甲状腺结节是一种常见的甲状腺疾病。既往研究表明,甲状腺疾病和乳腺肿瘤之间可能存在联系。然而,很少有研究深入探讨甲状腺结节和乳腺肿瘤之间的因果关系。本研究进行了孟德尔随机化(MR)分析,以进一步探讨它们之间的因果关系。方法本研究使用的数据来自于全基因组关联研究(GWAS)汇总数据集,以甲状腺结节、良性乳腺肿瘤、恶性乳腺癌为研究对象,并选择相关的单核苷酸多态性(SNP)作为工具变量(IV)。逆方差加权(IVW)为评估甲状腺结节和乳腺肿瘤之间的因果关系的主要分析方法,采用Cochran’s Q检验检测异质性,MR-Egger截距和MR-PRESSO检测多效性,留一法进行敏感性分析。结果甲状腺结节与乳腺癌存在显著因果关系[OR=0.88,95%CI(0.83,0.95),P<0.01],两者间不存在反向因果关系[OR=1.014,95%CI(0.994,1.033),P=0.16]。甲状腺结节与良性乳腺肿瘤间不存在因果关系[正向MR分析:OR=0.97,95%CI(0.889,1.061),P=0.51;反向MR分析:OR=0.97,95%CI(0.915,1.036),P=0.40]。敏感性分析表明,研究结果准确可靠。结论本研究发现甲状腺结节可能是乳腺癌的保护因素,为乳腺肿瘤患者制定个性化的监测和治疗策略提供参考。 展开更多
关键词 甲状腺结节 乳腺恶性肿瘤 乳腺良性肿瘤 孟德尔随机化 因果关系
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超声引导下微波消融与甲状腺腺叶切除术治疗甲状腺良性结节的效果及预后影响因素 被引量:2
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作者 范培培 杨超 王刚 《介入放射学杂志》 北大核心 2025年第4期385-389,共5页
目的探讨超声引导下微波消融与甲状腺腺叶切除术治疗甲状腺良性结节的效果及其预后的影响因素。方法选取2021年2月至2022年2月徐州市肿瘤医院诊治的甲状腺良性结节患者146例,按照治疗方式的不同分为消融组75例,手术组71例。比较两组患... 目的探讨超声引导下微波消融与甲状腺腺叶切除术治疗甲状腺良性结节的效果及其预后的影响因素。方法选取2021年2月至2022年2月徐州市肿瘤医院诊治的甲状腺良性结节患者146例,按照治疗方式的不同分为消融组75例,手术组71例。比较两组患者围术期相关指标、治疗前后的甲状腺功能、并发症发生情况,并分析预后的影响因素。结果术后6个月、1年两组患者的复发率比较,差异均无统计学意义(P>0.05)。消融组手术时间、手术瘢痕、住院时间、术中出血量均少于手术组(P<0.05)。治疗前,两组TSH、FT3、FT4比较,差异均无统计学意义(P>0.05);治疗后,两组TSH均较治疗前升高(P<0.05),两组FT3、FT4均较治疗前降低(P<0.05),但消融组TSH与手术组比较明显较低(P<0.05),消融组FT3、FT4与手术组比较明显较高(P<0.05)。消融组并发症发生率为2.67%,明显低于手术组的15.49%(P<0.05)。经单因素分析,结节数量、结节病变类型、结节病变位置、治疗方法是甲状腺良性结节患者预后不良的影响因素;多因素logistic回归分析显示,混合型结节、结节病变位于危险区域是甲状腺良性结节患者预后不良的危险因素。结论与甲状腺腺叶切除术相比较,超声引导下微波消融治疗甲状腺良性结节可减少手术瘢痕,缩短住院时间,降低术后并发症,且对甲状腺功能的影响更小。 展开更多
关键词 甲状腺良性结节 甲状腺腺叶切除术 超声引导 微波消融术 预后
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肿瘤干细胞基因Bmi-1在桥本甲状腺炎合并甲状腺肿瘤组织中的表达及临床意义 被引量:1
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作者 李仕亮 邵国安 《现代肿瘤医学》 2025年第7期1179-1183,共5页
目的:探讨肿瘤干细胞相关基因Bmi-1在桥本甲状腺炎(Hashimoto thyroiditis,HT)合并甲状腺良恶性肿瘤中的表达及其临床意义。方法:采用实时荧光定量PCR法(RT-PCR),在mRNA水平检测35例桥本甲状腺炎合并甲状腺乳头状癌和35例HT合并结节性... 目的:探讨肿瘤干细胞相关基因Bmi-1在桥本甲状腺炎(Hashimoto thyroiditis,HT)合并甲状腺良恶性肿瘤中的表达及其临床意义。方法:采用实时荧光定量PCR法(RT-PCR),在mRNA水平检测35例桥本甲状腺炎合并甲状腺乳头状癌和35例HT合并结节性甲状腺肿新鲜标本及其各自对应的病变旁组织中Bmi-1 mRNA的转录表达情况。结果:桥本合并甲状腺癌组比桥本合并结节性甲状腺肿组中Bmi-1 mRNA转录水平明显升高,其两组相对表达量差异有统计学意义(P<0.05)。桥本合并甲状腺癌组和桥本合并结节性甲状腺肿组Bmi-1 mRNA转录水平均比各自配对的病变旁组明显升高;其相对倍比关系为(2.13±0.41)和(1.98±0.35),差异均有统计学意义(P<0.05)。桥本合并甲状腺癌组中Bmi-1 mRNA的转录水平与患者性别、年龄及肿瘤大小无关(P>0.05);而与患者淋巴结转移、病理分期、BRAF基因突变、甲状腺乳头状癌病理亚型有关(P<0.05)。结论:Bmi-1 mRNA转录水平的高低可能在判断HT合并甲状腺肿瘤的良恶性方面具有一定的临床预测价值,其转录水平越高,桥本合并甲状腺肿物的恶性可能性越大,同时也可为甲状腺恶性肿瘤的临床诊断、疾病鉴别、预后判断提供科学的理论依据。 展开更多
