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Logistic Regression Modelling for Complex Survey Data with an Application for Bed Net Use in Mozambique
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作者 Sheyla Rodrigues Cassy Isabel Natário M. Rosário Martins 《Open Journal of Statistics》 2016年第5期898-907,共10页
Logistic Regression Models have been widely used in many areas of research, namely in health sciences, to study risk factors associated to diseases. Many population based surveys, such as Demographic and Health Survey... Logistic Regression Models have been widely used in many areas of research, namely in health sciences, to study risk factors associated to diseases. Many population based surveys, such as Demographic and Health Survey (DHS), are constructed assuming complex sampling, i.e., probabilistic, stratified and multistage sampling, with unequal weights in the observations;this complex design must be taken into account in order to have reliable results. However, this very relevant issue usually is not well analyzed in the literature. The aim of the study is to specify the logistic regression model with complex sample design, and to demonstrate how to estimate it using the R software survey package. More specifically, we used Mozambique Demographic Health and Survey data 2011 (MDHS 2011) to illustrate how to correct for the effect of sample design in the particular case of estimating the risk factors associated to the probability of using mosquito bed nets. Our results show that in the presence of complex sampling, appropriate methods must be used both in descriptive and inferential statistics. 展开更多
关键词 Survey Logistic Regression Complex Samples bed net MALARIA DHS
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Situational Analysis of Malaria Control Following the 2021 Distribution of Long Lasting Insecticide-Treated Bed Nets in the Tiko Health District, South West Region, Cameroon
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作者 Jini Victor Bongajum Nyasa Raymond Babila Esum Mathias Eyong 《Journal of Biosciences and Medicines》 2023年第4期153-172,共20页
Malaria is still a major public health concern in Cameroon as more than 20 million people are at risk of the disease. Despite the government’s effort to scale up the distribution of long lasting insecticide-treated b... Malaria is still a major public health concern in Cameroon as more than 20 million people are at risk of the disease. Despite the government’s effort to scale up the distribution of long lasting insecticide-treated bed nets (LLINs), full ownership and optimal use is still limited. In 2021, over a million LLINs were made available for distribution in the South West Region. However, the current situation of malaria has not yet been ascertained following the 2021 mass distribution campaign (MDC). Therefore, the aim of this study was to determine LLIN ownership, coverage, usage and the prevalence of malaria following the 2021 MDC in the Tiko Health District (THD), South West Region of Cameroon. A cross-sectional study was carried from May 1 to 27, 2022 in which a multi-stage sampling technique was used to enroll eligible participants. Data were collected from household heads using questionnaires and capillary blood samples collected from consented household members were used to test for malaria. Data were analyzed using SPSS version 25 at 0.05 significance level. From the 150 households surveyed, 96 (64.0%) owned a mosquito net before the recent MDC. There was an overall significant increase (p p = 0.644) in LLINs ownership between areas where door-to-door (79.5%) and fixed “Hit and Run” (75.8%) strategies were used in the distribution of LLINs in THD. The prevalence of malaria was 10.2%. The regular use of LLINs was significantly associated (p = 0.007) with low malaria prevalence. The 2021 MDC had an impact on malaria prevalence in those who properly used them. 展开更多
关键词 Long Lasting Insecticide Treated-bed nets OWNERSHIP COVERAGE Use Malaria Prevalence
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Socio-cultural factors influencing insecticide treated bed net utilization in a malaria endemic city in north-central Nigeria
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作者 Jombo GTA Mbaawuaga EM +7 位作者 Gyuse AN Enenebeaku MNO Okwori EE Peters EJ Akpan S Odey F Etukumana EA Akosu JT 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2010年第5期402-406,共5页
Objective:To ascertain the socio-cultural factors influencing the rate of utilization of insecticide treated bed nets(ITNs) in a malaria endemic city of Makurdi,north central Nigeria. Methods:The study was cross-secti... Objective:To ascertain the socio-cultural factors influencing the rate of utilization of insecticide treated bed nets(ITNs) in a malaria endemic city of Makurdi,north central Nigeria. Methods:The study was cross-sectional in nature using systematic sampling method to identify households.Both quantitative and qualitative data was generated from adult women using structured and semi structured questionnaires,and focused group discussions(FGDs) to obtain information on rate and patterns of utilization of ITNs.Information such as age,educational level, marital status,awareness or otherwise of the existence of