Objective To observe the clinical therapeutic effect on insomnia treated with acupuncture at back-shu points. Methods Sixty-four cases of insomnia were selected and divided randomly into a back-shu points group （grou...Objective To observe the clinical therapeutic effect on insomnia treated with acupuncture at back-shu points. Methods Sixty-four cases of insomnia were selected and divided randomly into a back-shu points group （group A） and a conventional acupoints group （group B） by a computer generated allocation list, 32 cases in each one. In the trial group, acupuncture was applied at xinshu （心俞 15）, Ganshu （刊俞 18）, Pishu （脾俞 BL 20） and Geshu （膈俞 BL 17）. In the control group, acupuncture was applied conventionally to Neiguan （内关 PC 6）, Shenmen （神门 HT 7）, Sanyinjiao （三阴交 SP 6）, Baihui （百会 GV 20） and Sishencong （四神聪 EX-HN 2）. Ten treatments made a session. The efficacy was analyzed statistically after 3 sessions of treatment. Results There were significant differences between the two groups in the relief of sleep disorders after the treatment （P〈0.O2）. The improvement in sleep efficiency was different significantly （P〈0.05）. The difference in sleep difficulty was significant in Chinese medicine （TCM） symptom score （P〈0.05）. Conclusion The clinical efficacy is achieved by either acupuncture at back-shu points or by acupuncture at conventional acupoints. The improvements of sleep efficiency and sleep disorder scores in PSO.I, and sleep difficulty in TCM as well as the long-term efficacy are superior in group A as compared with those in group B.展开更多
Objective To find therapeutic effect of acupuncture treating depression. Methods Eighteen cases of depression divided into two groups： one group treated with electroacupuncture （8 cases）, the other with medication ...Objective To find therapeutic effect of acupuncture treating depression. Methods Eighteen cases of depression divided into two groups： one group treated with electroacupuncture （8 cases）, the other with medication （10 cases）. For the group with electroacupuncture, Shenting （神庭 GV 24）, Baihui （百会 GV 20）, Pishu （脾俞 BL 20）, Weishu（胃俞 BL 21）, Dachangshu （大肠俞 BL 25）, Xiaochangshu （小肠俞BL 27） were selected for treatment; and for the group of medication, venlafaxine was given as usual. 30 days later, an open unidirectional qualitative response sequential method was taken to compare the therapeutic effects of two groups. Result The therapeutic effects from two 8 cases proved that the group of electroacupuncture was better than the group of medication. Conclusion For depression, scalp acupuncture accompanied by acupuncture on the Back-shu points has a better effect for depression, and is superior to medication.展开更多
Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In t...Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after treatment.Results: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(P<0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment(all P<0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced(both P<0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment(P< 0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group(P< 0.01, P< 0.05).Conclusions: Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient’s somatic fatigue, mental fatigue and psychological status.展开更多
BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use i...BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse reactions.Acupuncture has a good curative effect and unique advantages in the treatment of insomnia.AIM To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia.METHODS We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive days.After treatment,the sleep time and general behavior of the rats were determined.The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats.The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA.qRTPCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway.Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κB.RESULTS Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial memory.In addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway.CONCLUSION These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.展开更多
