A human semicircular canal(HSC)with“cupulolithiasis”(HSCC)causes abnormal perception and vertigo.Based on 3D printing technology and target tracking technology,models of a visualized bionic semicircular canal with c...A human semicircular canal(HSC)with“cupulolithiasis”(HSCC)causes abnormal perception and vertigo.Based on 3D printing technology and target tracking technology,models of a visualized bionic semicircular canal with cupulolithiasis(BSCC)were generated.The model,with careful scaling parameters,similar biomechanical responses to the vestibular-ocular reflex(VOR),and a similarly long time constant to the HSC,allows us to study the mechanics of the HSCC.The static experiments revealed that the bionic cupula of the BSCC continued to shift due to the effect of the gravity of the otolith after rotation stopped.The frequency broadband experiment indicated that the gain of the BSCC decreased as the phase difference increased,and the increase in otolith mass aggravated this trend.BSCCs can be used as a bionic model to study the pathology of human semicircular canal-related diseases and may promote the development of treatments.展开更多
基金supported by the National Key Research and Development Program of China(No.2024YFD2000203)the National Natural Science Foundation of China(No.51775483).
文摘A human semicircular canal(HSC)with“cupulolithiasis”(HSCC)causes abnormal perception and vertigo.Based on 3D printing technology and target tracking technology,models of a visualized bionic semicircular canal with cupulolithiasis(BSCC)were generated.The model,with careful scaling parameters,similar biomechanical responses to the vestibular-ocular reflex(VOR),and a similarly long time constant to the HSC,allows us to study the mechanics of the HSCC.The static experiments revealed that the bionic cupula of the BSCC continued to shift due to the effect of the gravity of the otolith after rotation stopped.The frequency broadband experiment indicated that the gain of the BSCC decreased as the phase difference increased,and the increase in otolith mass aggravated this trend.BSCCs can be used as a bionic model to study the pathology of human semicircular canal-related diseases and may promote the development of treatments.