malaria,and factors influencing rate of ownership and utilization of ITNs were obtained.FGDs were used to obtain qualitative information on rate of utilization of ITNs not captured in the questionnaires.Data obtained was analysed using Epi Info 6 statistical software.Results:Among the respondents interviewed,97.0% (2 013/2 075) were aware of existence of malaria and 87.0% of these(1 751/2 013) would associate it with mosquitoes.The rate of ownership of any bed net,ITNs and untreated bed nets(UTNs) was 25.1% ,17.0% and 8.3% ,respectively.Utilization of ITNs among children was 30.0% (112/373) and UTNs 12.9% (48/373).Positive contributors to ITNs utilization were literacy,enhanced economy, experience of marriage,and being gainfully employed(P【0.05);while negative contributors were ignorance,poverty and some cultural beliefs and values.Conclusions:A more synchronized advocacy should be carried out on the potential benefits of ITNs utilization and sustained.Also ITNs should be made available to the people of the community at minimal or no cost. 展开更多
关键词 INSECTICIDE TREATED bed nets UTILIZATION Households MALARIA ENDEMIC city
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Tailoring grain growth and nanoprecipitation behavior via laser-beam powder bed fusion and aging for magnetostrictive enhancement of Fe-Ga-B alloys
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作者 Xiong YAO Liyuan WANG +2 位作者 Jun ZHOU Cijun SHUAI Chengde GAO 《Science China(Technological Sciences)》 2026年第2期176-187,共12页
Fe-Ga-based alloys are considered promising magnetostrictive candidates because of their high permeability and favorable mechanical properties.However,currently developed Fe-Ga-based alloys often suffer from a limited... Fe-Ga-based alloys are considered promising magnetostrictive candidates because of their high permeability and favorable mechanical properties.However,currently developed Fe-Ga-based alloys often suffer from a limited capability for microstructure manipulation,which restricts their magnetostrictive performance.To address this limitation,this study proposes a novel strategy combining laser-beam powder bed fusion(LPBF)and aging treatment to modulate the microstructure and enhance magnetostrictive properties of Fe-Ga-B alloys.Considering the positive influence of B element on magnetostrictive property and ductility,B-doped magnetostrictive Fe-Ga alloys were prepared via the LPBF process and then aged at 600℃for varying times(1,2,and 3 h,respectively).The LPBF process,characterized by high thermal gradients and rapid solidification,produced a microstructure featuring<001>oriented grains and sparse m-D0_(3)nanoprecipitates embedded in an A2 matrix.After the aging treatment,sufficient nucleation and growth of nanoprecipitates were enhanced.Specifically,the sample aged for 2 h developed a high density of larger m-D0_(3)nanoprecipitates.This optimized microstructure yielded a high magnetostrictive strain of(109±12)ppm and a substantially reduced saturation field—decreased by~49.1%compared to the as-fabricated state—primarily due to the synergistic effect of the<001>texture and the dense nanoprecipitates.Moreover,all the prepared alloys exhibited good soft-magnetic characteristics and comparable mechanical properties.Therefore,the combination of LPBF and aging treatment offers a promising route for tailoring the macro/microstructure and performance of magnetostrictive Fe-Ga alloys for diverse applications. 展开更多
关键词 laser-beam powder bed fusion aging treatment Fe-Ga-based alloys magnetostrictive properties
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Assessment of household ownership of bed nets in areas with and without artemisinin resistance containment measures in Myanmar 被引量:1
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作者 Thae Maung Maung Tin Oo +6 位作者 Khin Thet Wai Thaung Hlaing Philip Owiti Binay Kumar Hemant Deepak Shewade Rony Zachariah Aung Thi 《Infectious Diseases of Poverty》 SCIE 2018年第1期199-205,共7页
Background:Myanmar lies in the Greater Mekong Subregion where there is artemisinin-resistant Plasmodium falciparum malaria.As the artemisinin compound is the pillar of effective antimalarial therapies,containing the s... Background:Myanmar lies in the Greater Mekong Subregion where there is artemisinin-resistant Plasmodium falciparum malaria.As the artemisinin compound is the pillar of effective antimalarial therapies,containing the spread of artemisinin resistance is a national and global priority.The use of insecticide-treated bed nets/long-lasting insecticidal nets(ITNs/LLINs)is the key intervention for ensuring the reduction of malaria transmission and the spread of resistant strains,and for eventually eliminating malaria.This study aimed at assessing household ownership of,access to,and utilization of bed nets in areas of Myanmar with and without artemisinin resistance containment measures.Methods:Secondary data from a nationwide community-based malaria survey conducted by the National Malaria Control Program in 2014 were analyzed.Based on evidence of artemisinin resistance,Myanmar was divided into tiers 1,2,and 3:townships in tiers 1 and 2 were aggregated as the Myanmar Artemisinin Resistance Containment(MARC)areas and were compared with tier 3 townships,which