Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant live...Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant liver tumors,who met the enrollment criteria,were randomly divided into experimental and control groups.During HAIC treatment,the patients in the experimental group,who were not confined to bed and could get out of bed,used electronic injection pumps to infuse chemotherapy drugs.The patients in the control group,who were strictly confined to bed and prohibited from getting out of bed,used infusion pumps to infuse chemotherapy drugs.The complications of the two groups were observed.The Christenson standard improved method was used to evaluate the bleeding and hematoma of limbs on the operation side.The Kolcaba General Comfort Questionnaire(GCQ)and Barthel Index(BI)were used to evaluate the two groups.Results:Ninety patients with malignant liver tumors were enrolled,including 53 with primary liver cancer and 37 with colorectal liver metastasis.There were 70 males and 20 females,aged 41-81 years old,with an average age of 61.6±9.248 years old.There were 60 patients in the experimental group and 30 patients in the control group.All patients underwent HAIC.The study showed that,during the treatment period,there were 3 cases of postoperative puncture point hematoma formation in the two groups,including 2 cases in the experimental group(2/60,3.3%)and 1 case in the control group(1/30,3.3%).The difference was not statistically significant(p>0.05).There were 5 cases of postoperative puncture point bleeding,including 4 cases in the experimental group(4/60,6.7%)and 1 case in the control group(1/30,3.3%),and the difference was not statistically significant(p>0.05).A total of 23 cases,with 6 cases in the experimental group(6/60,10%)and 17 cases in the control group(17/30,56.7%),complained of back pain after the operation,and the difference was statistically significant(p<0.05).Twenty-one cases complained of poor defecation after the operation,including 10 cases in the experimental group(10/60,16.7%)and 11 cases in the control group(11/30,36.7%).The difference was statistically significant(p<0.05).During the period of infusion chemotherapy,the two groups of patients had there was a significant difference between the two groups in terms of comfort status(GCQ)(88.78±6.705,78.47±9.519,p<0.001)and self-care ability(BI)(74.25±9.152,66.83±6.628,p<0.001).Conclusion:During HAIC treatment,getting out of bed is safe and reliable and can increase the patients’comfort and self-care ability.Hence,it merits clinical application.展开更多
<strong>Objective:</strong> Against a background of the two-child policy in China, the objective is to explore the effects of lower limb strengthening exercises on hospitalized pregnant women put on bed re...<strong>Objective:</strong> Against a background of the two-child policy in China, the objective is to explore the effects of lower limb strengthening exercises on hospitalized pregnant women put on bed rest for prevention of miscarriage. <strong>Method:</strong> Sixty cases of pregnant women admitted to the Department of Obstetrics in one of the highest ranking hospitals in Guangzhou, China, during the period from November 2018 to December 2019 for the purpose of preventing miscarriage were selected. They were divided into an experimental group and a control group of 30 cases each. The control group was put under routine care while the intervention group conducted lower limb muscle strengthening exercise on top of the routine care. After the intervention, the conditions of lower limbs, the psychological states and the results of pregnancy for the two groups were compared. <strong>Results: </strong>After the intervention, the scores of the experimental group in anxiety, depression and postpartum depression were lower and leg circumferences were smaller compared to the control group. The difference is statistically significant (<em>P</em> < 0.05). The experimental group had longer gestation than the control group and was able to get out of bed earlier than the control group after delivery, with statistically significant difference (<em>P</em> < 0.05). <strong>Conclusion:</strong> Lower limb muscle strengthening exercises can effectively improve the physiological and psychological states of pregnant women hospitalized for prevention of miscarriage and promote their postpartum recovery.展开更多
Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were stud...Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 days.We measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & BD.during HDT & BD experiment,and in course time of recovery with curcumin and without curcumin groups.Results:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery stage.However,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P】0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery stage.However,these levels were lower in curcumin groups in contrast to the groups without curcumin(P【0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest conditions.Since saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest conditions.Further study is required on antioxidation actions of curcumin in space microgravity conditions.展开更多
Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP...Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP） as a countermeasure. Methods： Fourteen healthy male volunteers were randomly divided into a control group and a Chinese medicine （CM） group （7 in each group） by a random digital table based on their body weight. Both groups underwent6^° HDBR for 60 days. Subjects in the CM group received daily TYP pills and subjects in the control group received daily placebo pills. Cardiac systolic and pumping functions were measured by echocardiography before HDBR; on days 20, 42, and 57 of HDBR; and on day 3 of recovery after HDBR （R＋3）. Cardiopulmonary functional reserve and exercise capacity were evaluated before HDBR, on day 29, and on day R＋3 by exercise testing. Results： The heart rate （HR） increased gradually during HDBR. The HR was significantly higher on day 57 than before HDBR in the control group （P〈0.05）, but did not increase significantly in the CM group. The stroke volume/stroke volume index, ejection fraction, and left ventricular fractional shortening tended to decrease over time in the control group, but not in the CM group. These parameters were significantly higher in the CM group than in the control group on day 42 （P〈0.05 or P〈0.01）. Exercise testing showed that maximum 02 consumption （VO2max）, metabolic equivalents, relative 02 consumption （VO2）, 02 pulse, and exercise duration were significantly lower on day 29 than before HDBR in the control group, but not in the CM group. Conclusions： Sixty days of 6^° HDBR induced a reduction in cardiac systolic and pumping functions, and reduced cardiopulmonary functional reserve and exercise capacity. Administration of TYP significantly improved cardiac systolic and pumping functions, and maintained cardiopulmonary functional reserve and exercise capacity.展开更多
Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The b...Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The benefits of bed-rest-exercise may alleviate or even prevent physiological distresses or deconditioning associated with activity restriction, thus, eliminating or stabilizing, factors that may augment existing complications. This is the first study to investigate the feasibility of incorporating a bed-rest exercise program in a specific hospitalized twin pregnancy case. The maternal physiological responses of heart rate, blood pressure and uterine contractions to a four week bed-rest resistance program were measured in a woman hospitalized due to complications during her twin pregnancy. A second participant (same diagnoses) was included as a control. The bed-rest-exercise reduced the degree of swelling in the lower extremities, promoted more energy during the day and a better night’s sleep. There were no significant differences in uterine contractions pre vs. post protocol and all babies were born healthy.展开更多
目的探讨颅内动脉瘤术后卧床患者抑郁情绪发生情况及影响因素。方法观察对象为2020年2月~2024年3月86例颅内动脉瘤患者,术后均处于卧床状态,采用17项汉密尔顿抑郁量表(Hamilton depression scale,HAMD)进行抑郁情绪筛查,对是否具有抑郁...目的探讨颅内动脉瘤术后卧床患者抑郁情绪发生情况及影响因素。方法观察对象为2020年2月~2024年3月86例颅内动脉瘤患者,术后均处于卧床状态,采用17项汉密尔顿抑郁量表(Hamilton depression scale,HAMD)进行抑郁情绪筛查,对是否具有抑郁情绪的患者进行年龄、美国国立卫生研究院卒中量表(National institutes of health stroke scale,NIHSS)等临床资料的单因素与多因素分析。结果86例患者共筛查出抑郁状态34例(39.53%),HAMD评分(20.45±3.12)分,无抑郁状态52例(60.47%),HAMD评分(15.21±1.69)分;两组患者HAMD评分、年龄、NHISS评分、失眠、完全瘫痪、家庭收入、病灶累及额叶、合并脑室出血、改良Fisher分级差异具有统计学意义(P<0.05),两组患者性别、婚姻、居住地、受教育年限差异无统计学意义(P>0.05);年龄、NHISS评分、失眠、完全瘫痪、病灶累及额叶、改良Fisher分级Ⅲ~Ⅳ是抑郁情绪的影响因素。结论颅内动脉瘤术后卧床患者抑郁情绪较为普遍,年龄大、神经功能缺损严重、失眠等会增加抑郁情绪发生风险,应予以重视。展开更多
目的探讨4 d头低位卧床(head-down bed rest,HDBR)模拟失重对人体运动能力的影响及人工重力联合中等强度运动锻炼的对抗效果。方法 12名健康男性志愿者随机分为2组:对照组(n=6)仅进行4 d HDBR;对抗组(n=6)HDBR期间每天上下午各进行1次30...目的探讨4 d头低位卧床(head-down bed rest,HDBR)模拟失重对人体运动能力的影响及人工重力联合中等强度运动锻炼的对抗效果。方法 12名健康男性志愿者随机分为2组:对照组(n=6)仅进行4 d HDBR;对抗组(n=6)HDBR期间每天上下午各进行1次30 min基于人工重力(足水平2 Gz)的中等强度运动锻炼。HDBR前后对所有志愿者分别进行有氧和无氧运动能力测试。结果 HDBR后对照组递增负荷累计运动应激指数、最大摄氧量、无氧阈及30 s最大负荷运动中的最小无氧功较卧床前均显著下降(P<0.05),无氧功递减率显著升高(P<0.05)而无氧功峰值、平均无氧功均无显著改变;HDBR后对抗组上述各项指标均无显著改变。结论 4 d HDBR可致人体运动能力下降,其中对有氧运动能力影响最大,对无氧运动能力影响较小。基于人工重力的中等强度运动锻炼可有效对抗模拟失重所致的有氧及无氧运动耐力下降。展开更多