Objective:To observe the effect of intradermal needle therapy on back-shu points of five zang organs in treating chronic fatigue syndrome(CFS)and provide evidence for the usage of unilateral back-shu point.Methods:Pat...Objective:To observe the effect of intradermal needle therapy on back-shu points of five zang organs in treating chronic fatigue syndrome(CFS)and provide evidence for the usage of unilateral back-shu point.Methods:Patients were randomly divided into bilateral back-shu point group,unilateral back-shu point group and non-acupoint group,remove shedding cases,each group remaining 30 patients.In bilateral back-shu point group,both sides of back-shu points of five zang organs were selected.In unilateral back-shu point group,only one side was selected,left or right alternately.The location where non-acupoint group inserted by intradermal needles were outward from the back-shu points,left or right alternately.Fatigue Scale-14(FS-14)was used to evaluate the fatigue level and the scores’improvement of physical fatigue and mental fatigue revealed the therapeutic effect on body constituents and spirits of CFS patient.Results:After the 8-week intradermal needle therapy,the total effective rate was 83.33%in the bilateral back-shu point group,which was 76.67%in the unilateral back-shu point group and 50.00%in the non-acupoint group.The curative effects of the two groups whose back-shu points of five zang organs were inserted by intradermal needles were better than the non-acupoint group(P<0.05).There was no significant difference in clinical efficacy between the bilateral back-shu point group and the unilateral back-shu point group(P>0.05).There were statistical differences in FS-14 questionnaires including total,physical and mental scores between before and after the treatment in both the two back-shu point groups(P<0.05).Only the scores of total and physical fatigue in decreased in non-acupoint group(P<0.05),which means it couldn’t help to alleviate mental fatigue statistically(P>0.05).Conclusions:(1)The intradermal needle therapy on back-shu points of five zang organs for CFS has a satisfying clinical efficacy in curing tiredness.It can help to reduce both physical and mental fatigue for the patients.Hence,it can regulate both body constituents and spirits simultaneously.(2)Needling the unilateral acupoints can get similar clinical efficacy to the bilateral points.It reveals that we can cut cost by reducing the consumption of the amount of intradermal needles used on one side.(3)Both the groups of back-shu points get better clinical efficacy than the non-acupoint group dramatically.The reason of why the intradermal needle can treat CFS maybe that back-shu points of five zang organs can regulate the functions of five zang organs characteristically.展开更多
To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods. The patients of acute bronchitis were randomly divided into 2 groups. In the observati...To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods. The patients of acute bronchitis were randomly divided into 2 groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results： The total effective rate of the observation group was 97.2% while that of the control group was 82,8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group （P 〈 0.01） and on the fifth and seventh days, the comparison showed no significant difference （P〉0.05）. Conclusion： The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.展开更多
Urticaria is a common and frequently encountered disease, which is mainly manifested by extreme pruritus and lumpish eruption of the skin. Acute urticaria with a short disease course can be cured, while the chronic on...Urticaria is a common and frequently encountered disease, which is mainly manifested by extreme pruritus and lumpish eruption of the skin. Acute urticaria with a short disease course can be cured, while the chronic one with repeated attacks is a lingering disorder. In the past few years, 40 cases of urticaria were treated by cupping at the back-shu points of the five zang-organs and Geshu (BL 17). Another 20 cases in the control group were treated with Fang Feng Tong Sheng Wan (防风通圣丸Miraculous Pills of Ledebouriella) and chlorpheniramine maleate. The therapeutic effect in the treatment group was significantly superior to that in the control group. The results are reported as follows.展开更多
The strong connection between braids and knots provides valuable insights into studying the topological state and phase classification of various physical systems.The phenomenon of non-Hermitian(NH)two-and three-band ...The strong connection between braids and knots provides valuable insights into studying the topological state and phase classification of various physical systems.The phenomenon of non-Hermitian(NH)two-and three-band braiding has received widespread attention.However,a systematic exploration and visualization of non-Abelian braiding and the associated knot transformations in four-band systems remains unexplored.Here,we propose a theoretical model of NH four-band braiding,provide its phase diagram,and establish its trivial,Abelian,and non-Abelian braiding rules.Additionally,we report on special knots,such as the Hopf and Solomon links in braided knots,and reveal that their transformations are accompanied by and mediated through exceptional points.Our work provides a detailed case for studying NH multiband braiding and knot structures in four-band systems,which could offer insights for topological photonics and analog information processing applications.展开更多
Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewa...Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.展开更多
Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detecti...Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detection of porcine deltacoronavirus.The fluorescent microsphere-based lateral flow test strip demonstrated a sensitivity of 10~(1.7)TCID_(50)/0.1 mL,which is fourfold higher than that of the colloidal gold-based assay.Porcine deltacoronavirus(PDCoV)is a recently identified enteric coronavirus that causes an acute infectious disease in piglets,leading to diarrhea,vomiting,dehydration,and mortality(Hu et al.2015).展开更多
Objective To observe the influences of electroacupuncture at the combination of back-shu and front-mu points on insulin sensitivity indicators and somatological parameter indicators in the patients with obesity compli...Objective To observe the influences of electroacupuncture at the combination of back-shu and front-mu points on insulin sensitivity indicators and somatological parameter indicators in the patients with obesity complicated with insulin resistance.Methods A total of 60 patients with obesity and insulin resistance were randomized into a control group(30 cases,4 cases of them dropped out)and a trial group(30 cases,2 cases of them dropped out).In the control group,the intervention with diet and exercise were provided.In the trial group,on the base of the treatment as the control group,electroacupuncture was added at the combination of back-shu points and front-mu points,3 times weekly.The duration of treatment was 12 weeks in two groups.The therapeutic effect and the somatological parameter indicators(body mass[BW],body mass index[BMI],waist circumference[WC],waist-to-hip ratio[WHR])as well as the insulin sensitivity indicators(fasting plasma glucose[FPG],fasting insulin[FIN],insulin sensitivity index[ISI]and insulin resistance index[HOMA-IR])before and after treatment were compared between two groups.Results①The effective rate was 92.86%in the trial group and was 57.69%in the control group.The effective rate of the trial group was higher than the control group,indicating the statistical difference(P<0.01).②BW,BMI,WC and WHR after treatment were all reduced obviously as compared with before treatment in two groups(all P<0.01).After treatment,BMI,WC and WHR in the trial group were all lower than those in the control group(all P<0.05)and the differences in BW,BMI,WC and WHR before and after treatment in the trial group were larger than those in the control group(all P<0.01).③After treatment,FIN and HOMA-IR were all lower significantly than those before treatment in two group and ISI was increased significantly as compared with before treatment(all P<0.01).After treatment,FPG was reduced significantly as compared with before treatment in the trial group(P<0.01)and the difference in FPG was not significant statistically in the control group(P>0.05).After treatment,FPG and HOMA-IR in the trial group were lower than the control group and ISI was higher than the control group(all P<0.05).Besides,the differences in FPG,FIN,ISI and HOMA-IR before and after treatment in the trial group were larger significantly than those in the control group(P<0.01,P<0.05).Conclusion Electroacupuncture at the combination of back-shu and front-mu points in association with the intervention with diet and exercise is effective on obesity complicated with insulin resistance.The effects of this combined therapy are superior as compared with simple intervention with diet and exercise in body mass,body mass index,waist circumference and waist-to-lip ratio as well as fasting blood glucose,fasting insulin,insulin sensitivity index and insulin resistance index in patients.展开更多
Ojective:To explored the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and its mechanism from the aspect of the anti-inflammatory response.Background:Bi...Ojective:To explored the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and its mechanism from the aspect of the anti-inflammatory response.Background:Bipolar disorder is a very common,often misdiagnosed mental disorder strongly associated with comorbidity,disability,and premature mortality.Bipolar depression(ie,depressive episode in bipolar disorder)is poorly responsive to available treatments.Acupuncture at back-shu points of five zang and Geshu(BL 17),a prescription from Dr.Leting Wang,is a popular therapy for depression in China.Its effectiveness and safety for bipolar depression are yet to be verified