Kashin-Beck disease(KBD)is a regionally endemic chronic osteoarthropathy,while osteoarthritis(OA)is a degenerative joint disease characterized by progressive articular cartilage degradation and extracellular matrix re...Kashin-Beck disease(KBD)is a regionally endemic chronic osteoarthropathy,while osteoarthritis(OA)is a degenerative joint disease characterized by progressive articular cartilage degradation and extracellular matrix remodeling.Although KBD and OA share overlapping clinical and pathological features,key differences exist in their etiology and disease progression.KBD preferentially affects children aged 3-12 years,whereas OA predominantly affects older individuals between the age of 40-60 years.KBD cartilage necrosis originates in the deep layers of the epiphyseal plate and articular cartilage,progressing toward the cartilage surface.In contrast,OA cartilage destruction initiates at the articular cartilage surface and gradually progresses to expose the subchondral bone[1,2].展开更多
基金supported by the 2023 training program for discipline leaders in natural science and engineering technology of Qinghai province-“Kunlun Talents·Science and Technology leaders.”。
文摘Kashin-Beck disease(KBD)is a regionally endemic chronic osteoarthropathy,while osteoarthritis(OA)is a degenerative joint disease characterized by progressive articular cartilage degradation and extracellular matrix remodeling.Although KBD and OA share overlapping clinical and pathological features,key differences exist in their etiology and disease progression.KBD preferentially affects children aged 3-12 years,whereas OA predominantly affects older individuals between the age of 40-60 years.KBD cartilage necrosis originates in the deep layers of the epiphyseal plate and articular cartilage,progressing toward the cartilage surface.In contrast,OA cartilage destruction initiates at the articular cartilage surface and gradually progresses to expose the subchondral bone[1,2].