文摘Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant liver tumors,who met the enrollment criteria,were randomly divided into experimental and control groups.During HAIC treatment,the patients in the experimental group,who were not confined to bed and could get out of bed,used electronic injection pumps to infuse chemotherapy drugs.The patients in the control group,who were strictly confined to bed and prohibited from getting out of bed,used infusion pumps to infuse chemotherapy drugs.The complications of the two groups were observed.The Christenson standard improved method was used to evaluate the bleeding and hematoma of limbs on the operation side.The Kolcaba General Comfort Questionnaire(GCQ)and Barthel Index(BI)were used to evaluate the two groups.Results:Ninety patients with malignant liver tumors were enrolled,including 53 with primary liver cancer and 37 with colorectal liver metastasis.There were 70 males and 20 females,aged 41-81 years old,with an average age of 61.6±9.248 years old.There were 60 patients in the experimental group and 30 patients in the control group.All patients underwent HAIC.The study showed that,during the treatment period,there were 3 cases of postoperative puncture point hematoma formation in the two groups,including 2 cases in the experimental group(2/60,3.3%)and 1 case in the control group(1/30,3.3%).The difference was not statistically significant(p>0.05).There were 5 cases of postoperative puncture point bleeding,including 4 cases in the experimental group(4/60,6.7%)and 1 case in the control group(1/30,3.3%),and the difference was not statistically significant(p>0.05).A total of 23 cases,with 6 cases in the experimental group(6/60,10%)and 17 cases in the control group(17/30,56.7%),complained of back pain after the operation,and the difference was statistically significant(p<0.05).Twenty-one cases complained of poor defecation after the operation,including 10 cases in the experimental group(10/60,16.7%)and 11 cases in the control group(11/30,36.7%).The difference was statistically significant(p<0.05).During the period of infusion chemotherapy,the two groups of patients had there was a significant difference between the two groups in terms of comfort status(GCQ)(88.78±6.705,78.47±9.519,p<0.001)and self-care ability(BI)(74.25±9.152,66.83±6.628,p<0.001).Conclusion:During HAIC treatment,getting out of bed is safe and reliable and can increase the patients’comfort and self-care ability.Hence,it merits clinical application.
文摘<strong>Objective:</strong> Against a background of the two-child policy in China, the objective is to explore the effects of lower limb strengthening exercises on hospitalized pregnant women put on bed rest for prevention of miscarriage. <strong>Method:</strong> Sixty cases of pregnant women admitted to the Department of Obstetrics in one of the highest ranking hospitals in Guangzhou, China, during the period from November 2018 to December 2019 for the purpose of preventing miscarriage were selected. They were divided into an experimental group and a control group of 30 cases each. The control group was put under routine care while the intervention group conducted lower limb muscle strengthening exercise on top of the routine care. After the intervention, the conditions of lower limbs, the psychological states and the results of pregnancy for the two groups were compared. <strong>Results: </strong>After the intervention, the scores of the experimental group in anxiety, depression and postpartum depression were lower and leg circumferences were smaller compared to the control group. The difference is statistically significant (<em>P</em> < 0.05). The experimental group had longer gestation than the control group and was able to get out of bed earlier than the control group after delivery, with statistically significant difference (<em>P</em> < 0.05). <strong>Conclusion:</strong> Lower limb muscle strengthening exercises can effectively improve the physiological and psychological states of pregnant women hospitalized for prevention of miscarriage and promote their postpartum recovery.
文摘Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 days.We measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & BD.during HDT & BD experiment,and in course time of recovery with curcumin and without curcumin groups.Results:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery stage.However,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P】0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery stage.However,these levels were lower in curcumin groups in contrast to the groups without curcumin(P【0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest conditions.Since saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest conditions.Further study is required on antioxidation actions of curcumin in space microgravity conditions.