were defined as non-MARC areas.The chi-square test was used to compare groups,and the level of significance was set at P≤0.05.Results:Of the 6328 households assessed,97.2%in both MARC and non-MARC areas had at least one bed net(any type),but only 63%of households had ITNs/LLINs.Only 44%of households in MARC areas and 24%in non-MARC areas had adequate numbers of ITNs/LLINs(one ITN/LLIN per two persons,P<0.001).Nearly 44%of household members had access to ITNs/LLINs.Regarding the utilization of ITNs/LLINs,45%of household members used them in MARC areas and 36%used them in non-MARC areas(P<0.001,desired target=100%).Utilization of ITNs/LLINs among children aged below five years and pregnant women(high malaria risk groups)was low,at 44%and 42%,respectively.Conclusions:This study highlights the nationwide shortfalls in the ownership of,access to,and utilization of ITNs/LLINs in Myanmar,which is of particular concern in terms of containing the spread of artemisinin resistance.It highlights the need for priority attention to be paid and mobilization of resources in order to improve bed net coverage and utilization through bed net distribution and/or social marketing,information dissemination,and awareness-raising. 展开更多
关键词 MALARIA Insecticide-treated bed nets Long-lasting insecticidal nets Myanmar artemisinin resistance containment bed nets ownership bed nets access bed nets utilization Myanmar
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Multifactorial impacts of B-doping on Fe_(81)Ga_(19) alloys prepared by laser-beam powder bed fusion:Microstructure,magnetostriction,and osteogenesis 被引量:1
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作者 Chengde Gao Liyuan Wang +2 位作者 Youwen Deng Shuping Peng Cijun Shuai 《Journal of Materials Science & Technology》 2025年第2期14-26,共13页
Magnetostrictive Fe-Ga alloys have captivated substantial focus in biomedical applications because of their exceptional transition efficiency and favorable cytocompatibility.Nevertheless,Fe-Ga alloys always exhibit fr... Magnetostrictive Fe-Ga alloys have captivated substantial focus in biomedical applications because of their exceptional transition efficiency and favorable cytocompatibility.Nevertheless,Fe-Ga alloys always exhibit frustrating magnetostriction coefficients when presented in bulk dimensions.It is well-established that the magnetostrictive performance of Fe-Ga alloys is intimately linked to their phase and crystal structures.In this study,various concentrations of boron(B)were doped into Fe_(81)Ga_(19) alloys via the laser-beam powder bed fusion(LPBF)technique to tailor the crystal and phase structures,thereby improving the magnetostrictive performance.The results revealed the capacity for quick solidification of the LPBF process in expediting the solid solution of B element,which increased both lattice distortion and dislocations within the Fe-Ga matrix.These factors contributed to an elevation in the density of the modified-D0_(3) phase structure.Moreover,the prepared Fe-Ga-B alloys also exhibited a(001)preferred grain orientation caused by the high thermal gradients during the LPBF process.As a result,a maximum magnetostriction coefficient of 105 ppm was achieved in the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy.In alternating magnetic fields,all the LPBF-prepared alloys showed good dynamic magnetostriction response without visible hysteresis,while the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy presented a notable enhancement of~30%in magnetostriction coefficient when compared with the Fe_(81)Ga_(19) alloy.Moreover.the(Fe_(81)Ga_(19))_(98.5)B_(1.5) alloy exhibited favorable biocompatibility and osteogenesis,as confirmed by increased alkaline phosphatase(ALP)activity and the formation of mineralized nodules.These findings suggest that the B-doped Fe-Ga alloys combined with the LPBF technique hold promise for the development of bulk magnetostrictive alloys that are applicable for bone repair applications. 展开更多
关键词 Fe-Ga alloys Laser-beam powder bed fusion Boron doping MAGnetOSTRICTION CYTOCOMPATIBILITY
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Lower size limit of raw coal for efficient beneficiation in air-fluidized bed with magnetite particles
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作者 Yalong Cao Donghui Liu Quanhong Zhu 《Chinese Journal of Chemical Engineering》 2025年第9期158-166,共9页
A feasible criterion was established to determine the lower size limit of raw coal(d_(pRm))for efficient beneficiation in the air-fluidized bed with magnetite particles.The feasibility of using small magnetite particl... A feasible criterion was established to determine the lower size limit of raw coal(d_(pRm))for efficient beneficiation in the air-fluidized bed with magnetite particles.The feasibility of using small magnetite particles to accommodate the fine raw coal was demonstrated from the experimental perspective.The minimum size for the magnetite particles to be fluidized smoothly was clarified as 47.1μm,which corresponded to the border between Geldart-B and-A groups.Since the gangue and coal components in the raw coal were crushed into the same size,d_(pRm)depended on the greater one between d_(pGm)(minimum size required for the gangue particles to