by clinical studies.Methods:The study is a single-center,prospective,randomized controlled trial involving 72 patients diagnosed with bipolar depression.Participants will be randomized either to the study group or the control group in a 1:1 ratio.All participants will receive mood stabilizer therapy.In addition,the study group will receive acupuncture therapy at back-shu points of five zang and Geshu(BL 17),three times per week.The control group will orally take the antidepressant bupropion.Observation and intervention will last for 8 consecutive weeks.Outcome measurements include Hamilton Depression Rating Scale-17,Hamilton Anxiety Rating Scale,Clinical Global Impression Scale,Young Manic Rating Scale,Treatment Emergent Symptom Scale,serum levels of anti-inflammatory cytokines[interleukin-4(IL-40),IL-10,and transforming growth factor–β,pro-inflammatory cytokines(IL-1β,IL-6,and tumor necrosis factor–α),brain-derived neurotrophic factor,and C-reactive protein.Assessments will be conducted at baseline,first,second,fourth,and eighth weeks after randomization.Safety assessments will be performed throughout the study.Discussion:The results of this study are expected to verify the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and explore its therapeutic mechanisms from the point of anti-inflammation.展开更多
Objective To observe the effects of electroacupuncture(EA)at different acupoints for fasting blood glucose(FBG)and oral glucose tolerance in type 2 diabetes rats so as to verify the glucose-lowering effects of EA.Meth...Objective To observe the effects of electroacupuncture(EA)at different acupoints for fasting blood glucose(FBG)and oral glucose tolerance in type 2 diabetes rats so as to verify the glucose-lowering effects of EA.Methods Total100 SD male rats were used as experimental objects。展开更多
Objective： To observe the clinical effect of puncturing Back-Shu points in treating chronic fatigue syndrome. Methods： Twenty-two subjects were recruited and treated by puncturing corresponding Back-Shu points based...Objective： To observe the clinical effect of puncturing Back-Shu points in treating chronic fatigue syndrome. Methods： Twenty-two subjects were recruited and treated by puncturing corresponding Back-Shu points based on syndrome differentiation. The short-form General Health Survey （MOSSF GHS） and the Chalder Questionnaires for Fatigue were adopted for evaluating the therapeutic effects. Results： Of the 22 patients, 4 cases showed a marked effect, 11 got effect, 7 got failure, and the total effective rate was 68.2%. Conclusion： Puncturing Back-Shu points is effective in relieving the symptoms of chronic fatigue syndrome and enhancing the patients＇ health standard.展开更多
针对菇房内杏鲍菇表型参数测量任务中,由于扫描设备视角受限,扫描的杏鲍菇点云出现残缺问题,基于AdaPoinTr(Adaptive geometry-aware point transformers)提出了改进的SwinPoinTr模型,实现了对残缺杏鲍菇点云的准确补全和杏鲍菇表型参...针对菇房内杏鲍菇表型参数测量任务中,由于扫描设备视角受限,扫描的杏鲍菇点云出现残缺问题,基于AdaPoinTr(Adaptive geometry-aware point transformers)提出了改进的SwinPoinTr模型,实现了对残缺杏鲍菇点云的准确补全和杏鲍菇表型参数的测量。该方法在使用提出的特征重塑模块的基础上,构建具有几何感知能力的层次化Transformer编码模块,提高了模型对输入点云的利用率和模型捕捉点云细节特征的能力。然后基于泊松重建方法完成了补全点云表面重建,并测量到杏鲍菇表型参数。实验结果表明,本文所提算法在残缺杏鲍菇点云补全任务中,模型倒角距离为1.316×10^(-4),地球移动距离为21.3282,F1分数为87.87%。在表型参数估测任务中,模型对杏鲍菇菌高、体积、表面积估测结果的决定系数分别为0.9582、0.9596、0.9605,均方根误差分别为4.4213 mm、10.8185 cm^(3)、7.5778 cm^(2)。结果证实了该研究方法可以有效地补全残缺的杏鲍菇点云,可以为菇房内杏鲍菇表型参数测量提供基础。展开更多
基金Supported by National Natural Science Foundation:No.81173335
文摘Objective To observe the clinical therapeutic effect on insomnia treated with acupuncture at back-shu points. Methods Sixty-four cases of insomnia were selected and divided randomly into a back-shu points group （group A） and a conventional acupoints group （group B） by a computer generated allocation list, 32 cases in each one. In the trial group, acupuncture was applied at xinshu （心俞 15）, Ganshu （刊俞 18）, Pishu （脾俞 BL 20） and Geshu （膈俞 BL 17）. In the control group, acupuncture was applied conventionally to Neiguan （内关 PC 6）, Shenmen （神门 HT 7）, Sanyinjiao （三阴交 SP 6）, Baihui （百会 GV 20） and Sishencong （四神聪 EX-HN 2）. Ten treatments made a session. The efficacy was analyzed statistically after 3 sessions of treatment. Results There were significant differences between the two groups in the relief of sleep disorders after the treatment （P〈0.O2）. The improvement in sleep efficiency was different significantly （P〈0.05）. The difference in sleep difficulty was significant in Chinese medicine （TCM） symptom score （P〈0.05）. Conclusion The clinical efficacy is achieved by either acupuncture at back-shu points or by acupuncture at conventional acupoints. The improvements of sleep efficiency and sleep disorder scores in PSO.I, and sleep difficulty in TCM as well as the long-term efficacy are superior in group A as compared with those in group B.
