The TiB+TiC dual-reinforced B_(4)C/TC4 composite was in-situ fabricated via incorporating 0.5wt%B_(4)C reinforcement during the laser melting deposition process.Different heat treatments of annealing and solid solutio...The TiB+TiC dual-reinforced B_(4)C/TC4 composite was in-situ fabricated via incorporating 0.5wt%B_(4)C reinforcement during the laser melting deposition process.Different heat treatments of annealing and solid solution were used to regulate the microstructure,mechanical properties,and corrosion properties of B_(4)C/TC4 composite.Results show that with the increase in temperature from 500℃to 800°C,partial lamellarα-Ti in the as-deposited sample is gradually transformed into equiaxedα-Ti,accompanied by the disappearance of basketweave microstructure.At 1100°C,a small portion of TiC phase suffers fusion.This composite exhibits the optimal combination of strength and plasticity after annealing at 500℃for 4 h followed by furnace cooling,which is attributed to the stress release effect and the refined basketweave microstructure.However,this composite shows a decline in corrosion resistance after various heat treatments due to grain coarsening and micro-galvanic corrosion.展开更多
目的:探究拉莫三嗪联合维生素B_(6)治疗小儿难治性癫痫的效果。方法:本研究纳入80例难治性癫痫患儿,均为2022年1月—2024年8月于上饶市人民医院接受治疗,按照随机数字表法将其分为两组:对照组(n=40)采用丙戊酸钠联合维生素B_(6)治疗,观...目的:探究拉莫三嗪联合维生素B_(6)治疗小儿难治性癫痫的效果。方法:本研究纳入80例难治性癫痫患儿,均为2022年1月—2024年8月于上饶市人民医院接受治疗,按照随机数字表法将其分为两组:对照组(n=40)采用丙戊酸钠联合维生素B_(6)治疗,观察组(n=40)采用拉莫三嗪联合维生素B_(6)治疗。对比观察组和对照组患者疗效、脑损伤指标、儿童癫痫生活质量量表简版(quality of life in childhood epilepsy-16,QOLCE-16)评分及不良反应发生情况。结果:治疗6个月后,相较于对照组,观察组总有效率更高(P<0.05);治疗前两组血清中胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)、S-100β蛋白(S-100βprotein,S-100β)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)水平比较,差异无统计学意义(P>0.05);治疗6个月后两组均显著降低且观察组水平均低于对照组(P<0.05);治疗前,两组QOLCE-16评分差异无统计学意义(P>0.05);治疗6个月后,两组QOLCE-16评分均显著升高且观察组各项评分均较对照组高(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:拉莫三嗪联合维生素B_(6)治疗小儿难治性癫痫在提高疗效、降低脑损伤指标和提升生活质量方面均较好,并且安全性与丙戊酸钠联合维生素B_(6)治疗相当。展开更多
基金Tianjin Municipal Natural Science Foundation(23JCYBJC00040)National Natural Science Foundation of China(52175369)。
文摘The TiB+TiC dual-reinforced B_(4)C/TC4 composite was in-situ fabricated via incorporating 0.5wt%B_(4)C reinforcement during the laser melting deposition process.Different heat treatments of annealing and solid solution were used to regulate the microstructure,mechanical properties,and corrosion properties of B_(4)C/TC4 composite.Results show that with the increase in temperature from 500℃to 800°C,partial lamellarα-Ti in the as-deposited sample is gradually transformed into equiaxedα-Ti,accompanied by the disappearance of basketweave microstructure.At 1100°C,a small portion of TiC phase suffers fusion.This composite exhibits the optimal combination of strength and plasticity after annealing at 500℃for 4 h followed by furnace cooling,which is attributed to the stress release effect and the refined basketweave microstructure.However,this composite shows a decline in corrosion resistance after various heat treatments due to grain coarsening and micro-galvanic corrosion.
文摘目的:探究拉莫三嗪联合维生素B_(6)治疗小儿难治性癫痫的效果。方法:本研究纳入80例难治性癫痫患儿,均为2022年1月—2024年8月于上饶市人民医院接受治疗,按照随机数字表法将其分为两组:对照组(n=40)采用丙戊酸钠联合维生素B_(6)治疗,观察组(n=40)采用拉莫三嗪联合维生素B_(6)治疗。对比观察组和对照组患者疗效、脑损伤指标、儿童癫痫生活质量量表简版(quality of life in childhood epilepsy-16,QOLCE-16)评分及不良反应发生情况。结果:治疗6个月后,相较于对照组,观察组总有效率更高(P<0.05);治疗前两组血清中胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)、S-100β蛋白(S-100βprotein,S-100β)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)水平比较,差异无统计学意义(P>0.05);治疗6个月后两组均显著降低且观察组水平均低于对照组(P<0.05);治疗前,两组QOLCE-16评分差异无统计学意义(P>0.05);治疗6个月后,两组QOLCE-16评分均显著升高且观察组各项评分均较对照组高(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:拉莫三嗪联合维生素B_(6)治疗小儿难治性癫痫在提高疗效、降低脑损伤指标和提升生活质量方面均较好,并且安全性与丙戊酸钠联合维生素B_(6)治疗相当。