关键词 桥本甲状腺炎 甲状腺肿瘤 肿瘤相关干细胞 BMI-1
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SPECT/CT联合血清TSH、TRAb水平在甲状腺结节性质鉴别中的应用 被引量:1
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作者 卢坤 孙新峰 范小涛 《临床和实验医学杂志》 2025年第6期663-667,共5页
目的探讨单光子发射计算机断层扫描/计算机断层扫描(SPECT/CT)联合血清促甲状腺激素(TSH)、促甲状腺激素受体抗体(TRAb)水平在甲状腺结节性质鉴别中的应用。方法回顾性分析2020年12月至2022年12月在黄河三门峡医院接受治疗的150例甲状... 目的探讨单光子发射计算机断层扫描/计算机断层扫描(SPECT/CT)联合血清促甲状腺激素(TSH)、促甲状腺激素受体抗体(TRAb)水平在甲状腺结节性质鉴别中的应用。方法回顾性分析2020年12月至2022年12月在黄河三门峡医院接受治疗的150例甲状腺结节患者的临床资料,所有患者均行甲状腺结节切除术,依据术后病理学检测结果将病理诊断有明确肿瘤异型性者归为恶性组(n=45),未见癌性病灶者归为良性组(n=105)。比较两组基础资料[性别、年龄、体重指数、病程、吸烟史、饮酒史、糖代谢情况、结节数、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甲状腺素(T4)、三碘甲状腺原氨酸(T3)水平]、SPECT/CT融合显像、血清TSH、TRAb水平;采用多因素Logistic回归分析影响甲状腺结节患者恶性病变的危险因素;绘制受试者操作特征(ROC)曲线分析SPECT/CT、血清TSH、TRAb及联合指标评估甲状腺结节患者恶性病变的效能。结果两组性别构成比、年龄、体重指数、病程、吸烟史、饮酒史、糖代谢、结节数、HDL-C、LDL-C、T4、T3比较,差异均无统计学意义(P>0.05);恶性组SPECT/CT融合显像阳性占比及血清TSH、TRAb水平分别为66.67%、(5.18±1.72)mIU/L、(4.25±1.33)IU/L,均显著高于良性组[9.52%、(3.79±1.22)mIU/L、(2.91±0.95)IU/L],差异均有统计学意义(P<0.05)。经多因素Logistic回归分析证实,SPECT/CT融合显像、血清TSH、TRAb水平均是影响甲状腺结节患者恶性病变的危险因素(P<0.05)。经ROC曲线分析证实,SPECT/CT、血清TSH、TRAb及联合指标检测均可用于甲状腺结节患者恶性病变的评估,曲线下面积分别为0.786、0.790、0.815、0.952,均有P<0.05,且联合检测评估甲状腺结节患者恶性病变的效能明显高于单独检测。结论SPECT/CT融合显像、血清TSH、TRAb水平变化与甲状腺结节患者恶性病变密切相关,且SPECT/CT联合血清TSH、TRAb水平检测在鉴别甲状腺结节患者病变性质中的效能较高,具有一定临床价值。 展开更多
关键词 甲状腺结节 良恶性鉴别 SPECT/CT 促甲状腺激素 促甲状腺激素受体抗体
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消瘿合剂对甲状腺消融区体积缩小率影响
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作者 赵璐璐 周绍荣 +4 位作者 盛建国 韩秋成 郭佳 李卓 卢峰 《辽宁中医药大学学报》 2025年第3期150-154,共5页