文摘Objective To find therapeutic effect of acupuncture treating depression. Methods Eighteen cases of depression divided into two groups： one group treated with electroacupuncture （8 cases）, the other with medication （10 cases）. For the group with electroacupuncture, Shenting （神庭 GV 24）, Baihui （百会 GV 20）, Pishu （脾俞 BL 20）, Weishu（胃俞 BL 21）, Dachangshu （大肠俞 BL 25）, Xiaochangshu （小肠俞BL 27） were selected for treatment; and for the group of medication, venlafaxine was given as usual. 30 days later, an open unidirectional qualitative response sequential method was taken to compare the therapeutic effects of two groups. Result The therapeutic effects from two 8 cases proved that the group of electroacupuncture was better than the group of medication. Conclusion For depression, scalp acupuncture accompanied by acupuncture on the Back-shu points has a better effect for depression, and is superior to medication.
基金Supported by the subject of clinical research on treating chronic fatigue syndrome by acupuncture on the reaction point of back-shu points in Dongzhimen Hospital Beijing University of Chinese Medicine:2016-DZM111-JC006~~
文摘Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after treatment.Results: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(P<0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment(all P<0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced(both P<0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment(P< 0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group(P< 0.01, P< 0.05).Conclusions: Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient’s somatic fatigue, mental fatigue and psychological status.
文摘BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse reactions.Acupuncture has a good curative effect and unique advantages in the treatment of insomnia.AIM To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia.METHODS We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive days.After treatment,the sleep time and general behavior of the rats were determined.The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats.The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA.qRTPCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway.Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κB.RESULTS Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial memory.In addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway.CONCLUSION These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.
基金Xin'ao Award Funded Project of Beijing University of Chinese Medicine(No.2018-XAJLJJ-015)。
文摘Objective:To observe the effect of intradermal needle therapy on back-shu points of five zang organs in treating chronic fatigue syndrome(CFS)and provide evidence for the usage of unilateral back-shu point.Methods:Patients were randomly divided into bilateral back-shu point group,unilateral back-shu point group and non-acupoint group,remove shedding cases,each group remaining 30 patients.In bilateral back-shu point group,both sides of back-shu points of five zang organs were selected.In unilateral back-shu point group,only one side was selected,left or right alternately.The location where non-acupoint group inserted by intradermal needles were outward from the back-shu points,left or right alternately.Fatigue Scale-14(FS-14)was used to evaluate the fatigue level and the scores’improvement of physical fatigue and mental fatigue revealed the therapeutic effect on body constituents and spirits of CFS patient.Results:After the 8-week intradermal needle therapy,the total effective rate was 83.33%in the bilateral back-shu point group,which was 76.67%in the unilateral back-shu point group and 50.00%in the non-acupoint group.The curative effects of the two groups whose back-shu points of five zang organs were inserted by intradermal needles were better than the non-acupoint group(P<0.05).There was no significant difference in clinical efficacy between the bilateral back-shu point group and the unilateral back-shu point group(P>0.05).There were statistical differences in FS-14 questionnaires including total,physical and mental scores between before and after the treatment in both the two back-shu point groups(P<0.05).Only the scores of total and physical fatigue in decreased in non-acupoint group(P<0.05),which means it couldn’t help to alleviate mental fatigue statistically(P>0.05).Conclusions:(1)The intradermal needle therapy on back-shu points of five zang organs for CFS has a satisfying clinical efficacy in curing tiredness.It can help to reduce both physical and mental fatigue for the patients.Hence,it can regulate both body constituents and spirits simultaneously.(2)Needling the unilateral acupoints can get similar clinical efficacy to the bilateral points.It reveals that we can cut cost by reducing the consumption of the amount of intradermal needles used on one side.(3)Both the groups of back-shu points get better clinical efficacy than the non-acupoint group dramatically.The reason of why the intradermal needle can treat CFS maybe that back-shu points of five zang organs can regulate the functions of five zang organs characteristically.