sink towards the bottom)and d_(pCm)(minimum size required for the coal particles to float towards the top).dpcm was determined as 259μm by supposing that provided the gangue particles accumulated in the lower half bed,they could be potentially extracted from the bottom.On the other hand,it was observed that the coal particles could always accumulate in the upper half bed.Under such circumstances,dpcm was revealed as 9.8μm since finer coal particles would be blown out by air before the 47.1μm sized magnetite particles became fluidized.Eventually,dpRm was clarified as 259μm,agreeing with the common view that raw coal coarser than 6 mm could be effectively beneficiated in the air-fluidized bed with magnetite particles.Additionally,the difficulty in beneficiating the fine raw coal was revealed to arise more from the remixing of sorted gangue particles than that of separated coal particles. 展开更多
关键词 Raw coal Dry beneficiation Fluidized bed Lower size limit Magnetite particles
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Restructuring the cell network of non-equiatomic CoCrFeNiMoC medium-entropy alloy fabricated by laser powder bed fusion
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作者 Hyeonseok Kwon Eun Seong Kim +7 位作者 Yoon-Uk Heo Jungho Choe Rae Eon Kim Soung Yeoul Ahn Sang-Ho Oh Jeong Min Park Byeong-Joo Lee Hyoung Seop Kim 《Journal of Materials Science & Technology》 2025年第11期143-152,共10页
Metal additive manufacturing(MAM)enables near-net shape production of components with minimized waste and excellent mechanical performance based on multi-scale microstructural heterogeneity.Espe-cially,the dislocation... Metal additive manufacturing(MAM)enables near-net shape production of components with minimized waste and excellent mechanical performance based on multi-scale microstructural heterogeneity.Espe-cially,the dislocation cell network that often bears elemental segregation or precipitation of a secondary phase contributes to enhancing the strength of additively manufactured materials.The cell boundaries can also act as active nucleation sites for the formation of precipitates under post-MAM heat treatment,as the chemical heterogeneity and profuse dislocations generate a driving force for precipitation.In this work,we subjected a Co_(18)Cr_(15)Fe_(50)Ni_(10)Mo_(6.5)C_(0.5)(at%)medium-entropy alloy fabricated by laser powder bed fusion(LPBF)to post-LPBF annealing at 900℃for 10 min.Microstructural investigation revealed that the cell boundaries of the as-built sample,which were decorated by Mo segregation,are replaced byμphase andM_(6)C typecarbide precipitatesduringannealingwhile thegrainstructureand sizeremain unaffected,indicating that the post-LPBF annealing delivered the proper amount of heat input to alter only the cell structure.The yield strength slightly decreased with annealing due to a reduction in the strengthening effect by the cell boundaries despite an increased precipitation strengthening effect.How-ever,the post-LPBF annealing improved the strain hardenability and the ultimate tensile strength was enhanced from∼1.02 to∼1.15 GPa owing to reinforced back stress hardening by the increased disloca-tion pile-up at the precipitates.Our results suggest that the cell structure with chemical heterogeneity can be successfully controlled by careful post-MAM heat treatment to tailor the mechanical performance,while also providing insight into alloy design for additive manufacturing. 展开更多
关键词 Laser powder bed fusion Medium-entropy alloy Cell structure Strain hardening Precipitation Back stress hardening
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Application of wavelet neural network with chaos theory for enhanced forecasting of pressure drop signals in vapor−liquid−solid fluidized bed evaporator
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作者 Xiaoping Xu Ting Zhang +2 位作者 Zhimin Mu Yongli Ma Mingyan Liu 《Chinese Journal of Chemical Engineering》 2025年第2期67-81,共15页
The dynamics of vapor−liquid−solid(V−L−S)flow boiling in fluidized bed evaporators exhibit inherent complexity and chaotic behavior,hindering accurate prediction of pressure drop signals.To address this challenge,this... The dynamics of vapor−liquid−solid(V−L−S)flow boiling in fluidized bed evaporators exhibit inherent complexity and chaotic behavior,hindering accurate prediction of pressure drop signals.To address this challenge,this study proposes an innovative hybrid approach that integrates wavelet neural network(WNN)with chaos analysis.By leveraging the Cross-Correlation(C−C)method,the minimum embedding dimension for phase space reconstruction is systematically calculated and then adopted as the input node configuration for the WNN.Simulation results demonstrate the remarkable effectiveness of this integrated method in predicting pressure drop signals,advancing our understanding of the intricate dynamic phenomena occurring with V−L−S fluidized bed evaporators.Moreover,this study offers a novel perspective on applying advanced data-driven techniques to handle the complexities of multi-phase flow systems and highlights the potential for improved operational prediction and control in industrial settings. 展开更多
关键词 Wavelet neural network forecasting Chaos theory Phase space reconstruction Pressure drop forecasting Fluidized bed evaporator Multi-phase dynamics
