Dopamine agonists （DA） are a first-line therapy for prolactinomas （PA）. However, nearly 10% of prolactinomas do not respond to DA therapy. A considerable number of studies have shown that estrogen plays an importa...Dopamine agonists （DA） are a first-line therapy for prolactinomas （PA）. However, nearly 10% of prolactinomas do not respond to DA therapy. A considerable number of studies have shown that estrogen plays an important role in the development of prolactinomas. However, the expression of estrogen receptors （ER） in prolactinomas has not been fully explored. Accordingly, we examined the levels of ESR1 and its subtypes A5-DeI-ESR1 and ESR2 mRNA in prolactinomas. In the present study,展开更多
Clay has a significant influence on the relationship between resistivity index I and water saturation Sw （i.e, I-Sw relationship） of reservoir rocks because it complicates the current paths of these rocks. It is dif...Clay has a significant influence on the relationship between resistivity index I and water saturation Sw （i.e, I-Sw relationship） of reservoir rocks because it complicates the current paths of these rocks. It is difficult to reveal the physical mechanisms of these clay effects on the conductivities of various rocks by physical laboratory measurements because the pore structure, micro distribution and content of clay inside a rock can not be observed and controlled during the experiments. We present a digital rock approach to study these clay effects on the electrical transport properties of reservoir rocks at pore scale using lattice gas automation （LGA） method. The digital rock samples are constructed with the information of grain size distribution from SEM images of reservoir rocks. The LGA is then applied on these digital rocks fully saturated with fluids to simulate the electrical transport properties for revealing the effects of volume and distribution patterns of clay on the non-Archie behaviors of the I-Sw relationship. The very good agreement between the simulated results and the laboratory measurements clearly demonstrates the validity of the LGA in numerical research of rock physics. Based on these studies, a new model has been developed for quantitatively describing the relationship between the saturation exponent and the volume of clay （Vsh）. This development may improve the evaluation for the fluid saturations in reservoir rocks.展开更多
Virtual hand is an important medium for implementation of human-computer interaction in the process of virtual assembly. And the comparability between the action of virtual hand and real man-hand has always been regar...Virtual hand is an important medium for implementation of human-computer interaction in the process of virtual assembly. And the comparability between the action of virtual hand and real man-hand has always been regarded as one of the important criteria to judge whether the virtual environment has the property of immersion. On the basis of analyzing the relative position,posture,and motion behavior relationship between virtual hand and the object to be operated during virtual assembly,this paper proposed an implementation method of combining grasp index with collision detecting technology for identifying grasp action of virtual hand. The method is to identify grasp/quit using grasp index and to implement joint angle adjustment through simulation cyclic iteration and joint angle interpolation calculation. Although some traditional method identifying the grasp action on the basis of the shape of the object is operated,the simulation result getting from virtual environment created by EON STUDIO shows that it has good features of serviceability and fidelity to realize operation control of virtual hand.展开更多
基金supported by the Research Special Fund for Public Welfare Industry of Health(201402008)
文摘Dopamine agonists （DA） are a first-line therapy for prolactinomas （PA）. However, nearly 10% of prolactinomas do not respond to DA therapy. A considerable number of studies have shown that estrogen plays an important role in the development of prolactinomas. However, the expression of estrogen receptors （ER） in prolactinomas has not been fully explored. Accordingly, we examined the levels of ESR1 and its subtypes A5-DeI-ESR1 and ESR2 mRNA in prolactinomas. In the present study,
基金sponsored by the National Natural Science Foundation of China（Grant No.41074103） the National Key Fundamental R＆D Project（Grant No.2007CB209601） the China National Petroleum Cooperation Fundamental Research Program（Grant No.06A30102）
文摘Clay has a significant influence on the relationship between resistivity index I and water saturation Sw （i.e, I-Sw relationship） of reservoir rocks because it complicates the current paths of these rocks. It is difficult to reveal the physical mechanisms of these clay effects on the conductivities of various rocks by physical laboratory measurements because the pore structure, micro distribution and content of clay inside a rock can not be observed and controlled during the experiments. We present a digital rock approach to study these clay effects on the electrical transport properties of reservoir rocks at pore scale using lattice gas automation （LGA） method. The digital rock samples are constructed with the information of grain size distribution from SEM images of reservoir rocks. The LGA is then applied on these digital rocks fully saturated with fluids to simulate the electrical transport properties for revealing the effects of volume and distribution patterns of clay on the non-Archie behaviors of the I-Sw relationship. The very good agreement between the simulated results and the laboratory measurements clearly demonstrates the validity of the LGA in numerical research of rock physics. Based on these studies, a new model has been developed for quantitatively describing the relationship between the saturation exponent and the volume of clay （Vsh）. This development may improve the evaluation for the fluid saturations in reservoir rocks.
基金Sponsored by the Heilongjiang Science and Technology Program ( Grant No GC02A125)
文摘Virtual hand is an important medium for implementation of human-computer interaction in the process of virtual assembly. And the comparability between the action of virtual hand and real man-hand has always been regarded as one of the important criteria to judge whether the virtual environment has the property of immersion. On the basis of analyzing the relative position,posture,and motion behavior relationship between virtual hand and the object to be operated during virtual assembly,this paper proposed an implementation method of combining grasp index with collision detecting technology for identifying grasp action of virtual hand. The method is to identify grasp/quit using grasp index and to implement joint angle adjustment through simulation cyclic iteration and joint angle interpolation calculation. Although some traditional method identifying the grasp action on the basis of the shape of the object is operated,the simulation result getting from virtual environment created by EON STUDIO shows that it has good features of serviceability and fidelity to realize operation control of virtual hand.