文摘To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods. The patients of acute bronchitis were randomly divided into 2 groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results： The total effective rate of the observation group was 97.2% while that of the control group was 82,8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group （P 〈 0.01） and on the fifth and seventh days, the comparison showed no significant difference （P〉0.05）. Conclusion： The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.
文摘Urticaria is a common and frequently encountered disease, which is mainly manifested by extreme pruritus and lumpish eruption of the skin. Acute urticaria with a short disease course can be cured, while the chronic one with repeated attacks is a lingering disorder. In the past few years, 40 cases of urticaria were treated by cupping at the back-shu points of the five zang-organs and Geshu (BL 17). Another 20 cases in the control group were treated with Fang Feng Tong Sheng Wan (防风通圣丸Miraculous Pills of Ledebouriella) and chlorpheniramine maleate. The therapeutic effect in the treatment group was significantly superior to that in the control group. The results are reported as follows.
基金supported by the National Natural Science Foundation of China(Grant Nos.62575099,62075059,61405058)Guangdong Basic and Applied Basic Research Foundation(Grant No.2024A1515011353)+2 种基金Open Project of the State Key Laboratory of Advanced Optical Communication Systems and Networks of China(Grant No.2024GZKF20)the Natural Science Foundation of Hunan Province(Grant Nos.2020JJ4161 and 2017JJ2048)Scientific Research Foundation of Hunan Provincial Education Department(Grant No.21A0013)。
文摘The strong connection between braids and knots provides valuable insights into studying the topological state and phase classification of various physical systems.The phenomenon of non-Hermitian(NH)two-and three-band braiding has received widespread attention.However,a systematic exploration and visualization of non-Abelian braiding and the associated knot transformations in four-band systems remains unexplored.Here,we propose a theoretical model of NH four-band braiding,provide its phase diagram,and establish its trivial,Abelian,and non-Abelian braiding rules.Additionally,we report on special knots,such as the Hopf and Solomon links in braided knots,and reveal that their transformations are accompanied by and mediated through exceptional points.Our work provides a detailed case for studying NH multiband braiding and knot structures in four-band systems,which could offer insights for topological photonics and analog information processing applications.
基金supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A04013)the National Natural Science Foundation of China(82204610)+1 种基金the Qihang Talent Program(L2022046)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.
基金financially supported by the National Key Research and Development Program of China(2021YFF0703600)。
文摘Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detection of porcine deltacoronavirus.The fluorescent microsphere-based lateral flow test strip demonstrated a sensitivity of 10~(1.7)TCID_(50)/0.1 mL,which is fourfold higher than that of the colloidal gold-based assay.Porcine deltacoronavirus(PDCoV)is a recently identified enteric coronavirus that causes an acute infectious disease in piglets,leading to diarrhea,vomiting,dehydration,and mortality(Hu et al.2015).