基金Supported by the Advance Research Project in Manned Spaceflight(No.010202)the National Natural Science Foundation of China(No.30772694)
文摘Objective： To study the changes in cardiopulmonary function induced by mid/long-term simulated microgravity with 6^° head down bed rest （HDBR）, and the effects of Taikong Yangxin Prescription （太空养心方, TYP） as a countermeasure. Methods： Fourteen healthy male volunteers were randomly divided into a control group and a Chinese medicine （CM） group （7 in each group） by a random digital table based on their body weight. Both groups underwent6^° HDBR for 60 days. Subjects in the CM group received daily TYP pills and subjects in the control group received daily placebo pills. Cardiac systolic and pumping functions were measured by echocardiography before HDBR; on days 20, 42, and 57 of HDBR; and on day 3 of recovery after HDBR （R＋3）. Cardiopulmonary functional reserve and exercise capacity were evaluated before HDBR, on day 29, and on day R＋3 by exercise testing. Results： The heart rate （HR） increased gradually during HDBR. The HR was significantly higher on day 57 than before HDBR in the control group （P〈0.05）, but did not increase significantly in the CM group. The stroke volume/stroke volume index, ejection fraction, and left ventricular fractional shortening tended to decrease over time in the control group, but not in the CM group. These parameters were significantly higher in the CM group than in the control group on day 42 （P〈0.05 or P〈0.01）. Exercise testing showed that maximum 02 consumption （VO2max）, metabolic equivalents, relative 02 consumption （VO2）, 02 pulse, and exercise duration were significantly lower on day 29 than before HDBR in the control group, but not in the CM group. Conclusions： Sixty days of 6^° HDBR induced a reduction in cardiac systolic and pumping functions, and reduced cardiopulmonary functional reserve and exercise capacity. Administration of TYP significantly improved cardiac systolic and pumping functions, and maintained cardiopulmonary functional reserve and exercise capacity.
文摘Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The benefits of bed-rest-exercise may alleviate or even prevent physiological distresses or deconditioning associated with activity restriction, thus, eliminating or stabilizing, factors that may augment existing complications. This is the first study to investigate the feasibility of incorporating a bed-rest exercise program in a specific hospitalized twin pregnancy case. The maternal physiological responses of heart rate, blood pressure and uterine contractions to a four week bed-rest resistance program were measured in a woman hospitalized due to complications during her twin pregnancy. A second participant (same diagnoses) was included as a control. The bed-rest-exercise reduced the degree of swelling in the lower extremities, promoted more energy during the day and a better night’s sleep. There were no significant differences in uterine contractions pre vs. post protocol and all babies were born healthy.
文摘目的探讨颅内动脉瘤术后卧床患者抑郁情绪发生情况及影响因素。方法观察对象为2020年2月~2024年3月86例颅内动脉瘤患者,术后均处于卧床状态,采用17项汉密尔顿抑郁量表(Hamilton depression scale,HAMD)进行抑郁情绪筛查,对是否具有抑郁情绪的患者进行年龄、美国国立卫生研究院卒中量表(National institutes of health stroke scale,NIHSS)等临床资料的单因素与多因素分析。结果86例患者共筛查出抑郁状态34例(39.53%),HAMD评分(20.45±3.12)分,无抑郁状态52例(60.47%),HAMD评分(15.21±1.69)分;两组患者HAMD评分、年龄、NHISS评分、失眠、完全瘫痪、家庭收入、病灶累及额叶、合并脑室出血、改良Fisher分级差异具有统计学意义(P<0.05),两组患者性别、婚姻、居住地、受教育年限差异无统计学意义(P>0.05);年龄、NHISS评分、失眠、完全瘫痪、病灶累及额叶、改良Fisher分级Ⅲ~Ⅳ是抑郁情绪的影响因素。结论颅内动脉瘤术后卧床患者抑郁情绪较为普遍,年龄大、神经功能缺损严重、失眠等会增加抑郁情绪发生风险,应予以重视。
文摘目的探讨4 d头低位卧床(head-down bed rest,HDBR)模拟失重对人体运动能力的影响及人工重力联合中等强度运动锻炼的对抗效果。方法 12名健康男性志愿者随机分为2组:对照组(n=6)仅进行4 d HDBR;对抗组(n=6)HDBR期间每天上下午各进行1次30 min基于人工重力(足水平2 Gz)的中等强度运动锻炼。HDBR前后对所有志愿者分别进行有氧和无氧运动能力测试。结果 HDBR后对照组递增负荷累计运动应激指数、最大摄氧量、无氧阈及30 s最大负荷运动中的最小无氧功较卧床前均显著下降(P<0.05),无氧功递减率显著升高(P<0.05)而无氧功峰值、平均无氧功均无显著改变;HDBR后对抗组上述各项指标均无显著改变。结论 4 d HDBR可致人体运动能力下降,其中对有氧运动能力影响最大,对无氧运动能力影响较小。基于人工重力的中等强度运动锻炼可有效对抗模拟失重所致的有氧及无氧运动耐力下降。