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Effect of Addition of Er-TiB_(2)Dual-Phase Nanoparticles on Strength-Ductility of Al-Mn-Mg-Sc-Zr Alloy Prepared by Laser Powder Bed Fusion
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作者 Li Suli Zhang Yanze +5 位作者 Yang Mengjia Zhang Longbo Xie Qidong Yang Laixia MaoFeng Chen Zhen 《稀有金属材料与工程》 北大核心 2026年第1期9-17,共9页
A dual-phase synergistic enhancement method was adopted to strengthen the Al-Mn-Mg-Sc-Zr alloy fabricated by laser powder bed fusion(LPBF)by leveraging the unique advantages of Er and TiB_(2).Spherical powders of 0.5w... A dual-phase synergistic enhancement method was adopted to strengthen the Al-Mn-Mg-Sc-Zr alloy fabricated by laser powder bed fusion(LPBF)by leveraging the unique advantages of Er and TiB_(2).Spherical powders of 0.5wt%Er-1wt%TiB_(2)/Al-Mn-Mg-Sc-Zr nanocomposite were prepared using vacuum homogenization technique,and the density of samples prepared through the LPBF process reached 99.8%.The strengthening and toughening mechanisms of Er-TiB_(2)were investigated.The results show that Al_(3)Er diffraction peaks are detected by X-ray diffraction analysis,and texture strength decreases according to electron backscatter diffraction results.The added Er and TiB_(2)nano-reinforcing phases act as heterogeneous nucleation sites during the LPBF forming process,hindering grain growth and effectively refining the grains.After incorporating the Er-TiB_(2)dual-phase nano-reinforcing phases,the tensile strength and elongation at break of the LPBF-deposited samples reach 550 MPa and 18.7%,which are 13.4%and 26.4%higher than those of the matrix material,respectively. 展开更多
关键词 Al-Mn-Mg-Sc-Zr alloy laser powder bed fusion nano-reinforcing phase synergistic enhancement
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Pore pressure evolution and entrainment mechanism of convex unsaturated colluvial beds with divergent compositions under debris flow overriding
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作者 Pu Li Kaiheng Hu Jiading Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期278-298,共21页
A debris flow descending through an erodible convex colluvial bed,originating from a landslide dam and its upstream deposits,can entrain massive amounts of sediment,dramatically increasing the debris flow volume.Most ... A debris flow descending through an erodible convex colluvial bed,originating from a landslide dam and its upstream deposits,can entrain massive amounts of sediment,dramatically increasing the debris flow volume.Most existing erosion models assume that bed sediments are fully saturated,although this condition is rarely observed in nature.Therefore,a thorough understanding of debris flow overtopping erosion on a convex unsaturated bed is crucial for quantifying disaster risk.In this study,we experimentally investigated the effects of sediment composition,specifically coarse-grain size distribution and fine particle content,on the pore pressure evolution and entrainment of debris flows overriding a convex unsaturated colluvial bed.The average entrainment rate at convex sites for continuously graded bed sediment was higher than its discontinuous counterpart.The measured pore pressures within the unsaturated bed sediments were primarily generated by the passing debris flows.Furthermore,it was found that these pressures decreased as the fine particle content increased and the coarse-grain size of the erodible substrates decreased.When the coarse-grain size of the debris flow was smaller than that of the bed sediment,only a portion of the eroded material was entrained by the moving debris flow.In contrast,when the coarse-grain size of the debris flow was equal to or greater than that of the bed sediment,nearly all of the eroded material was entrained.The findings of this study could contribute to the assessment of hazard amplification and inform the design of mitigation and prevention strategies. 展开更多
关键词 Debris flow Convex colluvial bed Sediment composition Unsaturated bed Pore pressure ENTRAINMENT
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Community assembly and nitrogen metabolic characteristics of size-fractionated microorganisms in floating bed restoration area
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作者 Yi SHI Rui ZHAO +1 位作者 Lingfeng HUANG Wenjing ZHANG 《Journal of Oceanology and Limnology》 2026年第1期184-200,共17页
Ecological floating bed is an important biological remediation method for water pollution control.During the removal of excess nutrients and pollutants,changes in environmental factors affect the characteristics of mi... Ecological floating bed is an important biological remediation method for water pollution control.During the removal of excess nutrients and pollutants,changes in environmental factors affect the characteristics of microorganisms in aquatic ecosystems.To understand the influences of ecological floating beds on size-fractionated microorganisms,we investigated the community assembly and nitrogen metabolic characteristics of three size-fractionated microorganism groups in the ecological floating bed area,using 18S rDNA,16S rDNA metabarcoding,and metagenomic sequencing