目的探讨消瘿合剂对甲状腺消融区体积缩小率(volume reduction ratio,VRR)的影响。方法回顾性分析于2021年6月—2023年3月就诊于上海中医药大学附属曙光医院的228例经微波消融治疗的单发甲状腺结节患者,其中联合治疗组98例患者在消融治... 目的探讨消瘿合剂对甲状腺消融区体积缩小率(volume reduction ratio,VRR)的影响。方法回顾性分析于2021年6月—2023年3月就诊于上海中医药大学附属曙光医院的228例经微波消融治疗的单发甲状腺结节患者,其中联合治疗组98例患者在消融治疗后服用了3个月的消瘿合剂(首诊于中医外科),对照组130例患者只进行了消融治疗(首诊于超声医学科)。比较术后即刻、术后1个月、术后3个月、术后6个月的消融区体积大小。结果(1)两组患者消融后即刻消融区体积大于治疗前结节的体积,术后1个月、3个月、6个月的消融区体积逐渐缩小,差异有统计学意义。(2)联合治疗组与对照组的消融后即刻消融区体积比较,差异无统计学意义。联合治疗组在术后1、3、6个月的消融区VRR均大于对照组,差异有统计学意义。(3)同一组各个随访时间节点,甲状腺乳头状微小癌(papillary thyroid microcarcinoma,PTMC)与≤10 mm良性结节的消融区VRR比较,差异没有统计学意义。结论甲状腺结节微波消融治疗安全、有效,消瘿合剂可以促进甲状腺消融区的吸收。两者联合应用标本兼治,疗效显著,值得进一步研究推广。 展开更多
关键词 微波消融 消瘿合剂 体积缩小率 甲状腺乳头状微小癌 良性甲状腺结节
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Extrathyroidal Implantation of Thyroid Hyperplastic/neoplastic Cells after Endoscopic Thyroid Surgery 被引量:2
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作者 Cao Xi Xie-qun Xu +2 位作者 Tao Hong Bing-lu Li Wei Liu 《Chinese Medical Sciences Journal》 CAS CSCD 2014年第3期180-184,共5页
Objective To report a case of the implantation of thyroid hyperplastic or neoplastic tissue after endoscopic thyroidectomy and discuss this complication in aspects of prevalence, pathogenesis, protection, and therapie... Objective To report a case of the implantation of thyroid hyperplastic or neoplastic tissue after endoscopic thyroidectomy and discuss this complication in aspects of prevalence, pathogenesis, protection, and therapies. Methods A systematic search of literature from the PubMed database was conducted for identifying eligible studies on implantation of thyroid hyperplastic or neoplastic cells after endoscopic thyroid surgery. Results Overall, 5 reported cases on patients suffering from endoscopic thyroid surgery with implantation of thyroid hyperplastic or neoplastic cells were included in the systematic review. Conclusions Unskilled surgeons, rough intraoperative surgical treatment, scarification or rupture of tumor, contamination of instruments, chimney effect, aerosolization of tumor cells may be associated with the implantation after endoscopic thyroidectomy. To minimize the risk of such complication, we should be more meticulous and strict the endoscopic surgery indications. 展开更多
关键词 endoscopic thyroid surgery benign thyroid tumor malignant thyroid tumor subcutaneous tissue IMPLANTATION
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