基金Supported by Clinical Medical Technology Innovation Guidance Project of Hunan Province:2017SK50114。
文摘Objective To observe the influences of electroacupuncture at the combination of back-shu and front-mu points on insulin sensitivity indicators and somatological parameter indicators in the patients with obesity complicated with insulin resistance.Methods A total of 60 patients with obesity and insulin resistance were randomized into a control group(30 cases,4 cases of them dropped out)and a trial group(30 cases,2 cases of them dropped out).In the control group,the intervention with diet and exercise were provided.In the trial group,on the base of the treatment as the control group,electroacupuncture was added at the combination of back-shu points and front-mu points,3 times weekly.The duration of treatment was 12 weeks in two groups.The therapeutic effect and the somatological parameter indicators(body mass[BW],body mass index[BMI],waist circumference[WC],waist-to-hip ratio[WHR])as well as the insulin sensitivity indicators(fasting plasma glucose[FPG],fasting insulin[FIN],insulin sensitivity index[ISI]and insulin resistance index[HOMA-IR])before and after treatment were compared between two groups.Results①The effective rate was 92.86%in the trial group and was 57.69%in the control group.The effective rate of the trial group was higher than the control group,indicating the statistical difference(P<0.01).②BW,BMI,WC and WHR after treatment were all reduced obviously as compared with before treatment in two groups(all P<0.01).After treatment,BMI,WC and WHR in the trial group were all lower than those in the control group(all P<0.05)and the differences in BW,BMI,WC and WHR before and after treatment in the trial group were larger than those in the control group(all P<0.01).③After treatment,FIN and HOMA-IR were all lower significantly than those before treatment in two group and ISI was increased significantly as compared with before treatment(all P<0.01).After treatment,FPG was reduced significantly as compared with before treatment in the trial group(P<0.01)and the difference in FPG was not significant statistically in the control group(P>0.05).After treatment,FPG and HOMA-IR in the trial group were lower than the control group and ISI was higher than the control group(all P<0.05).Besides,the differences in FPG,FIN,ISI and HOMA-IR before and after treatment in the trial group were larger significantly than those in the control group(P<0.01,P<0.05).Conclusion Electroacupuncture at the combination of back-shu and front-mu points in association with the intervention with diet and exercise is effective on obesity complicated with insulin resistance.The effects of this combined therapy are superior as compared with simple intervention with diet and exercise in body mass,body mass index,waist circumference and waist-to-lip ratio as well as fasting blood glucose,fasting insulin,insulin sensitivity index and insulin resistance index in patients.
基金funded by the Beijing Municipal Administration of Hospitals Incubating Program(No.PZ2022032).
文摘Ojective:To explored the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and its mechanism from the aspect of the anti-inflammatory response.Background:Bipolar disorder is a very common,often misdiagnosed mental disorder strongly associated with comorbidity,disability,and premature mortality.Bipolar depression(ie,depressive episode in bipolar disorder)is poorly responsive to available treatments.Acupuncture at back-shu points of five zang and Geshu(BL 17),a prescription from Dr.Leting Wang,is a popular therapy for depression in China.Its effectiveness and safety for bipolar depression are yet to be verified by clinical studies.Methods:The study is a single-center,prospective,randomized controlled trial involving 72 patients diagnosed with bipolar depression.Participants will be randomized either to the study group or the control group in a 1:1 ratio.All participants will receive mood stabilizer therapy.In addition,the study group will receive acupuncture therapy at back-shu points of five zang and Geshu(BL 17),three times per week.The control group will orally take the antidepressant bupropion.Observation and intervention will last for 8 consecutive weeks.Outcome measurements include Hamilton Depression Rating Scale-17,Hamilton Anxiety Rating Scale,Clinical Global Impression Scale,Young Manic Rating Scale,Treatment Emergent Symptom Scale,serum levels of anti-inflammatory cytokines[interleukin-4(IL-40),IL-10,and transforming growth factor–β,pro-inflammatory cytokines(IL-1β,IL-6,and tumor necrosis factor–α),brain-derived neurotrophic factor,and C-reactive protein.Assessments will be conducted at baseline,first,second,fourth,and eighth weeks after randomization.Safety assessments will be performed throughout the study.Discussion:The results of this study are expected to verify the effectiveness and safety of acupuncture at back-shu points of five zang and Geshu(BL 17)for bipolar depression,and explore its therapeutic mechanisms from the point of anti-inflammation.
文摘Objective To observe the effects of electroacupuncture(EA)at different acupoints for fasting blood glucose(FBG)and oral glucose tolerance in type 2 diabetes rats so as to verify the glucose-lowering effects of EA.Methods Total100 SD male rats were used as experimental objects。
文摘Objective： To observe the clinical effect of puncturing Back-Shu points in treating chronic fatigue syndrome. Methods： Twenty-two subjects were recruited and treated by puncturing corresponding Back-Shu points based on syndrome differentiation. The short-form General Health Survey （MOSSF GHS） and the Chalder Questionnaires for Fatigue were adopted for evaluating the therapeutic effects. Results： Of the 22 patients, 4 cases showed a marked effect, 11 got effect, 7 got failure, and the total effective rate was 68.2%. Conclusion： Puncturing Back-Shu points is effective in relieving the symptoms of chronic fatigue syndrome and enhancing the patients＇ health standard.