techniques.Firstly,we discovered substantial differences between size-fractionated groups in the diversity and compositions of both microeukaryotic and bacterial communities,as well as the influences of floating beds on specific groups.The floating beds appeared to provide more habitats for heterotrophs and symbiotes while potentially inhibiting the growth of certain phytoplankton(cyanobacteria).Secondly,we observed that microeukaryotic and bacterial communities were predominantly influenced by stochastic and deterministic processes,respectively,and they both exhibited distinct patterns across different size-fractionated groups.Notably,microeukaryotic community assembly demonstrated a greater sensitivity to ecological floating beds,as indicated by an increase in dispersal limitation processes.Finally,the nitrogen metabolism functional genes revealed that microbes associated with large-sized particles played a crucial role in dissimilatory nitrate reduction to ammonium(DNRA)and denitrification processes within the floating bed area,thereby facilitating the removal of excess nitrogen nutrients from the water.In contrast,freeliving microorganisms from small-sized groups were linked mainly to the genes involved in nitrogen assimilation and assimilatory nitrate reduction to ammonium(ANRA)processes.These findings help understand the impact of ecological floating beds on the diversity and functional characteristics of microorganism communities in different size-fractionated groups. 展开更多
关键词 size-fractionated MICROORGANISM METAGENOMIC nitrogen metabolism assembly process ecological floating bed
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Crushing evolution in pebble bed based on a novel method:a crushable DEM study
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作者 Jian Wang Ming‑Zhun Lei +4 位作者 Ming‑Zong Liu Qi‑Gang Wu Zi‑Cong Cai Kai‑Song Wang Hai‑Shun Deng 《Nuclear Science and Techniques》 2026年第1期212-224,共13页
In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical m... In this paper,a novel method for investigating the particle-crushing behavior of breeding particles in a fusion blanket is proposed.The fractal theory and Weibull distribution are combined to establish a theoretical model,and its validity was verified using a simple impact test.A crushable discrete element method(DEM)framework is built based on the previously established theoretical model.The tensile strength,which considers the fractal theory,size effect,and Weibull variation,was assigned to each generated particle.The assigned strength is then used for crush detection by comparing it with its maximum tensile stress.Mass conservation is ensured by inserting a series of sub-particles whose total mass was equal to the quality loss.Based on the crushable DEM framework,a numerical simulation of the crushing behavior of a pebble bed with hollow cylindrical geometry under a uniaxial compression test was performed.The results of this investigation showed that the particle withstands the external load by contact and sliding at the beginning of the compression process,and the results confirmed that crushing can be considered an important method of resisting the increasing external load.A relatively regular particle arrangement aids in resisting the load and reduces the occurrence of particle crushing.However,a limit exists to the promotion of resistance.When the strain increases beyond this limit,the distribution of the crushing position tends to be isotropic over the entire pebble bed.The theoretical model and crushable DEM framework provide a new method for exploring the pebble bed in a fusion reactor,considering particle crushing. 展开更多
关键词 Crushing behavior Granular material Discrete element method Pebble bed Fractal theory
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Numerical study on pebble-bed powder migration and clogging mechanism with purge gas
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作者 Xue-Tao Cui Qi-Gang Wu +2 位作者 Jian Wang Ming-Zhun Lei Yun-Tao Song 《Nuclear Science and Techniques》 2026年第2期194-207,共14页
As the primary functional component of a fusion reactor,the fusion blanket pebble bed,composed of numerous particles,is crucial for tritium breeding,neutron multiplication,and radiation shielding.Particles within trit... As the primary functional component of a fusion reactor,the fusion blanket pebble bed,composed of numerous particles,is crucial for tritium breeding,neutron multiplication,and radiation shielding.Particles within tritium-breeding pebble beds are subjected to prolonged neutron irradiation,high thermal loads,and strong magnetic fields in fusion environments.Such conditions render them susceptible to pulverization and fragmentation.The resulting fragments and powders migrate and are deposited into the gas channel,driven by the purge gas.The reduction in the effective flow area of the gas increases the flow resistance,resulting in tritium retention,degraded heat transfer,and other adverse effects.These conditions impair the thermodynamic properties of the pebble beds and hinder the self-maintenance of tritium.Limited information exists on powder migration and clogging mechanisms in fusion blanket pebble beds,particularly under diverse physical conditions.The aim of this study was to use a computational fluid dynamics model coupled with the discrete element method(CFD-DEM)to numerically explore powder migration and clogging in pebble beds.The model considers factors such as breeder orientation,purge velocity,powder size distribution,and friction coefficient.We propose two migration and clogging mechanisms.One involves powder with a large particle size,and the other does not.The results indicate that the powder migration velocity progresses through three stages:rapid decay,linear decay,and stability.Pebble-bed clogging manifests in two forms:extensive superficial clogging and uniform internal clogging.Two fitted curves were used to depict the migration and clogging tendencies.The powder size distribution significantly influenced the powder migration.The breeder orientation,powder size,and friction coefficient affected the distribution of the clogging powders.However,the impact of the purge velocity on powder migration and clogging in pebble beds was limited,and this effect varied significantly with different particle size ratios.Based on the analysis,a formula is proposed to characterize the behavior of the powder in the pebble beds.The results of this study can aid in analyzing and predicting powder dynamics in pebble beds. 展开更多
关键词 Coupled CFD-DEM Pebble beds Purge gas Powder flow Migration and clogging mechanism
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Laser powder bed fusion of biodegradable Zn-4 Cu alloy:Processing,microstructure and properties
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作者 WANG Han-dan ZHAO Yang +3 位作者 DONG An-ping HE Lin SHUAI Ci-jun GAO Cheng-de 《Journal of Central South University》 2026年第1期66-77,共12页
Zn's natural degradability and biocompatibility make it a promising candidate for implants,however,its mechanical properties remain insufficient for bone applications.In this study,the performance of Zn was enhanc... Zn's natural degradability and biocompatibility make it a promising candidate for implants,however,its mechanical properties remain insufficient for bone applications.In this study,the performance of Zn was enhanced by developing Zn-Cu alloys via laser powder bed fusion(LPBF).Optimal LPBF parameters for forming stable tracks were achieved by adjusting laser power and scanning speed.Under optimized conditions of 100 W and 100 mm/s,high density(99.58%)Zn-Cu alloys with improved hardness(68.2 HV)and yield strength(160 MPa)were achieved.These improvements are attributed to solid solution strengthening,segregation strengthening,and grain refinement.The Zn-Cu alloys also demonstrated favorable degradation behavior,with a rate of 0.16 mm/year.This degradation is primarily driven by micro-galvanic corrosion between the CuZn 5 phase and Zn matrix,along with refined grains and increased grain boundary density.This work demonstrates a viable strategy for fabricating Zn-based implants with enhanced structural integrity and mechanical performance via LPBF. 展开更多
关键词 laser powder bed fusion(LPBF) Zn-Cu alloys microstructure mechanical properties BIODEGRADATION
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Microstructure and mechanical properties evolution of Al−Mg−Sc−Zr alloy fabricated by laser powder bed fusion
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作者 Xiang LI Zheng-jiang GAO Yun-zhong LIU 《Transactions of Nonferrous Metals Society of China》 2026年第2期337-354,共18页
The densification characterization,phase constitution,precipitation evolution and mechanical performance of Al−Mg−Sc−Zr alloy processed by laser powder bed fusion(LPBF)were systematically investigated.Moreover,the evo... The densification characterization,phase constitution,precipitation evolution and mechanical performance of Al−Mg−Sc−Zr alloy processed by laser powder bed fusion(LPBF)were systematically investigated.Moreover,the evolution of phase constitution and precipitation behavior after heat treatment were characterized by using X-ray diffraction(XRD)and transmission electron microscope(TEM)analysis.The ultimate tensile strength(UTS)of as-built samples ranged from 396.8 to 414.6 MPa as the scanning speed decreased from 1600 to 1000 mm/s.After post heat treatment,the yield strength(YS)increased to(513.1±1.3)MPa,while the UTS increased from(414.6±5.1)to(539.2±1.5)MPa.The significant improvement of mechanical performance was ascribed to the formation of secondary Al3(Sc,Zr)precipitates. 展开更多
关键词 additive manufacturing laser powder bed fusion Al−Mg−Sc−Zr precipitation behavior microstructure mechanical performance
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Effect of laser remelting on microstructure and properties of Ti6Al4V titanium alloy prepared by laser powder bed fusion
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作者 Yue-yang LIU Yang YANG +1 位作者 Xiang CHEN Yu-xing ZHAN 《Transactions of Nonferrous Metals Society of China》 2026年第2期488-506,共19页
Laser remelting(LR)was used as an auxiliary post-treatment process for the Ti6Al4V titanium alloys fabricated by laser powder bed fusion(LPBF).Optical microscope(OM),scanning electron microscope(SEM)and electron back ... Laser remelting(LR)was used as an auxiliary post-treatment process for the Ti6Al4V titanium alloys fabricated by laser powder bed fusion(LPBF).Optical microscope(OM),scanning electron microscope(SEM)and electron back scattering diffraction(EBSD)observations showed that the grains in melted zone(MZ)transformed into equiaxial grains with an average size of 1.31μm,and the grains in heat affected zone(HAZ)were refined.Moreover,the texture intensity dropped significantly from 13.86 to 6.35 in MZ and 10.79 in HAZ.The temperature gradient(G)to solidification rate(R)ratio decreased when the laser scanning speed slowed down to a certain extent in the LR process,which effectively improved the highly preferred orientation and filled the hole defects in the surface of LPBF-Ti6Al4V.Furthermore,the hardness,wear resistance and corrosion resistance of the surface of the LPBF samples were improved by LR treatment. 展开更多
关键词 laser powder bed fusion laser remelting grain refinement preferred orientation wear behavior electrochemical properties TI6AL4V
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Fluidized-bed chlorination thermodynamics and kinetics of Kenya natural rutile ore 被引量:4
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作者 牛丽萍 张廷安 +2 位作者 倪培远 吕国志 欧阳全胜 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2013年第11期3448-3455,共8页
Natural rutile and gaseous chlorine with carbon as reductant were used to prepare titanium tetrachloride. Thermodynamics and kinetics of chlorination of Kenya natural rutile particles in a batch-type fluidized bed wer... Natural rutile and gaseous chlorine with carbon as reductant were used to prepare titanium tetrachloride. Thermodynamics and kinetics of chlorination of Kenya natural rutile particles in a batch-type fluidized bed were studied at 1173-1273 K. Thermodynamic analysis of this system revealed that the equation of producing CO was dominant at high temperatures. Based on the gas-solid multi-phase reaction theory and a two-phase model for the fluidized bed, the mathematical description for the chlorination reaction of rutile was proposed. The reaction parameters and the average concentration of gaseous chlorine in the emulsion phase were estimated. The average concentration of emulsion phase in the range of fluidized bed was calculated as 0.3 mol/m^3. The results showed that the chlorination of natural rutile proceeded principally in the emulsion phase, and the reaction rate was mainly controlled by the surface reaction. 展开更多
关键词 natural rutile THERMODYNAMICS KInetICS gas-solid reaction fluidized bed two-phase model
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Fluidization characteristics of magnetic particles and determination of stable fluidization zone in magnetically fluidized bed 被引量:1
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作者 王迎慧 归柯庭 施明恒 《Journal of Southeast University(English Edition)》 EI CAS 2006年第4期523-527,共5页
To determine and calculate the stable fluidization zone in a magnetically fluidized bed, the fluidization characteristics of magnetic particles are investigated. Four kinds of magnetic particles with different average... To determine and calculate the stable fluidization zone in a magnetically fluidized bed, the fluidization characteristics of magnetic particles are investigated. Four kinds of magnetic particles with different average diameters, ranging from 231 to 512 μm, are fluidized in the presence of magnetic fields with specified values of the intensity in the range of zero to 7330 A/m, and the particle fluidization curves are plotted. For marking the stable fluidization zone in the curves, the minimum bubbling velocities of particles are measured by the pressure-drop fluctuation. Based on the fluidization curves, the influences of the average particle diameter and magnetic field intensity on the zone are analyzed and discussed. A correlation to determine the stable fluidization zone is derived from the experimental data, using three dimensionless numbers, i. e., the ratio of magnetic potential to gravity potential, the Reynolds number and the Archimedes number. Compared with available data reported, it is shown that the correlation is more simplified to predict relative parameters for the bed operating in the state of stable fluidization under reasonable conditions. 展开更多
关键词 magnetically fluidized bed fluidization characteristics stable fluidization minimum bubbling gas velocity pressure-drop fluctuation
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ZBED2通过糖酵解代谢诱导肝细胞癌中PD-L1表达促进免疫逃逸的机制研究 被引量:2
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作者 黄金石 丁亚亭 曹建中 《中国免疫学杂志》 北大核心 2025年第2期367-373,共7页
目的:探讨锌指BED结构域含蛋白2(ZBED2)通过糖酵解通路对肝细胞癌(HCC)免疫逃逸的影响及潜在机制。方法:生物信息学数据库分析ZBED2在HCC组织中的表达情况及二者的结合位点,分析ZBED2调控的通路,以及ZBED2与糖酵解基因的相关性。qPCR和W... 目的:探讨锌指BED结构域含蛋白2(ZBED2)通过糖酵解通路对肝细胞癌(HCC)免疫逃逸的影响及潜在机制。方法:生物信息学数据库分析ZBED2在HCC组织中的表达情况及二者的结合位点,分析ZBED2调控的通路,以及ZBED2与糖酵解基因的相关性。qPCR和Western blot检测ZBED2及程序性细胞死亡配体1(PD-L1)在HCC细胞中的表达,MTT检测细胞活力,细胞毒性实验检测CD8+T细胞毒性,ELISA检测细胞因子表达;细胞外流量分析仪检测胞外酸化率(ECAR)和耗氧率(OCR),qPCR检测糖酵解相关基因表达,试剂盒检测糖酵解指标,免疫组织化学染色检测肿瘤组织中CD8^(+)T细胞表达。结果:ZBED2在HCC中表达上调,过表达ZBED2可促进PD-L1表达,抑制CD8^(+)T细胞对HCC细胞的毒性。过表达ZBED2通过激活糖酵解通路抑制HCC中CD8^(+)T细胞活性,进一步添加糖酵解抑制剂2-脱氧-D-葡萄糖(2-DG)减弱了以上结果。体内实验发现,敲低ZBED2可抑制小鼠肿瘤生长及PD-L1表达,促进体内CD8+T细胞浸润。结论:ZBED2通过糖酵解代谢诱导HCC中PDL1表达,促进免疫逃逸。 展开更多
关键词 锌指bed结构域含蛋白2 糖酵解 肝细胞癌 免疫逃逸
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